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Q9Y5P2

- CSAG2_HUMAN

UniProt

Q9Y5P2 - CSAG2_HUMAN

Protein

Chondrosarcoma-associated gene 2/3 protein

Gene

CSAG2

more
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Drug-resistance related protein, its expression is associated with the chemotherapy resistant and neoplastic phenotype. May also be linked to the malignant phenotype.

    GO - Biological processi

    1. response to drug Source: ProtInc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chondrosarcoma-associated gene 2/3 protein
    Alternative name(s):
    Cancer/testis antigen 24.2
    Short name:
    CT24.2
    Taxol-resistant-associated gene 3 protein
    Short name:
    TRAG-3
    Gene namesi
    Name:CSAG2
    Synonyms:TRAG3
    AND
    Name:CSAG3
    Synonyms:CSAG3A
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:16847. CSAG2.
    HGNC:26237. CSAG3.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134919230.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 127127Chondrosarcoma-associated gene 2/3 proteinPRO_0000079390Add
    BLAST

    Proteomic databases

    PaxDbiQ9Y5P2.
    PRIDEiQ9Y5P2.

    Expressioni

    Tissue specificityi

    Weakly expressed in kidney. Expressed in various tumor cell lines including carcinomas, myeloid and lymphoid malignancies, melanomas and prostate cancer. Overexpressed in taxol-resistant breast cancer line MDA 435TR and the doxorubicin-resistant multiple myelanoma lines RPMI-8226/Dox40 and RPMI-8226/MDR10V.

    Gene expression databases

    CleanExiHS_CSAG3.
    GenevestigatoriQ9Y5P2.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000349380.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y5P2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG75886.
    HOGENOMiHOG000112006.
    HOVERGENiHBG099380.
    InParanoidiQ9Y5P2.
    OMAiKDQGFLE.
    PhylomeDBiQ9Y5P2.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9Y5P2-1) [UniParc]FASTAAdd to Basket

    Also known as: Long, TRAG-3L

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MWMGLIQLVE GVKRKDQGFL EKEFYHKTNI KMRCEFLACW PAFTVLGEAW    50
    RDQVDWSRLL RDAGLVKMSR KPRASSPLSN NHPPTPKRRG SGRHPLNPGP 100
    EALSKFPRQP GREKGPIKEV PGTKGSP 127
    Length:127
    Mass (Da):14,430
    Last modified:July 22, 2008 - v2
    Checksum:iEC1B2C1758129BCC
    GO
    Isoform 2 (identifier: Q9Y5P2-2) [UniParc]FASTAAdd to Basket

    Also known as: Short, TRAG-3S

    The sequence of this isoform differs from the canonical sequence as follows:
         89-105: Missing.

    Show »
    Length:110
    Mass (Da):12,675
    Checksum:i060CB7D5E3D93027
    GO
    Isoform 3 (identifier: Q9Y5P2-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-67: Missing.
         94-105: Missing.

    Show »
    Length:48
    Mass (Da):5,217
    Checksum:iAAEC2A40DBA90889
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti33 – 331R → H in AAC29487. (PubMed:10095106)Curated
    Sequence conflicti33 – 331R → H in AAD37859. 1 PublicationCurated
    Sequence conflicti37 – 371L → H in AAC29487. (PubMed:10095106)Curated
    Sequence conflicti37 – 371L → H in AAD37859. 1 PublicationCurated
    Sequence conflicti58 – 581R → I in AAC29487. (PubMed:10095106)Curated
    Sequence conflicti58 – 581R → I in AAD37859. 1 PublicationCurated
    Sequence conflicti110 – 1101P → L in AAC29487. (PubMed:10095106)Curated
    Sequence conflicti110 – 1101P → L in AAD37859. 1 PublicationCurated
    Sequence conflicti118 – 1181K → E in AAC29487. (PubMed:10095106)Curated
    Sequence conflicti118 – 1181K → E in AAD37859. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 6767Missing in isoform 3. 1 PublicationVSP_034912Add
    BLAST
    Alternative sequencei89 – 10517Missing in isoform 2. 2 PublicationsVSP_004469Add
    BLAST
    Alternative sequencei94 – 10512Missing in isoform 3. 1 PublicationVSP_034913Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF080246 mRNA. Translation: AAC29487.1.
    AF136715 mRNA. Translation: AAD37859.1.
    CH471169 Genomic DNA. Translation: EAW99428.1.
    BC007228 mRNA. Translation: AAH07228.1.
    BC119734 mRNA. Translation: AAI19735.1.
    BC119735 mRNA. Translation: AAI19736.1.
    RefSeqiNP_001123298.1. NM_001129826.1. [Q9Y5P2-1]
    NP_001123300.1. NM_001129828.1. [Q9Y5P2-2]
    UniGeneiHs.721609.
    Hs.735281.
    Hs.741932.

    Genome annotation databases

    GeneIDi389903.
    KEGGihsa:389903.
    UCSCiuc004ffs.3. human. [Q9Y5P2-1]
    uc004fft.3. human. [Q9Y5P2-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF080246 mRNA. Translation: AAC29487.1 .
    AF136715 mRNA. Translation: AAD37859.1 .
    CH471169 Genomic DNA. Translation: EAW99428.1 .
    BC007228 mRNA. Translation: AAH07228.1 .
    BC119734 mRNA. Translation: AAI19735.1 .
    BC119735 mRNA. Translation: AAI19736.1 .
    RefSeqi NP_001123298.1. NM_001129826.1. [Q9Y5P2-1 ]
    NP_001123300.1. NM_001129828.1. [Q9Y5P2-2 ]
    UniGenei Hs.721609.
    Hs.735281.
    Hs.741932.

    3D structure databases

    ProteinModelPortali Q9Y5P2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000349380.

    Proteomic databases

    PaxDbi Q9Y5P2.
    PRIDEi Q9Y5P2.

    Protocols and materials databases

    DNASUi 389903.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 389903.
    KEGGi hsa:389903.
    UCSCi uc004ffs.3. human. [Q9Y5P2-1 ]
    uc004fft.3. human. [Q9Y5P2-2 ]

    Organism-specific databases

    CTDi 389903.
    GeneCardsi GC0XM151876.
    GC0XP151922.
    H-InvDB HIX0010307.
    HIX0056157.
    HIX0176527.
    HIX0176530.
    HGNCi HGNC:16847. CSAG2.
    HGNC:26237. CSAG3.
    neXtProti NX_Q9Y5P2.
    PharmGKBi PA134919230.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG75886.
    HOGENOMi HOG000112006.
    HOVERGENi HBG099380.
    InParanoidi Q9Y5P2.
    OMAi KDQGFLE.
    PhylomeDBi Q9Y5P2.

    Miscellaneous databases

    NextBioi 103206.
    PROi Q9Y5P2.

    Gene expression databases

    CleanExi HS_CSAG3.
    Genevestigatori Q9Y5P2.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "TRAG-3, a novel gene, isolated from a taxol-resistant ovarian carcinoma cell line."
      Duan Z., Feller A.J., Toh H.C., Makastorsis T., Seiden M.V.
      Gene 229:75-81(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Ovary.
    2. "Identification a novel TRAG-3 variant gene, TRAG-3L, from a taxol-resistant ovarian cancer cell line SKOV-3."
      Duan Z., Aynn F., Toh H.C., Seiden M.V.
      Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Ovary.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
      Tissue: Lung.

    Entry informationi

    Entry nameiCSAG2_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y5P2
    Secondary accession number(s): O75605, Q0VDC3, Q96IU8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: July 22, 2008
    Last modified: October 1, 2014
    This is version 103 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM

    External Data

    Dasty 3