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Reviewed, UniProtKB/Swiss-Prot Q9Y5N6 (ORC6_HUMAN)

Last modified July 7, 2009. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Origin recognition complex subunit 6
Gene names
Name: ORC6L
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length252 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. Binds to the ARS consensus sequence (ACS) of origins of replication in an ATP-dependent manner.

Subunit structure

ORC is composed of six subunits. Interacts with DBF4 By similarity.

Subcellular location

Nucleus.

Post-translational modification

Phosphorylated upon DNA damage, probably by ATM or ATR. Ref.3 Ref.4 Ref.5

Sequence similarities

Belongs to the ORC6 family.

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Ontologies

Keywords
   Biological processDNA replication
   Cellular componentNucleus
   Coding sequence diversityPolymorphism
   LigandDNA-binding
   PTMPhosphoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processDNA replication

Inferred from Experiment. Source: Reactome

   Cellular componentnuclear origin of replication recognition complex

Inferred from electronic annotation. Source: InterPro

nucleoplasm

Inferred from Experiment. Source: Reactome

   Molecular functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

protein binding

Inferred from physical interaction. Source: IntAct

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 252252Origin recognition complex subunit 6
PRO_0000127097

Amino acid modifications

Modified residue1951Phosphothreonine Ref.3 Ref.5
Modified residue2291Phosphothreonine Ref.4

Natural variations

Natural variant321R → W: dbSNP rs3218744.
VAR_029283
Natural variant1381P → Q: dbSNP rs3218745.
VAR_029284

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Sequences

Sequence LengthMass (Da)Tools
Q9Y5N6-1 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 78840387605F45FE

FASTA25228,107
        10         20         30         40         50         60 
MGSELIGRLA PRLGLAEPDM LRKAEEYLRL SRVKCVGLSA RTTETSSAVM CLDLAASWMK 

        70         80         90        100        110        120 
CPLDRAYLIK LSGLNKETYQ SCLKSFECLL GLNSNIGIRD LAVQFSCIEA VNMASKILKS 

       130        140        150        160        170        180 
YESSLPQTQQ VDLDLSRPLF TSAALLSACK ILKLKVDKNK MVATSGVKKA IFDRLCKQLE 

       190        200        210        220        230        240 
KIGQQVDREP GDVATPPRKR KKIVVEAPAK EMEKVEEMPH KPQKDEDLTQ DYEEWKRKIL 

       250 
ENAASAQKAT AE

« Hide

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References

« Hide 'large scale' references
[1]"cDNA cloning of a homolog for Saccharomyces cerevisiae ORC6 from Homo sapiens."
Dean F.B., O'Donnell M.
Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Cervix and Testis.
[3]"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
Cell 127:635-648(2006) [PubMed: 17081983] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-195, MASS SPECTROMETRY.
Tissue: Epithelium.
[4]"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.
Science 316:1160-1166(2007) [PubMed: 17525332] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-229, MASS SPECTROMETRY.
[5]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-195, MASS SPECTROMETRY.
+Additional computationally mapped references.

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Cross-references

Sequence databases

AF139658 mRNA. Translation: AAD32666.1.
BC039032 mRNA. Translation: AAH39032.1.
BC063565 mRNA. Translation: AAH63565.1.
IPIIPI00001641.
RefSeqNP_055136.1.
UniGeneHs.49760

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

IntActQ9Y5N6. 8 interactions.

PTM databases

PhosphoSiteQ9Y5N6.

Proteomic databases

PRIDEQ9Y5N6.

Genome annotation databases

EnsemblENSG00000091651. Homo sapiens. [Contig view]
GeneID23594.
KEGGhsa:23594.
UCSCuc002eeh.1. human.

Organism-specific databases

GeneCardsGC16P045281.
HGNCHGNC:17151. ORC6L.
HPACAB016330.
MIM607213. gene.
PharmGKBPA32813.
GenAtlasSearch...

Phylogenomic databases

HOGENOMQ9Y5N6.
HOVERGENQ9Y5N6.
OMAQ9Y5N6. TSGVKKA.

Enzyme and pathway databases

ReactomeREACT_152. Cell Cycle, Mitotic.
REACT_1538. Cell Cycle Checkpoints.
REACT_383. DNA Replication.

Gene expression databases

ArrayExpressQ9Y5N6.
BgeeQ9Y5N6.
CleanExHS_ORC6L.
GermOnlineENSG00000091651. Homo sapiens.

Family and domain databases

InterProIPR008721. ORC6.
[Graphical view]
PfamPF05460. ORC6. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio46248.
SOURCESearch...

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Entry information

Entry nameORC6_HUMAN
AccessionPrimary (citable) accession number: Q9Y5N6
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: July 7, 2009
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents