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Q9Y5P8

- P2R3B_HUMAN

UniProt

Q9Y5P8 - P2R3B_HUMAN

Protein

Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta

Gene

PPP2R3B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 126 (01 Oct 2014)
      Sequence version 2 (11 Sep 2007)
      Previous versions | rss
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    Functioni

    The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi401 – 41212PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. phosphoprotein phosphatase activity Source: Reactome
    3. protein binding Source: UniProtKB
    4. protein phosphatase type 2A regulator activity Source: ProtInc
    5. protein serine/threonine phosphatase activity Source: UniProtKB

    GO - Biological processi

    1. cell cycle arrest Source: ProtInc
    2. G1/S transition of mitotic cell cycle Source: Reactome
    3. mitotic cell cycle Source: Reactome
    4. protein dephosphorylation Source: UniProtKB
    5. regulation of catalytic activity Source: GOC

    Keywords - Ligandi

    Calcium, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_329. Inhibition of replication initiation of damaged DNA by RB1/E2F1.
    REACT_821. Cyclin D associated events in G1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta
    Alternative name(s):
    PP2A subunit B isoform PR48
    Protein phosphatase 2A 48 kDa regulatory subunit
    Gene namesi
    Name:PPP2R3B
    Synonyms:PPP2R3L
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:13417. PPP2R3B.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. nucleoplasm Source: Reactome
    2. nucleus Source: ProtInc
    3. protein phosphatase type 2A complex Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134878872.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 575575Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit betaPRO_0000071444Add
    BLAST

    Proteomic databases

    MaxQBiQ9Y5P8.
    PaxDbiQ9Y5P8.
    PRIDEiQ9Y5P8.

    PTM databases

    PhosphoSiteiQ9Y5P8.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9Y5P8.
    BgeeiQ9Y5P8.
    CleanExiHS_PPP2R3B.
    GenevestigatoriQ9Y5P8.

    Interactioni

    Subunit structurei

    PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with N-terminal region of CDC6.1 Publication

    Protein-protein interaction databases

    BioGridi118179. 6 interactions.
    IntActiQ9Y5P8. 6 interactions.
    STRINGi9606.ENSP00000375080.

    Structurei

    Secondary structure

    1
    575
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni122 – 1243
    Helixi141 – 15212
    Helixi156 – 1583
    Beta strandi159 – 1613
    Helixi162 – 1643
    Helixi165 – 1717
    Helixi176 – 1783
    Helixi179 – 1857
    Turni186 – 1927
    Helixi196 – 20914
    Helixi213 – 2219
    Turni224 – 2263
    Helixi231 – 2344
    Helixi235 – 24410
    Helixi246 – 2516
    Beta strandi253 – 2553
    Helixi256 – 27318
    Helixi283 – 2886
    Helixi291 – 2977
    Turni298 – 3003
    Helixi304 – 3063
    Turni308 – 3114
    Helixi313 – 32412
    Beta strandi331 – 3355
    Helixi336 – 34510
    Helixi349 – 3557
    Turni356 – 3583
    Beta strandi359 – 3646
    Helixi365 – 3695
    Beta strandi371 – 3733
    Helixi374 – 38512
    Helixi390 – 40011
    Beta strandi405 – 4084
    Helixi410 – 42516
    Turni426 – 4283
    Helixi434 – 44512
    Beta strandi448 – 4514
    Helixi455 – 4617
    Helixi464 – 4729
    Helixi474 – 4774

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4I5LX-ray2.43B/E122-490[»]
    4I5NX-ray2.80B/E122-490[»]
    ProteinModelPortaliQ9Y5P8.
    SMRiQ9Y5P8. Positions 121-478.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini388 – 42336EF-handPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 EF-hand domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG271066.
    HOGENOMiHOG000265086.
    HOVERGENiHBG000010.
    InParanoidiQ9Y5P8.
    KOiK11583.
    OMAiEMPSHLA.
    OrthoDBiEOG7XWPN3.
    PhylomeDBiQ9Y5P8.
    TreeFamiTF105554.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    [Graphical view]
    PfamiPF13499. EF-hand_7. 1 hit.
    [Graphical view]
    PROSITEiPS00018. EF_HAND_1. 1 hit.
    PS50222. EF_HAND_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9Y5P8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPPGKVLQPV LKMKVDELFL YWLSEASTQR MLQDCLRRIK APGRDQPTPG    50
    DGEQPGAWPT APLAAPRPSG LEPPGTPGPG PALPLGAASS PRNAPHVRGT 100
    RRSAGTRVVQ TRKEEPLPPA TSQSIPTFYF PRGRPQDSVN VDAVISKIES 150
    TFARFPHERA TMDDMGLVAK ACGCPLYWKG PLFYGAGGER TGSVSVHKFV 200
    AMWRKILQNC HDDAAKFVHL LMSPGCNYLV QEDFVPFLQD VVNTHPGLSF 250
    LKEASEFHSR YITTVIQRIF YAVNRSWSGR ITCAELRRSS FLQNVALLEE 300
    EADINQLTEF FSYEHFYVIY CKFWELDTDH DLLIDADDLA RHNDHALSTK 350
    MIDRIFSGAV TRGRKVQKEG KISYADFVWF LISEEDKKTP TSIEYWFRCM 400
    DLDGDGALSM FELEYFYEEQ CRRLDSMAIE ALPFQDCLCQ MLDLVKPRTE 450
    GKITLQDLKR CKLANVFFDT FFNIEKYLDH EQKEQISLLR DGDSGGPELS 500
    DWEKYAAEEY DILVAEETAG EPWEDGFEAE LSPVEQKLSA LRSPLAQRPF 550
    FEAPSPLGAV DLYEYACGDE DLEPL 575
    Length:575
    Mass (Da):65,061
    Last modified:September 11, 2007 - v2
    Checksum:i9FDE046345C1F85F
    GO
    Isoform 2 (identifier: Q9Y5P8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-399: Missing.

    Show »
    Length:176
    Mass (Da):20,111
    Checksum:i6B819D28EBF3AE5F
    GO

    Sequence cautioni

    The sequence AAD38515.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti163 – 1631D → E.
    Corresponds to variant rs3813594 [ dbSNP | Ensembl ].
    VAR_035109
    Natural varianti519 – 5191A → V.1 Publication
    Corresponds to variant rs1133520 [ dbSNP | Ensembl ].
    VAR_055356

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 399399Missing in isoform 2. 1 PublicationVSP_037310Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL954664 Genomic DNA. No translation available.
    BX000476 Genomic DNA. No translation available.
    BC009032 mRNA. Translation: AAH09032.1.
    BC063429 mRNA. Translation: AAH63429.1.
    AF135016 mRNA. Translation: AAD38515.1. Different initiation.
    BK000521 mRNA. Translation: DAA00385.1.
    CCDSiCCDS14104.1. [Q9Y5P8-1]
    RefSeqiNP_037371.2. NM_013239.4. [Q9Y5P8-1]
    XP_005274485.1. XM_005274428.2.
    XP_005274834.1. XM_005274777.2.
    XP_006724505.1. XM_006724442.1.
    XP_006724926.1. XM_006724863.1.
    XP_006725712.1. XM_006725649.1.
    UniGeneiHs.124942.

    Genome annotation databases

    EnsembliENST00000390665; ENSP00000375080; ENSG00000167393. [Q9Y5P8-1]
    GeneIDi102725016.
    28227.
    KEGGihsa:102725016.
    hsa:28227.
    UCSCiuc004cpf.3. human. [Q9Y5P8-2]
    uc004cpg.3. human. [Q9Y5P8-1]

    Polymorphism databases

    DMDMi158523346.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL954664 Genomic DNA. No translation available.
    BX000476 Genomic DNA. No translation available.
    BC009032 mRNA. Translation: AAH09032.1 .
    BC063429 mRNA. Translation: AAH63429.1 .
    AF135016 mRNA. Translation: AAD38515.1 . Different initiation.
    BK000521 mRNA. Translation: DAA00385.1 .
    CCDSi CCDS14104.1. [Q9Y5P8-1 ]
    RefSeqi NP_037371.2. NM_013239.4. [Q9Y5P8-1 ]
    XP_005274485.1. XM_005274428.2.
    XP_005274834.1. XM_005274777.2.
    XP_006724505.1. XM_006724442.1.
    XP_006724926.1. XM_006724863.1.
    XP_006725712.1. XM_006725649.1.
    UniGenei Hs.124942.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4I5L X-ray 2.43 B/E 122-490 [» ]
    4I5N X-ray 2.80 B/E 122-490 [» ]
    ProteinModelPortali Q9Y5P8.
    SMRi Q9Y5P8. Positions 121-478.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 118179. 6 interactions.
    IntActi Q9Y5P8. 6 interactions.
    STRINGi 9606.ENSP00000375080.

    PTM databases

    PhosphoSitei Q9Y5P8.

    Polymorphism databases

    DMDMi 158523346.

    Proteomic databases

    MaxQBi Q9Y5P8.
    PaxDbi Q9Y5P8.
    PRIDEi Q9Y5P8.

    Protocols and materials databases

    DNASUi 28227.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000390665 ; ENSP00000375080 ; ENSG00000167393 . [Q9Y5P8-1 ]
    GeneIDi 102725016.
    28227.
    KEGGi hsa:102725016.
    hsa:28227.
    UCSCi uc004cpf.3. human. [Q9Y5P8-2 ]
    uc004cpg.3. human. [Q9Y5P8-1 ]

    Organism-specific databases

    CTDi 28227.
    GeneCardsi GC0XM000264.
    H-InvDB HIX0038850.
    HIX0176522.
    HIX0177602.
    HGNCi HGNC:13417. PPP2R3B.
    MIMi 300339. gene.
    neXtProti NX_Q9Y5P8.
    PharmGKBi PA134878872.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG271066.
    HOGENOMi HOG000265086.
    HOVERGENi HBG000010.
    InParanoidi Q9Y5P8.
    KOi K11583.
    OMAi EMPSHLA.
    OrthoDBi EOG7XWPN3.
    PhylomeDBi Q9Y5P8.
    TreeFami TF105554.

    Enzyme and pathway databases

    Reactomei REACT_329. Inhibition of replication initiation of damaged DNA by RB1/E2F1.
    REACT_821. Cyclin D associated events in G1.

    Miscellaneous databases

    GeneWikii PPP2R3B.
    GenomeRNAii 28227.
    NextBioi 50538.
    PROi Q9Y5P8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y5P8.
    Bgeei Q9Y5P8.
    CleanExi HS_PPP2R3B.
    Genevestigatori Q9Y5P8.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    [Graphical view ]
    Pfami PF13499. EF-hand_7. 1 hit.
    [Graphical view ]
    PROSITEi PS00018. EF_HAND_1. 1 hit.
    PS50222. EF_HAND_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT VAL-519.
      Tissue: Brain.
    3. "PR48, a novel regulatory subunit of protein phosphatase 2A, interacts with cdc6 and modulates DNA replication in human cells."
      Yan Z., Fedorov S.A., Mumby M.C., Williams R.S.
      Mol. Cell. Biol. 20:1021-1029(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 125-475, SUBCELLULAR LOCATION, INTERACTION WITH CDC6.
      Tissue: Placenta.
    4. "Identification and characterization of B''-subunits of protein phosphatase 2 A in Xenopus laevis oocytes and adult tissues."
      Stevens I., Janssens V., Martens E., Dilworth S., Goris J., Van Hoof C.
      Eur. J. Biochem. 270:376-387(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION OF MISSING N-TERMINAL SEQUENCE.
    5. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiP2R3B_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y5P8
    Secondary accession number(s): Q6P4G9, Q7RTT1, Q96H01
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: September 11, 2007
    Last modified: October 1, 2014
    This is version 126 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3