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Protein

Olfactory receptor 51B4

Gene

OR51B4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

  • sensory perception of smell Source: UniProtKB
  • signal transduction Source: GO_Central

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 51B4
Alternative name(s):
Odorant receptor HOR5'beta1
Gene namesi
Name:OR51B4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000183251.3
HGNCiHGNC:14708 OR51B4
neXtProtiNX_Q9Y5P0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23ExtracellularSequence analysisAdd BLAST23
Transmembranei24 – 44Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini45 – 52CytoplasmicSequence analysis8
Transmembranei53 – 73Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini74 – 97ExtracellularSequence analysisAdd BLAST24
Transmembranei98 – 117Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini118 – 136CytoplasmicSequence analysisAdd BLAST19
Transmembranei137 – 157Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini158 – 193ExtracellularSequence analysisAdd BLAST36
Transmembranei194 – 214Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini215 – 234CytoplasmicSequence analysisAdd BLAST20
Transmembranei235 – 255Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini256 – 270ExtracellularSequence analysisAdd BLAST15
Transmembranei271 – 291Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini292 – 310CytoplasmicSequence analysisAdd BLAST19

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000183251
PharmGKBiPA32366

Polymorphism and mutation databases

BioMutaiOR51B4
DMDMi311033422

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507461 – 310Olfactory receptor 51B4Add BLAST310

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi95 ↔ 186PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9Y5P0
PeptideAtlasiQ9Y5P0
PRIDEiQ9Y5P0

PTM databases

iPTMnetiQ9Y5P0
PhosphoSitePlusiQ9Y5P0

Expressioni

Gene expression databases

BgeeiENSG00000183251
CleanExiHS_OR51B4
GenevisibleiQ9Y5P0 HS

Interactioni

Protein-protein interaction databases

BioGridi1226481 interactor.
STRINGi9606.ENSP00000369573

Structurei

3D structure databases

ProteinModelPortaliQ9Y5P0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVJQ Eukaryota
ENOG4111CPY LUCA
GeneTreeiENSGT00910000144090
HOGENOMiHOG000041363
HOVERGENiHBG017625
InParanoidiQ9Y5P0
KOiK04257
OMAiLIWNDHS
OrthoDBiEOG091G0AZH
PhylomeDBiQ9Y5P0
TreeFamiTF342735

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Y5P0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWYNNSAGPF LLTGFLGSEA VHYRISMSFF VIYFSVLFGN GTLLVLIWND
60 70 80 90 100
HSLHEPMYYF LAMLADTDLG MTFTTMPTVL GVLLLDQREI AHAACFTQSF
110 120 130 140 150
IHSLAIVESG ILLVLAYDCF IAIRTPLRYN CILTNSRVMN IGLGVLMRGF
160 170 180 190 200
MSILPIILSL YCYPYCGSRA LLHTFCLHQD VIKLACADIT FNHIYPIIQT
210 220 230 240 250
SLTVFLDALI IIFSYILILK TVMGIASGQE EAKSLNTCVS HISCVLVFHI
260 270 280 290 300
TVMGLSFIHR FGKHAPHVVP ITMSYVHFLF PPFVNPIIYS IKTKQIQRSI
310
IRLFSGQSRA
Length:310
Mass (Da):34,912
Last modified:November 2, 2010 - v3
Checksum:i9B7586B751BEE5FA
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02414136V → I2 PublicationsCorresponds to variant dbSNP:rs7118113Ensembl.1
Natural variantiVAR_030348147M → T1 PublicationCorresponds to variant dbSNP:rs10837771Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF137396 Genomic DNA Translation: AAD29426.2
AC104389 Genomic DNA No translation available.
BC069094 mRNA Translation: AAH69094.1
BC148186 mRNA Translation: AAI48187.1
BC153815 mRNA Translation: AAI53816.1
CCDSiCCDS7757.1
RefSeqiNP_149419.2, NM_033179.2
UniGeneiHs.679499

Genome annotation databases

EnsembliENST00000380224; ENSP00000369573; ENSG00000183251
GeneIDi79339
KEGGihsa:79339
UCSCiuc010qza.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiO51B4_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5P0
Secondary accession number(s): A7MAV5, Q6NTD7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: November 2, 2010
Last modified: February 28, 2018
This is version 147 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome