Q9Y5I2 (PCDAA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protocadherin alpha-10
Short name=PCDH-alpha-10

Gene names

Name:	PCDHA10
Synonyms:	CNRS8

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	948 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
Subcellular location	Cell membrane; Single-pass type I membrane protein By similarity. Isoform 2: Secreted Potential.
Sequence similarities	Contains 6 cadherin domains.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Cell membrane Membrane Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Signal Transmembrane Transmembrane helix
Ligand	Calcium
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell adhesion Traceable author statement Ref.1. Source: ProtInc homophilic cell adhesion Inferred from electronic annotation. Source: InterPro nervous system development Traceable author statement Ref.1. Source: ProtInc
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: Q9Y5I2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9Y5I2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     534-796: Missing.

Isoform 3 (identifier: Q9Y5I2-3)

The sequence of this isoform differs from the canonical sequence as follows:
     797-844: PRQPNPDWRY...QQWPTVSSAT → VGYYVFIFLL...LNISSDTFVI
     845-948: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 28	28	Potential
	Chain	29 – 948	920	Protocadherin alpha-10		PRO_0000003902
Regions
	Topological domain	29 – 695	667	Extracellular Potential
	Transmembrane	696 – 716	21	Helical; Potential
	Topological domain	717 – 948	232	Cytoplasmic Potential
	Domain	29 – 132	104	Cadherin 1
	Domain	133 – 241	109	Cadherin 2
	Domain	242 – 349	108	Cadherin 3
	Domain	350 – 454	105	Cadherin 4
	Domain	455 – 564	110	Cadherin 5
	Domain	587 – 689	103	Cadherin 6
	Repeat	732 – 735	4	PXXP 1
	Repeat	772 – 775	4	PXXP 2
	Repeat	797 – 800	4	PXXP 3
	Repeat	830 – 833	4	PXXP 4
	Repeat	871 – 874	4	PXXP 5
	Repeat	889 – 892	4	PXXP 6
	Region	732 – 892	161	6 X 4 AA repeats of P-X-X-P
	Compositional bias	921 – 928	8	Poly-Lys
Amino acid modifications
	Glycosylation	256	1	N-linked (GlcNAc...) Potential
	Glycosylation	264	1	N-linked (GlcNAc...) Potential
	Glycosylation	547	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	534 – 796	263	Missing in isoform 2.		VSP_000690
	Alternative sequence	797 – 844	48	PRQPN…VSSAT → VGYYVFIFLLCFMNNIFSYR IFSNMYQNISFLSTFHLCLN ISSDTFVI in isoform 3.		VSP_000691
	Alternative sequence	845 – 948	104	Missing in isoform 3.		VSP_000692
	Natural variant	439	1	S → R. Ref.2 Corresponds to variant rs251362 [ dbSNP | Ensembl ].		VAR_048535
	Natural variant	585	1	V → G. Corresponds to variant rs251364 [ dbSNP | Ensembl ].		VAR_048536
	Natural variant	639	1	T → A. Corresponds to variant rs630162 [ dbSNP | Ensembl ].		VAR_048537

