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Reviewed, UniProtKB/Swiss-Prot Q9Y5Q3 (MAFB_HUMAN)

Last modified November 4, 2008. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Transcription factor MafB
Alternative name(s):
    V-maf musculoaponeurotic fibrosarcoma oncogene homolog B
Gene names
Name: MAFB
Synonyms: KRML
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length323 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells By similarity.

Subunit structure

Interacts with the intracellular cytoplasmic domain of LRP1 (LRPICD). This interaction results in a moderate reduction of MAFB transcriptional potential.

Subcellular location

NucleusBy similarity.

Domain

The leucine-zipper domain is involved in the interaction with LRPICD.

Sequence similarities

Belongs to the bZIP family. Maf subfamily.

Contains 1 bZIP domain.

Ontologies

Keywords

   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   LigandDNA-binding
   Molecular functionRepressor

Gene Ontology (GO)

   Biological processnegative regulation of erythrocyte differentiation

Inferred from direct assay. Source: UniProtKB

sensory organ development

Traceable author statement. Source: ProtInc

   Cellular componentcytoplasm

Inferred from direct assay. Source: HPA

nucleus

Traceable author statement. Source: ProtInc

   Molecular functiontranscription factor binding

Inferred from direct assay. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 323323Transcription factor MafB
PRO_0000076494

Regions

Domain266 – 28722Leucine-zipper
DNA binding238 – 26427Basic motif
Compositional bias131 – 14313Poly-His
Compositional bias158 – 16710Poly-His

Experimental info

Sequence conflict521A → V in AAD30106. Ref.1
Sequence conflict2411Q → H in AAD30106. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9Y5Q3-1 [UniParc].

Last modified July 11, 2002. Version 2.
Checksum: A0F3C09F8936CB16

FASTA32335,792
        10         20         30         40         50         60 
MAAELSMGPE LPTSPLAMEY VNDFDLLKFD VKKEPLGRAE RPGRPCTRLQ PAGSVSSTPL 

        70         80         90        100        110        120 
STPCSSVPSS PSFSPTEQKT HLEDLYWMAS NYQQMNPEAL NLTPEDAVEA LIGSHPVPQP 

       130        140        150        160        170        180 
LQSFDSFRGA HHHHHHHHPH PHHAYPGAGV AHDELGPHAH PHHHHHHQAS PPPSSAASPA 

       190        200        210        220        230        240 
QQLPTSHPGP GPHATASATA AGGNGSVEDR FSDDQLVSMS VRELNRHLRG FTKDEVIRLK 

       250        260        270        280        290        300 
QKRRTLKNRG YAQSCRYKRV QQKHHLENEK TQLIQQVEQL KQEVSRLARE RDAYKVKCEK 

       310        320 
LANSGFREAG STSDSPSSPE FFL 

« Hide

References

« Hide 'large scale' references
[1]"Human KRML (MAFB): cDNA cloning, genomic structure, and evaluation as a candidate tumor suppressor gene in myeloid leukemias."
Wang P.W., Eisenbart J.D., Cordes S.P., Barsh G.S., Stoffel M., Le Beau M.M.
Genomics 59:275-281(1999) [PubMed: 10444328] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Bone marrow.
[2]"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. expand/collapse author list , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
Nature 414:865-871(2001) [PubMed: 11780052] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[4]"Low-density lipoprotein receptor-related protein interacts with MafB, a regulator of hindbrain development."
Petersen H.H., Hilpert J., Jacobsen C., Lauwers A., Roebroek A.J.M., Willnow T.E.
FEBS Lett. 565:23-27(2004) [PubMed: 15135046] [Abstract]
Cited for: INTERACTION WITH LRP1.
+Additional computationally mapped references.

Cross-references

Sequence databases

AF134157 mRNA. Translation: AAD30106.1.
AL035665 Genomic DNA. Translation: CAB75863.1.
BC028098 mRNA. Translation: AAH28098.1.
BC036689 mRNA. Translation: AAH36689.1.
RefSeqNP_005452.2.
UniGeneHs.702085

3D structure databases

HSSPHSSP built from PDB template 1K1V based on UniProtKB O54790.
ModBaseSearch...

PTM databases

PhosphoSiteQ9Y5Q3.

Genome annotation databases

EnsemblENSG00000204103. Homo sapiens. [Contig view]
GeneID9935.
KEGGhsa:9935.

Organism-specific databases

H-InvDBHIX0015816.
HGNCHGNC:6408. MAFB.
HPAHPA005653.
MIM608968. gene.
PharmGKBPA30535.
GenAtlasSearch...
GeneCardsSearch...

Phylogenomic databases

HOGENOMQ9Y5Q3.
HOVERGENQ9Y5Q3.

Gene expression databases

ArrayExpressQ9Y5Q3.
CleanExHS_MAFB.
GermOnlineENSG00000204103. Homo sapiens.

Family and domain databases

InterProIPR013592. Maf_TF_N.
IPR004827. TF_bZIP.
IPR004826. TF_Maf.
[Graphical view]
PfamPF03131. bZIP_Maf. 1 hit.
PF08383. Maf_N. 1 hit.
[Graphical view]
SMARTSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. False negative.
[Graphical view]
BLOCKSSearch...
ProtoNetSearch...

Other Resources

NextBio37480.
SOURCESearch...

Entry information

Entry nameMAFB_HUMAN
AccessionPrimary (citable) accession number: Q9Y5Q3
Secondary accession number(s): Q9H1F1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: July 11, 2002
Last modified: November 4, 2008
This is version 63 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 20

Human chromosome 20: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents