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Protein

Signal recognition particle receptor subunit beta

Gene

SRPRB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system. Has GTPase activity. May mediate the membrane association of SRPR (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei120 – 1201GTP; via amide nitrogenBy similarity
Binding sitei248 – 2481GTP; via amide nitrogenBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi71 – 799GTPBy similarity
Nucleotide bindingi92 – 954GTPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-381038. XBP1(S) activates chaperone genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Signal recognition particle receptor subunit beta
Short name:
SR-beta
Alternative name(s):
Protein APMCF1
Gene namesi
Name:SRPRB
ORF Names:PSEC0230
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:24085. SRPRB.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei37 – 5721HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytoplasmic microtubule Source: UniProtKB
  • endoplasmic reticulum membrane Source: Reactome
  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: MGI
  • signal recognition particle receptor complex Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA128394701.

Polymorphism and mutation databases

BioMutaiSRPRB.
DMDMi31340540.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 271271Signal recognition particle receptor subunit betaPRO_0000101227Add
BLAST

Proteomic databases

EPDiQ9Y5M8.
MaxQBiQ9Y5M8.
PaxDbiQ9Y5M8.
PeptideAtlasiQ9Y5M8.
PRIDEiQ9Y5M8.
TopDownProteomicsiQ9Y5M8.

PTM databases

iPTMnetiQ9Y5M8.
PhosphoSiteiQ9Y5M8.
SwissPalmiQ9Y5M8.

Expressioni

Gene expression databases

BgeeiQ9Y5M8.
CleanExiHS_SRPRB.
ExpressionAtlasiQ9Y5M8. baseline and differential.
GenevisibleiQ9Y5M8. HS.

Organism-specific databases

HPAiHPA011173.

Interactioni

Subunit structurei

Heterodimer with SRPRA.By similarity

Protein-protein interaction databases

BioGridi121810. 139 interactions.
DIPiDIP-50218N.
IntActiQ9Y5M8. 29 interactions.
MINTiMINT-1410114.
STRINGi9606.ENSP00000418401.

Structurei

3D structure databases

ProteinModelPortaliQ9Y5M8.
SMRiQ9Y5M8. Positions 65-271.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SRP receptor beta subunit family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0090. Eukaryota.
COG2229. LUCA.
GeneTreeiENSGT00510000048347.
HOGENOMiHOG000241847.
HOVERGENiHBG054206.
InParanoidiQ9Y5M8.
KOiK12272.
OMAiTSITDSC.
OrthoDBiEOG7D59N7.
PhylomeDBiQ9Y5M8.
TreeFamiTF106190.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR024156. Small_GTPase_ARF.
IPR019009. SRP_receptor_beta_su.
[Graphical view]
PfamiPF09439. SRPRB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Y5M8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASADSRRVA DGGGAGGTFQ PYLDTLRQEL QQTDPTLLSV VVAVLAVLLT
60 70 80 90 100
LVFWKLIRSR RSSQRAVLLV GLCDSGKTLL FVRLLTGLYR DTQTSITDSC
110 120 130 140 150
AVYRVNNNRG NSLTLIDLPG HESLRLQFLE RFKSSARAIV FVVDSAAFQR
160 170 180 190 200
EVKDVAEFLY QVLIDSMGLK NTPSFLIACN KQDIAMAKSA KLIQQQLEKE
210 220 230 240 250
LNTLRVTRSA APSTLDSSST APAQLGKKGK EFEFSQLPLK VEFLECSAKG
260 270
GRGDVGSADI QDLEKWLAKI A
Length:271
Mass (Da):29,702
Last modified:May 30, 2003 - v3
Checksum:iEC8DBCE9EE01B2B6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti137 – 1371R → G in BAB55176 (PubMed:14702039).Curated
Sequence conflicti216 – 2161D → Y in BAB55176 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti9 – 91V → L.2 Publications
Corresponds to variant rs1107413 [ dbSNP | Ensembl ].
VAR_057335

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF141882 mRNA. Translation: AAD34888.3.
AK027525 mRNA. Translation: BAB55176.1.
AK075531 mRNA. Translation: BAC11675.1.
BC063001 mRNA. Translation: AAH63001.1.
BC065299 mRNA. Translation: AAH65299.1.
CCDSiCCDS3081.1.
RefSeqiNP_067026.3. NM_021203.3.
UniGeneiHs.12152.

Genome annotation databases

EnsembliENST00000466490; ENSP00000418401; ENSG00000144867.
GeneIDi58477.
KEGGihsa:58477.
UCSCiuc003epx.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF141882 mRNA. Translation: AAD34888.3.
AK027525 mRNA. Translation: BAB55176.1.
AK075531 mRNA. Translation: BAC11675.1.
BC063001 mRNA. Translation: AAH63001.1.
BC065299 mRNA. Translation: AAH65299.1.
CCDSiCCDS3081.1.
RefSeqiNP_067026.3. NM_021203.3.
UniGeneiHs.12152.

3D structure databases

ProteinModelPortaliQ9Y5M8.
SMRiQ9Y5M8. Positions 65-271.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121810. 139 interactions.
DIPiDIP-50218N.
IntActiQ9Y5M8. 29 interactions.
MINTiMINT-1410114.
STRINGi9606.ENSP00000418401.

PTM databases

iPTMnetiQ9Y5M8.
PhosphoSiteiQ9Y5M8.
SwissPalmiQ9Y5M8.

Polymorphism and mutation databases

BioMutaiSRPRB.
DMDMi31340540.

Proteomic databases

EPDiQ9Y5M8.
MaxQBiQ9Y5M8.
PaxDbiQ9Y5M8.
PeptideAtlasiQ9Y5M8.
PRIDEiQ9Y5M8.
TopDownProteomicsiQ9Y5M8.

Protocols and materials databases

DNASUi58477.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000466490; ENSP00000418401; ENSG00000144867.
GeneIDi58477.
KEGGihsa:58477.
UCSCiuc003epx.2. human.

Organism-specific databases

CTDi58477.
GeneCardsiSRPRB.
HGNCiHGNC:24085. SRPRB.
HPAiHPA011173.
MIMi616883. gene.
neXtProtiNX_Q9Y5M8.
PharmGKBiPA128394701.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0090. Eukaryota.
COG2229. LUCA.
GeneTreeiENSGT00510000048347.
HOGENOMiHOG000241847.
HOVERGENiHBG054206.
InParanoidiQ9Y5M8.
KOiK12272.
OMAiTSITDSC.
OrthoDBiEOG7D59N7.
PhylomeDBiQ9Y5M8.
TreeFamiTF106190.

Enzyme and pathway databases

ReactomeiR-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-381038. XBP1(S) activates chaperone genes.

Miscellaneous databases

ChiTaRSiSRPRB. human.
GeneWikiiSRPRB.
GenomeRNAii58477.
PROiQ9Y5M8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y5M8.
CleanExiHS_SRPRB.
ExpressionAtlasiQ9Y5M8. baseline and differential.
GenevisibleiQ9Y5M8. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR024156. Small_GTPase_ARF.
IPR019009. SRP_receptor_beta_su.
[Graphical view]
PfamiPF09439. SRPRB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Yan W., Zhu F., Chai Y., Zhao Z., Li Q., Wang C.
    Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Mammary carcinoma.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-9.
  3. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-9.
    Tissue: Colon and Eye.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSRPRB_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5M8
Secondary accession number(s): Q6P595, Q8N2D8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 30, 2003
Last modified: June 8, 2016
This is version 141 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.