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Protein

Olfactory receptor 51B4

Gene

OR51B4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  • G-protein coupled receptor activity Source: UniProtKB-KW
  • olfactory receptor activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 51B4
Alternative name(s):
Odorant receptor HOR5'beta1
Gene namesi
Name:OR51B4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:14708. OR51B4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323ExtracellularSequence analysisAdd
BLAST
Transmembranei24 – 4421Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini45 – 528CytoplasmicSequence analysis
Transmembranei53 – 7321Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini74 – 9724ExtracellularSequence analysisAdd
BLAST
Transmembranei98 – 11720Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini118 – 13619CytoplasmicSequence analysisAdd
BLAST
Transmembranei137 – 15721Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini158 – 19336ExtracellularSequence analysisAdd
BLAST
Transmembranei194 – 21421Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini215 – 23420CytoplasmicSequence analysisAdd
BLAST
Transmembranei235 – 25521Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini256 – 27015ExtracellularSequence analysisAdd
BLAST
Transmembranei271 – 29121Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini292 – 31019CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
  • plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32366.

Polymorphism and mutation databases

BioMutaiOR51B4.
DMDMi311033422.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 310310Olfactory receptor 51B4PRO_0000150746Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence analysis
Disulfide bondi95 ↔ 186PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9Y5P0.
PRIDEiQ9Y5P0.

PTM databases

iPTMnetiQ9Y5P0.

Expressioni

Gene expression databases

CleanExiHS_OR51B4.
GenevisibleiQ9Y5P0. HS.

Interactioni

Protein-protein interaction databases

BioGridi122648. 1 interaction.
STRINGi9606.ENSP00000369573.

Structurei

3D structure databases

ProteinModelPortaliQ9Y5P0.
SMRiQ9Y5P0. Positions 2-215.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVJQ. Eukaryota.
ENOG4111CPY. LUCA.
GeneTreeiENSGT00840000129672.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ9Y5P0.
KOiK04257.
OMAiLIWNDHS.
OrthoDBiEOG754HPV.
PhylomeDBiQ9Y5P0.
TreeFamiTF342735.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y5P0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWYNNSAGPF LLTGFLGSEA VHYRISMSFF VIYFSVLFGN GTLLVLIWND
60 70 80 90 100
HSLHEPMYYF LAMLADTDLG MTFTTMPTVL GVLLLDQREI AHAACFTQSF
110 120 130 140 150
IHSLAIVESG ILLVLAYDCF IAIRTPLRYN CILTNSRVMN IGLGVLMRGF
160 170 180 190 200
MSILPIILSL YCYPYCGSRA LLHTFCLHQD VIKLACADIT FNHIYPIIQT
210 220 230 240 250
SLTVFLDALI IIFSYILILK TVMGIASGQE EAKSLNTCVS HISCVLVFHI
260 270 280 290 300
TVMGLSFIHR FGKHAPHVVP ITMSYVHFLF PPFVNPIIYS IKTKQIQRSI
310
IRLFSGQSRA
Length:310
Mass (Da):34,912
Last modified:November 2, 2010 - v3
Checksum:i9B7586B751BEE5FA
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti36 – 361V → I.2 Publications
Corresponds to variant rs7118113 [ dbSNP | Ensembl ].
VAR_024141
Natural varianti147 – 1471M → T.1 Publication
Corresponds to variant rs10837771 [ dbSNP | Ensembl ].
VAR_030348

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF137396 Genomic DNA. Translation: AAD29426.2.
AC104389 Genomic DNA. No translation available.
BC069094 mRNA. Translation: AAH69094.1.
BC148186 mRNA. Translation: AAI48187.1.
BC153815 mRNA. Translation: AAI53816.1.
CCDSiCCDS7757.1.
RefSeqiNP_149419.2. NM_033179.2.
UniGeneiHs.679499.

Genome annotation databases

EnsembliENST00000380224; ENSP00000369573; ENSG00000183251.
GeneIDi79339.
KEGGihsa:79339.
UCSCiuc010qza.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF137396 Genomic DNA. Translation: AAD29426.2.
AC104389 Genomic DNA. No translation available.
BC069094 mRNA. Translation: AAH69094.1.
BC148186 mRNA. Translation: AAI48187.1.
BC153815 mRNA. Translation: AAI53816.1.
CCDSiCCDS7757.1.
RefSeqiNP_149419.2. NM_033179.2.
UniGeneiHs.679499.

3D structure databases

ProteinModelPortaliQ9Y5P0.
SMRiQ9Y5P0. Positions 2-215.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122648. 1 interaction.
STRINGi9606.ENSP00000369573.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ9Y5P0.

Polymorphism and mutation databases

BioMutaiOR51B4.
DMDMi311033422.

Proteomic databases

PaxDbiQ9Y5P0.
PRIDEiQ9Y5P0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380224; ENSP00000369573; ENSG00000183251.
GeneIDi79339.
KEGGihsa:79339.
UCSCiuc010qza.3. human.

Organism-specific databases

CTDi79339.
GeneCardsiOR51B4.
H-InvDBHIX0035995.
HGNCiHGNC:14708. OR51B4.
neXtProtiNX_Q9Y5P0.
PharmGKBiPA32366.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVJQ. Eukaryota.
ENOG4111CPY. LUCA.
GeneTreeiENSGT00840000129672.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ9Y5P0.
KOiK04257.
OMAiLIWNDHS.
OrthoDBiEOG754HPV.
PhylomeDBiQ9Y5P0.
TreeFamiTF342735.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR51B4.
GenomeRNAii79339.
PROiQ9Y5P0.

Gene expression databases

CleanExiHS_OR51B4.
GenevisibleiQ9Y5P0. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Conservation of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes."
    Bulger M., van Doorninck J.H., Saitoh N., Telling A., Farrell C.M., Bender M.A., Felsenfeld G., Axel R., Groudine M.
    Proc. Natl. Acad. Sci. U.S.A. 96:5129-5134(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ILE-36.
  2. Erratum
    Bulger M., van Doorninck J.H., Saitoh N., Telling A., Farrell C.M., Bender M.A., Felsenfeld G., Axel R., Groudine M.
    Proc. Natl. Acad. Sci. U.S.A. 96:8307-8307(1999)
  3. "Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters."
    Bulger M., Bender M.A., van Doorninck J.H., Wertman B., Farrell C.M., Felsenfeld G., Groudine M., Hardison R.
    Proc. Natl. Acad. Sci. U.S.A. 97:14560-14565(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ILE-36 AND THR-147.

Entry informationi

Entry nameiO51B4_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5P0
Secondary accession number(s): A7MAV5, Q6NTD7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: November 2, 2010
Last modified: June 8, 2016
This is version 136 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.