Reviewed, UniProtKB/Swiss-Prot Q9Y5L2 (HIG2_HUMAN)

Names and origin

Protein names

Recommended name:
    Hypoxia-inducible gene 2 protein

Gene names

Name:	HIG2
Synonyms:	C7orf68

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	63 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subcellular location	Membrane; Single-pass membrane protein Potential.
Induction	By hypoxia. Ref.1

Ontologies

Keywords
Biological process	Stress response
Cellular component	Membrane
Domain	Transmembrane
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	response to stress Ref.1 Non-traceable author statement. Source: UniProtKB
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 63	63	Hypoxia-inducible gene 2 protein		PRO_0000083976
Regions
	Transmembrane	7 – 23	17	Potential
Amino acid modifications
	Modified residue	44	1	Phosphoserine Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Q9Y5L2-1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 91EA626A511FC8B7	FASTA	63	6,950
	10 20 30 40 50 60 MKHVLNLYLL GVVLTLLSIF VRVMESLEGL LESPSPGTSW TTRSQLANTE PTKGLPDHPS RSM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Epigenetic regulation of gene expression in cervical cancer cells by the tumor microenvironment." Denko N.C., Schindler C., Koong A., Laderoute K., Green C., Giaccia A.J. Clin. Cancer Res. 6:480-487(2000) [PubMed: 10690527] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION. Tissue: Cervix carcinoma.
[2]	"Human chromosome 7: DNA sequence and biology." Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C. Science 300:767-772(2003) [PubMed: 12690205] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain and Lung.
[4]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-44, MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF144755 mRNA. Translation: AAD37585.1. CH236947 Genomic DNA. Translation: EAL24309.1. BC001863 mRNA. Translation: AAH01863.1. BC093742 mRNA. Translation: AAH93742.1. BC112183 mRNA. Translation: AAI12184.1.
IPI	IPI00001583.
RefSeq	NP_001092256.1. NP_037464.1.
UniGene	Hs.710088
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q9Y5L2.
Proteomic databases
PRIDE	Q9Y5L2.
Genome annotation databases
Ensembl	ENSG00000135245. Homo sapiens. [Contig view]
GeneID	29923.
KEGG	hsa:29923.
Organism-specific databases
GeneCards	GC07P127883.
H-InvDB	HIX0007051.
HGNC	HGNC:28859. C7orf68.
HPA	HPA010515.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q9Y5L2.
HOVERGEN	Q9Y5L2.
OMA	Q9Y5L2. HPSRGVQ.
Gene expression databases
ArrayExpress	Q9Y5L2.
Bgee	Q9Y5L2.
GermOnline	ENSG00000135245. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	52530.

Entry information

Entry name

HIG2_HUMAN

Accession

Primary (citable) accession number: Q9Y5L2
Secondary accession number(s): A4D0Z5, Q52LY5

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1999
Last modified:	June 16, 2009
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)