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Q9Y5P2 (CSAG2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chondrosarcoma-associated gene 2/3 protein
Alternative name(s):
Cancer/testis antigen 24.2
Short name=CT24.2
Taxol-resistant-associated gene 3 protein
Short name=TRAG-3
Gene names
Name:CSAG2
Synonyms:TRAG3
AND
Name:CSAG3
Synonyms:CSAG3A
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length127 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Drug-resistance related protein, its expression is associated with the chemotherapy resistant and neoplastic phenotype. May also be linked to the malignant phenotype.

Tissue specificity

Weakly expressed in kidney. Expressed in various tumor cell lines including carcinomas, myeloid and lymphoid malignancies, melanomas and prostate cancer. Overexpressed in taxol-resistant breast cancer line MDA 435TR and the doxorubicin-resistant multiple myelanoma lines RPMI-8226/Dox40 and RPMI-8226/MDR10V.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processresponse to drug

Traceable author statement Ref.1. Source: ProtInc

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9Y5P2-1)

Also known as: Long; TRAG-3L;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9Y5P2-2)

Also known as: Short; TRAG-3S;

The sequence of this isoform differs from the canonical sequence as follows:
     89-105: Missing.
Isoform 3 (identifier: Q9Y5P2-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-67: Missing.
     94-105: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 127127Chondrosarcoma-associated gene 2/3 protein
PRO_0000079390

Natural variations

Alternative sequence1 – 6767Missing in isoform 3.
VSP_034912
Alternative sequence89 – 10517Missing in isoform 2.
VSP_004469
Alternative sequence94 – 10512Missing in isoform 3.
VSP_034913

Experimental info

Sequence conflict331R → H in AAC29487. Ref.1
Sequence conflict331R → H in AAD37859. Ref.2
Sequence conflict371L → H in AAC29487. Ref.1
Sequence conflict371L → H in AAD37859. Ref.2
Sequence conflict581R → I in AAC29487. Ref.1
Sequence conflict581R → I in AAD37859. Ref.2
Sequence conflict1101P → L in AAC29487. Ref.1
Sequence conflict1101P → L in AAD37859. Ref.2
Sequence conflict1181K → E in AAC29487. Ref.1
Sequence conflict1181K → E in AAD37859. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (Long) (TRAG-3L) [UniParc].

Last modified July 22, 2008. Version 2.
Checksum: EC1B2C1758129BCC

FASTA12714,430
        10         20         30         40         50         60 
MWMGLIQLVE GVKRKDQGFL EKEFYHKTNI KMRCEFLACW PAFTVLGEAW RDQVDWSRLL 

        70         80         90        100        110        120 
RDAGLVKMSR KPRASSPLSN NHPPTPKRRG SGRHPLNPGP EALSKFPRQP GREKGPIKEV 


PGTKGSP 

« Hide

Isoform 2 (Short) (TRAG-3S) [UniParc].

Checksum: 060CB7D5E3D93027
Show »

FASTA11012,675
Isoform 3 [UniParc].

Checksum: AAEC2A40DBA90889
Show »

FASTA485,217

References

« Hide 'large scale' references
[1]"TRAG-3, a novel gene, isolated from a taxol-resistant ovarian carcinoma cell line."
Duan Z., Feller A.J., Toh H.C., Makastorsis T., Seiden M.V.
Gene 229:75-81(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Ovary.
[2]"Identification a novel TRAG-3 variant gene, TRAG-3L, from a taxol-resistant ovarian cancer cell line SKOV-3."
Duan Z., Aynn F., Toh H.C., Seiden M.V.
Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
Tissue: Ovary.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
Tissue: Lung.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF080246 mRNA. Translation: AAC29487.1.
AF136715 mRNA. Translation: AAD37859.1.
CH471169 Genomic DNA. Translation: EAW99428.1.
BC007228 mRNA. Translation: AAH07228.1.
BC119734 mRNA. Translation: AAI19735.1.
BC119735 mRNA. Translation: AAI19736.1.
RefSeqNP_001074317.2. NM_001080848.2.
NP_001123298.1. NM_001129826.1.
NP_001123300.1. NM_001129828.1.
NP_004900.2. NM_004909.3.
UniGeneHs.721609.
Hs.735281.
Hs.741932.

3D structure databases

ProteinModelPortalQ9Y5P2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000349380.

Proteomic databases

PaxDbQ9Y5P2.
PRIDEQ9Y5P2.

Protocols and materials databases

DNASU389903.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID389903.
728461.
KEGGhsa:389903.
hsa:728461.
UCSCuc004ffs.3. human. [Q9Y5P2-1]
uc004fft.3. human. [Q9Y5P2-2]

Organism-specific databases

CTD389903.
728461.
GeneCardsGC0XM151876.
GC0XP151922.
H-InvDBHIX0010307.
HIX0056157.
HIX0176527.
HIX0176530.
HGNCHGNC:16847. CSAG2.
HGNC:26237. CSAG3.
neXtProtNX_Q9Y5P2.
PharmGKBPA134919230.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG75886.
HOGENOMHOG000112006.
HOVERGENHBG099380.
InParanoidQ9Y5P2.
OMALACWPAF.
PhylomeDBQ9Y5P2.

Gene expression databases

CleanExHS_CSAG3.
GenevestigatorQ9Y5P2.

Family and domain databases

ProtoNetSearch...

Other

NextBio103206.
PROQ9Y5P2.

Entry information

Entry nameCSAG2_HUMAN
AccessionPrimary (citable) accession number: Q9Y5P2
Secondary accession number(s): O75605, Q0VDC3, Q96IU8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 22, 2008
Last modified: March 19, 2014
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

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Human chromosome X: entries, gene names and cross-references to MIM