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Protein

Protocadherin alpha-3

Gene

PCDHA3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

GO - Molecular functioni

GO - Biological processi

  • cell adhesion Source: ProtInc
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
  • nervous system development Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin alpha-3
Short name:
PCDH-alpha-3
Gene namesi
Name:PCDHA3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:8669. PCDHA3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 697ExtracellularSequence analysisAdd BLAST668
Transmembranei698 – 718HelicalSequence analysisAdd BLAST21
Topological domaini719 – 950CytoplasmicSequence analysisAdd BLAST232

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi56145.
OpenTargetsiENSG00000255408.
PharmGKBiPA33015.

Polymorphism and mutation databases

BioMutaiPCDHA3.
DMDMi13878429.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000000388830 – 950Protocadherin alpha-3Add BLAST921

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi257N-linked (GlcNAc...)Sequence analysis1
Glycosylationi265N-linked (GlcNAc...)Sequence analysis1
Glycosylationi548N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9Y5H8.
PeptideAtlasiQ9Y5H8.
PRIDEiQ9Y5H8.

PTM databases

iPTMnetiQ9Y5H8.
PhosphoSitePlusiQ9Y5H8.

Expressioni

Gene expression databases

BgeeiENSG00000255408.
GenevisibleiQ9Y5H8. HS.

Organism-specific databases

HPAiHPA035667.

Interactioni

Protein-protein interaction databases

BioGridi121085. 29 interactors.
IntActiQ9Y5H8. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliQ9Y5H8.
SMRiQ9Y5H8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 133Cadherin 1PROSITE-ProRule annotationAdd BLAST104
Domaini134 – 242Cadherin 2PROSITE-ProRule annotationAdd BLAST109
Domaini243 – 350Cadherin 3PROSITE-ProRule annotationAdd BLAST108
Domaini351 – 455Cadherin 4PROSITE-ProRule annotationAdd BLAST105
Domaini456 – 565Cadherin 5PROSITE-ProRule annotationAdd BLAST110
Domaini581 – 678Cadherin 6PROSITE-ProRule annotationAdd BLAST98
Repeati734 – 737PXXP 14
Repeati774 – 777PXXP 24
Repeati799 – 802PXXP 34
Repeati832 – 835PXXP 44
Repeati873 – 876PXXP 54
Repeati891 – 894PXXP 64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni734 – 8946 X 4 AA repeats of P-X-X-PAdd BLAST161

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi923 – 930Poly-Lys8

Sequence similaritiesi

Contains 6 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00850000132246.
HOVERGENiHBG054878.
InParanoidiQ9Y5H8.
KOiK16493.
OMAiMSDHCTV.
OrthoDBiEOG091G00KR.
PhylomeDBiQ9Y5H8.
TreeFamiTF332299.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR031904. Cadherin_CBD.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF15974. Cadherin_tail. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y5H8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLFSWREDPG AQCLLLSLLL LAASEVGSGQ LHYSVSEEAK HGTFVGRIAQ
60 70 80 90 100
DLGLELAELV PRLFRVASKR HGDLLEVNLQ NGILFVNSRI DREELCGRSA
110 120 130 140 150
ECSIHLEVIV DRPLQVFHVE VEVKDINDNA PVFPMAVKNL FISESRQPGS
160 170 180 190 200
RFSLEGASDA DIGTNSLLTY SLDSTEYFTL DVKRNDEEIK SLGLVLKKNL
210 220 230 240 250
NREDTPKHYL LITAIDGGKP ELTGTTQLKI TVLDVNDNAP AFERTIYKVR
260 270 280 290 300
LLENAPNGTL VVTVNATDLD EGVNKDIAYS FNTDMSADIL SKFHLDPVNG
310 320 330 340 350
QISVKGNIDF EESKSYEIQV EATDKGNPPM SDHCTVLLEI VDINDNVPEL
360 370 380 390 400
VIQSLSLPVL EDSPLSTVIA LISVSDRDSG VNGQVTCSLT PHVPFKLVST
410 420 430 440 450
FKNYYSLVLD SPLDRESVSA YELVVTARDG GSPSLWATAS VSVEVADVND
460 470 480 490 500
NAPAFSQSEY TVFVKENNPP GCHIFTVSAR DADAQENALV SYSLVERRVG
510 520 530 540 550
ERALSSYVSV HAESGKVYAL QPLDHEELEL LQFQVSARDA GVPPLGSNVT
560 570 580 590 600
LQVFVLDEND NAPALLMPRV GGIGGAVSEL VPRSVGAGHV VAKVRAVDAD
610 620 630 640 650
SGYNAWLSYE LQPGTGGARI PFRVGLYTGE ISTTRALDEV DAPRHRLLVL
660 670 680 690 700
VKDHGEPSLT ATATVLVSLV ESGQAPKASS QASAGATGPE AALVDVNVYL
710 720 730 740 750
IVAICAVSSL LVLTLLLYTA LRCSAPPTEG DCGPGKPTLV CSSAVGSWSY
760 770 780 790 800
SQQRQQRVCS GEGLPKTDLM AFSPSLPPCP ISRDREEKQD VDVDLSAKPR
810 820 830 840 850
QPNPDWRYSA SLRAGMHSSV HLEEAGILRA GPGGPDQQWP TVSSATPEPE
860 870 880 890 900
AGEVSPPVGA GVNSNSWTFK YGPGNPKQSG PGELPDKFII PGSPAIISIR
910 920 930 940 950
QEPTNSQIDK SDFITFGKKE ETKKKKKKKK GNKTQEKKEK GNSTTDNSDQ
Length:950
Mass (Da):102,428
Last modified:November 1, 1999 - v1
Checksum:i0BF2CD4886D178B5
GO
Isoform 2 (identifier: Q9Y5H8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     799-824: PRQPNPDWRYSASLRAGMHSSVHLEE → VSNFYLFFPKCLCFSFLNVSTPLEIH
     825-950: Missing.

