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Protein

Protocadherin alpha-C2

Gene

PCDHAC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

GO - Molecular functioni

GO - Biological processi

  • cell adhesion Source: ProtInc
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
  • nervous system development Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin alpha-C2
Short name:
PCDH-alpha-C2
Gene namesi
Name:PCDHAC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:8677. PCDHAC2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini43 – 708666ExtracellularSequence analysisAdd
BLAST
Transmembranei709 – 72921HelicalSequence analysisAdd
BLAST
Topological domaini730 – 1007278CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33023.

Polymorphism and mutation databases

BioMutaiPCDHAC2.
DMDMi13878435.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4242Sequence analysisAdd
BLAST
Chaini43 – 1007965Protocadherin alpha-C2PRO_0000003912Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi280 – 2801N-linked (GlcNAc...)Sequence analysis
Glycosylationi436 – 4361N-linked (GlcNAc...)Sequence analysis
Glycosylationi586 – 5861N-linked (GlcNAc...)Sequence analysis
Glycosylationi657 – 6571N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9Y5I4.
PaxDbiQ9Y5I4.
PeptideAtlasiQ9Y5I4.
PRIDEiQ9Y5I4.
TopDownProteomicsiQ9Y5I4-2. [Q9Y5I4-2]

PTM databases

iPTMnetiQ9Y5I4.
PhosphoSiteiQ9Y5I4.

Expressioni

Gene expression databases

BgeeiQ9Y5I4.
GenevisibleiQ9Y5I4. HS.

Interactioni

Protein-protein interaction databases

BioGridi121074. 35 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9Y5I4.
SMRiQ9Y5I4. Positions 42-702.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini43 – 148106Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini149 – 257109Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini258 – 365108Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini374 – 46996Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Domaini470 – 579110Cadherin 5PROSITE-ProRule annotationAdd
BLAST
Domaini594 – 69198Cadherin 6PROSITE-ProRule annotationAdd
BLAST
Repeati856 – 8594PXXP 1
Repeati889 – 8924PXXP 2
Repeati930 – 9334PXXP 3
Repeati948 – 9514PXXP 4

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni856 – 951964 X 4 AA repeats of P-X-X-PAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi980 – 9878Poly-Lys

Sequence similaritiesi

Contains 6 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00840000129690.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.
InParanoidiQ9Y5I4.
KOiK16493.
OMAiFSEITLY.
OrthoDBiEOG7KSX80.
PhylomeDBiQ9Y5I4.
TreeFamiTF332299.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR031904. Cadherin_CBD.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
IPR030726. PCDHAC2.
[Graphical view]
PANTHERiPTHR24028:SF119. PTHR24028:SF119. 2 hits.
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
PF15974. Cadherin_tail. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Long (identifier: Q9Y5I4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEQAGTRPAA TEHPRLRRPM PWLLLLPLLL LLLLLLPGPA ASQLRYSVPE
60 70 80 90 100
EQAPGALVGN VARALGLELR RLGPGCLRIN HLGAPSPRYL ELDLTSGALF
110 120 130 140 150
VNERIDREAL CEQRPRCLLS LEVLAHNPVA VSAVEVEILD INDNSPRFPR
160 170 180 190 200
PNYQLQVSES VAPGARFHIE SAQDPDVGAN SVQTYELSPS EHFELDLKPL
210 220 230 240 250
QENSKVLELV LRKGLDREQA ALHHLVLTAV DGGIPARSGT AQISVRVLDT
260 270 280 290 300
NDNSPAFDQS TYRVQLREDS PPGTLVVKLN ASDPDEGSNG ELRYSLSSYT
310 320 330 340 350
SDRERQLFSI DASTGEVRVI GGLDYEEASS YQIYVQATDR GPVPMAGHCK
360 370 380 390 400
VLVDIVDVND NAPEVVLTDL YSPVPENATP NTIVAVLSVN DQDSGPNRKV
410 420 430 440 450
SLGLEATLPF RLNGFGNSYT LVVSGPLDRE RVAVYNITVT ATDGGIPQLT
460 470 480 490 500
SLRTLKVEIS DINDNPPSFL EDSYSIYIQE NNLPGVLLCT VQATDPDEKE
510 520 530 540 550
NAEVTYSLLE REIQGLPVTS YVSINSASGS LYAVNSFDYE KFREFFVTVE
560 570 580 590 600
AQDKGSPPLS STVTANVYVV DMNDHAPHIL YPTSTNSSAA FEMVPRTAPA
610 620 630 640 650
GYLVTKVIAM DSDSGQNAWL FYHLAQTSDL DLFKVELHTG EIRTTRKMGD
660 670 680 690 700
ESGSTFNLTV VVRDNGEPSL SASVAITVAV VDRVSKILPD TQRHVKSPRT
710 720 730 740 750
YSEITLYLII ALSTVSFIFL LTIIILSIIK CYRYTAYGTA CCGGFCGVRE
760 770 780 790 800
RSPAELYKQA NNNIDARIPH GLKVQPHFIE VRGNGSLTKT YCYKACLTAG
810 820 830 840 850
SGSDTFMFYN TGAQTGPGPS GAQAAVTDSR NLTGQSGQNA GNLIILKNEA
860 870 880 890 900
VSQNEPRQPN PDWRYSASLR AGMHSSVHLE EAGILRAGPG GPDQQWPTVS
910 920 930 940 950
SATPEPEAGE VSPPVGAGVN SNSWTFKYGP GNPKQSGPGE LPDKFIIPGS
960 970 980 990 1000
PAIISIRQEP TNSQIDKSDF ITFGKKEETK KKKKKKKGNK TQEKKEKGNS