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 8F3C734B05EF4FB8	FASTA	948	102,875
	10 20 30 40 50 60 MVSRCSCLGV QCLLLSLLLL AAWEVGSGQL HYSVYEEARH GTFVGRIAQD LGLELAELVQ 70 80 90 100 110 120 RLFRVASKRH GDLLEVNLQN GILFVNSRID REELCGRSVE CSIHLEVIVD RPLQVFHVDV 130 140 150 160 170 180 EVKDINDNPP RFSVTEQKLS IPESRLLDSR FPLEGASDAD VGENALLTYK LSPNEYFVLD 190 200 210 220 230 240 IINKKDKDKF PVLVLRKLLD REENPQLKLL LTATDGGKPE FTGSVSLLIL VLDANDNAPI 250 260 270 280 290 300 FDRPVYEVKM YENQVNQTLV IRLNASDSDE GINKEMMYSF SSLVPPTIRR KFWINERTGE 310 320 330 340 350 360 IKVNDAIDFE DSNTYEIHVD VTDKGNPPMV GHCTVLVELL DENDNSPEVI VTSLSLPVKE 370 380 390 400 410 420 DAQVGTVIAL ISVSDHDSGA NGQVTCSLTP HVPFKLVSTY KNYYSLVLDS ALDRERVSAY 430 440 450 460 470 480 ELVVTARDGG SPPLWATASV SVEVADVNDN APAFAQSEYT VFVKENNPPG CHIFTVSAWD 490 500 510 520 530 540 ADAQENALVS YSLVERRLGE RSLSSYVSVH AESGKVYALQ PLDHEELELL QFQVSARDGG 550 560 570 580 590 600 VPPLGSNLTL QVFVLDENDN APALLASPAG SAGGAVSELV LRSVVAGHVV AKVRAVDADS 610 620 630 640 650 660 GYNAWLSYEL QSAAVGARIP FRVGLYTGEI STTRALDETD SPRQRLLVLV KDHGEPSLTA 670 680 690 700 710 720 TATVLVSLVE GSQAPKASSR ASVGVAPEVA LVDVNVYLII AICAVSSLLV LTLLLYTALR 730 740 750 760 770 780 CSAAPTEGAC GPVKPTLVCS SAVGSWSYSQ QRRQRVCSGE GLPKADLMAF SPSLPPCPMV 790 800 810 820 830 840 DVDGEDQSIG GDHSRKPRQP NPDWRYSASL RAGMHSSVHL EEAGILRAGP GGPDQQWPTV 850 860 870 880 890 900 SSATPEPEAG EVSPPVGAGV NSNSWTFKYG PGNPKQSGPG ELPDKFIIPG SPAIISIRQE 910 920 930 940 PTNSQIDKSD FITFGKKEET KKKKKKKKGN KTQEKKEKGN STTDNSDQ
	Isoform 2 [UniParc]. Checksum: E193C3EEAA3774C9	FASTA	685	75,742
	10 20 30 40 50 60 MVSRCSCLGV QCLLLSLLLL AAWEVGSGQL HYSVYEEARH GTFVGRIAQD LGLELAELVQ 70 80 90 100 110 120 RLFRVASKRH GDLLEVNLQN GILFVNSRID REELCGRSVE CSIHLEVIVD RPLQVFHVDV 130 140 150 160 170 180 EVKDINDNPP RFSVTEQKLS IPESRLLDSR FPLEGASDAD VGENALLTYK LSPNEYFVLD 190 200 210 220 230 240 IINKKDKDKF PVLVLRKLLD REENPQLKLL LTATDGGKPE FTGSVSLLIL VLDANDNAPI 250 260 270 280 290 300 FDRPVYEVKM YENQVNQTLV IRLNASDSDE GINKEMMYSF SSLVPPTIRR KFWINERTGE 310 320 330 340 350 360 IKVNDAIDFE DSNTYEIHVD VTDKGNPPMV GHCTVLVELL DENDNSPEVI VTSLSLPVKE 370 380 390 400 410 420 DAQVGTVIAL ISVSDHDSGA NGQVTCSLTP HVPFKLVSTY KNYYSLVLDS ALDRERVSAY 430 440 450 460 470 480 ELVVTARDGG SPPLWATASV SVEVADVNDN APAFAQSEYT VFVKENNPPG CHIFTVSAWD 490 500 510 520 530 540 ADAQENALVS YSLVERRLGE RSLSSYVSVH AESGKVYALQ PLDHEELELL QFQPRQPNPD 550 560 570 580 590 600 WRYSASLRAG MHSSVHLEEA GILRAGPGGP DQQWPTVSSA TPEPEAGEVS PPVGAGVNSN 610 620 630 640 650 660 SWTFKYGPGN PKQSGPGELP DKFIIPGSPA IISIRQEPTN SQIDKSDFIT FGKKEETKKK 670 680 KKKKKGNKTQ EKKEKGNSTT DNSDQ
	Isoform 3 [UniParc]. Checksum: 1BEE925A84C9228F	FASTA	844	92,185
	10 20 30 40 50 60 MVSRCSCLGV QCLLLSLLLL AAWEVGSGQL HYSVYEEARH GTFVGRIAQD LGLELAELVQ 70 80 90 100 110 120 RLFRVASKRH GDLLEVNLQN GILFVNSRID REELCGRSVE CSIHLEVIVD RPLQVFHVDV 130 140 150 160 170 180 EVKDINDNPP RFSVTEQKLS IPESRLLDSR FPLEGASDAD VGENALLTYK LSPNEYFVLD 190 200 210 220 230 240 IINKKDKDKF PVLVLRKLLD REENPQLKLL LTATDGGKPE FTGSVSLLIL VLDANDNAPI 250 260 270 280 290 300 FDRPVYEVKM YENQVNQTLV IRLNASDSDE GINKEMMYSF SSLVPPTIRR KFWINERTGE 310 320 330 340 350 360 IKVNDAIDFE DSNTYEIHVD VTDKGNPPMV GHCTVLVELL DENDNSPEVI VTSLSLPVKE 370 380 390 400 410 420 DAQVGTVIAL ISVSDHDSGA NGQVTCSLTP HVPFKLVSTY KNYYSLVLDS ALDRERVSAY 430 440 450 460 470 480 ELVVTARDGG SPPLWATASV