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Q9Y5Q3

- MAFB_HUMAN

UniProt

Q9Y5Q3 - MAFB_HUMAN

Protein

Transcription factor MafB

Gene

MAFB

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 2 (11 Jul 2002)
      Previous versions | rss
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    Functioni

    Acts as a transcriptional activator or repressor. Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter By similarity. Involved either as an oncogene or as a tumor suppressor, depending on the cell context.By similarity1 Publication

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. sequence-specific DNA binding Source: InterPro
    3. sequence-specific DNA binding transcription factor activity Source: InterPro
    4. transcription factor binding Source: UniProtKB

    GO - Biological processi

    1. brain segmentation Source: Ensembl
    2. inner ear morphogenesis Source: Ensembl
    3. negative regulation of erythrocyte differentiation Source: UniProtKB
    4. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    5. respiratory gaseous exchange Source: Ensembl
    6. rhombomere 5 development Source: Ensembl
    7. rhombomere 6 development Source: Ensembl
    8. segment specification Source: Ensembl
    9. sensory organ development Source: ProtInc
    10. T cell differentiation in thymus Source: Ensembl
    11. thymus development Source: Ensembl
    12. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription factor MafB
    Short name:
    Maf-B
    Alternative name(s):
    V-maf musculoaponeurotic fibrosarcoma oncogene homolog B
    Gene namesi
    Name:MAFB
    Synonyms:KRML
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:6408. MAFB.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: ProtInc
    2. transcription factor complex Source: Ensembl

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    Multicentric carpotarsal osteolysis syndrome (MCTO) [MIM:166300]: A rare skeletal disorder, usually presenting in early childhood with a clinical picture mimicking juvenile rheumatoid arthritis. Progressive destruction of the carpal and tarsal bone usually occurs and other bones may also be involved. Chronic renal failure is a frequent component of the syndrome. Mental retardation and minor facial anomalies have been noted in some patients.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti54 – 541S → L in MCTO. 1 Publication
    VAR_067979
    Natural varianti59 – 591P → L in MCTO. 1 Publication
    VAR_067980
    Natural varianti62 – 621T → P in MCTO. 1 Publication
    VAR_067981
    Natural varianti63 – 631P → R in MCTO. 1 Publication
    VAR_067982
    Natural varianti66 – 661S → C in MCTO. 1 Publication
    VAR_067983
    Natural varianti69 – 691S → L in MCTO. 1 Publication
    VAR_067984
    Natural varianti70 – 701S → A in MCTO. 1 Publication
    VAR_067985
    Natural varianti70 – 701S → L in MCTO. 1 Publication
    VAR_067986
    Natural varianti71 – 711P → L in MCTO. 1 Publication
    VAR_067987
    Natural varianti71 – 711P → S in MCTO. 1 Publication
    VAR_067988

    Keywords - Diseasei

    Disease mutation, Proto-oncogene, Tumor suppressor

    Organism-specific databases

    MIMi166300. phenotype.
    Orphaneti2774. Multicentric carpo-tarsal osteolysis with or without nephropathy.
    PharmGKBiPA30535.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 323323Transcription factor MafBPRO_0000076494Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki32 – 32Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
    Cross-linki297 – 297Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity

    Post-translational modificationi

    Phosphorylated by GSK3 and MAPK13 on serine and threonine residues.2 Publications
    Sumoylated. Sumoylation on Lys-32 and Lys-297 stimulates its transcriptional repression activity and promotes macrophage differentiation from myeloid progenitors By similarity.By similarity

    Keywords - PTMi

    Isopeptide bond, Ubl conjugation

    Proteomic databases

    PaxDbiQ9Y5Q3.
    PRIDEiQ9Y5Q3.

    PTM databases

    PhosphoSiteiQ9Y5Q3.

    Expressioni

    Tissue specificityi

    Ubiquitous.1 Publication

    Gene expression databases

    BgeeiQ9Y5Q3.
    CleanExiHS_MAFB.
    GenevestigatoriQ9Y5Q3.

    Organism-specific databases

    HPAiHPA005653.

    Interactioni

    Subunit structurei

    Homodimer or heterodimer with other bHLH-Zip transcription factors. Binds DNA as a homodimer or a heterodimer. Forms homodimers and heterodimers with FOS, FOSB and FOSL2, but not with JUN proteins (JUN, JUNB and JUND). Interacts with PAX6; the interaction is direct. Interacts with ETS1 and LRP1 By similarity. Interacts with the intracellular cytoplasmic domain of LRP1 (LRPICD); the interaction results in a moderate reduction of MAFB transcriptional potential.By similarity1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    IRF3Q146534EBI-3649340,EBI-2650369

    Protein-protein interaction databases

    BioGridi115261. 14 interactions.
    IntActiQ9Y5Q3. 5 interactions.
    STRINGi9606.ENSP00000362410.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y5Q3.
    SMRiQ9Y5Q3. Positions 211-297.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini238 – 30164bZIPPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni238 – 26326Basic motifPROSITE-ProRule annotationAdd
    BLAST
    Regioni266 – 28722Leucine-zipperPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi131 – 14313Poly-HisAdd
    BLAST
    Compositional biasi158 – 16710Poly-His

    Domaini

    The leucine-zipper domain is involved in the interaction with LRPICD.

