Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Chondrosarcoma-associated gene 2/3 protein

Gene

CSAG2

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Drug-resistance related protein, its expression is associated with the chemotherapy resistant and neoplastic phenotype. May also be linked to the malignant phenotype.

GO - Biological processi

  • response to drug Source: ProtInc
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Chondrosarcoma-associated gene 2/3 protein
Alternative name(s):
Cancer/testis antigen 24.2
Short name:
CT24.2
Taxol-resistant-associated gene 3 protein
Short name:
TRAG-3
Gene namesi
Name:CSAG2
Synonyms:TRAG3
AND
Name:CSAG3
Synonyms:CSAG3A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:16847. CSAG2.
HGNC:26237. CSAG3.

Pathology & Biotechi

Organism-specific databases

DisGeNETi102723547.
389903.
PharmGKBiPA134919230.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000793901 – 127Chondrosarcoma-associated gene 2/3 proteinAdd BLAST127

Proteomic databases

PRIDEiQ9Y5P2.

PTM databases

iPTMnetiQ9Y5P2.
PhosphoSitePlusiQ9Y5P2.

Expressioni

Tissue specificityi

Weakly expressed in kidney. Expressed in various tumor cell lines including carcinomas, myeloid and lymphoid malignancies, melanomas and prostate cancer. Overexpressed in taxol-resistant breast cancer line MDA 435TR and the doxorubicin-resistant multiple myelanoma lines RPMI-8226/Dox40 and RPMI-8226/MDR10V.

Gene expression databases

CleanExiHS_CSAG3.

Structurei

3D structure databases

ProteinModelPortaliQ9Y5P2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000112006.
HOVERGENiHBG099380.
InParanoidiQ9Y5P2.
PhylomeDBiQ9Y5P2.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y5P2-1) [UniParc]FASTAAdd to basket
Also known as: Long, TRAG-3L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWMGLIQLVE GVKRKDQGFL EKEFYHKTNI KMRCEFLACW PAFTVLGEAW
60 70 80 90 100
RDQVDWSRLL RDAGLVKMSR KPRASSPLSN NHPPTPKRRG SGRHPLNPGP
110 120
EALSKFPRQP GREKGPIKEV PGTKGSP
Length:127
Mass (Da):14,430
Last modified:July 22, 2008 - v2
Checksum:iEC1B2C1758129BCC
GO
Isoform 2 (identifier: Q9Y5P2-2) [UniParc]FASTAAdd to basket
Also known as: Short, TRAG-3S

The sequence of this isoform differs from the canonical sequence as follows:
     89-105: Missing.

Show »
Length:110
Mass (Da):12,675
Checksum:i060CB7D5E3D93027
GO
Isoform 3 (identifier: Q9Y5P2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-67: Missing.
     94-105: Missing.

Show »
Length:48
Mass (Da):5,217
Checksum:iAAEC2A40DBA90889
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti33R → H in AAC29487 (PubMed:10095106).Curated1
Sequence conflicti33R → H in AAD37859 (Ref. 2) Curated1
Sequence conflicti37L → H in AAC29487 (PubMed:10095106).Curated1
Sequence conflicti37L → H in AAD37859 (Ref. 2) Curated1
Sequence conflicti58R → I in AAC29487 (PubMed:10095106).Curated1
Sequence conflicti58R → I in AAD37859 (Ref. 2) Curated1
Sequence conflicti110P → L in AAC29487 (PubMed:10095106).Curated1
Sequence conflicti110P → L in AAD37859 (Ref. 2) Curated1
Sequence conflicti118K → E in AAC29487 (PubMed:10095106).Curated1
Sequence conflicti118K → E in AAD37859 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0349121 – 67Missing in isoform 3. 1 PublicationAdd BLAST67
Alternative sequenceiVSP_00446989 – 105Missing in isoform 2. 2 PublicationsAdd BLAST17
Alternative sequenceiVSP_03491394 – 105Missing in isoform 3. 1 PublicationAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF080246 mRNA. Translation: AAC29487.1.
AF136715 mRNA. Translation: AAD37859.1.
CH471169 Genomic DNA. Translation: EAW99428.1.
BC007228 mRNA. Translation: AAH07228.1.
BC119734 mRNA. Translation: AAI19735.1.
BC119735 mRNA. Translation: AAI19736.1.
RefSeqiNP_001123298.1. NM_001129826.2. [Q9Y5P2-1]
NP_001123300.1. NM_001129828.2. [Q9Y5P2-2]
UniGeneiHs.721609.
Hs.735281.
Hs.741932.

Genome annotation databases

GeneIDi389903.
KEGGihsa:389903.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF080246 mRNA. Translation: AAC29487.1.
AF136715 mRNA. Translation: AAD37859.1.
CH471169 Genomic DNA. Translation: EAW99428.1.
BC007228 mRNA. Translation: AAH07228.1.
BC119734 mRNA. Translation: AAI19735.1.
BC119735 mRNA. Translation: AAI19736.1.
RefSeqiNP_001123298.1. NM_001129826.2. [Q9Y5P2-1]
NP_001123300.1. NM_001129828.2. [Q9Y5P2-2]
UniGeneiHs.721609.
Hs.735281.
Hs.741932.

3D structure databases

ProteinModelPortaliQ9Y5P2.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ9Y5P2.
PhosphoSitePlusiQ9Y5P2.

Proteomic databases

PRIDEiQ9Y5P2.

Protocols and materials databases

DNASUi389903.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi389903.
KEGGihsa:389903.

Organism-specific databases

CTDi389903.
DisGeNETi102723547.
389903.
GeneCardsiCSAG2.
CSAG3.
H-InvDBHIX0010307.
HIX0056157.
HIX0176527.
HIX0176530.
HGNCiHGNC:16847. CSAG2.
HGNC:26237. CSAG3.
neXtProtiNX_Q9Y5P2.
PharmGKBiPA134919230.
GenAtlasiSearch...

Phylogenomic databases

HOGENOMiHOG000112006.
HOVERGENiHBG099380.
InParanoidiQ9Y5P2.
PhylomeDBiQ9Y5P2.

Miscellaneous databases

GenomeRNAii389903.
PROiQ9Y5P2.

Gene expression databases

CleanExiHS_CSAG3.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiCSAG2_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5P2
Secondary accession number(s): O75605, Q0VDC3, Q96IU8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 22, 2008
Last modified: November 2, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.