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Protein

Olfactory receptor 51B4

Gene

OR51B4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  • G-protein coupled receptor activity Source: UniProtKB-KW
  • olfactory receptor activity Source: UniProtKB

GO - Biological processi

  • sensory perception of smell Source: UniProtKB
  • signal transduction Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:G66-33231-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 51B4
Alternative name(s):
Odorant receptor HOR5'beta1
Gene namesi
Name:OR51B4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:14708. OR51B4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23ExtracellularSequence analysisAdd BLAST23
Transmembranei24 – 44Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini45 – 52CytoplasmicSequence analysis8
Transmembranei53 – 73Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini74 – 97ExtracellularSequence analysisAdd BLAST24
Transmembranei98 – 117Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini118 – 136CytoplasmicSequence analysisAdd BLAST19
Transmembranei137 – 157Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini158 – 193ExtracellularSequence analysisAdd BLAST36
Transmembranei194 – 214Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini215 – 234CytoplasmicSequence analysisAdd BLAST20
Transmembranei235 – 255Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini256 – 270ExtracellularSequence analysisAdd BLAST15
Transmembranei271 – 291Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini292 – 310CytoplasmicSequence analysisAdd BLAST19

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
  • plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000183251.
PharmGKBiPA32366.

Polymorphism and mutation databases

BioMutaiOR51B4.
DMDMi311033422.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507461 – 310Olfactory receptor 51B4Add BLAST310

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi95 ↔ 186PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9Y5P0.
PRIDEiQ9Y5P0.

PTM databases

iPTMnetiQ9Y5P0.
PhosphoSitePlusiQ9Y5P0.

Expressioni

Gene expression databases

CleanExiHS_OR51B4.
GenevisibleiQ9Y5P0. HS.

Interactioni

Protein-protein interaction databases

BioGridi122648. 1 interactor.
STRINGi9606.ENSP00000369573.

Structurei

3D structure databases

ProteinModelPortaliQ9Y5P0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVJQ. Eukaryota.
ENOG4111CPY. LUCA.
GeneTreeiENSGT00840000129672.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ9Y5P0.
KOiK04257.
OMAiLIWNDHS.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ9Y5P0.
TreeFamiTF342735.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y5P0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWYNNSAGPF LLTGFLGSEA VHYRISMSFF VIYFSVLFGN GTLLVLIWND
60 70 80 90 100
HSLHEPMYYF LAMLADTDLG MTFTTMPTVL GVLLLDQREI AHAACFTQSF
110 120 130 140 150
IHSLAIVESG ILLVLAYDCF IAIRTPLRYN CILTNSRVMN IGLGVLMRGF
160 170 180 190 200
MSILPIILSL YCYPYCGSRA LLHTFCLHQD VIKLACADIT FNHIYPIIQT
210 220 230 240 250
SLTVFLDALI IIFSYILILK TVMGIASGQE EAKSLNTCVS HISCVLVFHI
260 270 280 290 300
TVMGLSFIHR FGKHAPHVVP ITMSYVHFLF PPFVNPIIYS IKTKQIQRSI
310
IRLFSGQSRA
Length:310
Mass (Da):34,912
Last modified:November 2, 2010 - v3
Checksum:i9B7586B751BEE5FA
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02414136V → I.2 PublicationsCorresponds to variant rs7118113dbSNPEnsembl.1
Natural variantiVAR_030348147M → T.1 PublicationCorresponds to variant rs10837771dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF137396 Genomic DNA. Translation: AAD29426.2.
AC104389 Genomic DNA. No translation available.
BC069094 mRNA. Translation: AAH69094.1.
BC148186 mRNA. Translation: AAI48187.1.
BC153815 mRNA. Translation: AAI53816.1.
CCDSiCCDS7757.1.
RefSeqiNP_149419.2. NM_033179.2.
UniGeneiHs.679499.

Genome annotation databases

EnsembliENST00000380224; ENSP00000369573; ENSG00000183251.
GeneIDi79339.
KEGGihsa:79339.
UCSCiuc010qza.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF137396 Genomic DNA. Translation: AAD29426.2.
AC104389 Genomic DNA. No translation available.
BC069094 mRNA. Translation: AAH69094.1.
BC148186 mRNA. Translation: AAI48187.1.
BC153815 mRNA. Translation: AAI53816.1.
CCDSiCCDS7757.1.
RefSeqiNP_149419.2. NM_033179.2.
UniGeneiHs.679499.

3D structure databases

ProteinModelPortaliQ9Y5P0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122648. 1 interactor.
STRINGi9606.ENSP00000369573.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ9Y5P0.
PhosphoSitePlusiQ9Y5P0.

Polymorphism and mutation databases

BioMutaiOR51B4.
DMDMi311033422.

Proteomic databases

PaxDbiQ9Y5P0.
PRIDEiQ9Y5P0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380224; ENSP00000369573; ENSG00000183251.
GeneIDi79339.
KEGGihsa:79339.
UCSCiuc010qza.3. human.

Organism-specific databases

CTDi79339.
GeneCardsiOR51B4.
H-InvDBHIX0035995.
HGNCiHGNC:14708. OR51B4.
neXtProtiNX_Q9Y5P0.
OpenTargetsiENSG00000183251.
PharmGKBiPA32366.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVJQ. Eukaryota.
ENOG4111CPY. LUCA.
GeneTreeiENSGT00840000129672.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ9Y5P0.
KOiK04257.
OMAiLIWNDHS.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ9Y5P0.
TreeFamiTF342735.

Enzyme and pathway databases

BioCyciZFISH:G66-33231-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR51B4.
GenomeRNAii79339.
PROiQ9Y5P0.

Gene expression databases

CleanExiHS_OR51B4.
GenevisibleiQ9Y5P0. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO51B4_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5P0
Secondary accession number(s): A7MAV5, Q6NTD7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: November 2, 2010
Last modified: November 2, 2016
This is version 140 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.