Q9Y5M8 (SRPRB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Signal recognition particle receptor subunit beta
Short name=SR-beta

Alternative name(s):
Protein APMCF1

Gene names

Name:	SRPRB
ORF Names:	PSEC0230

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	271 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system. Has GTPase activity. May mediate the membrane association of SRPR By similarity.
Subunit structure	Heterodimer with SRPR By similarity.
Subcellular location	Endoplasmic reticulum membrane; Single-pass membrane protein By similarity.
Sequence similarities	Belongs to the SRP receptor beta subunit family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Ligand	GTP-binding Nucleotide-binding
Molecular function	Receptor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro
Cellular component	endoplasmic reticulum membrane Traceable author statement. Source: Reactome integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW receptor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 271	271	Signal recognition particle receptor subunit beta		PRO_0000101227
Regions
	Transmembrane	37 – 57	21	Helical; Potential
	Nucleotide binding	71 – 79	9	GTP By similarity
	Nucleotide binding	92 – 95	4	GTP By similarity
Sites
	Binding site	120	1	GTP; via amide nitrogen By similarity
	Binding site	248	1	GTP; via amide nitrogen By similarity
Natural variations
	Natural variant	9	1	V → L. Ref.2 Ref.4 Corresponds to variant rs1107413 [ dbSNP | Ensembl ].		VAR_057335
Experimental info
	Sequence conflict	137	1	R → G in BAB55176. Ref.2
	Sequence conflict	216	1	D → Y in BAB55176. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q9Y5M8 [UniParc]. Last modified May 30, 2003. Version 3. Checksum: EC8DBCE9EE01B2B6	FASTA	271	29,702
	10 20 30 40 50 60 MASADSRRVA DGGGAGGTFQ PYLDTLRQEL QQTDPTLLSV VVAVLAVLLT LVFWKLIRSR 70 80 90 100 110 120 RSSQRAVLLV GLCDSGKTLL FVRLLTGLYR DTQTSITDSC AVYRVNNNRG NSLTLIDLPG 130 140 150 160 170 180 HESLRLQFLE RFKSSARAIV FVVDSAAFQR EVKDVAEFLY QVLIDSMGLK NTPSFLIACN 190 200 210 220 230 240 KQDIAMAKSA KLIQQQLEKE LNTLRVTRSA APSTLDSSST APAQLGKKGK EFEFSQLPLK 250 260 270 VEFLECSAKG GRGDVGSADI QDLEKWLAKI A

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Yan W., Zhu F., Chai Y., Zhao Z., Li Q., Wang C. Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Mammary carcinoma.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-9.
[3]	"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries." Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y. , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T. DNA Res. 12:117-126(2005) [PubMed: 16303743] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-9. Tissue: Colon and Eye.
[5]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF141882 mRNA. Translation: AAD34888.3. AK027525 mRNA. Translation: BAB55176.1. AK075531 mRNA. Translation: BAC11675.1. BC063001 mRNA. Translation: AAH63001.1. BC065299 mRNA. Translation: AAH65299.1.
IPI	IPI00295098.
RefSeq	NP_067026.3. NM_021203.3.
UniGene	Hs.12152.
3D structure databases
ProteinModelPortal	Q9Y5M8.
SMR	Q9Y5M8. Positions 65-271.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9Y5M8. 4 interactions.
MINT	MINT-1410114.
STRING	Q9Y5M8.
PTM databases
PhosphoSite	Q9Y5M8.
Polymorphism databases
DMDM	31340540.
Proteomic databases
PeptideAtlas	Q9Y5M8.
PRIDE	Q9Y5M8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000273406; ENSP00000273406; ENSG00000144867. ENST00000466490; ENSP00000418401; ENSG00000144867.
GeneID	58477.
KEGG	hsa:58477.
Organism-specific databases
CTD	58477.
GeneCards	GC03P133503.
HGNC	HGNC:24085. SRPRB.
HPA	HPA011173.
neXtProt	NX_Q9Y5M8.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00510000048347.
HOGENOM	HBG714035.
HOVERGEN	HBG054206.
InParanoid	Q9Y5M8.
OMA	TLVFWKL.
OrthoDB	EOG42Z4QX.
PhylomeDB	Q9Y5M8.
Enzyme and pathway databases
Reactome	REACT_15380. Diabetes pathways.
Gene expression databases
ArrayExpress	Q9Y5M8.
Bgee	Q9Y5M8.
CleanEx	HS_SRPRB.
Genevestigator	Q9Y5M8.
GermOnline	ENSG00000144867. Homo sapiens.
Family and domain databases
InterPro	IPR024156. Small_GTPase_ARF. IPR019009. SRP_receptor_beta_su. [Graphical view]
KO	K12272.
Pfam	PF09439. SRPRB. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	64918.

Entry information

Entry name

SRPRB_HUMAN

Accession

Primary (citable) accession number: Q9Y5M8
Secondary accession number(s): Q6P595, Q8N2D8

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	May 30, 2003
Last modified:	January 25, 2012
This is version 99 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.