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Protein

Protocadherin alpha-11

Gene

PCDHA11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

GO - Molecular functioni

GO - Biological processi

  • cell adhesion Source: ProtInc
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
  • nervous system development Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin alpha-11
Short name:
PCDH-alpha-11
Gene namesi
Name:PCDHA11
Synonyms:CNRS7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:8665. PCDHA11.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini30 – 696667ExtracellularSequence analysisAdd
BLAST
Transmembranei697 – 71721HelicalSequence analysisAdd
BLAST
Topological domaini718 – 949232CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33011.

Polymorphism and mutation databases

BioMutaiPCDHA11.
DMDMi13878432.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence analysisAdd
BLAST
Chaini30 – 949920Protocadherin alpha-11PRO_0000003904Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi265 – 2651N-linked (GlcNAc...)Sequence analysis
Glycosylationi304 – 3041N-linked (GlcNAc...)Sequence analysis
Glycosylationi547 – 5471N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9Y5I1.
PRIDEiQ9Y5I1.

PTM databases

iPTMnetiQ9Y5I1.
PhosphoSiteiQ9Y5I1.

Expressioni

Gene expression databases

BgeeiQ9Y5I1.
ExpressionAtlasiQ9Y5I1. baseline and differential.
GenevisibleiQ9Y5I1. HS.

Interactioni

Protein-protein interaction databases

BioGridi121078. 4 interactions.
IntActiQ9Y5I1. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9Y5I1.
SMRiQ9Y5I1. Positions 27-695.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 133104Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini157 – 24286Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini243 – 349107Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini350 – 454105Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Domaini455 – 564110Cadherin 5PROSITE-ProRule annotationAdd
BLAST
Domaini580 – 67798Cadherin 6PROSITE-ProRule annotationAdd
BLAST
Repeati733 – 7364PXXP 1
Repeati773 – 7764PXXP 2
Repeati795 – 7984PXXP 3
Repeati831 – 8344PXXP 4
Repeati872 – 8754PXXP 5
Repeati890 – 8934PXXP 6

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni733 – 8931616 X 4 AA repeats of P-X-X-PAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi922 – 9298Poly-Lys

Sequence similaritiesi

Contains 6 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00840000129695.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.
InParanoidiQ9Y5I1.
KOiK16493.
OMAiVICFLTP.
OrthoDBiEOG7KSX80.
PhylomeDBiQ9Y5I1.
TreeFamiTF332299.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR031904. Cadherin_CBD.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF15974. Cadherin_tail. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y5I1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFGFQRRGLG TPRLQLWLLL LEFWEVGSGQ LHYSVSEEAK HGTFVGRIAQ
60 70 80 90 100
DLGLELAELV QRLFRVASKT HGDLLEVNLQ NGILFVNSRI DREELCGQSA
110 120 130 140 150
ECSIHLEVIV DRPLQVFHVN VEVKDINDNP PVFSLREQKL LIAESKQSDS
160 170 180 190 200
RFPLEGASDA DIEENALLTY RLSKNEYFSL DSPTNGKQIK RLSLILKKSL
210 220 230 240 250
DREKTPELNL LLTATDGGKP ELTGTVRLLV QVLDVNDNDP EFDKSEYKVS
260 270 280 290 300
LMENAAKETL VLKLNATDRD EGVNGEVTYS LMSIKPNGRH LFTLDQNNGE
310 320 330 340 350
VRVNGTLDYE ENKFYKIEVQ ATDKGTPPMA GHCTVWVEIL DTNDNSPEVA
360 370 380 390 400
VTSLSLPVRE DAQPSTVIAL ISVSDRDSGV NGQVTCSLTP HVPFKLVSTF
410 420 430 440 450
KNYYSLVLDS ALDRENVWAY ELVVTARDGG SPSLWATARV SVEVADVNDN
460 470 480 490 500
APAFAQPEYT VFVKENNPPG CHIFTVSARD ADAQENALVS YSLVERRLGD
510 520 530 540 550
RALSSYVSVH AESGKVYALQ PLDHEELELL QFQVSARDAG VPPLSSNVTL
560 570 580 590 600
QVFVLDENDN APALLATQAG SAGGAVNKLV PRSVGAGHVV AKVRAVDADS
610 620 630 640 650
GYNAWLSYEL QPAAGGSRIP FRVGLYTGEI STTRALDEAD SPRHRLLVLV
660 670 680 690 700
KDHGEPALTA TATVLVSLVE SGQAPKASSR TLAGAASPEA ALVDVNVYLI
710 720 730 740 750
IAICVVSSLL VLTLLLYTAL WWSATPTEGA CAPGKPTLVC SRAVGSWSYS
760 770 780 790 800
QQRRQRVCSE EGPPKTDLMA FSPSLPLGLN KEEEGERQEP GSNHPGQPRQ
810 820 830 840 850
PNPDWRYSAS LRAGMHSSVH LEEAGILRAG PGGPDQQWPT VSSATPEPEA
860 870 880 890 900
GEVSPPVGAG VNSNSWTFKY GPGNPKQSGP GELPDKFIIP GSPAIISIRQ
910 920 930 940
EPTNSQIDKS DFITFGKKEE TKKKKKKKKG NKTQEKKEKG NSTTDNSDQ
Length:949
Mass (Da):103,298
Last modified:November 1, 1999 - v1
Checksum:i3063589B60A125CB
GO
Isoform 2 (identifier: Q9Y5I1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     798-810: PRQPNPDWRYSAS → VSFLQIPPIRKCM
     811-949: Missing.

