Reviewed, UniProtKB/Swiss-Prot Q9Y5N6 (ORC6_HUMAN)

Names and origin

Protein names

Recommended name:
    Origin recognition complex subunit 6

Gene names

Name:

ORC6L

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	252 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Component of the origin recognition complex (ORC) that binds origins of replication. Binds to the ARS consensus sequence (ACS) of origins of replication in an ATP-dependent manner.
Subunit structure	ORC is composed of six subunits. Interacts with DBF4 By similarity.
Subcellular location	Nucleus.
Post-translational modification	Phosphorylated upon DNA damage, probably by ATM or ATR. Ref.5 Ref.6 Ref.7
Sequence similarities	Belongs to the ORC6 family.

Ontologies

Keywords
Biological process	DNA replication
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Ligand	DNA-binding
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA replication Inferred from Experiment. Source: Reactome
Cellular component	nuclear origin of replication recognition complex Inferred from electronic annotation. Source: InterPro nucleoplasm Inferred from Experiment. Source: Reactome
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CDC6	Q99741	1	EBI-374840,EBI-374862
CDC7	O00311	1	EBI-374840,EBI-374980
MCM2	P49736	1	EBI-374840,EBI-374819
MCM4	P33991	1	EBI-374840,EBI-374938
MCM6	Q14566	1	EBI-374840,EBI-374900
MCM7	P33993	1	EBI-374840,EBI-355924
ORC3L	Q9UBD5	1	EBI-374840,EBI-374916
ORC4L	O43929	1	EBI-374840,EBI-374889

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 252	252	Origin recognition complex subunit 6		PRO_0000127097
Amino acid modifications
	Modified residue	195	1	Phosphothreonine Ref.5 Ref.7
	Modified residue	229	1	Phosphothreonine Ref.6
Natural variations
	Natural variant	32	1	R → W: dbSNP rs3218744.		VAR_029283
	Natural variant	138	1	P → Q: dbSNP rs3218745.		VAR_029284

Sequences

	Sequence		Length	Mass (Da)
	Q9Y5N6-1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 78840387605F45FE	FASTA	252	28,107
	10 20 30 40 50 60 MGSELIGRLA PRLGLAEPDM LRKAEEYLRL SRVKCVGLSA RTTETSSAVM CLDLAASWMK 70 80 90 100 110 120 CPLDRAYLIK LSGLNKETYQ SCLKSFECLL GLNSNIGIRD LAVQFSCIEA VNMASKILKS 130 140 150 160 170 180 YESSLPQTQQ VDLDLSRPLF TSAALLSACK ILKLKVDKNK MVATSGVKKA IFDRLCKQLE 190 200 210 220 230 240 KIGQQVDREP GDVATPPRKR KKIVVEAPAK EMEKVEEMPH KPQKDEDLTQ DYEEWKRKIL 250 ENAASAQKAT AE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"cDNA cloning of a homolog for Saccharomyces cerevisiae ORC6 from Homo sapiens." Dean F.B., O'Donnell M. Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Cervix and Testis.
[5]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-195, MASS SPECTROMETRY. Tissue: Epithelium.
[6]	"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science 316:1160-1166(2007) [PubMed: 17525332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-229, MASS SPECTROMETRY.
[7]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-195, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF139658 mRNA. Translation: AAD32666.1. AK024019 mRNA. Translation: BAG51251.1. CH471092 Genomic DNA. Translation: EAW82685.1. BC039032 mRNA. Translation: AAH39032.1. BC063565 mRNA. Translation: AAH63565.1.
IPI	IPI00001641.
RefSeq	NP_055136.1.
UniGene	Hs.49760
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9Y5N6. 8 interactions.
STRING	Q9Y5N6.
PTM databases
PhosphoSite	Q9Y5N6.
Proteomic databases
PRIDE	Q9Y5N6.
Genome annotation databases
Ensembl	ENST00000219097; ENSP00000219097; ENSG00000091651; Homo sapiens. [Genome view]
GeneID	23594.
KEGG	hsa:23594.
UCSC	uc002eeh.1. human.
Organism-specific databases
CTD	23594.
GeneCards	GC16P045281.
HGNC	HGNC:17151. ORC6L.
HPA	CAB016330.
MIM	607213. gene.
PharmGKB	PA32813.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q9Y5N6.
HOVERGEN	Q9Y5N6.
OMA	LNSNIGI
OrthoDB	EOG9ZSCPK
Enzyme and pathway databases
Reactome	REACT_152. Cell Cycle, Mitotic. REACT_1538. Cell Cycle Checkpoints. REACT_383. DNA Replication.
Gene expression databases
ArrayExpress	Q9Y5N6.
Bgee	Q9Y5N6.
CleanEx	HS_ORC6L.
Genevestigator	Q9Y5N6.
GermOnline	ENSG00000091651. Homo sapiens.
Family and domain databases
InterPro	IPR008721. ORC6. IPR020529. ORC6_met/pln. [Graphical view]
Pfam	PF05460. ORC6. 1 hit. [Graphical view]
ProDom	PD315657. Origin_recog_cplx_su6-like. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...
Other Resources
NextBio	46248.
SOURCE	Search...

Entry information

Entry name

ORC6_HUMAN

Accession

Primary (citable) accession number: Q9Y5N6
Secondary accession number(s): B3KN89

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	November 1, 1999
Last modified:	November 24, 2009
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.