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Q9Y5J3

- HEY1_HUMAN

UniProt

Q9Y5J3 - HEY1_HUMAN

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Protein
Hairy/enhancer-of-split related with YRPW motif protein 1
Gene
HEY1, BHLHB31, CHF2, HERP2, HESR1, HRT1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6.2 Publications

GO - Molecular functioni

  1. RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity Source: UniProtKB
  2. microsatellite binding Source: UniProtKB
  3. protein binding Source: UniProtKB
  4. protein binding transcription factor activity Source: UniProtKB
  5. sequence-specific DNA binding transcription factor activity Source: UniProtKB
  6. transcription factor binding Source: UniProtKB

GO - Biological processi

  1. Notch signaling involved in heart development Source: BHF-UCL
  2. Notch signaling pathway Source: UniProtKB
  3. angiogenesis Source: UniProtKB
  4. anterior/posterior axis specification Source: Ensembl
  5. arterial endothelial cell differentiation Source: BHF-UCL
  6. atrioventricular valve formation Source: BHF-UCL
  7. cardiac epithelial to mesenchymal transition Source: BHF-UCL
  8. cardiac septum morphogenesis Source: BHF-UCL
  9. cardiac ventricle morphogenesis Source: BHF-UCL
  10. cellular response to glucocorticoid stimulus Source: Ensembl
  11. dorsal aorta morphogenesis Source: BHF-UCL
  12. endocardial cushion morphogenesis Source: BHF-UCL
  13. endocardial cushion to mesenchymal transition involved in heart valve formation Source: Ensembl
  14. epithelial to mesenchymal transition involved in endocardial cushion formation Source: UniProtKB
  15. heart trabecula formation Source: BHF-UCL
  16. labyrinthine layer blood vessel development Source: BHF-UCL
  17. negative regulation of Notch signaling pathway Source: BHF-UCL
  18. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  19. negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation Source: BHF-UCL
  20. negative regulation of transcription regulatory region DNA binding Source: BHF-UCL
  21. negative regulation of transcription, DNA-templated Source: UniProtKB
  22. osteoblast development Source: Ensembl
  23. positive regulation of osteoblast differentiation Source: Ensembl
  24. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  25. pulmonary valve morphogenesis Source: BHF-UCL
  26. regulation of vasculogenesis Source: BHF-UCL
  27. transcription from RNA polymerase II promoter Source: GOC
  28. umbilical cord morphogenesis Source: BHF-UCL
  29. vasculogenesis Source: Ensembl
  30. ventricular septum morphogenesis Source: BHF-UCL
  31. ventricular trabecula myocardium morphogenesis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Repressor

Keywords - Biological processi

Notch signaling pathway, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_118780. NOTCH1 Intracellular Domain Regulates Transcription.
REACT_160243. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
REACT_160254. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.

Names & Taxonomyi

Protein namesi
Recommended name:
Hairy/enhancer-of-split related with YRPW motif protein 1
Alternative name(s):
Cardiovascular helix-loop-helix factor 2
Short name:
CHF-2
Class B basic helix-loop-helix protein 31
Short name:
bHLHb31
HES-related repressor protein 1
Hairy and enhancer of split-related protein 1
Short name:
HESR-1
Hairy-related transcription factor 1
Short name:
HRT-1
Short name:
hHRT1
Gene namesi
Name:HEY1
Synonyms:BHLHB31, CHF2, HERP2, HESR1, HRT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:4880. HEY1.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. nucleoplasm Source: Reactome
  3. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29258.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 304304Hairy/enhancer-of-split related with YRPW motif protein 1
PRO_0000127217Add
BLAST

Proteomic databases

MaxQBiQ9Y5J3.
PaxDbiQ9Y5J3.
PRIDEiQ9Y5J3.

PTM databases

PhosphoSiteiQ9Y5J3.

Expressioni

Tissue specificityi

Expressed in the somitic mesoderm, the central nervous system, the kidney, the heart, nasal epithelium, and limbs.

Gene expression databases

ArrayExpressiQ9Y5J3.
BgeeiQ9Y5J3.
CleanExiHS_HEY1.
GenevestigatoriQ9Y5J3.

Organism-specific databases

HPAiHPA055599.

Interactioni

Subunit structurei

Self-associates By similarity. Interacts with HES1 and HEYL By similarity. Interacts with HDAC1, NCOR1 and SIN3A By similarity. Interacts with GATA4 and GATA6 By similarity. Interacts with CCDC89/BOIP By similarity.

Protein-protein interaction databases

BioGridi117025. 13 interactions.
IntActiQ9Y5J3. 6 interactions.
MINTiMINT-1179634.
STRINGi9606.ENSP00000338272.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi115 – 1206
Helixi122 – 14019
Helixi149 – 16416

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DB7X-ray1.90A/B111-167[»]
ProteinModelPortaliQ9Y5J3.
SMRiQ9Y5J3. Positions 39-107, 111-165.