    Sequence similaritiesi

    Belongs to the bZIP family. Maf subfamily.Curated
    Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG241084.
    HOGENOMiHOG000261683.
    HOVERGENiHBG000313.
    InParanoidiQ9Y5Q3.
    KOiK09036.
    OMAiHPHHGYP.
    OrthoDBiEOG7BGHMQ.
    PhylomeDBiQ9Y5Q3.
    TreeFamiTF325689.

    Family and domain databases

    Gene3Di1.10.880.10. 1 hit.
    InterProiIPR004827. bZIP.
    IPR004826. bZIP_Maf.
    IPR013592. Maf_TF_N.
    IPR028571. MafB.
    IPR008917. TF_DNA-bd.
    IPR024874. Transciption_factor_Maf.
    [Graphical view]
    PANTHERiPTHR10129. PTHR10129. 1 hit.
    PTHR10129:SF10. PTHR10129:SF10. 1 hit.
    PfamiPF03131. bZIP_Maf. 1 hit.
    PF08383. Maf_N. 1 hit.
    [Graphical view]
    SMARTiSM00338. BRLZ. 1 hit.
    [Graphical view]
    SUPFAMiSSF47454. SSF47454. 1 hit.
    PROSITEiPS50217. BZIP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Y5Q3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAELSMGPE LPTSPLAMEY VNDFDLLKFD VKKEPLGRAE RPGRPCTRLQ    50
    PAGSVSSTPL STPCSSVPSS PSFSPTEQKT HLEDLYWMAS NYQQMNPEAL 100
    NLTPEDAVEA LIGSHPVPQP LQSFDSFRGA HHHHHHHHPH PHHAYPGAGV 150
    AHDELGPHAH PHHHHHHQAS PPPSSAASPA QQLPTSHPGP GPHATASATA 200
    AGGNGSVEDR FSDDQLVSMS VRELNRHLRG FTKDEVIRLK QKRRTLKNRG 250
    YAQSCRYKRV QQKHHLENEK TQLIQQVEQL KQEVSRLARE RDAYKVKCEK 300
    LANSGFREAG STSDSPSSPE FFL 323
    Length:323
    Mass (Da):35,792
    Last modified:July 11, 2002 - v2
    Checksum:iA0F3C09F8936CB16
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti52 – 521A → V in AAD30106. (PubMed:10444328)Curated
    Sequence conflicti241 – 2411Q → H in AAD30106. (PubMed:10444328)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti54 – 541S → L in MCTO. 1 Publication
    VAR_067979
    Natural varianti59 – 591P → L in MCTO. 1 Publication
    VAR_067980
    Natural varianti62 – 621T → P in MCTO. 1 Publication
    VAR_067981
    Natural varianti63 – 631P → R in MCTO. 1 Publication
    VAR_067982
    Natural varianti66 – 661S → C in MCTO. 1 Publication
    VAR_067983
    Natural varianti69 – 691S → L in MCTO. 1 Publication
    VAR_067984
    Natural varianti70 – 701S → A in MCTO. 1 Publication
    VAR_067985
    Natural varianti70 – 701S → L in MCTO. 1 Publication
    VAR_067986
    Natural varianti71 – 711P → L in MCTO. 1 Publication
    VAR_067987
    Natural varianti71 – 711P → S in MCTO. 1 Publication
    VAR_067988

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF134157 mRNA. Translation: AAD30106.1.
    AK027324 mRNA. Translation: BAG51303.1.
    AL035665 Genomic DNA. Translation: CAB75863.1.
    CH471077 Genomic DNA. Translation: EAW76000.1.
    BC028098 mRNA. Translation: AAH28098.1.
    BC036689 mRNA. Translation: AAH36689.1.
    CCDSiCCDS13311.1.
    RefSeqiNP_005452.2. NM_005461.4.
    UniGeneiHs.169487.

    Genome annotation databases

    EnsembliENST00000373313; ENSP00000362410; ENSG00000204103.
    GeneIDi9935.
    KEGGihsa:9935.
    UCSCiuc002xji.3. human.

