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Q9Y5K8

- VATD_HUMAN

UniProt

Q9Y5K8 - VATD_HUMAN

Protein

V-type proton ATPase subunit D

Gene

ATP6V1D

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 131 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Subunit of the peripheral V1 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system By similarity. May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium.By similarity1 Publication

    GO - Molecular functioni

    1. ATPase activity, coupled to transmembrane movement of substances Source: InterPro
    2. protein binding Source: UniProtKB

    GO - Biological processi

    1. cellular iron ion homeostasis Source: Reactome
    2. cilium assembly Source: UniProtKB
    3. insulin receptor signaling pathway Source: Reactome
    4. interaction with host Source: Reactome
    5. phagosome maturation Source: Reactome
    6. protein localization to cilium Source: UniProtKB
    7. proton transport Source: UniProtKB-KW
    8. transferrin transport Source: Reactome
    9. transmembrane transport Source: Reactome

    Keywords - Biological processi

    Cilium biogenesis/degradation, Hydrogen ion transport, Ion transport, Transport

    Enzyme and pathway databases

    BioCyciMetaCyc:HS02107-MONOMER.
    ReactomeiREACT_1109. Insulin receptor recycling.
    REACT_121256. Phagosomal maturation (early endosomal stage).
    REACT_25283. Transferrin endocytosis and recycling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    V-type proton ATPase subunit D
    Short name:
    V-ATPase subunit D
    Alternative name(s):
    V-ATPase 28 kDa accessory protein
    Vacuolar proton pump subunit D
    Gene namesi
    Name:ATP6V1D
    Synonyms:ATP6M, VATD
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:13527. ATP6V1D.

    Subcellular locationi

    Membrane 1 Publication; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication
    Note: Localizes to centrosome and the base of the cilium.

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. extracellular vesicular exosome Source: UniProt
    3. lysosomal membrane Source: UniProtKB
    4. membrane Source: UniProtKB
    5. vacuolar proton-transporting V-type ATPase complex Source: UniProtKB

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25157.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 247247V-type proton ATPase subunit DPRO_0000144231Add
    BLAST

    Proteomic databases

    MaxQBiQ9Y5K8.
    PaxDbiQ9Y5K8.
    PeptideAtlasiQ9Y5K8.
    PRIDEiQ9Y5K8.

    PTM databases

    PhosphoSiteiQ9Y5K8.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9Y5K8.
    BgeeiQ9Y5K8.
    CleanExiHS_ATP6V1D.
    GenevestigatoriQ9Y5K8.

    Organism-specific databases

    HPAiHPA031515.

    Interactioni

    Subunit structurei

    V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d). Interacts with SNX10; may play a role in ciliogenesis.1 Publication

    Protein-protein interaction databases

    BioGridi119513. 20 interactions.
    IntActiQ9Y5K8. 5 interactions.
    STRINGi9606.ENSP00000216442.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y5K8.
    SMRiQ9Y5K8. Positions 8-208.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the V-ATPase D subunit family.Curated

    Phylogenomic databases

    eggNOGiCOG1394.
    HOGENOMiHOG000230791.
    HOVERGENiHBG000483.
    InParanoidiQ9Y5K8.
    KOiK02149.
    OMAiQTAFMIL.
    OrthoDBiEOG7QG46J.
    PhylomeDBiQ9Y5K8.
    TreeFamiTF300160.

    Family and domain databases

    InterProiIPR002699. V_ATPase_D.
    [Graphical view]
    PANTHERiPTHR11671. PTHR11671. 1 hit.
    PfamiPF01813. ATP-synt_D. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00309. V_ATPase_subD. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9Y5K8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGKDRIEIF PSRMAQTIMK ARLKGAQTGR NLLKKKSDAL TLRFRQILKK    50
    IIETKMLMGE VMREAAFSLA EAKFTAGDFS TTVIQNVNKA QVKIRAKKDN 100
    VAGVTLPVFE HYHEGTDSYE LTGLARGGEQ LAKLKRNYAK AVELLVELAS 150
    LQTSFVTLDE AIKITNRRVN AIEHVIIPRI ERTLAYIITE LDEREREEFY 200
    RLKKIQEKKK ILKEKSEKDL EQRRAAGEVL EPANLLAEEK DEDLLFE 247
    Length:247
    Mass (Da):28,263
    Last modified:November 1, 1999 - v1
    Checksum:i4185E5F6A74EFB1C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti228 – 2358EVLEPANL → RCWSLLIF in AAD40384. (PubMed:10931946)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF145316 mRNA. Translation: AAD33953.1.
    AF100741 mRNA. Translation: AAD40384.1.
    AF104629 mRNA. Translation: AAG30726.1.
    AK315784 mRNA. Translation: BAG38130.1.
    CH471061 Genomic DNA. Translation: EAW80931.1.
    BC001411 mRNA. Translation: AAH01411.1.
    CCDSiCCDS9780.1.
    RefSeqiNP_057078.1. NM_015994.3.
    UniGeneiHs.272630.

    Genome annotation databases

    EnsembliENST00000216442; ENSP00000216442; ENSG00000100554.
    ENST00000554087; ENSP00000451167; ENSG00000100554.
    GeneIDi51382.
    KEGGihsa:51382.
    UCSCiuc001xjf.3. human.

    Polymorphism databases

    DMDMi10720351.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF145316 mRNA. Translation: AAD33953.1 .
    AF100741 mRNA. Translation: AAD40384.1 .
    AF104629 mRNA. Translation: AAG30726.1 .
    AK315784 mRNA. Translation: BAG38130.1 .
    CH471061 Genomic DNA. Translation: EAW80931.1 .
    BC001411 mRNA. Translation: AAH01411.1 .
    CCDSi CCDS9780.1.
    RefSeqi NP_057078.1. NM_015994.3.
    UniGenei Hs.272630.

    3D structure databases

    ProteinModelPortali Q9Y5K8.
    SMRi Q9Y5K8. Positions 8-208.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119513. 20 interactions.
    IntActi Q9Y5K8. 5 interactions.
    STRINGi 9606.ENSP00000216442.

    PTM databases

    PhosphoSitei Q9Y5K8.

    Polymorphism databases

    DMDMi 10720351.

    Proteomic databases

    MaxQBi Q9Y5K8.
    PaxDbi Q9Y5K8.
    PeptideAtlasi Q9Y5K8.
    PRIDEi Q9Y5K8.

    Protocols and materials databases

    DNASUi 51382.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000216442 ; ENSP00000216442 ; ENSG00000100554 .
    ENST00000554087 ; ENSP00000451167 ; ENSG00000100554 .
    GeneIDi 51382.
    KEGGi hsa:51382.
    UCSCi uc001xjf.3. human.

    Organism-specific databases

    CTDi 51382.
    GeneCardsi GC14M067804.
    HGNCi HGNC:13527. ATP6V1D.
    HPAi HPA031515.
    MIMi 609398. gene.
    neXtProti NX_Q9Y5K8.
    PharmGKBi PA25157.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1394.
    HOGENOMi HOG000230791.
    HOVERGENi HBG000483.
    InParanoidi Q9Y5K8.
    KOi K02149.
    OMAi QTAFMIL.
    OrthoDBi EOG7QG46J.
    PhylomeDBi Q9Y5K8.
    TreeFami TF300160.

    Enzyme and pathway databases

    BioCyci MetaCyc:HS02107-MONOMER.
    Reactomei REACT_1109. Insulin receptor recycling.
    REACT_121256. Phagosomal maturation (early endosomal stage).
    REACT_25283. Transferrin endocytosis and recycling.

    Miscellaneous databases

    ChiTaRSi ATP6V1D. human.
    GeneWikii ATP6V1D.
    GenomeRNAii 51382.
    NextBioi 54891.
    PROi Q9Y5K8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y5K8.
    Bgeei Q9Y5K8.
    CleanExi HS_ATP6V1D.
    Genevestigatori Q9Y5K8.

    Family and domain databases

    InterProi IPR002699. V_ATPase_D.
    [Graphical view ]
    PANTHERi PTHR11671. PTHR11671. 1 hit.
    Pfami PF01813. ATP-synt_D. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00309. V_ATPase_subD. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Zhao Y., Cao H.Q., Wei Y.J., Jiang Y.X., Zhao X.W., Liu D.Q., Meng X.M., Liu Y.Q., Xu Y.Y., Sheng H., Liu S., Qiao M., Hui R.T., Ding J.F.
      Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Heart.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Pituitary.
    3. "cDNA of human vacuolar H-ATPase subunit D (VATD) interacts with Rb."
      Quan L., Hong W., Shizhou A.
      Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Trachea.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "A SNX10/V-ATPase pathway regulates ciliogenesis in vitro and in vivo."
      Chen Y., Wu B., Xu L., Li H., Xia J., Yin W., Li Z., Shi D., Li S., Lin S., Shu X., Pei D.
      Cell Res. 22:333-345(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN CILIOGENESIS, INTERACTION WITH SNX10, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiVATD_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y5K8
    Secondary accession number(s): B2RE33, Q9Y688
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 131 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3