Show »
Length:810
Mass (Da):88,392
Checksum:iC08A31F9A9A14D4A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti199 – 1991S → Y.
Corresponds to variant rs10071369 [ dbSNP | Ensembl ].
VAR_048538
Natural varianti418 – 4181W → S.
Corresponds to variant rs17119218 [ dbSNP | Ensembl ].
VAR_048539

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei798 – 81013PRQPN…RYSAS → VSFLQIPPIRKCM in isoform 2. 2 PublicationsVSP_000693Add
BLAST
Alternative sequencei811 – 949139Missing in isoform 2. 2 PublicationsVSP_000694Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152307 mRNA. Translation: AAD43701.1.
AF152476 mRNA. Translation: AAD43737.1.
AJ007609 mRNA. Translation: CAC22256.1.
AC005609 Genomic DNA. Translation: AAC34316.1.
CH471062 Genomic DNA. Translation: EAW61995.1.
BC136706 mRNA. Translation: AAI36707.1.
CCDSiCCDS47284.1. [Q9Y5I1-1]
CCDS75326.1. [Q9Y5I1-2]
RefSeqiNP_061725.1. NM_018902.4. [Q9Y5I1-1]
NP_114067.1. NM_031861.2. [Q9Y5I1-2]
UniGeneiHs.199343.
Hs.624176.
Hs.670031.

Genome annotation databases

EnsembliENST00000398640; ENSP00000381636; ENSG00000249158. [Q9Y5I1-1]
ENST00000616325; ENSP00000482503; ENSG00000249158. [Q9Y5I1-2]
GeneIDi56138.
KEGGihsa:56138.
UCSCiuc003lia.4. human. [Q9Y5I1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152307 mRNA. Translation: AAD43701.1.
AF152476 mRNA. Translation: AAD43737.1.
AJ007609 mRNA. Translation: CAC22256.1.
AC005609 Genomic DNA. Translation: AAC34316.1.
CH471062 Genomic DNA. Translation: EAW61995.1.
BC136706 mRNA. Translation: AAI36707.1.
CCDSiCCDS47284.1. [Q9Y5I1-1]
CCDS75326.1. [Q9Y5I1-2]
RefSeqiNP_061725.1. NM_018902.4. [Q9Y5I1-1]
NP_114067.1. NM_031861.2. [Q9Y5I1-2]
UniGeneiHs.199343.
Hs.624176.
Hs.670031.

3D structure databases

ProteinModelPortaliQ9Y5I1.
SMRiQ9Y5I1. Positions 27-695.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121078. 4 interactions.
IntActiQ9Y5I1. 1 interaction.

PTM databases

iPTMnetiQ9Y5I1.
PhosphoSiteiQ9Y5I1.

Polymorphism and mutation databases

BioMutaiPCDHA11.
DMDMi13878432.

Proteomic databases

PaxDbiQ9Y5I1.
PRIDEiQ9Y5I1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000398640; ENSP00000381636; ENSG00000249158. [Q9Y5I1-1]
ENST00000616325; ENSP00000482503; ENSG00000249158. [Q9Y5I1-2]
GeneIDi56138.
KEGGihsa:56138.
UCSCiuc003lia.4. human. [Q9Y5I1-1]

Organism-specific databases

CTDi56138.
GeneCardsiPCDHA11.
H-InvDBHIX0032477.
HGNCiHGNC:8665. PCDHA11.
MIMi604966. gene.
606317. gene.
neXtProtiNX_Q9Y5I1.
PharmGKBiPA33011.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00840000129695.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.
InParanoidiQ9Y5I1.
KOiK16493.
OMAiVICFLTP.
OrthoDBiEOG7KSX80.
PhylomeDBiQ9Y5I1.
TreeFamiTF332299.

Miscellaneous databases

GenomeRNAii56138.
PROiQ9Y5I1.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y5I1.
ExpressionAtlasiQ9Y5I1. baseline and differential.
GenevisibleiQ9Y5I1. HS.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR031904. Cadherin_CBD.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF15974. Cadherin_tail. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A striking organization of a large family of human neural cadherin-like cell adhesion genes."
    Wu Q., Maniatis T.
    Cell 97:779-790(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain.
  2. "In silico identification and molecular cloning of novel human protocadherin genes having identical 3' exons."
    Kools P.F.J., van Roy F.
    Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1).
  3. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.

Entry informationi

Entry nameiPCDAB_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5I1
Secondary accession number(s): B2RN58, O75279
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1999
Last modified: June 8, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.