SVEVADVNDN APAFAQSEYT VFVKENNPPG CHIFTVSAWD 490 500 510 520 530 540 ADAQENALVS YSLVERRLGE RSLSSYVSVH AESGKVYALQ PLDHEELELL QFQVSARDGG 550 560 570 580 590 600 VPPLGSNLTL QVFVLDENDN APALLASPAG SAGGAVSELV LRSVVAGHVV AKVRAVDADS 610 620 630 640 650 660 GYNAWLSYEL QSAAVGARIP FRVGLYTGEI STTRALDETD SPRQRLLVLV KDHGEPSLTA 670 680 690 700 710 720 TATVLVSLVE GSQAPKASSR ASVGVAPEVA LVDVNVYLII AICAVSSLLV LTLLLYTALR 730 740 750 760 770 780 CSAAPTEGAC GPVKPTLVCS SAVGSWSYSQ QRRQRVCSGE GLPKADLMAF SPSLPPCPMV 790 800 810 820 830 840 DVDGEDQSIG GDHSRKVGYY VFIFLLCFMN NIFSYRIFSN MYQNISFLST FHLCLNISSD TFVI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A striking organization of a large family of human neural cadherin-like cell adhesion genes." Wu Q., Maniatis T. Cell 97:779-790(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3). Tissue: Brain.
[2]	"Alternative splicing within the human CNR family of protocadherins (PCDH-alpha) produces transcripts encoding secreted proteins." Kools P.F.J., van Roy F. Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT ARG-439. Tissue: Brain.
[3]	"The DNA sequence and comparative analysis of human chromosome 5." Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M. Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF152306 mRNA. Translation: AAD43700.1. AF152475 mRNA. Translation: AAD43736.1. AF169689 mRNA. Translation: AAF89329.1. AC005609 Genomic DNA. Translation: AAC34317.1. BC130447 mRNA. Translation: AAI30448.1.
IPI	IPI00001513. IPI00218625. IPI00218626.
RefSeq	NP_061724.1. NM_018901.2. NP_114065.1. NM_031859.1. NP_114066.1. NM_031860.1.
UniGene	Hs.199343.
3D structure databases
ProteinModelPortal	Q9Y5I2.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9Y5I2. 1 interaction.
MINT	MINT-7242676.
STRING	9606.ENSP00000253807.
PTM databases
PhosphoSite	Q9Y5I2.
Polymorphism databases
DMDM	13878433.
Proteomic databases
PaxDb	Q9Y5I2.
PRIDE	Q9Y5I2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000307360; ENSP00000304234; ENSG00000250120. ENST00000506939; ENSP00000421030; ENSG00000250120.
GeneID	56139.
KEGG	hsa:56139.
UCSC	uc003lhw.2. human. uc003lhx.2. human. uc011dad.2. human.
Organism-specific databases
CTD	56139.
GeneCards	GC05P140400.
HGNC	HGNC:8664. PCDHA10.
HPA	HPA008712.
MIM	604966. gene. 606316. gene.
neXtProt	NX_Q9Y5I2.
PharmGKB	PA33010.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG267459.
HOVERGEN	HBG054878.
KO	K16493.
OMA	SNLTLQV.
Gene expression databases
Bgee	Q9Y5I2.
Genevestigator	Q9Y5I2.
Family and domain databases
Gene3D	2.60.40.60. 6 hits.
InterPro	IPR002126. Cadherin. IPR015919. Cadherin-like. IPR020894. Cadherin_CS. IPR013164. Cadherin_N. [Graphical view]
Pfam	PF00028. Cadherin. 4 hits. PF08266. Cadherin_2. 1 hit. [Graphical view]
PRINTS	PR00205. CADHERIN.
SMART	SM00112. CA. 6 hits. [Graphical view]
SUPFAM	SSF49313. Cadherin. 6 hits.
PROSITE	PS00232. CADHERIN_1. 5 hits. PS50268. CADHERIN_2. 6 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	56139.
NextBio	61698.
SOURCE	Search...

Entry information

Entry name

PCDAA_HUMAN

Accession

Primary (citable) accession number: Q9Y5I2
Secondary accession number(s): A1L493, O75280, Q9NRU2

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	November 1, 1999
Last modified:	May 1, 2013
This is version 103 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.