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Q9Y5Q6

- INSL5_HUMAN

UniProt

Q9Y5Q6 - INSL5_HUMAN

Protein

Insulin-like peptide INSL5

Gene

INSL5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor.

    Keywords - Molecular functioni

    Hormone

    Enzyme and pathway databases

    ReactomeiREACT_19231. G alpha (i) signalling events.
    REACT_21314. Relaxin receptors.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Insulin-like peptide INSL5
    Short name:
    Insulin-like peptide 5
    Cleaved into the following 2 chains:
    Gene namesi
    Name:INSL5
    ORF Names:UNQ156/PRO182
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:6088. INSL5.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Reactome

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29895.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 22221 PublicationAdd
    BLAST
    Peptidei23 – 4624Insulin-like peptide INSL5 B chainPRO_0000016163Add
    BLAST
    Propeptidei49 – 11466Connecting peptideSequence AnalysisPRO_0000016164Add
    BLAST
    Peptidei115 – 13521Insulin-like peptide INSL5 A chainPRO_0000016165Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi29 ↔ 122Interchain (between B and A chains)1 Publication
    Disulfide bondi41 ↔ 135Interchain (between B and A chains)1 Publication
    Modified residuei115 – 1151Pyrrolidone carboxylic acid1 Publication
    Disulfide bondi121 ↔ 1261 Publication

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Pyrrolidone carboxylic acid

    Proteomic databases

    PaxDbiQ9Y5Q6.
    PRIDEiQ9Y5Q6.

    Expressioni

    Tissue specificityi

    Highly expressed in rectum with lower levels in uterus and ascending and descending colon.1 Publication

    Gene expression databases

    BgeeiQ9Y5Q6.
    CleanExiHS_INSL5.
    GenevestigatoriQ9Y5Q6.

    Organism-specific databases

    HPAiCAB033849.
    HPA030100.

    Interactioni

    Subunit structurei

    Heterodimer of a B chain and an A chain linked by two disulfide bonds.

    Protein-protein interaction databases

    STRINGi9606.ENSP00000302724.

    Structurei

    Secondary structure

    1
    135
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi31 – 4515
    Turni116 – 1183
    Helixi119 – 1235
    Helixi128 – 1314
    Turni132 – 1343

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2K1VNMR-A116-135[»]
    2KBCNMR-A116-135[»]
    B23-46[»]
    ProteinModelPortaliQ9Y5Q6.
    SMRiQ9Y5Q6. Positions 21-46, 110-135.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9Y5Q6.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the insulin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG38979.
    HOGENOMiHOG000111888.
    HOVERGENiHBG052135.
    InParanoidiQ9Y5Q6.
    OMAiIRTVIYI.
    OrthoDBiEOG73V6N0.
    PhylomeDBiQ9Y5Q6.
    TreeFamiTF333404.

    Family and domain databases

    InterProiIPR016179. Insulin-like.
    IPR022353. Insulin_CS.
    [Graphical view]
    PfamiPF00049. Insulin. 1 hit.
    [Graphical view]
    SMARTiSM00078. IlGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF56994. SSF56994. 2 hits.
    PROSITEiPS00262. INSULIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9Y5Q6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKGSIFTLFL FSVLFAISEV RSKESVRLCG LEYIRTVIYI CASSRWRRHQ    50
    EGIPQAQQAE TGNSFQLPHK REFSEENPAQ NLPKVDASGE DRLWGGQMPT 100
    EELWKSKKHS VMSRQDLQTL CCTDGCSMTD LSALC 135
    Length:135
    Mass (Da):15,333
    Last modified:September 2, 2008 - v2
    Checksum:iA932D7EDE9D173F5
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti50 – 501Q → L.3 Publications
    Corresponds to variant rs549148 [ dbSNP | Ensembl ].
    VAR_046099

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF133816 mRNA. Translation: AAD29686.1.
    AY359030 mRNA. Translation: AAQ89389.1.
    AL354978 Genomic DNA. Translation: CAH71844.1.
    BC101646 mRNA. Translation: AAI01647.1.
    BC101648 mRNA. Translation: AAI01649.1.
    CCDSiCCDS634.1.
    RefSeqiNP_005469.2. NM_005478.4.
    UniGeneiHs.251380.

    Genome annotation databases

    EnsembliENST00000304526; ENSP00000302724; ENSG00000172410.
    GeneIDi10022.
    KEGGihsa:10022.
    UCSCiuc001dcw.3. human.

    Polymorphism databases

    DMDMi205371762.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF133816 mRNA. Translation: AAD29686.1 .
    AY359030 mRNA. Translation: AAQ89389.1 .
    AL354978 Genomic DNA. Translation: CAH71844.1 .
    BC101646 mRNA. Translation: AAI01647.1 .
    BC101648 mRNA. Translation: AAI01649.1 .
    CCDSi CCDS634.1.
    RefSeqi NP_005469.2. NM_005478.4.
    UniGenei Hs.251380.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2K1V NMR - A 116-135 [» ]
    2KBC NMR - A 116-135 [» ]
    B 23-46 [» ]
    ProteinModelPortali Q9Y5Q6.
    SMRi Q9Y5Q6. Positions 21-46, 110-135.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000302724.

    Polymorphism databases

    DMDMi 205371762.

    Proteomic databases

    PaxDbi Q9Y5Q6.
    PRIDEi Q9Y5Q6.

    Protocols and materials databases

    DNASUi 10022.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000304526 ; ENSP00000302724 ; ENSG00000172410 .
    GeneIDi 10022.
    KEGGi hsa:10022.
    UCSCi uc001dcw.3. human.

    Organism-specific databases

    CTDi 10022.
    GeneCardsi GC01M067223.
    H-InvDB HIX0028561.
    HGNCi HGNC:6088. INSL5.
    HPAi CAB033849.
    HPA030100.
    MIMi 606413. gene.
    neXtProti NX_Q9Y5Q6.
    PharmGKBi PA29895.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG38979.
    HOGENOMi HOG000111888.
    HOVERGENi HBG052135.
    InParanoidi Q9Y5Q6.
    OMAi IRTVIYI.
    OrthoDBi EOG73V6N0.
    PhylomeDBi Q9Y5Q6.
    TreeFami TF333404.

    Enzyme and pathway databases

    Reactomei REACT_19231. G alpha (i) signalling events.
    REACT_21314. Relaxin receptors.

    Miscellaneous databases

    EvolutionaryTracei Q9Y5Q6.
    GeneWikii INSL5.
    GenomeRNAii 10022.
    NextBioi 37869.
    PROi Q9Y5Q6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9Y5Q6.
    CleanExi HS_INSL5.
    Genevestigatori Q9Y5Q6.

    Family and domain databases

    InterProi IPR016179. Insulin-like.
    IPR022353. Insulin_CS.
    [Graphical view ]
    Pfami PF00049. Insulin. 1 hit.
    [Graphical view ]
    SMARTi SM00078. IlGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56994. SSF56994. 2 hits.
    PROSITEi PS00262. INSULIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of INSL5, a new member of the insulin superfamily."
      Conklin D., Lofton-Day C.E., Haldeman B.A., Ching A., Whitmore T.E., Lok S., Jaspers S.
      Genomics 60:50-56(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT LEU-50.
      Tissue: Colon.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-50.
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-50.
      Tissue: Brain.
    5. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 23-37.
    6. Cited for: BINDING TO RXFP4.
    7. Cited for: SYNTHESIS OF 23-46 AND 115-135, DISULFIDE BONDS, PYROGLUTAMATE FORMATION AT GLN-115.
    8. "Structure of human insulin-like peptide 5 and characterization of conserved hydrogen bonds and electrostatic interactions within the relaxin framework."
      Haugaard-Joensson L.M., Hossain M.A., Daly N.L., Craik D.J., Wade J.D., Rosengren K.J.
      Biochem. J. 419:619-627(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 23-46 AND 115-135.

    Entry informationi

    Entry nameiINSL5_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y5Q6
    Secondary accession number(s): Q3MIY4, Q5VYD8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: September 2, 2008
    Last modified: October 1, 2014
    This is version 118 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3