Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Olfactory receptor 51B2

Gene

OR51B2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:G66-31162-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 51B2
Alternative name(s):
Odorant receptor HOR5'beta3
Olfactory receptor 51B1
Gene namesi
Name:OR51B2
Synonyms:OR51B1P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:14703. OR51B2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23ExtracellularSequence analysisAdd BLAST23
Transmembranei24 – 44Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini45 – 52CytoplasmicSequence analysis8
Transmembranei53 – 73Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini74 – 97ExtracellularSequence analysisAdd BLAST24
Transmembranei98 – 118Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini119 – 137CytoplasmicSequence analysisAdd BLAST19
Transmembranei138 – 158Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini159 – 194ExtracellularSequence analysisAdd BLAST36
Transmembranei195 – 215Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini216 – 235CytoplasmicSequence analysisAdd BLAST20
Transmembranei236 – 256Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini257 – 271ExtracellularSequence analysisAdd BLAST15
Transmembranei272 – 292Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini293 – 312CytoplasmicSequence analysisAdd BLAST20

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000279012.
PharmGKBiPA32364.

Polymorphism and mutation databases

BioMutaiOR51B2.
DMDMi296439490.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507451 – 312Olfactory receptor 51B2Add BLAST312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi95 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9Y5P1.
PeptideAtlasiQ9Y5P1.
PRIDEiQ9Y5P1.

PTM databases

iPTMnetiQ9Y5P1.
PhosphoSitePlusiQ9Y5P1.

Expressioni

Gene expression databases

BgeeiENSG00000184881.
CleanExiHS_OR51B2.
ExpressionAtlasiQ9Y5P1. baseline and differential.
GenevisibleiQ9Y5P1. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000327540.

Structurei

3D structure databases

ProteinModelPortaliQ9Y5P1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVJQ. Eukaryota.
ENOG4111CPY. LUCA.
GeneTreeiENSGT00840000129672.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ9Y5P1.
KOiK04257.
OMAiIFYVTVM.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ9Y5P1.
TreeFamiTF342735.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y5P1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWPNITAAPF LLTGFPGLEA AHHWISIPFF AVYVCILLGN GMLLYLIKHD
60 70 80 90 100
HSLHEPMYYF LTMLAGTDLM VTLTTMPTVM GILWVNHREI SSVGCFLQAY
110 120 130 140 150
FIHSLSVVES GSLLAMAYDC FIAIRNPLRY ASILTNTRVI ALGVGVFLRG
160 170 180 190 200
FVSILPVILR LFSFSYCKSH VITRAFCLHQ EIMRLACADI TFNRLYPVIL
210 220 230 240 250
ISLTIFLDCL IILFSYILIL NTVIGIASGE ERAKALNTCI SHISCVLIFY
260 270 280 290 300
VTVMGLTFIY RFGKNVPEVV HIIMSYIYFL FPPLMNPVIY SIKTKQIQYG
310
IIRLLSKHRF SS
Length:312
Mass (Da):35,373
Last modified:May 18, 2010 - v4
Checksum:i47E1BA5852C36966
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_063114120C → R.2 PublicationsCorresponds to variant rs7952293dbSNPEnsembl.1
Natural variantiVAR_063115134L → F.2 PublicationsCorresponds to variant rs10837814dbSNPEnsembl.1
Natural variantiVAR_063116209C → S.2 PublicationsCorresponds to variant rs7937237dbSNPEnsembl.1
Natural variantiVAR_057576283P → S.Corresponds to variant rs11036815dbSNPEnsembl.1
Natural variantiVAR_063117312S → R.1 PublicationCorresponds to variant rs11036814dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF137396 Genomic DNA. Translation: AAD29425.2.
AC104389 Genomic DNA. No translation available.
AF399503 Genomic DNA. Translation: AAK94988.1.
RefSeqiNP_149420.4. NM_033180.4.
UniGeneiHs.680163.

Genome annotation databases

EnsembliENST00000624187; ENSP00000485407; ENSG00000279012.
GeneIDi79345.
KEGGihsa:79345.
UCSCiuc001mao.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF137396 Genomic DNA. Translation: AAD29425.2.
AC104389 Genomic DNA. No translation available.
AF399503 Genomic DNA. Translation: AAK94988.1.
RefSeqiNP_149420.4. NM_033180.4.
UniGeneiHs.680163.

3D structure databases

ProteinModelPortaliQ9Y5P1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000327540.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ9Y5P1.
PhosphoSitePlusiQ9Y5P1.

Polymorphism and mutation databases

BioMutaiOR51B2.
DMDMi296439490.

Proteomic databases

PaxDbiQ9Y5P1.
PeptideAtlasiQ9Y5P1.
PRIDEiQ9Y5P1.

Protocols and materials databases

DNASUi79345.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000624187; ENSP00000485407; ENSG00000279012.
GeneIDi79345.
KEGGihsa:79345.
UCSCiuc001mao.2. human.

Organism-specific databases

CTDi79345.
GeneCardsiOR51B2.
HGNCiHGNC:14703. OR51B2.
neXtProtiNX_Q9Y5P1.
OpenTargetsiENSG00000279012.
PharmGKBiPA32364.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVJQ. Eukaryota.
ENOG4111CPY. LUCA.
GeneTreeiENSGT00840000129672.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ9Y5P1.
KOiK04257.
OMAiIFYVTVM.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ9Y5P1.
TreeFamiTF342735.

Enzyme and pathway databases

BioCyciZFISH:G66-31162-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR51B2.
GenomeRNAii79345.
PROiQ9Y5P1.

Gene expression databases

BgeeiENSG00000184881.
CleanExiHS_OR51B2.
ExpressionAtlasiQ9Y5P1. baseline and differential.
GenevisibleiQ9Y5P1. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO51B2_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5P1
Secondary accession number(s): Q96RD4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: May 18, 2010
Last modified: November 30, 2016
This is version 141 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.