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Q9Y5K2

- KLK4_HUMAN

UniProt

Q9Y5K2 - KLK4_HUMAN

Protein

Kallikrein-4

Gene

KLK4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 2 (11 Jan 2011)
      Previous versions | rss
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    Functioni

    Involved in enamel formation.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi40 – 401Zinc
    Active sitei71 – 711Charge relay system1 Publication
    Metal bindingi91 – 911Zinc
    Active sitei116 – 1161Charge relay system1 Publication
    Active sitei207 – 2071Charge relay system1 Publication

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. serine-type endopeptidase activity Source: InterPro
    3. serine-type peptidase activity Source: UniProtKB

    GO - Biological processi

    1. amelogenesis Source: UniProtKB
    2. proteolysis Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Keywords - Ligandi

    Metal-binding, Zinc

    Protein family/group databases

    MEROPSiS01.251.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Kallikrein-4 (EC:3.4.21.-)
    Alternative name(s):
    Enamel matrix serine proteinase 1
    Kallikrein-like protein 1
    Short name:
    KLK-L1
    Prostase
    Serine protease 17
    Gene namesi
    Name:KLK4
    Synonyms:EMSP1, PRSS17, PSTS
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:6365. KLK4.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: ProtInc

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Involvement in diseasei

    Amelogenesis imperfecta, hypomaturation type, 2A1 (AI2A1) [MIM:204700]: A defect of enamel formation. The disorder involves both primary and secondary dentitions. The teeth have a shiny agar jelly appearance and the enamel is softer than normal. Brown pigment is present in middle layers of enamel.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Keywords - Diseasei

    Amelogenesis imperfecta

    Organism-specific databases

    MIMi204700. phenotype.
    Orphaneti100033. Hypomaturation amelogenesis imperfecta.
    PharmGKBiPA30154.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Propeptidei27 – 304Sequence AnalysisPRO_0000027937
    Chaini31 – 254224Kallikrein-4PRO_0000027938Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi37 ↔ 1671 PublicationPROSITE-ProRule annotation
    Disulfide bondi56 ↔ 721 PublicationPROSITE-ProRule annotation
    Disulfide bondi141 ↔ 2411 PublicationPROSITE-ProRule annotation
    Disulfide bondi148 ↔ 2131 PublicationPROSITE-ProRule annotation
    Glycosylationi169 – 1691N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi178 ↔ 1921 PublicationPROSITE-ProRule annotation
    Disulfide bondi203 ↔ 2281 PublicationPROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Proteomic databases

    PaxDbiQ9Y5K2.
    PRIDEiQ9Y5K2.

    Expressioni

    Tissue specificityi

    Expressed in prostate.

    Gene expression databases

    ArrayExpressiQ9Y5K2.
    BgeeiQ9Y5K2.
    CleanExiHS_KLK4.
    GenevestigatoriQ9Y5K2.

    Organism-specific databases

    HPAiHPA051839.

    Interactioni

    Protein-protein interaction databases

    BioGridi114982. 1 interaction.
    STRINGi9606.ENSP00000326159.

    Structurei

    Secondary structure

    1
    254
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi45 – 506
    Beta strandi53 – 6210
    Beta strandi65 – 684
    Helixi70 – 723
    Beta strandi75 – 828
    Beta strandi84 – 863
    Helixi88 – 903
    Beta strandi95 – 995
    Beta strandi101 – 1044
    Turni106 – 1094
    Beta strandi118 – 1214
    Beta strandi130 – 1323
    Beta strandi147 – 1548
    Beta strandi157 – 1604
    Beta strandi166 – 1727
    Helixi175 – 1828
    Turni183 – 1853
    Beta strandi190 – 1934
    Beta strandi210 – 2134
    Beta strandi216 – 22712
    Beta strandi235 – 2395
    Helixi240 – 2423
    Helixi244 – 2529

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2BDGX-ray1.95A/B31-247[»]
    2BDHX-ray3.00A/B/C/D31-247[»]
    2BDIX-ray3.00A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P31-247[»]
    4K1EX-ray1.30A31-253[»]
    4K8YX-ray1.00A31-253[»]
    4KELX-ray1.15A31-253[»]
    4KGAX-ray2.32A/B31-253[»]
    ProteinModelPortaliQ9Y5K2.
    SMRiQ9Y5K2. Positions 31-253.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9Y5K2.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini31 – 252222Peptidase S1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S1 family. Kallikrein subfamily.PROSITE-ProRule annotation
    Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG5640.
    HOGENOMiHOG000251820.
    HOVERGENiHBG013304.
    InParanoidiQ9Y5K2.
    KOiK08666.
    OMAiLCKFTDW.
    OrthoDBiEOG75B84T.
    PhylomeDBiQ9Y5K2.
    TreeFamiTF331065.

    Family and domain databases

    InterProiIPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00089. Trypsin. 1 hit.
    [Graphical view]
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9Y5K2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MATAGNPWGW FLGYLILGVA GSLVSGSCSQ IINGEDCSPH SQPWQAALVM    50
    ENELFCSGVL VHPQWVLSAA HCFQNSYTIG LGLHSLEADQ EPGSQMVEAS 100
    LSVRHPEYNR PLLANDLMLI KLDESVSESD TIRSISIASQ CPTAGNSCLV 150
    SGWGLLANGR MPTVLQCVNV SVVSEEVCSK LYDPLYHPSM FCAGGGHDQK 200
    DSCNGDSGGP LICNGYLQGL VSFGKAPCGQ VGVPGVYTNL CKFTEWIEKT 250
    VQAS 254
    Length:254
    Mass (Da):27,032
    Last modified:January 11, 2011 - v2
    Checksum:i9C5E4722AFF70CB8
    GO
    Isoform 2 (identifier: Q9Y5K2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-49: Missing.
         160-254: Missing.

    Show »
    Length:110
    Mass (Da):11,858
    Checksum:iB6F9C135EA93B116
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti22 – 221S → A.1 Publication
    Corresponds to variant rs1654551 [ dbSNP | Ensembl ].
    VAR_028364
    Natural varianti159 – 1591G → D.
    Corresponds to variant rs34626614 [ dbSNP | Ensembl ].
    VAR_033009
    Natural varianti197 – 1971H → Q.7 Publications
    Corresponds to variant rs2569527 [ dbSNP | Ensembl ].
    VAR_028365

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 4949Missing in isoform 2. 1 PublicationVSP_056629Add
    BLAST
    Alternative sequencei160 – 25495Missing in isoform 2. 1 PublicationVSP_056630Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF113140 mRNA. Translation: AAD21580.1.
    AF113141 Genomic DNA. Translation: AAD21581.1.
    AF135023 Genomic DNA. Translation: AAD26424.2.
    AF148532 Genomic DNA. Translation: AAD38019.1.
    AF243527 Genomic DNA. Translation: AAG33357.1.
    AF228497 Genomic DNA. Translation: AAF70620.1.
    AF259969 mRNA. Translation: AAF81227.1.
    AF259971 mRNA. Translation: AAK71706.1.
    AC037199 Genomic DNA. No translation available.
    BC069325 mRNA. Translation: AAH69325.1.
    BC069403 mRNA. Translation: AAH69403.1.
    BC069429 mRNA. Translation: AAH69429.1.
    BC069489 mRNA. Translation: AAH69489.1.
    BC096175 mRNA. Translation: AAH96175.1.
    BC096178 mRNA. Translation: AAH96178.1.
    AF126401 mRNA. Translation: AAG43246.1.
    CCDSiCCDS12809.1.
    RefSeqiNP_004908.3. NM_004917.3.
    UniGeneiHs.218366.

    Genome annotation databases

    EnsembliENST00000324041; ENSP00000326159; ENSG00000167749.
    ENST00000431178; ENSP00000399448; ENSG00000167749.
    GeneIDi9622.
    KEGGihsa:9622.
    UCSCiuc002pua.1. human.

    Polymorphism databases

    DMDMi317373372.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF113140 mRNA. Translation: AAD21580.1 .
    AF113141 Genomic DNA. Translation: AAD21581.1 .
    AF135023 Genomic DNA. Translation: AAD26424.2 .
    AF148532 Genomic DNA. Translation: AAD38019.1 .
    AF243527 Genomic DNA. Translation: AAG33357.1 .
    AF228497 Genomic DNA. Translation: AAF70620.1 .
    AF259969 mRNA. Translation: AAF81227.1 .
    AF259971 mRNA. Translation: AAK71706.1 .
    AC037199 Genomic DNA. No translation available.
    BC069325 mRNA. Translation: AAH69325.1 .
    BC069403 mRNA. Translation: AAH69403.1 .
    BC069429 mRNA. Translation: AAH69429.1 .
    BC069489 mRNA. Translation: AAH69489.1 .
    BC096175 mRNA. Translation: AAH96175.1 .
    BC096178 mRNA. Translation: AAH96178.1 .
    AF126401 mRNA. Translation: AAG43246.1 .
    CCDSi CCDS12809.1.
    RefSeqi NP_004908.3. NM_004917.3.
    UniGenei Hs.218366.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2BDG X-ray 1.95 A/B 31-247 [» ]
    2BDH X-ray 3.00 A/B/C/D 31-247 [» ]
    2BDI X-ray 3.00 A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P 31-247 [» ]
    4K1E X-ray 1.30 A 31-253 [» ]
    4K8Y X-ray 1.00 A 31-253 [» ]
    4KEL X-ray 1.15 A 31-253 [» ]
    4KGA X-ray 2.32 A/B 31-253 [» ]
    ProteinModelPortali Q9Y5K2.
    SMRi Q9Y5K2. Positions 31-253.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114982. 1 interaction.
    STRINGi 9606.ENSP00000326159.

    Chemistry

    BindingDBi Q9Y5K2.
    ChEMBLi CHEMBL4446.

    Protein family/group databases

    MEROPSi S01.251.

    Polymorphism databases

    DMDMi 317373372.