Show »
Length:824
Mass (Da):89,057
Checksum:i13A3DB786D3A1947
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06106061P → Q.Corresponds to variant rs7731327dbSNPEnsembl.1
Natural variantiVAR_048524289I → T.Corresponds to variant rs3733709dbSNPEnsembl.1
Natural variantiVAR_021874318I → V.Corresponds to variant rs3733708dbSNPEnsembl.1
Natural variantiVAR_048525440S → I.Corresponds to variant rs7701755dbSNPEnsembl.1
Natural variantiVAR_021875759C → Y.Corresponds to variant rs2240694dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_000675799 – 824PRQPN…VHLEE → VSNFYLFFPKCLCFSFLNVS TPLEIH in isoform 2. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_000676825 – 950Missing in isoform 2. 1 PublicationAdd BLAST126

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152311 mRNA. Translation: AAD43705.1.
AF152481 mRNA. Translation: AAD43742.1.
AC005609 Genomic DNA. Translation: AAC34323.1.
CCDSiCCDS54915.1. [Q9Y5H8-1]
RefSeqiNP_061729.1. NM_018906.2. [Q9Y5H8-1]
NP_113685.1. NM_031497.1. [Q9Y5H8-2]
UniGeneiHs.199343.

Genome annotation databases

EnsembliENST00000522353; ENSP00000429808; ENSG00000255408. [Q9Y5H8-1]
ENST00000532566; ENSP00000434086; ENSG00000255408. [Q9Y5H8-2]
GeneIDi56145.
KEGGihsa:56145.
UCSCiuc003lhf.2. human. [Q9Y5H8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152311 mRNA. Translation: AAD43705.1.
AF152481 mRNA. Translation: AAD43742.1.
AC005609 Genomic DNA. Translation: AAC34323.1.
CCDSiCCDS54915.1. [Q9Y5H8-1]
RefSeqiNP_061729.1. NM_018906.2. [Q9Y5H8-1]
NP_113685.1. NM_031497.1. [Q9Y5H8-2]
UniGeneiHs.199343.

3D structure databases

ProteinModelPortaliQ9Y5H8.
SMRiQ9Y5H8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121085. 29 interactors.
IntActiQ9Y5H8. 1 interactor.

PTM databases

iPTMnetiQ9Y5H8.
PhosphoSitePlusiQ9Y5H8.

Polymorphism and mutation databases

BioMutaiPCDHA3.
DMDMi13878429.

Proteomic databases

PaxDbiQ9Y5H8.
PeptideAtlasiQ9Y5H8.
PRIDEiQ9Y5H8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000522353; ENSP00000429808; ENSG00000255408. [Q9Y5H8-1]
ENST00000532566; ENSP00000434086; ENSG00000255408. [Q9Y5H8-2]
GeneIDi56145.
KEGGihsa:56145.
UCSCiuc003lhf.2. human. [Q9Y5H8-1]

Organism-specific databases

CTDi56145.
DisGeNETi56145.
GeneCardsiPCDHA3.
HGNCiHGNC:8669. PCDHA3.
HPAiHPA035667.
MIMi604966. gene.
606309. gene.
neXtProtiNX_Q9Y5H8.
OpenTargetsiENSG00000255408.
PharmGKBiPA33015.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00850000132246.
HOVERGENiHBG054878.
InParanoidiQ9Y5H8.
KOiK16493.
OMAiMSDHCTV.
OrthoDBiEOG091G00KR.
PhylomeDBiQ9Y5H8.
TreeFamiTF332299.

Miscellaneous databases

GeneWikiiPCDHA3.
GenomeRNAii56145.
PROiQ9Y5H8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000255408.
GenevisibleiQ9Y5H8. HS.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR031904. Cadherin_CBD.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF15974. Cadherin_tail. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPCDA3_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5H8
Secondary accession number(s): O75286
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 142 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.