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Reviewed, UniProtKB/Swiss-Prot Q9Y5L2 (HIG2_HUMAN)

Last modified January 19, 2010. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Hypoxia-inducible gene 2 protein
Gene names
Name: HIG2
Synonyms: C7orf68
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length63 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level.

General annotation (Comments)

Subcellular location

Membrane; Single-pass membrane protein Potential.

Induction

By hypoxia. Ref.1

Ontologies

Keywords
   Biological processStress response
   Cellular componentMembrane
   DomainTransmembrane
   PTMPhosphoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processresponse to stress Ref.1

Non-traceable author statement. Source: UniProtKB

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 6363Hypoxia-inducible gene 2 protein
PRO_0000083976

Regions

Transmembrane7 – 2317 Potential

Amino acid modifications

Modified residue441Phosphoserine Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q9Y5L2-1 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 91EA626A511FC8B7

FASTA636,950
        10         20         30         40         50         60 
MKHVLNLYLL GVVLTLLSIF VRVMESLEGL LESPSPGTSW TTRSQLANTE PTKGLPDHPS 


RSM 

« Hide

References

« Hide 'large scale' references
[1]"Epigenetic regulation of gene expression in cervical cancer cells by the tumor microenvironment."
Denko N.C., Schindler C., Koong A., Laderoute K., Green C., Giaccia A.J.
Clin. Cancer Res. 6:480-487(2000) [PubMed: 10690527] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION.
Tissue: Cervix carcinoma.
[2]"Human chromosome 7: DNA sequence and biology."
Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. expand/collapse author list , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
Science 300:767-772(2003) [PubMed: 12690205] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain and Lung.
[4]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-44, MASS SPECTROMETRY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF144755 mRNA. Translation: AAD37585.1.
CH236947 Genomic DNA. Translation: EAL24309.1.
BC001863 mRNA. Translation: AAH01863.1.
BC093742 mRNA. Translation: AAH93742.1.
BC112183 mRNA. Translation: AAI12184.1.
IPIIPI00001583.
RefSeqNP_001092256.1.
NP_037464.1.
UniGeneHs.710088

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ9Y5L2.

PTM databases

PhosphoSiteQ9Y5L2.

Proteomic databases

PRIDEQ9Y5L2.

Genome annotation databases

EnsemblENST00000257696; ENSP00000257696; ENSG00000135245; Homo sapiens. [Genome view]
ENST00000435296; ENSP00000388871; ENSG00000135245; Homo sapiens. [Genome view]
GeneID29923.
KEGGhsa:29923.
UCSCuc003vne.2. human.

Organism-specific databases

CTD29923.
GeneCardsGC07P127883.
H-InvDBHIX0007051.
HGNCHGNC:28859. C7orf68.
HPAHPA010515.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG21757.
HOGENOMHBG126666.
HOVERGENQ9Y5L2.
InParanoidQ9Y5L2.
OMAPGSSWTT.
OrthoDBEOG9RV5BD.
PhylomeDBQ9Y5L2.

Gene expression databases

ArrayExpressQ9Y5L2.
BgeeQ9Y5L2.
GenevestigatorQ9Y5L2.
GermOnlineENSG00000135245. Homo sapiens.

Family and domain databases

ProtoNetSearch...

Other Resources

NextBio52530.

Entry information

Entry nameHIG2_HUMAN
AccessionPrimary (citable) accession number: Q9Y5L2
Secondary accession number(s): A4D0Z5, Q52LY5
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: January 19, 2010
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents