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Reviewed, UniProtKB/Swiss-Prot Q9Y5J6 (TIM9B_HUMAN)

Last modified November 4, 2008. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Mitochondrial import inner membrane translocase subunit Tim9 B
Alternative name(s):
    TIMM10B
      Short name=Tim10b
    Fracture callus protein 1
    FxC1
Gene names
Name: FXC1
Synonyms: TIM9B, TIMM9B
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length103 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as external driving force. In the TIM22 complex, it may act as a docking point for the soluble 70 kDa complex that guides the target proteins in transit through the aqueous mitochondrial intermembrane space.

Subunit structure

Component of the TIM22 complex, whose core is composed of TIMM22, associated with peripheral protein FXC1/TIM10B and the 70 kDa heterohexamer. In most cases, the 70 kDa complex is composed of TIMM9 and TIMM10. Also forms a complex composed of TIMM9, TIMM10/TIM10A and FXC1/TIM10B.

Subcellular location

Mitochondrion inner membrane; Peripheral membrane protein.

Tissue specificity

Ubiquitous, with highest expression in heart, kidney, liver and skeletal muscle.

Domain

The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of FXC1/TIM10B from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane By similarity.

Sequence similarities

Belongs to the small Tim family.

Ontologies

Keywords

   Biological processProtein transport
Translocation
Transport
   Cellular componentMembrane
Mitochondrion
Mitochondrion inner membrane
   Coding sequence diversityPolymorphism
   LigandMetal-binding
Zinc

Gene Ontology (GO)

   Biological processcell-matrix adhesion

Traceable author statement. Source: ProtInc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 103103Mitochondrial import inner membrane translocase subunit Tim9 B
PRO_0000193598

Regions

Motif28 – 5225Twin CX3C motif

Amino acid modifications

Disulfide bond28 ↔ 52 By similarity
Disulfide bond32 ↔ 48 By similarity

Natural variations

Natural variant901G → S: dbSNP rs17850713.
VAR_025665

Sequences

Sequence LengthMass (Da)Tools
Q9Y5J6-1 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: B76CCC81668B1F31

FASTA10311,586
        10         20         30         40         50         60 
MERQQQQQQQ LRNLRDFLLV YNRMTELCFQ RCVPSLHHRA LDAEEEACLH SCAGKLIHSN 

        70         80         90        100 
HRLMAAYVQL MPALVQRRIA DYEAASAVPG VAAEQPGVSP SGS 

« Hide

References

« Hide 'large scale' references
[1]"The human family of deafness/dystonia peptide (DDP) related mitochondrial import proteins."
Jin H., Kendall E., Freeman T.C., Roberts R.G., Vetrie D.L.P.
Genomics 61:259-267(1999) [PubMed: 10552927] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom."
Bauer M.F., Rothbauer U., Muehlenbein N., Smith R.J.H., Gerbitz K.-D., Neupert W., Brunner M., Hofmann S.
FEBS Lett. 464:41-47(1999) [PubMed: 10611480] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[3]"A novel gene expressed in human pheochromocytoma."
Peng Y., Li Y., Jia J., Xu S., Han Z., Fu G., Chen Z.
Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Pheochromocytoma.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-90.
Tissue: Bone marrow.
[5]"Role of the deafness dystonia peptide 1 (DDP1) in import of human Tim23 into the inner membrane of mitochondria."
Rothbauer U., Hofmann S., Muehlenbein N., Paschen S.A., Gerbitz K.-D., Neupert W., Brunner M., Bauer M.F.
J. Biol. Chem. 276:37327-37334(2001) [PubMed: 11489896] [Abstract]
Cited for: SUBCELLULAR LOCATION.
[6]"Organization and function of the small Tim complexes acting along the import pathway of metabolite carriers into mammalian mitochondria."
Muehlenbein N., Hofmann S., Rothbauer U., Bauer M.F.
J. Biol. Chem. 279:13540-13546(2004) [PubMed: 14726512] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH TIMM9; TIMM10 AND TIMM22.

Cross-references

Sequence databases

AF152355 mRNA. Translation: AAF15105.1.
AF150105 mRNA. Translation: AAD40011.1.
AF183415 mRNA. Translation: AAG09684.1.
BC011014 mRNA. Translation: AAH11014.1.
RefSeqNP_036324.1.
UniGeneHs.54943

3D structure databases

ModBaseSearch...

Proteomic databases

PeptideAtlasQ9Y5J6.

Genome annotation databases

EnsemblENSG00000132286. Homo sapiens. [Contig view]
GeneID26515.
KEGGhsa:26515.

Organism-specific databases

H-InvDBHIX0009401.
HGNCHGNC:4022. FXC1.
MIM607388. gene.
PharmGKBPA28438.
GenAtlasSearch...
GeneCardsSearch...

Phylogenomic databases

HOGENOMQ9Y5J6.
HOVERGENQ9Y5J6.

Gene expression databases

ArrayExpressQ9Y5J6.
CleanExHS_FXC1.
GermOnlineENSG00000132286. Homo sapiens.

Family and domain databases

InterProIPR004217. Znf_Tim10_DDP.
[Graphical view]
PfamPF02953. zf-Tim10_DDP. 1 hit.
[Graphical view]
BLOCKSSearch...
ProtoNetSearch...

Other Resources

NextBio48824.
SOURCESearch...

Entry information

Entry nameTIM9B_HUMAN
AccessionPrimary (citable) accession number: Q9Y5J6
Secondary accession number(s): Q96FF3
Entry history
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 1, 1999
Last modified: November 4, 2008
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents