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Q9Y5K8 (VATD_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 126. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
V-type proton ATPase subunit D

Short name=V-ATPase subunit D
Alternative name(s):
V-ATPase 28 kDa accessory protein
Vacuolar proton pump subunit D
Gene names
Name:ATP6V1D
Synonyms:ATP6M, VATD
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length247 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Subunit of the peripheral V1 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system By similarity. May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium. Ref.8

Subunit structure

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d). Interacts with SNX10; may play a role in ciliogenesis. Ref.8

Subcellular location

Membrane; Peripheral membrane protein; Cytoplasmic side Probable. Note: Localizes to centrosome and the base of the cilium. Ref.8

Sequence similarities

Belongs to the V-ATPase D subunit family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 247247V-type proton ATPase subunit D
PRO_0000144231

Experimental info

Sequence conflict228 – 2358EVLEPANL → RCWSLLIF in AAD40384. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9Y5K8 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 4185E5F6A74EFB1C

FASTA24728,263
        10         20         30         40         50         60 
MSGKDRIEIF PSRMAQTIMK ARLKGAQTGR NLLKKKSDAL TLRFRQILKK IIETKMLMGE 

        70         80         90        100        110        120 
VMREAAFSLA EAKFTAGDFS TTVIQNVNKA QVKIRAKKDN VAGVTLPVFE HYHEGTDSYE 

       130        140        150        160        170        180 
LTGLARGGEQ LAKLKRNYAK AVELLVELAS LQTSFVTLDE AIKITNRRVN AIEHVIIPRI 

       190        200        210        220        230        240 
ERTLAYIITE LDEREREEFY RLKKIQEKKK ILKEKSEKDL EQRRAAGEVL EPANLLAEEK 


DEDLLFE 

« Hide

References

« Hide 'large scale' references
[1]Zhao Y., Cao H.Q., Wei Y.J., Jiang Y.X., Zhao X.W., Liu D.Q., Meng X.M., Liu Y.Q., Xu Y.Y., Sheng H., Liu S., Qiao M., Hui R.T., Ding J.F.
Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Heart.
[2]"Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning."
Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X., Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W., Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M. expand/collapse author list , Zhou J., Xu S.-H., Gu J., Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z., Chen M.-D., Chen J.-L.
Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Pituitary.
[3]"cDNA of human vacuolar H-ATPase subunit D (VATD) interacts with Rb."
Quan L., Hong W., Shizhou A.
Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Trachea.
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.
[7]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[8]"A SNX10/V-ATPase pathway regulates ciliogenesis in vitro and in vivo."
Chen Y., Wu B., Xu L., Li H., Xia J., Yin W., Li Z., Shi D., Li S., Lin S., Shu X., Pei D.
Cell Res. 22:333-345(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION IN CILIOGENESIS, INTERACTION WITH SNX10, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF145316 mRNA. Translation: AAD33953.1.
AF100741 mRNA. Translation: AAD40384.1.
AF104629 mRNA. Translation: AAG30726.1.
AK315784 mRNA. Translation: BAG38130.1.
CH471061 Genomic DNA. Translation: EAW80931.1.
BC001411 mRNA. Translation: AAH01411.1.
RefSeqNP_057078.1. NM_015994.3.
UniGeneHs.272630.

3D structure databases

ProteinModelPortalQ9Y5K8.
SMRQ9Y5K8. Positions 8-208.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid119513. 20 interactions.
IntActQ9Y5K8. 5 interactions.
STRING9606.ENSP00000216442.

PTM databases

PhosphoSiteQ9Y5K8.

Polymorphism databases

DMDM10720351.

Proteomic databases

PaxDbQ9Y5K8.
PeptideAtlasQ9Y5K8.
PRIDEQ9Y5K8.

Protocols and materials databases

DNASU51382.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000216442; ENSP00000216442; ENSG00000100554.
ENST00000554087; ENSP00000451167; ENSG00000100554.
GeneID51382.
KEGGhsa:51382.
UCSCuc001xjf.3. human.

Organism-specific databases

CTD51382.
GeneCardsGC14M067804.
HGNCHGNC:13527. ATP6V1D.
HPAHPA031515.
MIM609398. gene.
neXtProtNX_Q9Y5K8.
PharmGKBPA25157.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1394.
HOGENOMHOG000230791.
HOVERGENHBG000483.
InParanoidQ9Y5K8.
KOK02149.
OMAQSKNIMG.
OrthoDBEOG7QG46J.
PhylomeDBQ9Y5K8.
TreeFamTF300160.

Enzyme and pathway databases

BioCycMetaCyc:HS02107-MONOMER.
ReactomeREACT_111102. Signal Transduction.
REACT_116125. Disease.
REACT_15518. Transmembrane transport of small molecules.

Gene expression databases

ArrayExpressQ9Y5K8.
BgeeQ9Y5K8.
CleanExHS_ATP6V1D.
GenevestigatorQ9Y5K8.

Family and domain databases

InterProIPR002699. V_ATPase_D.
[Graphical view]
PANTHERPTHR11671. PTHR11671. 1 hit.
PfamPF01813. ATP-synt_D. 1 hit.
[Graphical view]
TIGRFAMsTIGR00309. V_ATPase_subD. 1 hit.
ProtoNetSearch...

Other

ChiTaRSATP6V1D. human.
GeneWikiATP6V1D.
GenomeRNAi51382.
NextBio54891.
PROQ9Y5K8.
SOURCESearch...

Entry information

Entry nameVATD_HUMAN
AccessionPrimary (citable) accession number: Q9Y5K8
Secondary accession number(s): B2RE33, Q9Y688
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: April 16, 2014
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM