Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Mitochondrial import inner membrane translocase subunit Tim8 B

Gene

TIMM8B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity).By similarity

GO - Molecular functioni

  • metal ion transmembrane transporter activity Source: GO_Central
  • zinc ion binding Source: ProtInc

GO - Biological processi

  • cation transmembrane transport Source: GO_Central
  • chaperone-mediated protein transport Source: BHF-UCL
  • protein targeting to mitochondrion Source: ProtInc
  • sensory perception of sound Source: ProtInc

Keywordsi

Molecular functionChaperone
Biological processProtein transport, Translocation, Transport
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-1268020 Mitochondrial protein import

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import inner membrane translocase subunit Tim8 B
Alternative name(s):
DDP-like protein
Deafness dystonia protein 2
Gene namesi
Name:TIMM8B
Synonyms:DDP2, DDPL, TIM8B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000150779.11
HGNCiHGNC:11818 TIMM8B
MIMi606659 gene
neXtProtiNX_Q9Y5J9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi26521
OpenTargetsiENSG00000150779
PharmGKBiPA36524

Polymorphism and mutation databases

BioMutaiTIMM8B

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001935872 – 83Mitochondrial import inner membrane translocase subunit Tim8 BAdd BLAST82

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Disulfide bondi36 ↔ 59By similarity
Disulfide bondi40 ↔ 55By similarity

Keywords - PTMi

Acetylation, Disulfide bond

Proteomic databases

EPDiQ9Y5J9
MaxQBiQ9Y5J9
PaxDbiQ9Y5J9
PeptideAtlasiQ9Y5J9
PRIDEiQ9Y5J9
TopDownProteomicsiQ9Y5J9

PTM databases

iPTMnetiQ9Y5J9
PhosphoSitePlusiQ9Y5J9

Expressioni

Tissue specificityi

Ubiquitous, with highest expression in heart, kidney, liver and skeletal muscle.1 Publication

Gene expression databases

BgeeiENSG00000150779
CleanExiHS_TIMM8B
ExpressionAtlasiQ9Y5J9 baseline and differential
GenevisibleiQ9Y5J9 HS

Organism-specific databases

HPAiHPA041173

Interactioni

Subunit structurei

Heterohexamer; possibly composed of 3 copies of TIMM8B and 3 copies of TIMM13, named soluble 70 kDa complex. Associates with the TIM22 complex, whose core is composed of TIMM22 (By similarity).By similarity

Protein-protein interaction databases

BioGridi117725, 18 interactors
IntActiQ9Y5J9, 14 interactors
MINTiQ9Y5J9
STRINGi9606.ENSP00000438455

Structurei

3D structure databases

ProteinModelPortaliQ9Y5J9
SMRiQ9Y5J9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi36 – 59Twin CX3C motifAdd BLAST24

Domaini

The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIMM8B from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (By similarity).By similarity

Sequence similaritiesi

Belongs to the small Tim family.Curated

Phylogenomic databases

eggNOGiKOG3489 Eukaryota
ENOG41126D5 LUCA
GeneTreeiENSGT00390000016102
HOGENOMiHOG000115758
HOVERGENiHBG060492
InParanoidiQ9Y5J9
KOiK17780
PhylomeDBiQ9Y5J9

Family and domain databases

Gene3Di1.10.287.810, 1 hit
InterProiView protein in InterPro
IPR004217 Tim10-like
IPR035427 Tim10-like_dom_sf
PfamiView protein in Pfam
PF02953 zf-Tim10_DDP, 1 hit
SUPFAMiSSF144122 SSF144122, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y5J9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAELGEADEA ELQRLVAAEQ QKAQFTAQVH HFMELCWDKC VEKPGNRLDS
60 70 80
RTENCLSSCV DRFIDTTLAI TSRFAQIVQK GGQ
Length:83
Mass (Da):9,344
Last modified:November 1, 1999 - v1
Checksum:i9DC47BB475DB8692
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152350 mRNA Translation: AAF15100.1
AF150087 mRNA Translation: AAD39994.1
AK312169 mRNA Translation: BAG35103.1
EF445036 Genomic DNA Translation: ACA06083.1
BC000711 mRNA Translation: AAH00711.1
BC105986 mRNA Translation: AAI05987.1
BC106067 mRNA Translation: AAI06068.1
AF165967 mRNA Translation: AAD51801.1
RefSeqiNP_036591.2, NM_012459.2
UniGeneiHs.279915

Genome annotation databases

EnsembliENST00000504148; ENSP00000422122; ENSG00000150779
GeneIDi26521
KEGGihsa:26521
UCSCiuc058hho.1 human

Similar proteinsi

Entry informationi

Entry nameiTIM8B_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5J9
Secondary accession number(s): B0YJA5, Q3KQS9, Q9UN04
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 1, 1999
Last modified: May 23, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health