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Protein

Hairy/enhancer-of-split related with YRPW motif protein 1

Gene

HEY1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6.2 Publications

GO - Molecular functioni

  • microsatellite binding Source: UniProtKB
  • protein binding transcription factor activity Source: UniProtKB
  • RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity Source: UniProtKB
  • sequence-specific DNA binding transcription factor activity Source: UniProtKB
  • transcription factor binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Repressor

Keywords - Biological processi

Notch signaling pathway, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_118780. NOTCH1 Intracellular Domain Regulates Transcription.
REACT_160243. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
REACT_160254. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.

Names & Taxonomyi

Protein namesi
Recommended name:
Hairy/enhancer-of-split related with YRPW motif protein 1
Alternative name(s):
Cardiovascular helix-loop-helix factor 2
Short name:
CHF-2
Class B basic helix-loop-helix protein 31
Short name:
bHLHb31
HES-related repressor protein 1
Hairy and enhancer of split-related protein 1
Short name:
HESR-1
Hairy-related transcription factor 1
Short name:
HRT-1
Short name:
hHRT1
Gene namesi
Name:HEY1
Synonyms:BHLHB31, CHF2, HERP2, HESR1, HRT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:4880. HEY1.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29258.

Polymorphism and mutation databases

BioMutaiHEY1.
DMDMi13124298.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 304304Hairy/enhancer-of-split related with YRPW motif protein 1PRO_0000127217Add
BLAST

Proteomic databases

MaxQBiQ9Y5J3.
PaxDbiQ9Y5J3.
PRIDEiQ9Y5J3.

PTM databases

PhosphoSiteiQ9Y5J3.

Expressioni

Tissue specificityi

Expressed in the somitic mesoderm, the central nervous system, the kidney, the heart, nasal epithelium, and limbs.

Gene expression databases

BgeeiQ9Y5J3.
CleanExiHS_HEY1.
ExpressionAtlasiQ9Y5J3. baseline and differential.
GenevisibleiQ9Y5J3. HS.

Organism-specific databases

HPAiHPA055599.

Interactioni

Subunit structurei

Self-associates. Interacts with HES1 and HEYL. Interacts with HDAC1, NCOR1 and SIN3A. Interacts with GATA4 and GATA6. Interacts with CCDC89/BOIP.By similarity

Protein-protein interaction databases

BioGridi117025. 13 interactions.
IntActiQ9Y5J3. 6 interactions.
MINTiMINT-1179634.
STRINGi9606.ENSP00000338272.

Structurei

Secondary structure

1
304
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi115 – 1206
Helixi122 – 14019
Helixi149 – 16416

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DB7X-ray1.90A/B111-167[»]
ProteinModelPortaliQ9Y5J3.
SMRiQ9Y5J3. Positions 39-107, 111-165.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y5J3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini49 – 10456bHLHPROSITE-ProRule annotationAdd
BLAST
Domaini122 – 15837OrangePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni48 – 11770Transcriptional repression and interaction with NCOR1 and SIN3ABy similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi294 – 2974YRPW motif

Sequence similaritiesi

Belongs to the HEY family.Curated
Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation
Contains 1 Orange domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG241271.
GeneTreeiENSGT00700000104130.
HOGENOMiHOG000286035.
HOVERGENiHBG003275.
InParanoidiQ9Y5J3.
KOiK09091.
OMAiADENGNM.
OrthoDBiEOG76MK98.
PhylomeDBiQ9Y5J3.
TreeFamiTF323617.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR003650. Orange.
[Graphical view]
PfamiPF07527. Hairy_orange. 1 hit.
PF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
SM00511. ORANGE. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
PS51054. ORANGE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y5J3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKRAHPEYSS SDSELDETIE VEKESADENG NLSSALGSMS PTTSSQILAR
60 70 80 90 100
KRRRGIIEKR RRDRINNSLS ELRRLVPSAF EKQGSAKLEK AEILQMTVDH
110 120 130 140 150
LKMLHTAGGK GYFDAHALAM DYRSLGFREC LAEVARYLSI IEGLDASDPL
160 170 180 190 200
RVRLVSHLNN YASQREAASG AHAGLGHIPW GTVFGHHPHI AHPLLLPQNG
210 220 230 240 250
HGNAGTTASP TEPHHQGRLG SAHPEAPALR APPSGSLGPV LPVVTSASKL
260 270 280 290 300
SPPLLSSVAS LSAFPFSFGS FHLLSPNALS PSAPTQAANL GKPYRPWGTE