Miscellaneous databases

EvolutionaryTraceiQ9Y5J3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini49 – 10456bHLH
Add
BLAST
Domaini122 – 15837Orange
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni48 – 11770Transcriptional repression and interaction with NCOR1 and SIN3A By similarity
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi294 – 2974YRPW motif

Sequence similaritiesi

Belongs to the HEY family.
Contains 1 Orange domain.

Phylogenomic databases

eggNOGiNOG241271.
HOGENOMiHOG000286035.
HOVERGENiHBG003275.
KOiK09091.
OMAiADENGNM.
OrthoDBiEOG76MK98.
PhylomeDBiQ9Y5J3.
TreeFamiTF323617.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR003650. Orange.
IPR018352. Orange_subgr.
[Graphical view]
PfamiPF07527. Hairy_orange. 1 hit.
PF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
SM00511. ORANGE. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
PS51054. ORANGE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9Y5J3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MKRAHPEYSS SDSELDETIE VEKESADENG NLSSALGSMS PTTSSQILAR    50
KRRRGIIEKR RRDRINNSLS ELRRLVPSAF EKQGSAKLEK AEILQMTVDH 100
LKMLHTAGGK GYFDAHALAM DYRSLGFREC LAEVARYLSI IEGLDASDPL 150
RVRLVSHLNN YASQREAASG AHAGLGHIPW GTVFGHHPHI AHPLLLPQNG 200
HGNAGTTASP TEPHHQGRLG SAHPEAPALR APPSGSLGPV LPVVTSASKL 250
SPPLLSSVAS LSAFPFSFGS FHLLSPNALS PSAPTQAANL GKPYRPWGTE 300
IGAF 304
Length:304
Mass (Da):32,613
Last modified:November 1, 1999 - v1
Checksum:iF130991A99E9CA54
GO
Isoform 2 (identifier: Q9Y5J3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     82-82: K → KQVME

Show »
Length:308
Mass (Da):33,100
Checksum:i99A47C7EE29AC7B8
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei82 – 821K → KQVME in isoform 2.
VSP_040997

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti237 – 2371L → F in AAF37297. 1 Publication
Sequence conflicti237 – 2371L → P in BAC03890. 1 Publication
Sequence conflicti252 – 2521P → L in AAF37297. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF151522 mRNA. Translation: AAD38967.1.
AF176422 mRNA. Translation: AAD51749.1.
AJ272214 mRNA. Translation: CAB75715.1.
AF232239 mRNA. Translation: AAF37297.1.
AF311883 mRNA. Translation: AAG31156.1.
BT020065 mRNA. Translation: AAV38868.1.
AK092437 mRNA. Translation: BAC03890.1.
AK313271 mRNA. Translation: BAG36080.1.
AC016240 Genomic DNA. No translation available.
CH471068 Genomic DNA. Translation: EAW87066.1.
BC001873 mRNA. Translation: AAH01873.1.
CCDSiCCDS43749.1. [Q9Y5J3-2]
CCDS6225.1. [Q9Y5J3-1]
RefSeqiNP_001035798.1. NM_001040708.1. [Q9Y5J3-2]
NP_001269780.1. NM_001282851.1.
NP_036390.3. NM_012258.3. [Q9Y5J3-1]
UniGeneiHs.234434.

Genome annotation databases

EnsembliENST00000337919; ENSP00000338272; ENSG00000164683. [Q9Y5J3-2]
ENST00000354724; ENSP00000346761; ENSG00000164683. [Q9Y5J3-1]
GeneIDi23462.
KEGGihsa:23462.
UCSCiuc003ybl.3. human. [Q9Y5J3-2]
uc003ybm.3. human. [Q9Y5J3-1]

Polymorphism databases

DMDMi13124298.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF151522 mRNA. Translation: AAD38967.1 .
AF176422 mRNA. Translation: AAD51749.1 .
AJ272214 mRNA. Translation: CAB75715.1 .
AF232239 mRNA. Translation: AAF37297.1 .
AF311883 mRNA. Translation: AAG31156.1 .
BT020065 mRNA. Translation: AAV38868.1 .
AK092437 mRNA. Translation: BAC03890.1 .
AK313271 mRNA. Translation: BAG36080.1 .
AC016240 Genomic DNA. No translation available.
CH471068 Genomic DNA. Translation: EAW87066.1 .
BC001873 mRNA. Translation: AAH01873.1 .
CCDSi CCDS43749.1. [Q9Y5J3-2 ]
CCDS6225.1. [Q9Y5J3-1 ]
RefSeqi NP_001035798.1. NM_001040708.1. [Q9Y5J3-2 ]
NP_001269780.1. NM_001282851.1.
NP_036390.3. NM_012258.3. [Q9Y5J3-1 ]
UniGenei Hs.234434.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2DB7 X-ray 1.90 A/B 111-167 [» ]
ProteinModelPortali Q9Y5J3.
SMRi Q9Y5J3. Positions 39-107, 111-165.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117025. 13 interactions.
IntActi Q9Y5J3. 6 interactions.
MINTi MINT-1179634.
STRINGi 9606.ENSP00000338272.

