Q9Y5L0 (TNPO3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transportin-3

Alternative name(s):
Importin-12
Short name=Imp12
Transportin-SR
Short name=TRN-SR

Gene names

Name:	TNPO3
Synonyms:	IPO12

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	923 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Seems to function in nuclear protein import as nuclear transport receptor. In vitro, mediates the nuclear import of splicing factor SR proteins RBM4, SFRS1 and SFRS2, by recognizing phosphorylated RS domains. Ref.1 Ref.7 Ref.8 Ref.9
Subunit structure	Interacts with phosphorylated SFRS1 and SFRS2. Interacts with NUP62 and RBM4. Ref.1 Ref.7 Ref.8 Ref.9
Subcellular location	Cytoplasm. Nucleus Ref.7.
Sequence caution	The sequence AAD38537.1 differs from that shown. Reason: Frameshift at position 920.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	splicing factor protein import into nucleus Inferred from direct assay Ref.9. Source: UniProtKB
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from direct assay. Source: HPA
Molecular_function	receptor activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 2 (identifier: Q9Y5L0-2)

Also known as: TRN-SR2;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 1 (identifier: Q9Y5L0-1)

The sequence of this isoform differs from the canonical sequence as follows:
     453-453: P → PKKPFSNAACHHSLLFGQNITSEISNCEYLPPVLR

Isoform 3 (identifier: Q9Y5L0-3)

The sequence of this isoform differs from the canonical sequence as follows:
     904-923: SAEECKQVCWALRDFTRLFR → RNVFFN

Note: No experimental confirmation available.

Isoform 4 (identifier: Q9Y5L0-5)

