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Protein

Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta

Gene

PPP2R3B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

Miscellaneous

The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi401 – 412PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

  • cell cycle arrest Source: ProtInc
  • protein dephosphorylation Source: UniProtKB

Keywordsi

LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-113501. Inhibition of replication initiation of damaged DNA by RB1/E2F1.
R-HSA-69231. Cyclin D associated events in G1.
R-HSA-69273. Cyclin A/B1 associated events during G2/M transition.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta
Alternative name(s):
PP2A subunit B isoform PR48
Protein phosphatase 2A 48 kDa regulatory subunit
Gene namesi
Name:PPP2R3B
Synonyms:PPP2R3L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:13417. PPP2R3B.

Subcellular locationi

GO - Cellular componenti

  • nucleoplasm Source: Reactome
  • nucleus Source: ProtInc
  • protein phosphatase type 2A complex Source: UniProtKB

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi28227.
OpenTargetsiENSG00000167393.
PharmGKBiPA134878872.

Polymorphism and mutation databases

BioMutaiPPP2R3B.
DMDMi158523346.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000714441 – 575Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit betaAdd BLAST575

Proteomic databases

EPDiQ9Y5P8.
PaxDbiQ9Y5P8.
PeptideAtlasiQ9Y5P8.
PRIDEiQ9Y5P8.

PTM databases

iPTMnetiQ9Y5P8.
PhosphoSitePlusiQ9Y5P8.

Expressioni

Gene expression databases

BgeeiENSG00000167393.
CleanExiHS_PPP2R3B.
ExpressionAtlasiQ9Y5P8. baseline and differential.
GenevisibleiQ9Y5P8. HS.

Organism-specific databases

HPAiHPA074545.

Interactioni

Subunit structurei

PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with N-terminal region of CDC6.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
DUSP12Q9UNI64EBI-2479826,EBI-715161

Protein-protein interaction databases

BioGridi118179. 19 interactors.
IntActiQ9Y5P8. 9 interactors.
STRINGi9606.ENSP00000375080.

Structurei

Secondary structure

1575
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni122 – 124Combined sources3
Helixi141 – 152Combined sources12
Helixi156 – 158Combined sources3
Beta strandi159 – 161Combined sources3
Helixi162 – 164Combined sources3
Helixi165 – 171Combined sources7
Helixi176 – 178Combined sources3
Helixi179 – 185Combined sources7
Helixi188 – 191Combined sources4
Beta strandi192 – 195Combined sources4
Helixi196 – 209Combined sources14
Helixi213 – 221Combined sources9
Turni224 – 226Combined sources3
Beta strandi227 – 229Combined sources3
Helixi231 – 234Combined sources4
Helixi235 – 244Combined sources10
Helixi246 – 248Combined sources3
Helixi249 – 252Combined sources4
Helixi255 – 257Combined sources3
Helixi258 – 273Combined sources16
Helixi283 – 287Combined sources5
Helixi291 – 297Combined sources7
Turni298 – 300Combined sources3
Helixi304 – 306Combined sources3
Turni308 – 311Combined sources4
Helixi313 – 326Combined sources14
Beta strandi331 – 334Combined sources4
Helixi336 – 341Combined sources6
Turni342 – 344Combined sources3
Helixi349 – 355Combined sources7
Turni356 – 358Combined sources3
Beta strandi359 – 364Combined sources6
Helixi365 – 369Combined sources5
Beta strandi371 – 373Combined sources3
Helixi374 – 385Combined sources12
Helixi390 – 400Combined sources11
Beta strandi405 – 409Combined sources5
Helixi410 – 425Combined sources16
Turni426 – 428Combined sources3
Helixi434 – 445Combined sources12
Beta strandi448 – 451Combined sources4
Beta strandi452 – 454Combined sources3
Helixi455 – 461Combined sources7
Helixi464 – 472Combined sources9
Helixi477 – 479Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4I5LX-ray2.43B/E122-490[»]
4I5NX-ray2.80B/E122-490[»]
4MEWX-ray1.99A130-483[»]
ProteinModelPortaliQ9Y5P8.
SMRiQ9Y5P8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini388 – 423EF-handPROSITE-ProRule annotationAdd BLAST36

Phylogenomic databases

eggNOGiKOG2562. Eukaryota.
ENOG410XRBK. LUCA.
GeneTreeiENSGT00530000063265.
HOGENOMiHOG000265086.
HOVERGENiHBG000010.
KOiK11583.
OMAiAKACECP.
OrthoDBiEOG091G03UQ.
PhylomeDBiQ9Y5P8.
TreeFamiTF105554.

Family and domain databases

InterProiView protein in InterPro
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
PfamiView protein in Pfam
PF13499. EF-hand_7. 1 hit.
SUPFAMiSSF47473. SSF47473. 2 hits.
PROSITEiView protein in PROSITE
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y5P8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPPGKVLQPV LKMKVDELFL YWLSEASTQR MLQDCLRRIK APGRDQPTPG
60 70 80 90 100
DGEQPGAWPT APLAAPRPSG LEPPGTPGPG PALPLGAASS PRNAPHVRGT
110 120 130 140 150
RRSAGTRVVQ TRKEEPLPPA TSQSIPTFYF PRGRPQDSVN VDAVISKIES
160 170 180 190 200
TFARFPHERA TMDDMGLVAK ACGCPLYWKG PLFYGAGGER TGSVSVHKFV
210 220 230 240 250
AMWRKILQNC HDDAAKFVHL LMSPGCNYLV QEDFVPFLQD VVNTHPGLSF
260 270 280 290 300
LKEASEFHSR YITTVIQRIF YAVNRSWSGR ITCAELRRSS FLQNVALLEE
310 320 330 340 350
EADINQLTEF FSYEHFYVIY CKFWELDTDH DLLIDADDLA RHNDHALSTK
360 370 380 390 400
MIDRIFSGAV TRGRKVQKEG KISYADFVWF LISEEDKKTP TSIEYWFRCM
410 420 430 440 450
DLDGDGALSM FELEYFYEEQ CRRLDSMAIE ALPFQDCLCQ MLDLVKPRTE
460 470 480 490 500
GKITLQDLKR CKLANVFFDT FFNIEKYLDH EQKEQISLLR DGDSGGPELS
510 520 530 540 550
DWEKYAAEEY DILVAEETAG EPWEDGFEAE LSPVEQKLSA LRSPLAQRPF
560 570
FEAPSPLGAV DLYEYACGDE DLEPL
Length:575
Mass (Da):65,061
Last modified:September 11, 2007 - v2
Checksum:i9FDE046345C1F85F
GO
Isoform 2 (identifier: Q9Y5P8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-399: Missing.

Show »
Length:176
Mass (Da):20,111
Checksum:i6B819D28EBF3AE5F
GO

Sequence cautioni

The sequence AAD38515 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035109163D → E. Corresponds to variant dbSNP:rs3813594Ensembl.1
Natural variantiVAR_055356519A → V1 PublicationCorresponds to variant dbSNP:rs1133520Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0373101 – 399Missing in isoform 2. 1 PublicationAdd BLAST399

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL954664 Genomic DNA. No translation available.
BX000476 Genomic DNA. No translation available.
BC009032 mRNA. Translation: AAH09032.1.
BC063429 mRNA. Translation: AAH63429.1.
AF135016 mRNA. Translation: AAD38515.1. Different initiation.
BK000521 mRNA. Translation: DAA00385.1.
CCDSiCCDS14104.1. [Q9Y5P8-1]
RefSeqiNP_037371.2. NM_013239.4. [Q9Y5P8-1]
UniGeneiHs.124942.

Genome annotation databases

EnsembliENST00000390665; ENSP00000375080; ENSG00000167393. [Q9Y5P8-1]
GeneIDi28227.
KEGGihsa:28227.
UCSCiuc004cpg.4. human. [Q9Y5P8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiP2R3B_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5P8
Secondary accession number(s): Q6P4G9, Q7RTT1, Q96H01
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: September 11, 2007
Last modified: August 30, 2017
This is version 154 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references