PTM databases

PhosphoSitei Q9Y5J3.

Polymorphism databases

DMDMi 13124298.

Proteomic databases

MaxQBi Q9Y5J3.
PaxDbi Q9Y5J3.
PRIDEi Q9Y5J3.

Protocols and materials databases

DNASUi 23462.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000337919 ; ENSP00000338272 ; ENSG00000164683 . [Q9Y5J3-2 ]
ENST00000354724 ; ENSP00000346761 ; ENSG00000164683 . [Q9Y5J3-1 ]
GeneIDi 23462.
KEGGi hsa:23462.
UCSCi uc003ybl.3. human. [Q9Y5J3-2 ]
uc003ybm.3. human. [Q9Y5J3-1 ]

Organism-specific databases

CTDi 23462.
GeneCardsi GC08M080676.
HGNCi HGNC:4880. HEY1.
HPAi HPA055599.
MIMi 602953. gene.
neXtProti NX_Q9Y5J3.
PharmGKBi PA29258.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG241271.
HOGENOMi HOG000286035.
HOVERGENi HBG003275.
KOi K09091.
OMAi ADENGNM.
OrthoDBi EOG76MK98.
PhylomeDBi Q9Y5J3.
TreeFami TF323617.

Enzyme and pathway databases

Reactomei REACT_118780. NOTCH1 Intracellular Domain Regulates Transcription.
REACT_160243. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
REACT_160254. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.

Miscellaneous databases

ChiTaRSi HEY1. human.
EvolutionaryTracei Q9Y5J3.
GeneWikii HEY1.
GenomeRNAii 23462.
NextBioi 45771.
PROi Q9Y5J3.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9Y5J3.
Bgeei Q9Y5J3.
CleanExi HS_HEY1.
Genevestigatori Q9Y5J3.

Family and domain databases

Gene3Di 4.10.280.10. 1 hit.
InterProi IPR011598. bHLH_dom.
IPR003650. Orange.
IPR018352. Orange_subgr.
[Graphical view ]
Pfami PF07527. Hairy_orange. 1 hit.
PF00010. HLH. 1 hit.
[Graphical view ]
SMARTi SM00353. HLH. 1 hit.
SM00511. ORANGE. 1 hit.
[Graphical view ]
SUPFAMi SSF47459. SSF47459. 1 hit.
PROSITEi PS50888. BHLH. 1 hit.
PS51054. ORANGE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and expression of a novel family of bHLH cDNAs related to Drosophila hairy and enhancer of split."
    Kokubo H., Lun Y., Johnson R.L.
    Biochem. Biophys. Res. Commun. 260:459-465(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "Hey genes: a novel subfamily of hairy- and enhancer of split related genes specifically expressed during mouse embryogenesis."
    Leimeister C., Externbrinck A., Klamt B., Gessler M.
    Mech. Dev. 85:173-177(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Characterization of the human and mouse HEY1, HEY2, and HEYL genes: cloning, mapping, and mutation screening of a new bHLH gene family."
    Steidl C., Leimeister C., Klamt B., Maier M., Nanda I., Dixon M., Clarke R., Schmid M., Gessler M.
    Genomics 66:195-203(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  4. "Cardiovascular basic helix loop helix factor 1, a novel transcriptional repressor expressed preferentially in the developing and adult cardiovascular system."
    Chin M.T., Maemura K., Fukumoto S., Jain M.K., Layne M.D., Watanabe M., Hsieh C.-M., Lee M.-E.
    J. Biol. Chem. 275:6381-6387(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  5. "The HERP repressors, novel partners for HES/hairy in notch signaling."
    Iso T., Sartorelli V., Poizat C., Chen T., Sucov H.M., Chung G., Wu H.-Y., Kedes L., Hamamori Y.
    Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  6. "Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling."
    Nakagawa O., McFadden D.G., Nakagawa M., Yanagisawa H., Hu T., Srivastava D., Olson E.N.
    Proc. Natl. Acad. Sci. U.S.A. 97:13655-13660(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, DNA-BINDING.
  7. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  8. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Placenta.
  9. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  11. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung.
  12. "Hairy-related transcription factors inhibit GATA-dependent cardiac gene expression through a signal-responsive mechanism."
    Kathiriya I.S., King I.N., Murakami M., Nakagawa M., Astle J.M., Gardner K.A., Gerard R.D., Olson E.N., Srivastava D., Nakagawa O.
    J. Biol. Chem. 279:54937-54943(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  13. "Crystal structure of hypothetical protein MS0332."
    RIKEN structural genomics initiative (RSGI)
    Submitted (FEB-2009) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 111-167.

Entry informationi

Entry nameiHEY1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5J3
Secondary accession number(s): B2R883
, Q5TZS3, Q8NAM2, Q9NYP4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: November 1, 1999
Last modified: September 3, 2014
This is version 141 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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