Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Chondrosarcoma-associated gene 2/3 protein

Gene

CSAG2

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Drug-resistance related protein, its expression is associated with the chemotherapy resistant and neoplastic phenotype. May also be linked to the malignant phenotype.

GO - Biological processi

  • response to drug Source: ProtInc
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Chondrosarcoma-associated gene 2/3 protein
Alternative name(s):
Cancer/testis antigen 24.2
Short name:
CT24.2
Taxol-resistant-associated gene 3 protein
Short name:
TRAG-3
Gene namesi
Name:CSAG2
Synonyms:TRAG3
AND
Name:CSAG3
Synonyms:CSAG3A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:16847. CSAG2.
HGNC:26237. CSAG3.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134919230.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 127127Chondrosarcoma-associated gene 2/3 proteinPRO_0000079390Add
BLAST

Proteomic databases

PaxDbiQ9Y5P2.
PRIDEiQ9Y5P2.

Expressioni

Tissue specificityi

Weakly expressed in kidney. Expressed in various tumor cell lines including carcinomas, myeloid and lymphoid malignancies, melanomas and prostate cancer. Overexpressed in taxol-resistant breast cancer line MDA 435TR and the doxorubicin-resistant multiple myelanoma lines RPMI-8226/Dox40 and RPMI-8226/MDR10V.

Gene expression databases

CleanExiHS_CSAG3.
GenevestigatoriQ9Y5P2.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000349380.

Structurei

3D structure databases

ProteinModelPortaliQ9Y5P2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG75886.
HOGENOMiHOG000112006.
HOVERGENiHBG099380.
InParanoidiQ9Y5P2.
OMAiRCEFLAC.
PhylomeDBiQ9Y5P2.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y5P2-1) [UniParc]FASTAAdd to basket

Also known as: Long, TRAG-3L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWMGLIQLVE GVKRKDQGFL EKEFYHKTNI KMRCEFLACW PAFTVLGEAW
60 70 80 90 100
RDQVDWSRLL RDAGLVKMSR KPRASSPLSN NHPPTPKRRG SGRHPLNPGP
110 120
EALSKFPRQP GREKGPIKEV PGTKGSP
Length:127
Mass (Da):14,430
Last modified:July 22, 2008 - v2
Checksum:iEC1B2C1758129BCC
GO
Isoform 2 (identifier: Q9Y5P2-2) [UniParc]FASTAAdd to basket

Also known as: Short, TRAG-3S

The sequence of this isoform differs from the canonical sequence as follows:
     89-105: Missing.

Show »
Length:110
Mass (Da):12,675
Checksum:i060CB7D5E3D93027
GO
Isoform 3 (identifier: Q9Y5P2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-67: Missing.
     94-105: Missing.

Show »
Length:48
Mass (Da):5,217
Checksum:iAAEC2A40DBA90889
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti33 – 331R → H in AAC29487 (PubMed:10095106).Curated
Sequence conflicti33 – 331R → H in AAD37859 (Ref. 2) Curated
Sequence conflicti37 – 371L → H in AAC29487 (PubMed:10095106).Curated
Sequence conflicti37 – 371L → H in AAD37859 (Ref. 2) Curated
Sequence conflicti58 – 581R → I in AAC29487 (PubMed:10095106).Curated
Sequence conflicti58 – 581R → I in AAD37859 (Ref. 2) Curated
Sequence conflicti110 – 1101P → L in AAC29487 (PubMed:10095106).Curated
Sequence conflicti110 – 1101P → L in AAD37859 (Ref. 2) Curated
Sequence conflicti118 – 1181K → E in AAC29487 (PubMed:10095106).Curated
Sequence conflicti118 – 1181K → E in AAD37859 (Ref. 2) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 6767Missing in isoform 3. 1 PublicationVSP_034912Add
BLAST
Alternative sequencei89 – 10517Missing in isoform 2. 2 PublicationsVSP_004469Add
BLAST
Alternative sequencei94 – 10512Missing in isoform 3. 1 PublicationVSP_034913Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF080246 mRNA. Translation: AAC29487.1.
AF136715 mRNA. Translation: AAD37859.1.
CH471169 Genomic DNA. Translation: EAW99428.1.
BC007228 mRNA. Translation: AAH07228.1.
BC119734 mRNA. Translation: AAI19735.1.
BC119735 mRNA. Translation: AAI19736.1.
RefSeqiNP_001123298.1. NM_001129826.2. [Q9Y5P2-1]
NP_001123300.1. NM_001129828.2. [Q9Y5P2-2]
UniGeneiHs.721609.
Hs.735281.
Hs.741932.

Genome annotation databases

GeneIDi389903.
KEGGihsa:389903.
UCSCiuc004ffs.3. human. [Q9Y5P2-1]
uc004fft.3. human. [Q9Y5P2-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF080246 mRNA. Translation: AAC29487.1.
AF136715 mRNA. Translation: AAD37859.1.
CH471169 Genomic DNA. Translation: EAW99428.1.
BC007228 mRNA. Translation: AAH07228.1.
BC119734 mRNA. Translation: AAI19735.1.
BC119735 mRNA. Translation: AAI19736.1.
RefSeqiNP_001123298.1. NM_001129826.2. [Q9Y5P2-1]
NP_001123300.1. NM_001129828.2. [Q9Y5P2-2]
UniGeneiHs.721609.
Hs.735281.
Hs.741932.

3D structure databases

ProteinModelPortaliQ9Y5P2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000349380.

Proteomic databases

PaxDbiQ9Y5P2.
PRIDEiQ9Y5P2.

Protocols and materials databases

DNASUi389903.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi389903.
KEGGihsa:389903.
UCSCiuc004ffs.3. human. [Q9Y5P2-1]
uc004fft.3. human. [Q9Y5P2-2]

Organism-specific databases

CTDi389903.
GeneCardsiGC0XM151876.
GC0XP151922.
H-InvDBHIX0010307.
HIX0056157.
HIX0176527.
HIX0176530.
HGNCiHGNC:16847. CSAG2.
HGNC:26237. CSAG3.
neXtProtiNX_Q9Y5P2.
PharmGKBiPA134919230.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG75886.
HOGENOMiHOG000112006.
HOVERGENiHBG099380.
InParanoidiQ9Y5P2.
OMAiRCEFLAC.
PhylomeDBiQ9Y5P2.

Miscellaneous databases

GenomeRNAii389903.
NextBioi103206.
PROiQ9Y5P2.

Gene expression databases

CleanExiHS_CSAG3.
GenevestigatoriQ9Y5P2.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "TRAG-3, a novel gene, isolated from a taxol-resistant ovarian carcinoma cell line."
    Duan Z., Feller A.J., Toh H.C., Makastorsis T., Seiden M.V.
    Gene 229:75-81(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Ovary.
  2. "Identification a novel TRAG-3 variant gene, TRAG-3L, from a taxol-resistant ovarian cancer cell line SKOV-3."
    Duan Z., Aynn F., Toh H.C., Seiden M.V.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Ovary.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Lung.

Entry informationi

Entry nameiCSAG2_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5P2
Secondary accession number(s): O75605, Q0VDC3, Q96IU8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 22, 2008
Last modified: March 4, 2015
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.