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Q9Y5J3

- HEY1_HUMAN

UniProt

Q9Y5J3 - HEY1_HUMAN

Protein

Hairy/enhancer-of-split related with YRPW motif protein 1

Gene

HEY1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 142 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6.2 Publications

    GO - Molecular functioni

    1. microsatellite binding Source: UniProtKB
    2. protein binding Source: UniProtKB
    3. protein binding transcription factor activity Source: UniProtKB
    4. RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity Source: UniProtKB
    5. sequence-specific DNA binding transcription factor activity Source: UniProtKB
    6. transcription factor binding Source: UniProtKB

    GO - Biological processi

    1. angiogenesis Source: UniProtKB
    2. anterior/posterior axis specification Source: Ensembl
    3. arterial endothelial cell differentiation Source: BHF-UCL
    4. atrioventricular valve formation Source: BHF-UCL
    5. cardiac epithelial to mesenchymal transition Source: BHF-UCL
    6. cardiac septum morphogenesis Source: BHF-UCL
    7. cardiac ventricle morphogenesis Source: BHF-UCL
    8. cellular response to glucocorticoid stimulus Source: Ensembl
    9. dorsal aorta morphogenesis Source: BHF-UCL
    10. endocardial cushion morphogenesis Source: BHF-UCL
    11. endocardial cushion to mesenchymal transition involved in heart valve formation Source: Ensembl
    12. epithelial to mesenchymal transition involved in endocardial cushion formation Source: UniProtKB
    13. heart trabecula formation Source: BHF-UCL
    14. labyrinthine layer blood vessel development Source: BHF-UCL
    15. negative regulation of Notch signaling pathway Source: BHF-UCL
    16. negative regulation of transcription, DNA-templated Source: UniProtKB
    17. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    18. negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation Source: BHF-UCL
    19. negative regulation of transcription regulatory region DNA binding Source: BHF-UCL
    20. Notch signaling involved in heart development Source: BHF-UCL
    21. Notch signaling pathway Source: UniProtKB
    22. osteoblast development Source: Ensembl
    23. positive regulation of osteoblast differentiation Source: Ensembl
    24. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    25. pulmonary valve morphogenesis Source: BHF-UCL
    26. regulation of vasculogenesis Source: BHF-UCL
    27. transcription from RNA polymerase II promoter Source: GOC
    28. umbilical cord morphogenesis Source: BHF-UCL
    29. vasculogenesis Source: Ensembl
    30. ventricular septum morphogenesis Source: BHF-UCL
    31. ventricular trabecula myocardium morphogenesis Source: Ensembl

    Keywords - Molecular functioni

    Developmental protein, Repressor

    Keywords - Biological processi

    Notch signaling pathway, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_118780. NOTCH1 Intracellular Domain Regulates Transcription.
    REACT_160243. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
    REACT_160254. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hairy/enhancer-of-split related with YRPW motif protein 1
    Alternative name(s):
    Cardiovascular helix-loop-helix factor 2
    Short name:
    CHF-2
    Class B basic helix-loop-helix protein 31
    Short name:
    bHLHb31
    HES-related repressor protein 1
    Hairy and enhancer of split-related protein 1
    Short name:
    HESR-1
    Hairy-related transcription factor 1
    Short name:
    HRT-1
    Short name:
    hHRT1
    Gene namesi
    Name:HEY1
    Synonyms:BHLHB31, CHF2, HERP2, HESR1, HRT1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:4880. HEY1.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. nucleoplasm Source: Reactome
    3. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29258.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 304304Hairy/enhancer-of-split related with YRPW motif protein 1PRO_0000127217Add
    BLAST

    Proteomic databases

    MaxQBiQ9Y5J3.
    PaxDbiQ9Y5J3.
    PRIDEiQ9Y5J3.

    PTM databases

    PhosphoSiteiQ9Y5J3.

    Expressioni

    Tissue specificityi

    Expressed in the somitic mesoderm, the central nervous system, the kidney, the heart, nasal epithelium, and limbs.

    Gene expression databases

    ArrayExpressiQ9Y5J3.
    BgeeiQ9Y5J3.
    CleanExiHS_HEY1.
    GenevestigatoriQ9Y5J3.

    Organism-specific databases

    HPAiHPA055599.

    Interactioni

    Subunit structurei

    Self-associates. Interacts with HES1 and HEYL. Interacts with HDAC1, NCOR1 and SIN3A. Interacts with GATA4 and GATA6. Interacts with CCDC89/BOIP.By similarity

    Protein-protein interaction databases

    BioGridi117025. 13 interactions.
    IntActiQ9Y5J3. 6 interactions.
    MINTiMINT-1179634.
    STRINGi9606.ENSP00000338272.

    Structurei

    Secondary structure

    1
    304
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi115 – 1206
    Helixi122 – 14019
    Helixi149 – 16416

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2DB7X-ray1.90A/B111-167[»]
    ProteinModelPortaliQ9Y5J3.
    SMRiQ9Y5J3. Positions 39-107, 111-165.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9Y5J3.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini49 – 10456bHLHPROSITE-ProRule annotationAdd
    BLAST
    Domaini122 – 15837OrangePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni48 – 11770Transcriptional repression and interaction with NCOR1 and SIN3ABy similarityAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi294 – 2974YRPW motif

    Sequence similaritiesi

    Belongs to the HEY family.Curated
    Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation
    Contains 1 Orange domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG241271.
    HOGENOMiHOG000286035.
    HOVERGENiHBG003275.
    KOiK09091.
    OMAiADENGNM.
    OrthoDBiEOG76MK98.
    PhylomeDBiQ9Y5J3.
    TreeFamiTF323617.

    Family and domain databases

    Gene3Di4.10.280.10. 1 hit.
    InterProiIPR011598. bHLH_dom.
    IPR003650. Orange.
    IPR018352. Orange_subgr.
    [Graphical view]
    PfamiPF07527. Hairy_orange. 1 hit.
    PF00010. HLH. 1 hit.
    [Graphical view]
    SMARTiSM00353. HLH. 1 hit.
    SM00511. ORANGE. 1 hit.
    [Graphical view]
    SUPFAMiSSF47459. SSF47459. 1 hit.
    PROSITEiPS50888. BHLH. 1 hit.
    PS51054. ORANGE. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9Y5J3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKRAHPEYSS SDSELDETIE VEKESADENG NLSSALGSMS PTTSSQILAR    50
    KRRRGIIEKR RRDRINNSLS ELRRLVPSAF EKQGSAKLEK AEILQMTVDH 100
    LKMLHTAGGK GYFDAHALAM DYRSLGFREC LAEVARYLSI IEGLDASDPL 150
    RVRLVSHLNN YASQREAASG AHAGLGHIPW GTVFGHHPHI AHPLLLPQNG 200
    HGNAGTTASP TEPHHQGRLG SAHPEAPALR APPSGSLGPV LPVVTSASKL 250
    SPPLLSSVAS LSAFPFSFGS FHLLSPNALS PSAPTQAANL GKPYRPWGTE 300
    IGAF 304
    Length:304
    Mass (Da):32,613
    Last modified:November 1, 1999 - v1
    Checksum:iF130991A99E9CA54
    GO
    Isoform 2 (identifier: Q9Y5J3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         82-82: K → KQVME

    Show »
    Length:308
    Mass (Da):33,100
    Checksum:i99A47C7EE29AC7B8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti237 – 2371L → F in AAF37297. 1 PublicationCurated
    Sequence conflicti237 – 2371L → P in BAC03890. (PubMed:14702039)Curated
    Sequence conflicti252 – 2521P → L in AAF37297. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei82 – 821K → KQVME in isoform 2. 1 PublicationVSP_040997

