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Protein

Protocadherin alpha-10

Gene

PCDHA10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

GO - Molecular functioni

GO - Biological processi

  • cell adhesion Source: ProtInc
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
  • nervous system development Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin alpha-10
Short name:
PCDH-alpha-10
Gene namesi
Name:PCDHA10
Synonyms:CNRS8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:8664. PCDHA10.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini29 – 695667ExtracellularSequence analysisAdd
BLAST
Transmembranei696 – 71621HelicalSequence analysisAdd
BLAST
Topological domaini717 – 948232CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • extracellular region Source: UniProtKB-SubCell
  • integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33010.

Polymorphism and mutation databases

BioMutaiPCDHA10.
DMDMi13878433.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence analysisAdd
BLAST
Chaini29 – 948920Protocadherin alpha-10PRO_0000003902Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi256 – 2561N-linked (GlcNAc...)Sequence analysis
Glycosylationi264 – 2641N-linked (GlcNAc...)Sequence analysis
Glycosylationi547 – 5471N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9Y5I2.
PRIDEiQ9Y5I2.

PTM databases

iPTMnetiQ9Y5I2.
PhosphoSiteiQ9Y5I2.

Expressioni

Gene expression databases

BgeeiQ9Y5I2.
GenevisibleiQ9Y5I2. HS.

Interactioni

Protein-protein interaction databases

BioGridi121079. 19 interactions.
IntActiQ9Y5I2. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9Y5I2.
SMRiQ9Y5I2. Positions 26-676.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 132104Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini133 – 241109Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini242 – 349108Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini350 – 454105Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Domaini455 – 564110Cadherin 5PROSITE-ProRule annotationAdd
BLAST
Domaini587 – 689103Cadherin 6PROSITE-ProRule annotationAdd
BLAST
Repeati732 – 7354PXXP 1
Repeati772 – 7754PXXP 2
Repeati797 – 8004PXXP 3
Repeati830 – 8334PXXP 4
Repeati871 – 8744PXXP 5
Repeati889 – 8924PXXP 6

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni732 – 8921616 X 4 AA repeats of P-X-X-PAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi921 – 9288Poly-Lys

Sequence similaritiesi

Contains 6 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00840000129695.
HOVERGENiHBG054878.
InParanoidiQ9Y5I2.
KOiK16493.
OMAiKFWINER.
OrthoDBiEOG7KSX80.
PhylomeDBiQ9Y5I2.
TreeFamiTF332299.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR031904. Cadherin_CBD.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 4 hits.
PF08266. Cadherin_2. 1 hit.
PF15974. Cadherin_tail. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: Q9Y5I2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVSRCSCLGV QCLLLSLLLL AAWEVGSGQL HYSVYEEARH GTFVGRIAQD
60 70 80 90 100
LGLELAELVQ RLFRVASKRH GDLLEVNLQN GILFVNSRID REELCGRSVE
110 120 130 140 150
CSIHLEVIVD RPLQVFHVDV EVKDINDNPP RFSVTEQKLS IPESRLLDSR
160 170 180 190 200
FPLEGASDAD VGENALLTYK LSPNEYFVLD IINKKDKDKF PVLVLRKLLD
210 220 230 240 250
REENPQLKLL LTATDGGKPE FTGSVSLLIL VLDANDNAPI FDRPVYEVKM
260 270 280 290 300
YENQVNQTLV IRLNASDSDE GINKEMMYSF SSLVPPTIRR KFWINERTGE
310 320 330 340 350
IKVNDAIDFE DSNTYEIHVD VTDKGNPPMV GHCTVLVELL DENDNSPEVI
360 370 380 390 400
VTSLSLPVKE DAQVGTVIAL ISVSDHDSGA NGQVTCSLTP HVPFKLVSTY
410 420 430 440 450
KNYYSLVLDS ALDRERVSAY ELVVTARDGG SPPLWATASV SVEVADVNDN
460 470 480 490 500
APAFAQSEYT VFVKENNPPG CHIFTVSAWD ADAQENALVS YSLVERRLGE
510 520 530 540 550
RSLSSYVSVH AESGKVYALQ PLDHEELELL QFQVSARDGG VPPLGSNLTL
560 570 580 590 600
QVFVLDENDN APALLASPAG SAGGAVSELV LRSVVAGHVV AKVRAVDADS
610 620 630 640 650
GYNAWLSYEL QSAAVGARIP FRVGLYTGEI STTRALDETD SPRQRLLVLV
660 670 680 690 700
KDHGEPSLTA TATVLVSLVE GSQAPKASSR ASVGVAPEVA LVDVNVYLII
710 720 730 740 750
AICAVSSLLV LTLLLYTALR CSAAPTEGAC GPVKPTLVCS SAVGSWSYSQ
760 770 780 790 800
QRRQRVCSGE GLPKADLMAF SPSLPPCPMV DVDGEDQSIG GDHSRKPRQP
810 820 830 840 850
NPDWRYSASL RAGMHSSVHL EEAGILRAGP GGPDQQWPTV SSATPEPEAG
860 870 880 890 900
EVSPPVGAGV NSNSWTFKYG PGNPKQSGPG ELPDKFIIPG SPAIISIRQE
910 920 930 940
PTNSQIDKSD FITFGKKEET KKKKKKKKGN KTQEKKEKGN STTDNSDQ
Length:948
Mass (Da):102,875
Last modified:November 1, 1999 - v1
Checksum:i8F3C734B05EF4FB8
GO
Isoform 2 (identifier: Q9Y5I2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     534-796: Missing.

Show »
Length:685
Mass (Da):75,742
Checksum:iE193C3EEAA3774C9
GO
Isoform 3 (identifier: Q9Y5I2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     797-844: PRQPNPDWRY...QQWPTVSSAT → VGYYVFIFLL...LNISSDTFVI
     845-948: Missing.

Show »
Length:844
Mass (Da):92,185
Checksum:i1BEE925A84C9228F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti439 – 4391S → R.1 Publication
Corresponds to variant rs251362 [ dbSNP | Ensembl ].
VAR_048535
Natural varianti585 – 5851V → G.
Corresponds to variant rs251364 [ dbSNP | Ensembl ].
VAR_048536
Natural varianti639 – 6391T → A.
Corresponds to variant rs630162 [ dbSNP | Ensembl ].
VAR_048537

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei534 – 796263Missing in isoform 2. 2 PublicationsVSP_000690Add
BLAST
Alternative sequencei797 – 84448PRQPN…VSSAT → VGYYVFIFLLCFMNNIFSYR IFSNMYQNISFLSTFHLCLN ISSDTFVI in isoform 3. 1 PublicationVSP_000691Add
BLAST
Alternative sequencei845 – 948104Missing in isoform 3. 1 PublicationVSP_000692Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152306 mRNA. Translation: AAD43700.1.
AF152475 mRNA. Translation: AAD43736.1.
AF169689 mRNA. Translation: AAF89329.1.
AC005609 Genomic DNA. Translation: AAC34317.1.
BC130447 mRNA. Translation: AAI30448.1.
CCDSiCCDS34255.1. [Q9Y5I2-2]
CCDS54921.1. [Q9Y5I2-1]
CCDS75325.1. [Q9Y5I2-3]
RefSeqiNP_061724.1. NM_018901.3. [Q9Y5I2-1]
NP_114065.1. NM_031859.2. [Q9Y5I2-3]
NP_114066.1. NM_031860.2. [Q9Y5I2-2]
UniGeneiHs.199343.

Genome annotation databases

EnsembliENST00000307360; ENSP00000304234; ENSG00000250120. [Q9Y5I2-1]
ENST00000506939; ENSP00000421030; ENSG00000250120. [Q9Y5I2-2]
ENST00000562220; ENSP00000478748; ENSG00000250120. [Q9Y5I2-3]
GeneIDi56139.
KEGGihsa:56139.
UCSCiuc003lhw.4. human. [Q9Y5I2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152306 mRNA. Translation: AAD43700.1.
AF152475 mRNA. Translation: AAD43736.1.
AF169689 mRNA. Translation: AAF89329.1.
AC005609 Genomic DNA. Translation: AAC34317.1.
BC130447 mRNA. Translation: AAI30448.1.
CCDSiCCDS34255.1. [Q9Y5I2-2]
CCDS54921.1. [Q9Y5I2-1]
CCDS75325.1. [Q9Y5I2-3]
RefSeqiNP_061724.1. NM_018901.3. [Q9Y5I2-1]
NP_114065.1. NM_031859.2. [Q9Y5I2-3]
NP_114066.1. NM_031860.2. [Q9Y5I2-2]
UniGeneiHs.199343.

3D structure databases

ProteinModelPortaliQ9Y5I2.
SMRiQ9Y5I2. Positions 26-676.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121079. 19 interactions.
IntActiQ9Y5I2. 1 interaction.

PTM databases

iPTMnetiQ9Y5I2.
PhosphoSiteiQ9Y5I2.

Polymorphism and mutation databases

BioMutaiPCDHA10.
DMDMi13878433.

Proteomic databases

PaxDbiQ9Y5I2.
PRIDEiQ9Y5I2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307360; ENSP00000304234; ENSG00000250120. [Q9Y5I2-1]
ENST00000506939; ENSP00000421030; ENSG00000250120. [Q9Y5I2-2]
ENST00000562220; ENSP00000478748; ENSG00000250120. [Q9Y5I2-3]
GeneIDi56139.
KEGGihsa:56139.
UCSCiuc003lhw.4. human. [Q9Y5I2-1]

Organism-specific databases

CTDi56139.
GeneCardsiPCDHA10.
HGNCiHGNC:8664. PCDHA10.
MIMi604966. gene.
606316. gene.
neXtProtiNX_Q9Y5I2.
PharmGKBiPA33010.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00840000129695.
HOVERGENiHBG054878.
InParanoidiQ9Y5I2.
KOiK16493.
OMAiKFWINER.
OrthoDBiEOG7KSX80.
PhylomeDBiQ9Y5I2.
TreeFamiTF332299.

Miscellaneous databases

GenomeRNAii56139.
PROiQ9Y5I2.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y5I2.
GenevisibleiQ9Y5I2. HS.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR031904. Cadherin_CBD.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 4 hits.
PF08266. Cadherin_2. 1 hit.
PF15974. Cadherin_tail. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A striking organization of a large family of human neural cadherin-like cell adhesion genes."
    Wu Q., Maniatis T.
    Cell 97:779-790(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3).
    Tissue: Brain.
  2. "Alternative splicing within the human CNR family of protocadherins (PCDH-alpha) produces transcripts encoding secreted proteins."
    Kools P.F.J., van Roy F.
    Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT ARG-439.
    Tissue: Brain.
  3. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.

Entry informationi

Entry nameiPCDAA_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5I2
Secondary accession number(s): A1L493, O75280, Q9NRU2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1999
Last modified: June 8, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.