The sequence of this isoform differs from the canonical sequence as follows:
     500-563: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 923	923	Transportin-3		PRO_0000120781
Amino acid modifications
	Modified residue	896	1	Phosphothreonine Ref.10
Natural variations
	Alternative sequence	453	1	P → PKKPFSNAACHHSLLFGQNI TSEISNCEYLPPVLR in isoform 1.		VSP_030174
	Alternative sequence	500 – 563	64	Missing in isoform 4.		VSP_045494
	Alternative sequence	904 – 923	20	SAEEC…TRLFR → RNVFFN in isoform 3.		VSP_011178
Experimental info
	Sequence conflict	87	1	R → W in AAD38537. Ref.1
	Sequence conflict	265	1	L → S in AK225999. Ref.3
	Sequence conflict	358	1	D → G in AK225999. Ref.3
	Sequence conflict	480	1	T → A in AK225999. Ref.3
	Sequence conflict	624	1	P → L in AK225999. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 2 (TRN-SR2) [UniParc]. Last modified January 15, 2008. Version 3. Checksum: CF7CDC14CDBA56AB	FASTA	923	104,203
	10 20 30 40 50 60 MEGAKPTLQL VYQAVQALYH DPDPSGKERA SFWLGELQRS VHAWEISDQL LQIRQDVESC 70 80 90 100 110 120 YFAAQTMKMK IQTSFYELPT DSHASLRDSL LTHIQNLKDL SPVIVTQLAL AIADLALQMP 130 140 150 160 170 180 SWKGCVQTLV EKYSNDVTSL PFLLEILTVL PEEVHSRSLR IGANRRTEII EDLAFYSSTV 190 200 210 220 230 240 VSLLMTCVEK AGTDEKMLMK VFRCLGSWFN LGVLDSNFMA NNKLLALLFE VLQQDKTSSN 250 260 270 280 290 300 LHEAASDCVC SALYAIENVE TNLPLAMQLF QGVLTLETAY HMAVAREDLD KVLNYCRIFT 310 320 330 340 350 360 ELCETFLEKI VCTPGQGLGD LRTLELLLIC AGHPQYEVVE ISFNFWYRLG EHLYKTNDEV 370 380 390 400 410 420 IHGIFKAYIQ RLLHALARHC QLEPDHEGVP EETDDFGEFR MRVSDLVKDL IFLIGSMECF 430 440 450 460 470 480 AQLYSTLKEG NPPWEVTEAV LFIMAAIAKS VDPENNPTLV EVLEGVVRLP ETVHTAVRYT 490 500 510 520 530 540 SIELVGEMSE VVDRNPQFLD PVLGYLMKGL CEKPLASAAA KAIHNICSVC RDHMAQHFNG 550 560 570 580 590 600 LLEIARSLDS FLLSPEAAVG LLKGTALVLA RLPLDKITEC LSELCSVQVM ALKKLLSQEP 610 620 630 640 650 660 SNGISSDPTV FLDRLAVIFR HTNPIVENGQ THPCQKVIQE IWPVLSETLN KHRADNRIVE 670 680 690 700 710 720 RCCRCLRFAV RCVGKGSAAL LQPLVTQMVN VYHVHQHSCF LYLGSILVDE YGMEEGCRQG 730 740 750 760 770 780 LLDMLQALCI PTFQLLEQQN GLQNHPDTVD DLFRLATRFI QRSPVTLLRS QVVIPILQWA 790 800 810 820 830 840 IASTTLDHRD ANCSVMRFLR DLIHTGVAND HEEDFELRKE LIGQVMNQLG QQLVSQLLHT 850 860 870 880 890 900 CCFCLPPYTL PDVAEVLWEI MQVDRPTFCR WLENSLKGLP KETTVGAVTV THKQLTDFHK 910 920 QVTSAEECKQ VCWALRDFTR LFR
	Isoform 1 [UniParc]. Checksum: 6CDFAD0922CBA87F	FASTA	957	108,001
	10 20 30 40 50 60 MEGAKPTLQL VYQAVQALYH DPDPSGKERA SFWLGELQRS VHAWEISDQL LQIRQDVESC 70 80 90 100 110 120 YFAAQTMKMK IQTSFYELPT DSHASLRDSL LTHIQNLKDL SPVIVTQLAL AIADLALQMP 130 140 150 160 170 180 SWKGCVQTLV EKYSNDVTSL PFLLEILTVL PEEVHSRSLR IGANRRTEII EDLAFYSSTV 190 200 210 220 230 240 VSLLMTCVEK AGTDEKMLMK VFRCLGSWFN LGVLDSNFMA NNKLLALLFE VLQQDKTSSN 250 260 270 280 290 300 LHEAASDCVC SALYAIENVE TNLPLAMQLF QGVLTLETAY HMAVAREDLD KVLNYCRIFT 310 320 330 340 350 360 ELCETFLEKI VCTPGQGLGD LRTLELLLIC AGHPQYEVVE ISFNFWYRLG EHLYKTNDEV 370 380 390 400 410 420 IHGIFKAYIQ RLLHALARHC QLEPDHEGVP EETDDFGEFR MRVSDLVKDL IFLIGSMECF 430 440 450 460 470 480 AQLYSTLKEG NPPWEVTEAV LFIMAAIAKS VDPKKPFSNA ACHHSLLFGQ NITSEISNCE 490 500 510 520 530 540 YLPPVLRENN PTLVEVLEGV VRLPETVHTA VRYTSIELVG EMSEVVDRNP QFLDPVLGYL 550 560 570 580 590 600 MKGLCEKPLA SAAAKAIHNI CSVCRDHMAQ HFNGLLEIAR SLDSFLLSPE AAVGLLKGTA 610 620 630 640 650 660 LVLARLPLDK ITECLSELCS VQVMALKKLL SQEPSNGISS DPTVFLDRLA VIFRHTNPIV 670 680 690 700 710 720 ENGQTHPCQK VIQEIWPVLS ETLNKHRADN RIVERCCRCL RFAVRCVGKG SAALLQPLVT 730 740 750 760 770 780 QMVNVYHVHQ HSCFLYLGSI LVDEYGMEEG CRQGLLDMLQ ALCIPTFQLL EQQNGLQNHP 790 800 810 820 830 840 DTVDDLFRLA TRFIQRSPVT LLRSQVVIPI LQWAIASTTL DHRDANCSVM RFLRDLIHTG 850 860 870 880 890 900 VANDHEEDFE LRKELIGQVM NQLGQQLVSQ LLHTCCFCLP PYTLPDVAEV LWEIMQVDRP 910 920 930 940 950 TFCRWLENSL KGLPKETTVG AVTVTHKQLT DFHKQVTSAE ECKQVCWALR DFTRLFR