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF151522 mRNA. Translation: AAD38967.1.
    AF176422 mRNA. Translation: AAD51749.1.
    AJ272214 mRNA. Translation: CAB75715.1.
    AF232239 mRNA. Translation: AAF37297.1.
    AF311883 mRNA. Translation: AAG31156.1.
    BT020065 mRNA. Translation: AAV38868.1.
    AK092437 mRNA. Translation: BAC03890.1.
    AK313271 mRNA. Translation: BAG36080.1.
    AC016240 Genomic DNA. No translation available.
    CH471068 Genomic DNA. Translation: EAW87066.1.
    BC001873 mRNA. Translation: AAH01873.1.
    CCDSiCCDS43749.1. [Q9Y5J3-2]
    CCDS6225.1. [Q9Y5J3-1]
    RefSeqiNP_001035798.1. NM_001040708.1. [Q9Y5J3-2]
    NP_001269780.1. NM_001282851.1.
    NP_036390.3. NM_012258.3. [Q9Y5J3-1]
    UniGeneiHs.234434.

    Genome annotation databases

    EnsembliENST00000337919; ENSP00000338272; ENSG00000164683. [Q9Y5J3-2]
    ENST00000354724; ENSP00000346761; ENSG00000164683. [Q9Y5J3-1]
    GeneIDi23462.
    KEGGihsa:23462.
    UCSCiuc003ybl.3. human. [Q9Y5J3-2]
    uc003ybm.3. human. [Q9Y5J3-1]

    Polymorphism databases

    DMDMi13124298.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF151522 mRNA. Translation: AAD38967.1 .
    AF176422 mRNA. Translation: AAD51749.1 .
    AJ272214 mRNA. Translation: CAB75715.1 .
    AF232239 mRNA. Translation: AAF37297.1 .
    AF311883 mRNA. Translation: AAG31156.1 .
    BT020065 mRNA. Translation: AAV38868.1 .
    AK092437 mRNA. Translation: BAC03890.1 .
    AK313271 mRNA. Translation: BAG36080.1 .
    AC016240 Genomic DNA. No translation available.
    CH471068 Genomic DNA. Translation: EAW87066.1 .
    BC001873 mRNA. Translation: AAH01873.1 .
    CCDSi CCDS43749.1. [Q9Y5J3-2 ]
    CCDS6225.1. [Q9Y5J3-1 ]
    RefSeqi NP_001035798.1. NM_001040708.1. [Q9Y5J3-2 ]
    NP_001269780.1. NM_001282851.1.
    NP_036390.3. NM_012258.3. [Q9Y5J3-1 ]
    UniGenei Hs.234434.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2DB7 X-ray 1.90 A/B 111-167 [» ]
    ProteinModelPortali Q9Y5J3.
    SMRi Q9Y5J3. Positions 39-107, 111-165.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117025. 13 interactions.
    IntActi Q9Y5J3. 6 interactions.
    MINTi MINT-1179634.
    STRINGi 9606.ENSP00000338272.

    PTM databases

    PhosphoSitei Q9Y5J3.

    Polymorphism databases

    DMDMi 13124298.

    Proteomic databases

    MaxQBi Q9Y5J3.
    PaxDbi Q9Y5J3.
    PRIDEi Q9Y5J3.

    Protocols and materials databases

    DNASUi 23462.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000337919 ; ENSP00000338272 ; ENSG00000164683 . [Q9Y5J3-2 ]
    ENST00000354724 ; ENSP00000346761 ; ENSG00000164683 . [Q9Y5J3-1 ]
    GeneIDi 23462.
    KEGGi hsa:23462.
    UCSCi uc003ybl.3. human. [Q9Y5J3-2 ]
    uc003ybm.3. human. [Q9Y5J3-1 ]

    Organism-specific databases

    CTDi 23462.
    GeneCardsi GC08M080676.
    HGNCi HGNC:4880. HEY1.
    HPAi HPA055599.
    MIMi 602953. gene.
    neXtProti NX_Q9Y5J3.
    PharmGKBi PA29258.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG241271.
    HOGENOMi HOG000286035.
    HOVERGENi HBG003275.
    KOi K09091.
    OMAi ADENGNM.
    OrthoDBi EOG76MK98.
    PhylomeDBi Q9Y5J3.
    TreeFami TF323617.

    Enzyme and pathway databases

    Reactomei REACT_118780. NOTCH1 Intracellular Domain Regulates Transcription.
    REACT_160243. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
    REACT_160254. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.

    Miscellaneous databases

    ChiTaRSi HEY1. human.
    EvolutionaryTracei Q9Y5J3.
    GeneWikii HEY1.
    GenomeRNAii 23462.
    NextBioi 45771.
    PROi Q9Y5J3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y5J3.
    Bgeei Q9Y5J3.
    CleanExi HS_HEY1.
    Genevestigatori Q9Y5J3.

    Family and domain databases

    Gene3Di 4.10.280.10. 1 hit.
    InterProi IPR011598. bHLH_dom.
    IPR003650. Orange.
    IPR018352. Orange_subgr.
    [Graphical view ]
    Pfami PF07527. Hairy_orange. 1 hit.
    PF00010. HLH. 1 hit.
    [Graphical view ]
    SMARTi SM00353. HLH. 1 hit.
    SM00511. ORANGE. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47459. SSF47459. 1 hit.
    PROSITEi PS50888. BHLH. 1 hit.
    PS51054. ORANGE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and expression of a novel family of bHLH cDNAs related to Drosophila hairy and enhancer of split."
      Kokubo H., Lun Y., Johnson R.L.
      Biochem. Biophys. Res. Commun. 260:459-465(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Brain.
    2. "Hey genes: a novel subfamily of hairy- and enhancer of split related genes specifically expressed during mouse embryogenesis."
      Leimeister C., Externbrinck A., Klamt B., Gessler M.
      Mech. Dev. 85:173-177(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "Characterization of the human and mouse HEY1, HEY2, and HEYL genes: cloning, mapping, and mutation screening of a new bHLH gene family."
      Steidl C., Leimeister C., Klamt B., Maier M., Nanda I., Dixon M., Clarke R., Schmid M., Gessler M.
      Genomics 66:195-203(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    4. "Cardiovascular basic helix loop helix factor 1, a novel transcriptional repressor expressed preferentially in the developing and adult cardiovascular system."
      Chin M.T., Maemura K., Fukumoto S., Jain M.K., Layne M.D., Watanabe M., Hsieh C.-M., Lee M.-E.
      J. Biol. Chem. 275:6381-6387(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    5. "The HERP repressors, novel partners for HES/hairy in notch signaling."
      Iso T., Sartorelli V., Poizat C., Chen T., Sucov H.M., Chung G., Wu H.-Y., Kedes L., Hamamori Y.
      Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    6. "Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling."
      Nakagawa O., McFadden D.G., Nakagawa M., Yanagisawa H., Hu T., Srivastava D., Olson E.N.
      Proc. Natl. Acad. Sci. U.S.A. 97:13655-13660(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, DNA-BINDING.
    7. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    8. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Placenta.
    9. "DNA sequence and analysis of human chromosome 8."
      Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
      , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
      Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    11. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lung.
    12. "Hairy-related transcription factors inhibit GATA-dependent cardiac gene expression through a signal-responsive mechanism."
      Kathiriya I.S., King I.N., Murakami M., Nakagawa M., Astle J.M., Gardner K.A., Gerard R.D., Olson E.N., Srivastava D., Nakagawa O.
      J. Biol. Chem. 279:54937-54943(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    13. "Crystal structure of hypothetical protein MS0332."
      RIKEN structural genomics initiative (RSGI)
      Submitted (FEB-2009) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 111-167.

    Entry informationi

    Entry nameiHEY1_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y5J3
    Secondary accession number(s): B2R883
    , Q5TZS3, Q8NAM2, Q9NYP4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2001
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 142 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3