Reviewed, UniProtKB/Swiss-Prot Q9Y5M8 (SRPRB_HUMAN)

Names and origin

Protein names

Recommended name:
    Signal recognition particle receptor subunit beta
      Short name=SR-beta
Alternative name(s):
    Protein APMCF1

Gene names

Name:	SRPRB
ORF Names:	PSEC0230

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	271 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Has GTPase activity. May mediate the membrane association of SR alpha By similarity.
Subunit structure	Heterodimer of an alpha and a beta chain By similarity.
Subcellular location	Endoplasmic reticulum membrane; Single-pass membrane protein By similarity.
Sequence similarities	Belongs to the SRP receptor beta subunit family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane
Ligand	GTP-binding Nucleotide-binding
Molecular function	Receptor Ribonucleoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW ribonucleoprotein complex Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from physical interaction. Source: IntAct receptor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CASP4	P49662	1	EBI-355393,EBI-1057327
NDN	Q99608	1	EBI-355393,EBI-718177
PTP4A3	O75365	1	EBI-355393,EBI-1043866
TSC22D1	Q15714	1	EBI-355393,EBI-712609
UQCRC1	P31930	1	EBI-355393,EBI-1052596

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 271	271	Signal recognition particle receptor subunit beta		PRO_0000101227
Regions
	Transmembrane	37 – 57	21	Potential
	Nucleotide binding	71 – 78	8	GTP Potential
	Nucleotide binding	117 – 121	5	GTP Potential
	Nucleotide binding	180 – 183	4	GTP Potential
Natural variations
	Natural variant	9	1	V → L: dbSNP rs1107413.		VAR_057335
Experimental info
	Sequence conflict	137	1	R → G in BAB55176. Ref.2
	Sequence conflict	216	1	D → Y in BAB55176. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q9Y5M8-1 [UniParc]. Last modified May 30, 2003. Version 3. Checksum: EC8DBCE9EE01B2B6	FASTA	271	29,702
	10 20 30 40 50 60 MASADSRRVA DGGGAGGTFQ PYLDTLRQEL QQTDPTLLSV VVAVLAVLLT LVFWKLIRSR 70 80 90 100 110 120 RSSQRAVLLV GLCDSGKTLL FVRLLTGLYR DTQTSITDSC AVYRVNNNRG NSLTLIDLPG 130 140 150 160 170 180 HESLRLQFLE RFKSSARAIV FVVDSAAFQR EVKDVAEFLY QVLIDSMGLK NTPSFLIACN 190 200 210 220 230 240 KQDIAMAKSA KLIQQQLEKE LNTLRVTRSA APSTLDSSST APAQLGKKGK EFEFSQLPLK 250 260 270 VEFLECSAKG GRGDVGSADI QDLEKWLAKI A

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Yan W., Zhu F., Chai Y., Zhao Z., Li Q., Wang C. Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Mammary carcinoma.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-9.
[3]	"HRI human cDNA sequencing project." Ota T., Nishikawa T., Suzuki Y., Kawai-Hio Y., Hayashi K., Ishii S., Saito K., Yamamoto J., Wakamatsu A., Nagai T., Nakamura Y., Nagahari K., Sugano S., Isogai T. Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye.
[5]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF141882 mRNA. Translation: AAD34888.3. AK027525 mRNA. Translation: BAB55176.1. AK075531 mRNA. Translation: BAC11675.1. BC065299 mRNA. Translation: AAH65299.1.
IPI	IPI00295098.
RefSeq	NP_067026.2.
UniGene	Hs.12152
3D structure databases
HSSP	HSSP built from PDB template 1NRJ based on UniProtKB P36057.
SMR	Q9Y5M8. Positions 65-271.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9Y5M8. 21 interactions.
Proteomic databases
PeptideAtlas	Q9Y5M8.
PRIDE	Q9Y5M8.
Genome annotation databases
Ensembl	ENSG00000144867. Homo sapiens. [Contig view]
GeneID	58477.
KEGG	hsa:58477.
Organism-specific databases
GeneCards	GC03P135007.
HGNC	HGNC:24085. SRPRB.
HPA	HPA011173.
PharmGKB	PA128394701.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q9Y5M8.
HOVERGEN	Q9Y5M8.
OMA	Q9Y5M8. TLVFWKL.
Enzyme and pathway databases
Reactome	REACT_15380. Diabetes pathways.
Gene expression databases
ArrayExpress	Q9Y5M8.
Bgee	Q9Y5M8.
CleanEx	HS_SRPRB.
GermOnline	ENSG00000144867. Homo sapiens.
Family and domain databases
InterPro	IPR019009. SRP_receptor_beta_su. [Graphical view]
Pfam	PF09439. SRPRB. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	64918.

Entry information

Entry name

SRPRB_HUMAN

Accession

Primary (citable) accession number: Q9Y5M8
Secondary accession number(s): Q8N2D8

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	May 30, 2003
Last modified:	July 7, 2009
This is version 71 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)