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Protein

Retinoic acid-induced protein 2

Gene

RAI2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • embryo development Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Retinoic acid-induced protein 2
Gene namesi
Name:RAI2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:9835. RAI2.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34193.

Polymorphism and mutation databases

BioMutaiRAI2.
DMDMi205371817.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 530530Retinoic acid-induced protein 2PRO_0000097161Add
BLAST

Proteomic databases

PaxDbiQ9Y5P3.
PeptideAtlasiQ9Y5P3.
PRIDEiQ9Y5P3.

PTM databases

iPTMnetiQ9Y5P3.
PhosphoSiteiQ9Y5P3.

Expressioni

Gene expression databases

BgeeiQ9Y5P3.
CleanExiHS_RAI2.
ExpressionAtlasiQ9Y5P3. baseline and differential.
GenevisibleiQ9Y5P3. HS.

Organism-specific databases

HPAiHPA051054.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CTBP2P565454EBI-746228,EBI-741533
CTBP2Q8IY443EBI-746228,EBI-10171902
FHL2Q141923EBI-746228,EBI-701903
SGTBQ96EQ04EBI-746228,EBI-744081
UBQLN4Q9NRR53EBI-746228,EBI-711226

Protein-protein interaction databases

BioGridi115965. 9 interactions.
IntActiQ9Y5P3. 12 interactions.
MINTiMINT-1447745.
STRINGi9606.ENSP00000333456.

Structurei

3D structure databases

ProteinModelPortaliQ9Y5P3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi200 – 25354Pro-richAdd
BLAST

Phylogenomic databases

eggNOGiENOG410IE37. Eukaryota.
ENOG4110FZK. LUCA.
GeneTreeiENSGT00730000111296.
HOGENOMiHOG000133031.
HOVERGENiHBG017703.
InParanoidiQ9Y5P3.
OMAiKSVPWLK.
OrthoDBiEOG7DZ8JT.
PhylomeDBiQ9Y5P3.
TreeFamiTF331261.

Family and domain databases

InterProiIPR026092. RAI2/SOBP.
[Graphical view]
PANTHERiPTHR23186. PTHR23186. 1 hit.
PfamiPF15279. SOBP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y5P3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDDLQSQNLS MDMTDSPPAL ANNRLENGMA QLITTEAWNI NSTDLVKKAL
60 70 80 90 100
VTVPAPSILN PPAESQSGMA LKVAATVLQP LCLGESPVVM PIHMQVEGSS
110 120 130 140 150
APELNPNGNA TYVMTTQGPV QLPVVLEQHV FQHLNSPLVL PQEAPCSSST
160 170 180 190 200
IHNNLFQGAE DPEAQPQLLD LRIPSQPQEP TLPFEAVLQN LFPSQGTLGP
210 220 230 240 250
PPCQPPPGYA PVPPQPFSSP LSPLVPPATL LVPYPVIVPL PVPVPIPIPI
260 270 280 290 300
PMPQSSESKF SSSFPKPPSS FGLHPFKGTQ TPLEKDELKP FDILQPKEYF
310 320 330 340 350
QLSRHTVIKM GSENEALDLS MKSVPWLKAG EVSPPIFQED AALDLSVAAH
360 370 380 390 400
RKSEPPPETL YDSGASVDSS GHTVMEKLPS GMEISFAPAT SHEAPAMMDS
410 420 430 440 450
HISSSDAATE MLSQPNHPSG EVKAENNIEM VGESQAAKVI VSVEDAVPTI
460 470 480 490 500
FCGKIKGLSG VSTKNFSFKR EDSVLQGYDI NSQGEESMGN AEPLRKPIKN
510 520 530
RSIKLKKVNS QEIHMLPIKK QRLATFFPRK
Length:530
Mass (Da):57,180
Last modified:September 2, 2008 - v2
Checksum:iF5BEE12367961C9A
GO
Isoform 2 (identifier: Q9Y5P3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     46-95: Missing.

Note: No experimental confirmation available.
Show »
Length:480
Mass (Da):52,035
Checksum:iC6C67BE6340854CD
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti252 – 2521M → V.3 Publications
Corresponds to variant rs6527818 [ dbSNP | Ensembl ].
VAR_046100
Natural varianti342 – 3421A → P.1 Publication
Corresponds to variant rs17855524 [ dbSNP | Ensembl ].
VAR_046101

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei46 – 9550Missing in isoform 2. 1 PublicationVSP_047524Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF136587 Genomic DNA. Translation: AAD33688.1.
AK298873 mRNA. Translation: BAG60991.1.
Z93242 Genomic DNA. Translation: CAI42725.1.
BC027937 mRNA. Translation: AAH27937.1.
CCDSiCCDS14183.1. [Q9Y5P3-1]
CCDS55374.1. [Q9Y5P3-2]
RefSeqiNP_001166203.1. NM_001172732.1.
NP_001166210.1. NM_001172739.1.
NP_001166214.1. NM_001172743.1.
NP_068557.3. NM_021785.4.
XP_006724522.1. XM_006724459.2. [Q9Y5P3-1]
XP_006724523.1. XM_006724460.1. [Q9Y5P3-1]
XP_011543741.1. XM_011545439.1. [Q9Y5P3-1]
XP_011543742.1. XM_011545440.1. [Q9Y5P3-1]
XP_011543743.1. XM_011545441.1. [Q9Y5P3-1]
UniGeneiHs.446680.

Genome annotation databases

EnsembliENST00000331511; ENSP00000333456; ENSG00000131831. [Q9Y5P3-1]
ENST00000360011; ENSP00000353106; ENSG00000131831. [Q9Y5P3-1]
ENST00000415486; ENSP00000392578; ENSG00000131831. [Q9Y5P3-2]
ENST00000451717; ENSP00000401323; ENSG00000131831. [Q9Y5P3-1]
ENST00000545871; ENSP00000444210; ENSG00000131831. [Q9Y5P3-1]
GeneIDi10742.
KEGGihsa:10742.
UCSCiuc004cyf.4. human. [Q9Y5P3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF136587 Genomic DNA. Translation: AAD33688.1.
AK298873 mRNA. Translation: BAG60991.1.
Z93242 Genomic DNA. Translation: CAI42725.1.
BC027937 mRNA. Translation: AAH27937.1.
CCDSiCCDS14183.1. [Q9Y5P3-1]
CCDS55374.1. [Q9Y5P3-2]
RefSeqiNP_001166203.1. NM_001172732.1.
NP_001166210.1. NM_001172739.1.
NP_001166214.1. NM_001172743.1.
NP_068557.3. NM_021785.4.
XP_006724522.1. XM_006724459.2. [Q9Y5P3-1]
XP_006724523.1. XM_006724460.1. [Q9Y5P3-1]
XP_011543741.1. XM_011545439.1. [Q9Y5P3-1]
XP_011543742.1. XM_011545440.1. [Q9Y5P3-1]
XP_011543743.1. XM_011545441.1. [Q9Y5P3-1]
UniGeneiHs.446680.

3D structure databases

ProteinModelPortaliQ9Y5P3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115965. 9 interactions.
IntActiQ9Y5P3. 12 interactions.
MINTiMINT-1447745.
STRINGi9606.ENSP00000333456.

PTM databases

iPTMnetiQ9Y5P3.
PhosphoSiteiQ9Y5P3.

Polymorphism and mutation databases

BioMutaiRAI2.
DMDMi205371817.

Proteomic databases

PaxDbiQ9Y5P3.
PeptideAtlasiQ9Y5P3.
PRIDEiQ9Y5P3.

Protocols and materials databases

DNASUi10742.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000331511; ENSP00000333456; ENSG00000131831. [Q9Y5P3-1]
ENST00000360011; ENSP00000353106; ENSG00000131831. [Q9Y5P3-1]
ENST00000415486; ENSP00000392578; ENSG00000131831. [Q9Y5P3-2]
ENST00000451717; ENSP00000401323; ENSG00000131831. [Q9Y5P3-1]
ENST00000545871; ENSP00000444210; ENSG00000131831. [Q9Y5P3-1]
GeneIDi10742.
KEGGihsa:10742.
UCSCiuc004cyf.4. human. [Q9Y5P3-1]

Organism-specific databases

CTDi10742.
GeneCardsiRAI2.
HGNCiHGNC:9835. RAI2.
HPAiHPA051054.
MIMi300217. gene.
neXtProtiNX_Q9Y5P3.
PharmGKBiPA34193.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE37. Eukaryota.
ENOG4110FZK. LUCA.
GeneTreeiENSGT00730000111296.
HOGENOMiHOG000133031.
HOVERGENiHBG017703.
InParanoidiQ9Y5P3.
OMAiKSVPWLK.
OrthoDBiEOG7DZ8JT.
PhylomeDBiQ9Y5P3.
TreeFamiTF331261.

Miscellaneous databases

GeneWikiiRAI2.
GenomeRNAii10742.
PROiQ9Y5P3.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y5P3.
CleanExiHS_RAI2.
ExpressionAtlasiQ9Y5P3. baseline and differential.
GenevisibleiQ9Y5P3. HS.

Family and domain databases

InterProiIPR026092. RAI2/SOBP.
[Graphical view]
PANTHERiPTHR23186. PTHR23186. 1 hit.
PfamiPF15279. SOBP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of the human homologue (RAI2) of a mouse retinoic acid-induced gene in Xp22."
    Walpole S.M., Hiriyana K.T., Nicolaou A., Bingham E.L., Durham J., Vaudin M., Ross M.T., Yates J.R.W., Sieving P.A., Trump D.
    Genomics 55:275-283(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-252.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT VAL-252.
  3. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS VAL-252 AND PRO-342.
    Tissue: Lung.

Entry informationi

Entry nameiRAI2_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5P3
Secondary accession number(s): B1B1K2
, B4DQM9, E7EMN4, Q8N6X7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: September 2, 2008
Last modified: July 6, 2016
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.