Reviewed, UniProtKB/Swiss-Prot Q9Y5K8 (VATD_HUMAN)

Names and origin

Protein names

Recommended name:
    V-type proton ATPase subunit D
      Short name=V-ATPase subunit D
Alternative name(s):
    Vacuolar proton pump subunit D
    V-ATPase 28 kDa accessory protein

Gene names

Name:	ATP6V1D
Synonyms:	ATP6M, VATD

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	247 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Subunit of the peripheral V1 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system By similarity.
Subunit structure	V-ATPase is an heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).
Sequence similarities	Belongs to the V-ATPase D subunit family.

Ontologies

Keywords
Biological process	Hydrogen ion transport Ion transport Transport
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	ATP synthesis coupled proton transport Inferred from electronic annotation. Source: InterPro
Cellular component	proton-transporting two-sector ATPase complex, catalytic domain Inferred from electronic annotation. Source: InterPro vacuolar proton-transporting V-type ATPase complex Inferred from direct assay. Source: UniProtKB
Molecular function	protein binding Inferred from physical interaction. Source: UniProtKB proton-transporting ATPase activity, rotational mechanism Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 247	247	V-type proton ATPase subunit D		PRO_0000144231
Experimental info
	Sequence conflict	228 – 235	8	EVLEPANL → RCWSLLIF in AAD40384. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q9Y5K8-1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 4185E5F6A74EFB1C	FASTA	247	28,263
	10 20 30 40 50 60 MSGKDRIEIF PSRMAQTIMK ARLKGAQTGR NLLKKKSDAL TLRFRQILKK IIETKMLMGE 70 80 90 100 110 120 VMREAAFSLA EAKFTAGDFS TTVIQNVNKA QVKIRAKKDN VAGVTLPVFE HYHEGTDSYE 130 140 150 160 170 180 LTGLARGGEQ LAKLKRNYAK AVELLVELAS LQTSFVTLDE AIKITNRRVN AIEHVIIPRI 190 200 210 220 230 240 ERTLAYIITE LDEREREEFY RLKKIQEKKK ILKEKSEKDL EQRRAAGEVL EPANLLAEEK DEDLLFE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Zhao Y., Cao H.Q., Wei Y.J., Jiang Y.X., Zhao X.W., Liu D.Q., Meng X.M., Liu Y.Q., Xu Y.Y., Sheng H., Liu S., Qiao M., Hui R.T., Ding J.F. Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Heart.
[2]	"Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning." Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X., Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W., Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M. , Zhou J., Xu S.-H., Gu J., Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z., Chen M.-D., Chen J.-L. Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed: 10931946] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pituitary.
[3]	"cDNA of human vacuolar H-ATPase subunit D (VATD) interacts with Rb." Quan L., Hong W., Shizhou A. Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[5]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF145316 mRNA. Translation: AAD33953.1. AF100741 mRNA. Translation: AAD40384.1. AF104629 mRNA. Translation: AAG30726.1. BC001411 mRNA. Translation: AAH01411.1.
IPI	IPI00001568.
RefSeq	NP_057078.1.
UniGene	Hs.272630
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q9Y5K8.
PTM databases
PhosphoSite	Q9Y5K8.
Proteomic databases
PeptideAtlas	Q9Y5K8.
PRIDE	Q9Y5K8.
Genome annotation databases
Ensembl	ENST00000216442; ENSP00000216442; ENSG00000100554; Homo sapiens. [Genome view]
GeneID	51382.
KEGG	hsa:51382.
UCSC	uc001xjf.1. human.
Organism-specific databases
CTD	51382.
GeneCards	GC14M066874.
HGNC	HGNC:13527. ATP6V1D.
MIM	609398. gene.
PharmGKB	PA25157.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q9Y5K8.
HOVERGEN	Q9Y5K8.
OMA	FYRLKKV
Enzyme and pathway databases
BRENDA	3.6.3.14. 247.
Gene expression databases
ArrayExpress	Q9Y5K8.
Bgee	Q9Y5K8.
CleanEx	HS_ATP6V1D.
Genevestigator	Q9Y5K8.
Family and domain databases
InterPro	IPR002699. ATPase_V1/A1-cplx_dsu. [Graphical view]
PANTHER	PTHR11671. ATPase_V1/A1_D. 1 hit.
Pfam	PF01813. ATP-synt_D. 1 hit. [Graphical view]
TIGRFAMs	TIGR00309. V_ATPase_subD. 1 hit.
ProtoNet	Search...
Other Resources
NextBio	54891.
SOURCE	Search...

Entry information

Entry name

VATD_HUMAN

Accession

Primary (citable) accession number: Q9Y5K8
Secondary accession number(s): Q9Y688

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	November 1, 1999
Last modified:	November 24, 2009
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.