	Isoform 3 [UniParc]. Checksum: 03F2BCEFA4FAA203	FASTA	909	102,541
	10 20 30 40 50 60 MEGAKPTLQL VYQAVQALYH DPDPSGKERA SFWLGELQRS VHAWEISDQL LQIRQDVESC 70 80 90 100 110 120 YFAAQTMKMK IQTSFYELPT DSHASLRDSL LTHIQNLKDL SPVIVTQLAL AIADLALQMP 130 140 150 160 170 180 SWKGCVQTLV EKYSNDVTSL PFLLEILTVL PEEVHSRSLR IGANRRTEII EDLAFYSSTV 190 200 210 220 230 240 VSLLMTCVEK AGTDEKMLMK VFRCLGSWFN LGVLDSNFMA NNKLLALLFE VLQQDKTSSN 250 260 270 280 290 300 LHEAASDCVC SALYAIENVE TNLPLAMQLF QGVLTLETAY HMAVAREDLD KVLNYCRIFT 310 320 330 340 350 360 ELCETFLEKI VCTPGQGLGD LRTLELLLIC AGHPQYEVVE ISFNFWYRLG EHLYKTNDEV 370 380 390 400 410 420 IHGIFKAYIQ RLLHALARHC QLEPDHEGVP EETDDFGEFR MRVSDLVKDL IFLIGSMECF 430 440 450 460 470 480 AQLYSTLKEG NPPWEVTEAV LFIMAAIAKS VDPENNPTLV EVLEGVVRLP ETVHTAVRYT 490 500 510 520 530 540 SIELVGEMSE VVDRNPQFLD PVLGYLMKGL CEKPLASAAA KAIHNICSVC RDHMAQHFNG 550 560 570 580 590 600 LLEIARSLDS FLLSPEAAVG LLKGTALVLA RLPLDKITEC LSELCSVQVM ALKKLLSQEP 610 620 630 640 650 660 SNGISSDPTV FLDRLAVIFR HTNPIVENGQ THPCQKVIQE IWPVLSETLN KHRADNRIVE 670 680 690 700 710 720 RCCRCLRFAV RCVGKGSAAL LQPLVTQMVN VYHVHQHSCF LYLGSILVDE YGMEEGCRQG 730 740 750 760 770 780 LLDMLQALCI PTFQLLEQQN GLQNHPDTVD DLFRLATRFI QRSPVTLLRS QVVIPILQWA 790 800 810 820 830 840 IASTTLDHRD ANCSVMRFLR DLIHTGVAND HEEDFELRKE LIGQVMNQLG QQLVSQLLHT 850 860 870 880 890 900 CCFCLPPYTL PDVAEVLWEI MQVDRPTFCR WLENSLKGLP KETTVGAVTV THKQLTDFHK QVTRNVFFN
	Isoform 4 [UniParc]. Checksum: 52D04D72633709DC	FASTA	859	97,372
	10 20 30 40 50 60 MEGAKPTLQL VYQAVQALYH DPDPSGKERA SFWLGELQRS VHAWEISDQL LQIRQDVESC 70 80 90 100 110 120 YFAAQTMKMK IQTSFYELPT DSHASLRDSL LTHIQNLKDL SPVIVTQLAL AIADLALQMP 130 140 150 160 170 180 SWKGCVQTLV EKYSNDVTSL PFLLEILTVL PEEVHSRSLR IGANRRTEII EDLAFYSSTV 190 200 210 220 230 240 VSLLMTCVEK AGTDEKMLMK VFRCLGSWFN LGVLDSNFMA NNKLLALLFE VLQQDKTSSN 250 260 270 280 290 300 LHEAASDCVC SALYAIENVE TNLPLAMQLF QGVLTLETAY HMAVAREDLD KVLNYCRIFT 310 320 330 340 350 360 ELCETFLEKI VCTPGQGLGD LRTLELLLIC AGHPQYEVVE ISFNFWYRLG EHLYKTNDEV 370 380 390 400 410 420 IHGIFKAYIQ RLLHALARHC QLEPDHEGVP EETDDFGEFR MRVSDLVKDL IFLIGSMECF 430 440 450 460 470 480 AQLYSTLKEG NPPWEVTEAV LFIMAAIAKS VDPENNPTLV EVLEGVVRLP ETVHTAVRYT 490 500 510 520 530 540 SIELVGEMSE VVDRNPQFLG TALVLARLPL DKITECLSEL CSVQVMALKK LLSQEPSNGI 550 560 570 580 590 600 SSDPTVFLDR LAVIFRHTNP IVENGQTHPC QKVIQEIWPV LSETLNKHRA DNRIVERCCR 610 620 630 640 650 660 CLRFAVRCVG KGSAALLQPL VTQMVNVYHV HQHSCFLYLG SILVDEYGME EGCRQGLLDM 670 680 690 700 710 720 LQALCIPTFQ LLEQQNGLQN HPDTVDDLFR LATRFIQRSP VTLLRSQVVI PILQWAIAST 730 740 750 760 770 780 TLDHRDANCS VMRFLRDLIH TGVANDHEED FELRKELIGQ VMNQLGQQLV SQLLHTCCFC 790 800 810 820 830 840 LPPYTLPDVA EVLWEIMQVD RPTFCRWLEN SLKGLPKETT VGAVTVTHKQ LTDFHKQVTS 850 AEECKQVCWA LRDFTRLFR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Transportin-SR, a nuclear import receptor for SR proteins." Kataoka N., Bachorik J.L., Dreyfuss G. J. Cell Biol. 145:1145-1152(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH SFRS1 AND SFRS2.
[2]	"A human homologue of yeast Mtr10p and its role in nuclear protein import." Kutay U., Izaurralde E., Hartmann E., Goerlich D. Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[3]	Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Colon.
[4]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"Human chromosome 7: DNA sequence and biology." Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C. Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 586-923 (ISOFORM 3). Tissue: Ovary.
[7]	"A human importin-beta family protein, transportin-SR2, interacts with the phosphorylated RS domain of SR proteins." Lai M.-C., Lin R.-I., Huang S.-Y., Tsai C.-W., Tarn W.-Y. J. Biol. Chem. 275:7950-7957(2000) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH SFRS1, SUBCELLULAR LOCATION.
[8]	"Transportin-SR2 mediates nuclear import of phosphorylated SR proteins." Lai M.-C., Lin R.-I., Tarn W.-Y. Proc. Natl. Acad. Sci. U.S.A. 98:10154-10159(2001) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH SFRS1 AND NUP62.
[9]	"A novel splicing regulator shares a nuclear import pathway with SR proteins." Lai M.-C., Kuo H.-W., Chang W.-C., Tarn W.-Y. EMBO J. 22:1359-1369(2003) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH RBM4.
[10]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-896, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[11]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF145029 mRNA. Translation: AAD38537.1. Frameshift. AJ133769 mRNA. Translation: CAB42643.1. AK225999 mRNA. No translation available. AC018639 Genomic DNA. No translation available. AC025594 Genomic DNA. No translation available. CH236950 Genomic DNA. Translation: EAL24106.1. BC009221 mRNA. Translation: AAH09221.2.
IPI	IPI00395694. IPI00455127. IPI00944945. IPI01009481.
RefSeq	NP_001177957.2. NM_001191028.2. NP_036602.1. NM_012470.3.
UniGene	Hs.193613.
3D structure databases
ProteinModelPortal	Q9Y5L0.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9Y5L0. 3 interactions.
MINT	MINT-1194798.
STRING	9606.ENSP00000265388.
PTM databases
PhosphoSite	Q9Y5L0.
Polymorphism databases
DMDM	166215035.
Proteomic databases
PaxDb	Q9Y5L0.
PRIDE	Q9Y5L0.
Protocols and materials databases
DNASU	23534.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000265388; ENSP00000265388; ENSG00000064419. ENST00000471234; ENSP00000418646; ENSG00000064419.
GeneID	23534.
KEGG	hsa:23534.
UCSC	uc003vol.2. human.
Organism-specific databases
CTD	23534.
GeneCards	GC07M128594.
HGNC	HGNC:17103. TNPO3.
HPA	HPA039555.
MIM	610032. gene.
neXtProt	NX_Q9Y5L0.
Orphanet	186. Primary biliary cirrhosis.
PharmGKB	PA134888159.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG237172.
HOGENOM	HOG000273876.
HOVERGEN	HBG057505.
KO	K15436.
OrthoDB	EOG4QRH3B.
Gene expression databases
ArrayExpress	Q9Y5L0.
Bgee	Q9Y5L0.
CleanEx	HS_TNPO3.
Genevestigator	Q9Y5L0.
GermOnline	ENSG00000064419. Homo sapiens.
Family and domain databases
Gene3D	1.25.10.10. 3 hits.
InterPro	IPR011989. ARM-like. IPR016024. ARM-type_fold. IPR013598. Exportin-1/Importin-b-like. [Graphical view]
Pfam	PF08389. Xpo1. 1 hit. [Graphical view]
SUPFAM	SSF48371. ARM-type_fold. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	23534.
NextBio	46030.
SOURCE	Search...

Entry information

Entry name

TNPO3_HUMAN

Accession

Primary (citable) accession number: Q9Y5L0
Secondary accession number(s): A4D1K9 , C9IZM0, Q6NUM1, Q96G71, Q96GU9, Q9Y3R2

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2004
Last sequence update:	January 15, 2008
Last modified:	May 1, 2013
This is version 95 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.