    Polymorphism databases

    DMDMi21759268.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF134157 mRNA. Translation: AAD30106.1 .
    AK027324 mRNA. Translation: BAG51303.1 .
    AL035665 Genomic DNA. Translation: CAB75863.1 .
    CH471077 Genomic DNA. Translation: EAW76000.1 .
    BC028098 mRNA. Translation: AAH28098.1 .
    BC036689 mRNA. Translation: AAH36689.1 .
    CCDSi CCDS13311.1.
    RefSeqi NP_005452.2. NM_005461.4.
    UniGenei Hs.169487.

    3D structure databases

    ProteinModelPortali Q9Y5Q3.
    SMRi Q9Y5Q3. Positions 211-297.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115261. 14 interactions.
    IntActi Q9Y5Q3. 5 interactions.
    STRINGi 9606.ENSP00000362410.

    PTM databases

    PhosphoSitei Q9Y5Q3.

    Polymorphism databases

    DMDMi 21759268.

    Proteomic databases

    PaxDbi Q9Y5Q3.
    PRIDEi Q9Y5Q3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000373313 ; ENSP00000362410 ; ENSG00000204103 .
    GeneIDi 9935.
    KEGGi hsa:9935.
    UCSCi uc002xji.3. human.

    Organism-specific databases

    CTDi 9935.
    GeneCardsi GC20M039314.
    HGNCi HGNC:6408. MAFB.
    HPAi HPA005653.
    MIMi 166300. phenotype.
    608968. gene.
    neXtProti NX_Q9Y5Q3.
    Orphaneti 2774. Multicentric carpo-tarsal osteolysis with or without nephropathy.
    PharmGKBi PA30535.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG241084.
    HOGENOMi HOG000261683.
    HOVERGENi HBG000313.
    InParanoidi Q9Y5Q3.
    KOi K09036.
    OMAi HPHHGYP.
    OrthoDBi EOG7BGHMQ.
    PhylomeDBi Q9Y5Q3.
    TreeFami TF325689.

    Miscellaneous databases

    ChiTaRSi MAFB. human.
    GeneWikii MAFB_(gene).
    GenomeRNAii 9935.
    NextBioi 37480.
    PROi Q9Y5Q3.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9Y5Q3.
    CleanExi HS_MAFB.
    Genevestigatori Q9Y5Q3.

    Family and domain databases

    Gene3Di 1.10.880.10. 1 hit.
    InterProi IPR004827. bZIP.
    IPR004826. bZIP_Maf.
    IPR013592. Maf_TF_N.
    IPR028571. MafB.
    IPR008917. TF_DNA-bd.
    IPR024874. Transciption_factor_Maf.
    [Graphical view ]
    PANTHERi PTHR10129. PTHR10129. 1 hit.
    PTHR10129:SF10. PTHR10129:SF10. 1 hit.
    Pfami PF03131. bZIP_Maf. 1 hit.
    PF08383. Maf_N. 1 hit.
    [Graphical view ]
    SMARTi SM00338. BRLZ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47454. SSF47454. 1 hit.
    PROSITEi PS50217. BZIP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human KRML (MAFB): cDNA cloning, genomic structure, and evaluation as a candidate tumor suppressor gene in myeloid leukemias."
      Wang P.W., Eisenbart J.D., Cordes S.P., Barsh G.S., Stoffel M., Le Beau M.M.
      Genomics 59:275-281(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Bone marrow.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo.
    3. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    6. "Low-density lipoprotein receptor-related protein interacts with MafB, a regulator of hindbrain development."
      Petersen H.H., Hilpert J., Jacobsen C., Lauwers A., Roebroek A.J.M., Willnow T.E.
      FEBS Lett. 565:23-27(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH LRP1.
    7. Cited for: PHOSPHORYLATION.
    8. Cited for: PHOSPHORYLATION.
    9. Cited for: REVIEW, FUNCTION.
    10. "Multicentric carpotarsal osteolysis is caused by mutations clustering in the amino-terminal transcriptional activation domain of MAFB."
      Zankl A., Duncan E.L., Leo P.J., Clark G.R., Glazov E.A., Addor M.C., Herlin T., Kim C.A., Leheup B.P., McGill J., McTaggart S., Mittas S., Mitchell A.L., Mortier G.R., Robertson S.P., Schroeder M., Terhal P., Brown M.A.
      Am. J. Hum. Genet. 90:494-501(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS MCTO LEU-54; LEU-59; PRO-62; ARG-63; CYS-66; LEU-69; ALA-70; LEU-70; SER-71 AND LEU-71.

    Entry informationi

    Entry nameiMAFB_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y5Q3
    Secondary accession number(s): B3KNE1, Q9H1F1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2002
    Last sequence update: July 11, 2002
    Last modified: October 1, 2014
    This is version 118 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3