IGAF
Length:304
Mass (Da):32,613
Last modified:November 1, 1999 - v1
Checksum:iF130991A99E9CA54
GO
Isoform 2 (identifier: Q9Y5J3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     82-82: K → KQVME

Show »
Length:308
Mass (Da):33,100
Checksum:i99A47C7EE29AC7B8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti237 – 2371L → F in AAF37297 (Ref. 5) Curated
Sequence conflicti237 – 2371L → P in BAC03890 (PubMed:14702039).Curated
Sequence conflicti252 – 2521P → L in AAF37297 (Ref. 5) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei82 – 821K → KQVME in isoform 2. 1 PublicationVSP_040997

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151522 mRNA. Translation: AAD38967.1.
AF176422 mRNA. Translation: AAD51749.1.
AJ272214 mRNA. Translation: CAB75715.1.
AF232239 mRNA. Translation: AAF37297.1.
AF311883 mRNA. Translation: AAG31156.1.
BT020065 mRNA. Translation: AAV38868.1.
AK092437 mRNA. Translation: BAC03890.1.
AK313271 mRNA. Translation: BAG36080.1.
AC016240 Genomic DNA. No translation available.
CH471068 Genomic DNA. Translation: EAW87066.1.
BC001873 mRNA. Translation: AAH01873.1.
CCDSiCCDS43749.1. [Q9Y5J3-2]
CCDS6225.1. [Q9Y5J3-1]
RefSeqiNP_001035798.1. NM_001040708.1. [Q9Y5J3-2]
NP_001269780.1. NM_001282851.1.
NP_036390.3. NM_012258.3. [Q9Y5J3-1]
UniGeneiHs.234434.

Genome annotation databases

EnsembliENST00000337919; ENSP00000338272; ENSG00000164683. [Q9Y5J3-2]
ENST00000354724; ENSP00000346761; ENSG00000164683.
GeneIDi23462.
KEGGihsa:23462.
UCSCiuc003ybl.3. human. [Q9Y5J3-2]
uc003ybm.3. human. [Q9Y5J3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151522 mRNA. Translation: AAD38967.1.
AF176422 mRNA. Translation: AAD51749.1.
AJ272214 mRNA. Translation: CAB75715.1.
AF232239 mRNA. Translation: AAF37297.1.
AF311883 mRNA. Translation: AAG31156.1.
BT020065 mRNA. Translation: AAV38868.1.
AK092437 mRNA. Translation: BAC03890.1.
AK313271 mRNA. Translation: BAG36080.1.
AC016240 Genomic DNA. No translation available.
CH471068 Genomic DNA. Translation: EAW87066.1.
BC001873 mRNA. Translation: AAH01873.1.
CCDSiCCDS43749.1. [Q9Y5J3-2]
CCDS6225.1. [Q9Y5J3-1]
RefSeqiNP_001035798.1. NM_001040708.1. [Q9Y5J3-2]
NP_001269780.1. NM_001282851.1.
NP_036390.3. NM_012258.3. [Q9Y5J3-1]
UniGeneiHs.234434.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DB7X-ray1.90A/B111-167[»]
ProteinModelPortaliQ9Y5J3.
SMRiQ9Y5J3. Positions 39-107, 111-165.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117025. 13 interactions.
IntActiQ9Y5J3. 6 interactions.
MINTiMINT-1179634.
STRINGi9606.ENSP00000338272.

PTM databases

PhosphoSiteiQ9Y5J3.

Polymorphism and mutation databases

BioMutaiHEY1.
DMDMi13124298.

Proteomic databases

MaxQBiQ9Y5J3.
PaxDbiQ9Y5J3.
PRIDEiQ9Y5J3.

Protocols and materials databases

DNASUi23462.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000337919; ENSP00000338272; ENSG00000164683. [Q9Y5J3-2]
ENST00000354724; ENSP00000346761; ENSG00000164683.
GeneIDi23462.
KEGGihsa:23462.
UCSCiuc003ybl.3. human. [Q9Y5J3-2]
uc003ybm.3. human. [Q9Y5J3-1]

Organism-specific databases

CTDi23462.
GeneCardsiGC08M080676.
HGNCiHGNC:4880. HEY1.
HPAiHPA055599.
MIMi602953. gene.
neXtProtiNX_Q9Y5J3.
PharmGKBiPA29258.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG241271.
GeneTreeiENSGT00700000104130.
HOGENOMiHOG000286035.
HOVERGENiHBG003275.
InParanoidiQ9Y5J3.
KOiK09091.
OMAiADENGNM.
OrthoDBiEOG76MK98.
PhylomeDBiQ9Y5J3.
TreeFamiTF323617.

Enzyme and pathway databases

ReactomeiREACT_118780. NOTCH1 Intracellular Domain Regulates Transcription.
REACT_160243. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
REACT_160254. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.

Miscellaneous databases

ChiTaRSiHEY1. human.
EvolutionaryTraceiQ9Y5J3.
GeneWikiiHEY1.
GenomeRNAii23462.
NextBioi45771.
PROiQ9Y5J3.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y5J3.
CleanExiHS_HEY1.
ExpressionAtlasiQ9Y5J3. baseline and differential.
GenevisibleiQ9Y5J3. HS.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR003650. Orange.
[Graphical view]
PfamiPF07527. Hairy_orange. 1 hit.
PF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
SM00511. ORANGE. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
PS51054. ORANGE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and expression of a novel family of bHLH cDNAs related to Drosophila hairy and enhancer of split."
    Kokubo H., Lun Y., Johnson R.L.
    Biochem. Biophys. Res. Commun. 260:459-465(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "Hey genes: a novel subfamily of hairy- and enhancer of split related genes specifically expressed during mouse embryogenesis."
    Leimeister C., Externbrinck A., Klamt B., Gessler M.
    Mech. Dev. 85:173-177(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Characterization of the human and mouse HEY1, HEY2, and HEYL genes: cloning, mapping, and mutation screening of a new bHLH gene family."
    Steidl C., Leimeister C., Klamt B., Maier M., Nanda I., Dixon M., Clarke R., Schmid M., Gessler M.
    Genomics 66:195-203(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  4. "Cardiovascular basic helix loop helix factor 1, a novel transcriptional repressor expressed preferentially in the developing and adult cardiovascular system."
    Chin M.T., Maemura K., Fukumoto S., Jain M.K., Layne M.D., Watanabe M., Hsieh C.-M., Lee M.-E.
    J. Biol. Chem. 275:6381-6387(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  5. "The HERP repressors, novel partners for HES/hairy in notch signaling."
    Iso T., Sartorelli V., Poizat C., Chen T., Sucov H.M., Chung G., Wu H.-Y., Kedes L., Hamamori Y.
    Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  6. "Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling."
    Nakagawa O., McFadden D.G., Nakagawa M., Yanagisawa H., Hu T., Srivastava D., Olson E.N.
    Proc. Natl. Acad. Sci. U.S.A. 97:13655-13660(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, DNA-BINDING.
  7. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  8. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Placenta.
  9. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  11. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung.
  12. "Hairy-related transcription factors inhibit GATA-dependent cardiac gene expression through a signal-responsive mechanism."
    Kathiriya I.S., King I.N., Murakami M., Nakagawa M., Astle J.M., Gardner K.A., Gerard R.D., Olson E.N., Srivastava D., Nakagawa O.
    J. Biol. Chem. 279:54937-54943(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  13. "Crystal structure of hypothetical protein MS0332."
    RIKEN structural genomics initiative (RSGI)
    Submitted (FEB-2009) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 111-167.

Entry informationi

Entry nameiHEY1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5J3
Secondary accession number(s): B2R883
, Q5TZS3, Q8NAM2, Q9NYP4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: November 1, 1999
Last modified: July 22, 2015
This is version 148 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.