TTDNSDQ
Length:1,007
Mass (Da):109,450
Last modified:November 1, 1999 - v1
Checksum:i39BF2356923E3B67
GO
Isoform Short (identifier: Q9Y5I4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     856-884: PRQPNPDWRYSASLRAGMHSSVHLEEAGI → VRQWSGGLLQTHAFVTHPPISCDLALLSH
     885-1007: Missing.

Show »
Length:884
Mass (Da):96,197
Checksum:i87C84D767A888375
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei856 – 88429PRQPN…EEAGI → VRQWSGGLLQTHAFVTHPPI SCDLALLSH in isoform Short. 2 PublicationsVSP_000701Add
BLAST
Alternative sequencei885 – 1007123Missing in isoform Short. 2 PublicationsVSP_000702Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152304 mRNA. Translation: AAD43698.1.
AF152474 mRNA. Translation: AAD43735.1.
CH471062 Genomic DNA. Translation: EAW62000.1.
BC104776 mRNA. Translation: AAI04777.1.
BC105111 mRNA. Translation: AAI05112.1.
CCDSiCCDS4242.1. [Q9Y5I4-1]
RefSeqiNP_061722.1. NM_018899.5. [Q9Y5I4-1]
NP_114089.1. NM_031883.2. [Q9Y5I4-2]
UniGeneiHs.199343.

Genome annotation databases

EnsembliENST00000289269; ENSP00000289269; ENSG00000243232. [Q9Y5I4-1]
ENST00000615316; ENSP00000478629; ENSG00000243232. [Q9Y5I4-2]
GeneIDi56134.
KEGGihsa:56134.
UCSCiuc003lii.4. human. [Q9Y5I4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152304 mRNA. Translation: AAD43698.1.
AF152474 mRNA. Translation: AAD43735.1.
CH471062 Genomic DNA. Translation: EAW62000.1.
BC104776 mRNA. Translation: AAI04777.1.
BC105111 mRNA. Translation: AAI05112.1.
CCDSiCCDS4242.1. [Q9Y5I4-1]
RefSeqiNP_061722.1. NM_018899.5. [Q9Y5I4-1]
NP_114089.1. NM_031883.2. [Q9Y5I4-2]
UniGeneiHs.199343.

3D structure databases

ProteinModelPortaliQ9Y5I4.
SMRiQ9Y5I4. Positions 42-702.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121074. 35 interactions.

PTM databases

iPTMnetiQ9Y5I4.
PhosphoSiteiQ9Y5I4.

Polymorphism and mutation databases

BioMutaiPCDHAC2.
DMDMi13878435.

Proteomic databases

EPDiQ9Y5I4.
PaxDbiQ9Y5I4.
PeptideAtlasiQ9Y5I4.
PRIDEiQ9Y5I4.
TopDownProteomicsiQ9Y5I4-2. [Q9Y5I4-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000289269; ENSP00000289269; ENSG00000243232. [Q9Y5I4-1]
ENST00000615316; ENSP00000478629; ENSG00000243232. [Q9Y5I4-2]
GeneIDi56134.
KEGGihsa:56134.
UCSCiuc003lii.4. human. [Q9Y5I4-1]

Organism-specific databases

CTDi56134.
GeneCardsiPCDHAC2.
HGNCiHGNC:8677. PCDHAC2.
MIMi604966. gene.
606321. gene.
neXtProtiNX_Q9Y5I4.
PharmGKBiPA33023.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00840000129690.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.
InParanoidiQ9Y5I4.
KOiK16493.
OMAiFSEITLY.
OrthoDBiEOG7KSX80.
PhylomeDBiQ9Y5I4.
TreeFamiTF332299.

Miscellaneous databases

GeneWikiiPCDHAC2.
GenomeRNAii56134.
PROiQ9Y5I4.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y5I4.
GenevisibleiQ9Y5I4. HS.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR031904. Cadherin_CBD.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
IPR030726. PCDHAC2.
[Graphical view]
PANTHERiPTHR24028:SF119. PTHR24028:SF119. 2 hits.
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
PF15974. Cadherin_tail. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A striking organization of a large family of human neural cadherin-like cell adhesion genes."
    Wu Q., Maniatis T.
    Cell 97:779-790(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT).
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SHORT).
    Tissue: Cerebellum.

Entry informationi

Entry nameiPCDC2_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5I4
Secondary accession number(s): Q2M3V1, Q9Y5F4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1999
Last modified: July 6, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.