Reviewed, UniProtKB/Swiss-Prot Q9Y5Q3 (MAFB_HUMAN)

Names and origin

Protein names

Recommended name:
    Transcription factor MafB
Alternative name(s):
    V-maf musculoaponeurotic fibrosarcoma oncogene homolog B

Gene names

Name:	MAFB
Synonyms:	KRML

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	323 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells By similarity.
Subunit structure	Interacts with the intracellular cytoplasmic domain of LRP1 (LRPICD). This interaction results in a moderate reduction of MAFB transcriptional potential.
Subcellular location	NucleusBy similarity.
Domain	The leucine-zipper domain is involved in the interaction with LRPICD.
Sequence similarities	Belongs to the bZIP family. Maf subfamily. Contains 1 bZIP domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Ligand	DNA-binding
Molecular function	Repressor
Gene Ontology (GO)
Biological process	negative regulation of erythrocyte differentiation Inferred from direct assay. Source: UniProtKB sensory organ development Traceable author statement. Source: ProtInc
Cellular component	cytoplasm Inferred from direct assay. Source: HPA nucleus Traceable author statement. Source: ProtInc
Molecular function	transcription factor binding Inferred from direct assay. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 323	323	Transcription factor MafB		PRO_0000076494
Regions
	Domain	266 – 287	22	Leucine-zipper
	DNA binding	238 – 264	27	Basic motif
	Compositional bias	131 – 143	13	Poly-His
	Compositional bias	158 – 167	10	Poly-His
Experimental info
	Sequence conflict	52	1	A → V in AAD30106. Ref.1
	Sequence conflict	241	1	Q → H in AAD30106. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9Y5Q3-1 [UniParc]. Last modified July 11, 2002. Version 2. Checksum: A0F3C09F8936CB16	FASTA	323	35,792
	10 20 30 40 50 60 MAAELSMGPE LPTSPLAMEY VNDFDLLKFD VKKEPLGRAE RPGRPCTRLQ PAGSVSSTPL 70 80 90 100 110 120 STPCSSVPSS PSFSPTEQKT HLEDLYWMAS NYQQMNPEAL NLTPEDAVEA LIGSHPVPQP 130 140 150 160 170 180 LQSFDSFRGA HHHHHHHHPH PHHAYPGAGV AHDELGPHAH PHHHHHHQAS PPPSSAASPA 190 200 210 220 230 240 QQLPTSHPGP GPHATASATA AGGNGSVEDR FSDDQLVSMS VRELNRHLRG FTKDEVIRLK 250 260 270 280 290 300 QKRRTLKNRG YAQSCRYKRV QQKHHLENEK TQLIQQVEQL KQEVSRLARE RDAYKVKCEK 310 320 LANSGFREAG STSDSPSSPE FFL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human KRML (MAFB): cDNA cloning, genomic structure, and evaluation as a candidate tumor suppressor gene in myeloid leukemias." Wang P.W., Eisenbart J.D., Cordes S.P., Barsh G.S., Stoffel M., Le Beau M.M. Genomics 59:275-281(1999) [PubMed: 10444328] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Bone marrow.
[2]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed: 11780052] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[4]	"Low-density lipoprotein receptor-related protein interacts with MafB, a regulator of hindbrain development." Petersen H.H., Hilpert J., Jacobsen C., Lauwers A., Roebroek A.J.M., Willnow T.E. FEBS Lett. 565:23-27(2004) [PubMed: 15135046] [Abstract] Cited for: INTERACTION WITH LRP1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF134157 mRNA. Translation: AAD30106.1. AL035665 Genomic DNA. Translation: CAB75863.1. BC028098 mRNA. Translation: AAH28098.1. BC036689 mRNA. Translation: AAH36689.1.
RefSeq	NP_005452.2.
UniGene	Hs.702085
3D structure databases
HSSP	HSSP built from PDB template 1K1V based on UniProtKB O54790.
ModBase	Search...
PTM databases
PhosphoSite	Q9Y5Q3.
Genome annotation databases
Ensembl	ENSG00000204103. Homo sapiens. [Contig view]
GeneID	9935.
KEGG	hsa:9935.
Organism-specific databases
H-InvDB	HIX0015816.
HGNC	HGNC:6408. MAFB.
HPA	HPA005653.
MIM	608968. gene.
PharmGKB	PA30535.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	Q9Y5Q3.
HOVERGEN	Q9Y5Q3.
Gene expression databases
ArrayExpress	Q9Y5Q3.
CleanEx	HS_MAFB.
GermOnline	ENSG00000204103. Homo sapiens.
Family and domain databases
InterPro	IPR013592. Maf_TF_N. IPR004827. TF_bZIP. IPR004826. TF_Maf. [Graphical view]
Pfam	PF03131. bZIP_Maf. 1 hit. PF08383. Maf_N. 1 hit. [Graphical view]
SMART	SM00338. BRLZ. 1 hit. [Graphical view]
PROSITE	PS50217. BZIP. 1 hit. PS00036. BZIP_BASIC. False negative. [Graphical view]
BLOCKS	Search...
ProtoNet	Search...
Other Resources
NextBio	37480.
SOURCE	Search...

Entry information

Entry name

MAFB_HUMAN

Accession

Primary (citable) accession number: Q9Y5Q3
Secondary accession number(s): Q9H1F1

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2002
Last sequence update:	July 11, 2002
Last modified:	November 4, 2008
This is version 63 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)