    Proteomic databases

    PaxDbi Q9Y5K2.
    PRIDEi Q9Y5K2.

    Protocols and materials databases

    DNASUi 9622.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000324041 ; ENSP00000326159 ; ENSG00000167749 .
    ENST00000431178 ; ENSP00000399448 ; ENSG00000167749 .
    GeneIDi 9622.
    KEGGi hsa:9622.
    UCSCi uc002pua.1. human.

    Organism-specific databases

    CTDi 9622.
    GeneCardsi GC19M051409.
    H-InvDB HIX0039968.
    HGNCi HGNC:6365. KLK4.
    HPAi HPA051839.
    MIMi 204700. phenotype.
    603767. gene.
    neXtProti NX_Q9Y5K2.
    Orphaneti 100033. Hypomaturation amelogenesis imperfecta.
    PharmGKBi PA30154.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5640.
    HOGENOMi HOG000251820.
    HOVERGENi HBG013304.
    InParanoidi Q9Y5K2.
    KOi K08666.
    OMAi LCKFTDW.
    OrthoDBi EOG75B84T.
    PhylomeDBi Q9Y5K2.
    TreeFami TF331065.

    Miscellaneous databases

    EvolutionaryTracei Q9Y5K2.
    GeneWikii KLK4.
    GenomeRNAii 9622.
    NextBioi 36105.
    PROi Q9Y5K2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y5K2.
    Bgeei Q9Y5K2.
    CleanExi HS_KLK4.
    Genevestigatori Q9Y5K2.

    Family and domain databases

    InterProi IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of prostase, an androgen-regulated serine protease with prostate-restricted expression."
      Nelson P.S., Gan L., Ferguson C., Moss P., Gelinas R., Hood L., Wang K.
      Proc. Natl. Acad. Sci. U.S.A. 96:3114-3119(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
    2. "Prostase/KLK-L1 is a new member of the human kallikrein gene family, is expressed in prostate and breast tissues, and is hormonally regulated."
      Yousef G.M., Obiezu C.V., Luo L.-Y., Black M.H., Diamandis E.P.
      Cancer Res. 59:4252-4256(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLN-197.
    3. "Localization of a new prostate-specific antigen-related serine protease gene, KLK4, is evidence for an expanded human kallikrein gene family cluster on chromosome 19q13.3-13.4."
      Stephenson S.A., Verity K., Ashworth L.K., Clements J.A.
      J. Biol. Chem. 274:23210-23214(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLN-197.
    4. "Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region."
      Gan L., Lee I., Smith R., Argonza-Barrett R., Lei H., McCuaig J., Moss P., Paeper B., Wang K.
      Gene 257:119-130(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    5. "Characterization of the mouse and human PRSS17 genes, their relationship to other serine proteases, and the expression of PRSS17 in developing mouse incisors."
      Hu J.C.-C., Zhang C., Sun X., Yang Y., Cao X., Ryu O., Simmer J.P.
      Gene 251:1-8(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION, VARIANT GLN-197.
    6. "Distinctly different gene structure of KLK4/KLK-L1/prostase/ARM1 compared with other members of the kallikrein family: intracellular localization, alternative cDNA forms, and Regulation by multiple hormones."
      Korkmaz K.S., Korkmaz C.G., Pretlow T.G., Saatcioglu F.
      DNA Cell Biol. 20:435-445(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANT GLN-197, ALTERNATIVE SPLICING.
      Tissue: Prostatic carcinoma.
    7. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT GLN-197.
    9. "Cloning and characterization of a cDNA encoding human EMSP1."
      Simmer J.P., Ryu O.H., Qian Q., Zhang C., Cao X., Sun X., Hu C.-C.
      (In) Goldberg M. (eds.); Chemistry and biology of mineralized tissues, pp.1-1, American Academy of Orthopaedic Surgeons, Vittel (2000)
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 22-254 (ISOFORM 1), VARIANT GLN-197.
    10. "Crystal structures of human tissue kallikrein 4: activity modulation by a specific zinc binding site."
      Debela M., Magdolen V., Grimminger V., Sommerhoff C., Messerschmidt A., Huber R., Friedrich R., Bode W., Goettig P.
      J. Mol. Biol. 362:1094-1107(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 31-35, X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 31-253, ACTIVE SITE, ZINC-BINDING SITES, DISULFIDE BONDS, VARIANT GLN-197.
    11. "Mutation in kallikrein 4 causes autosomal recessive hypomaturation amelogenesis imperfecta."
      Hart P.S., Hart T.C., Michalec M.D., Ryu O.H., Simmons D., Hong S., Wright J.T.
      J. Med. Genet. 41:545-549(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INVOLVEMENT IN AI2A1, VARIANT ALA-22.

    Entry informationi

    Entry nameiKLK4_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y5K2
    Secondary accession number(s): Q4VB16
    , Q96RU5, Q9GZL6, Q9UBJ6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: January 11, 2011
    Last modified: October 1, 2014
    This is version 127 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. Peptidase families
      Classification of peptidase families and list of entries
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3