Q9Y5H8 (PCDA3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protocadherin alpha-3
Short name=PCDH-alpha-3

Gene names

Name:

PCDHA3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	950 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
Subcellular location	Cell membrane; Single-pass type I membrane protein By similarity.
Sequence similarities	Contains 6 cadherin domains.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Signal Transmembrane Transmembrane helix
Ligand	Calcium
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell adhesion Traceable author statement Ref.1. Source: ProtInc homophilic cell adhesion Inferred from electronic annotation. Source: InterPro nervous system development Traceable author statement Ref.1. Source: ProtInc
Cellular_component	integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9Y5H8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9Y5H8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     799-824: PRQPNPDWRYSASLRAGMHSSVHLEE → VSNFYLFFPKCLCFSFLNVSTPLEIH
     825-950: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 29	29	Potential
	Chain	30 – 950	921	Protocadherin alpha-3		PRO_0000003888
Regions
	Topological domain	30 – 697	668	Extracellular Potential
	Transmembrane	698 – 718	21	Helical; Potential
	Topological domain	719 – 950	232	Cytoplasmic Potential
	Domain	30 – 133	104	Cadherin 1
	Domain	134 – 242	109	Cadherin 2
	Domain	243 – 350	108	Cadherin 3
	Domain	351 – 455	105	Cadherin 4
	Domain	456 – 565	110	Cadherin 5
	Domain	581 – 678	98	Cadherin 6
	Repeat	734 – 737	4	PXXP 1
	Repeat	774 – 777	4	PXXP 2
	Repeat	799 – 802	4	PXXP 3
	Repeat	832 – 835	4	PXXP 4
	Repeat	873 – 876	4	PXXP 5
	Repeat	891 – 894	4	PXXP 6
	Region	734 – 894	161	6 X 4 AA repeats of P-X-X-P
	Compositional bias	923 – 930	8	Poly-Lys
Amino acid modifications
	Glycosylation	257	1	N-linked (GlcNAc...) Potential
	Glycosylation	265	1	N-linked (GlcNAc...) Potential
	Glycosylation	548	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	799 – 824	26	PRQPN…VHLEE → VSNFYLFFPKCLCFSFLNVS TPLEIH in isoform 2.		VSP_000675
	Alternative sequence	825 – 950	126	Missing in isoform 2.		VSP_000676
	Natural variant	61	1	P → Q. Corresponds to variant rs7731327 [ dbSNP | Ensembl ].		VAR_061060
	Natural variant	289	1	I → T. Corresponds to variant rs3733709 [ dbSNP | Ensembl ].		VAR_048524
	Natural variant	318	1	I → V. Corresponds to variant rs3733708 [ dbSNP | Ensembl ].		VAR_021874
	Natural variant	440	1	S → I. Corresponds to variant rs7701755 [ dbSNP | Ensembl ].		VAR_048525
	Natural variant	759	1	C → Y. Corresponds to variant rs2240694 [ dbSNP | Ensembl ].		VAR_021875

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 0BF2CD4886D178B5	FASTA	950	102,428
	10 20 30 40 50 60 MLFSWREDPG AQCLLLSLLL LAASEVGSGQ LHYSVSEEAK HGTFVGRIAQ DLGLELAELV 70 80 90 100 110 120 PRLFRVASKR HGDLLEVNLQ NGILFVNSRI DREELCGRSA ECSIHLEVIV DRPLQVFHVE 130 140 150 160 170 180 VEVKDINDNA PVFPMAVKNL FISESRQPGS RFSLEGASDA DIGTNSLLTY SLDSTEYFTL 190 200 210 220 230 240 DVKRNDEEIK SLGLVLKKNL NREDTPKHYL LITAIDGGKP ELTGTTQLKI TVLDVNDNAP 250 260 270 280 290 300 AFERTIYKVR LLENAPNGTL VVTVNATDLD EGVNKDIAYS FNTDMSADIL SKFHLDPVNG 310 320 330 340 350 360 QISVKGNIDF EESKSYEIQV EATDKGNPPM SDHCTVLLEI VDINDNVPEL VIQSLSLPVL 370 380 390 400 410 420 EDSPLSTVIA LISVSDRDSG VNGQVTCSLT PHVPFKLVST FKNYYSLVLD SPLDRESVSA 430 440 450 460 470 480 YELVVTARDG GSPSLWATAS VSVEVADVND NAPAFSQSEY TVFVKENNPP GCHIFTVSAR 490 500 510 520 530 540 DADAQENALV SYSLVERRVG ERALSSYVSV HAESGKVYAL QPLDHEELEL LQFQVSARDA 550 560 570 580 590 600 GVPPLGSNVT LQVFVLDEND NAPALLMPRV GGIGGAVSEL VPRSVGAGHV VAKVRAVDAD 610 620 630 640 650 660 SGYNAWLSYE LQPGTGGARI PFRVGLYTGE ISTTRALDEV DAPRHRLLVL VKDHGEPSLT 670 680 690 700 710 720 ATATVLVSLV ESGQAPKASS QASAGATGPE AALVDVNVYL IVAICAVSSL LVLTLLLYTA 730 740 750 760 770 780 LRCSAPPTEG DCGPGKPTLV CSSAVGSWSY SQQRQQRVCS GEGLPKTDLM AFSPSLPPCP 790 800 810 820 830 840 ISRDREEKQD VDVDLSAKPR QPNPDWRYSA SLRAGMHSSV HLEEAGILRA GPGGPDQQWP 850 860 870 880 890 900 TVSSATPEPE AGEVSPPVGA GVNSNSWTFK YGPGNPKQSG PGELPDKFII PGSPAIISIR 910 920 930 940 950 QEPTNSQIDK SDFITFGKKE ETKKKKKKKK GNKTQEKKEK GNSTTDNSDQ
	Isoform 2 [UniParc]. Checksum: 13A3DB786D3A1947	FASTA	824	89,057
	10 20 30 40 50 60 MLFSWREDPG AQCLLLSLLL LAASEVGSGQ LHYSVSEEAK HGTFVGRIAQ DLGLELAELV 70 80 90 100 110 120 PRLFRVASKR HGDLLEVNLQ NGILFVNSRI DREELCGRSA ECSIHLEVIV DRPLQVFHVE 130 140 150 160 170 180 VEVKDINDNA PVFPMAVKNL FISESRQPGS RFSLEGASDA DIGTNSLLTY SLDSTEYFTL 190 200 210 220 230 240 DVKRNDEEIK SLGLVLKKNL NREDTPKHYL LITAIDGGKP ELTGTTQLKI TVLDVNDNAP 250 260 270 280 290 300 AFERTIYKVR LLENAPNGTL VVTVNATDLD EGVNKDIAYS FNTDMSADIL SKFHLDPVNG 310 320 330 340 350 360 QISVKGNIDF EESKSYEIQV EATDKGNPPM SDHCTVLLEI VDINDNVPEL VIQSLSLPVL 370 380 390 400 410 420 EDSPLSTVIA LISVSDRDSG VNGQVTCSLT PHVPFKLVST FKNYYSLVLD SPLDRESVSA 430 440 450 460 470 480 YELVVTARDG GSPSLWATAS VSVEVADVND NAPAFSQSEY TVFVKENNPP GCHIFTVSAR 490 500 510 520 530 540 DADAQENALV SYSLVERRVG ERALSSYVSV HAESGKVYAL QPLDHEELEL LQFQVSARDA 550 560 570 580 590 600 GVPPLGSNVT LQVFVLDEND NAPALLMPRV GGIGGAVSEL VPRSVGAGHV VAKVRAVDAD 610 620 630 640 650 660 SGYNAWLSYE LQPGTGGARI PFRVGLYTGE ISTTRALDEV DAPRHRLLVL VKDHGEPSLT 670 680 690 700 710 720 ATATVLVSLV ESGQAPKASS QASAGATGPE AALVDVNVYL IVAICAVSSL LVLTLLLYTA 730 740 750 760 770 780 LRCSAPPTEG DCGPGKPTLV CSSAVGSWSY SQQRQQRVCS GEGLPKTDLM AFSPSLPPCP 790 800 810 820 ISRDREEKQD VDVDLSAKVS NFYLFFPKCL CFSFLNVSTP LEIH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A striking organization of a large family of human neural cadherin-like cell adhesion genes." Wu Q., Maniatis T. Cell 97:779-790(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2). Tissue: Brain.
[2]	"The DNA sequence and comparative analysis of human chromosome 5." Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M. Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF152311 mRNA. Translation: AAD43705.1. AF152481 mRNA. Translation: AAD43742.1. AC005609 Genomic DNA. Translation: AAC34323.1.
IPI	IPI00001497. IPI00221243.
RefSeq	NP_061729.1. NM_018906.2. NP_113685.1. NM_031497.1.
UniGene	Hs.199343.
3D structure databases
ProteinModelPortal	Q9Y5H8.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9Y5H8. 1 interaction.
MINT	MINT-7242624.
PTM databases
PhosphoSite	Q9Y5H8.
Polymorphism databases
DMDM	13878429.
Proteomic databases
PaxDb	Q9Y5H8.
PRIDE	Q9Y5H8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000522353; ENSP00000429808; ENSG00000255408. ENST00000532566; ENSP00000434086; ENSG00000255408.
GeneID	56145.
KEGG	hsa:56145.
UCSC	uc003lhf.2. human. uc011czz.2. human.
Organism-specific databases
CTD	56145.
GeneCards	GC05P140161.
HGNC	HGNC:8669. PCDHA3.
HPA	HPA008712. HPA035667.
MIM	604966. gene. 606309. gene.
neXtProt	NX_Q9Y5H8.
PharmGKB	PA33015.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG267459.
HOVERGEN	HBG054878.
InParanoid	Q9Y5H8.
KO	K16493.
OMA	FNTDMSA.
OrthoDB	EOG4QVCBC.
Gene expression databases
Bgee	Q9Y5H8.
Genevestigator	Q9Y5H8.
GermOnline	ENSG00000204968. Homo sapiens.
Family and domain databases
Gene3D	2.60.40.60. 6 hits.
InterPro	IPR002126. Cadherin. IPR015919. Cadherin-like. IPR020894. Cadherin_CS. IPR013164. Cadherin_N. [Graphical view]
Pfam	PF00028. Cadherin. 5 hits. PF08266. Cadherin_2. 1 hit. [Graphical view]
PRINTS	PR00205. CADHERIN.
SMART	SM00112. CA. 6 hits. [Graphical view]
SUPFAM	SSF49313. Cadherin. 6 hits.
PROSITE	PS00232. CADHERIN_1. 5 hits. PS50268. CADHERIN_2. 6 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	56145.
NextBio	61738.
SOURCE	Search...

Entry information

Entry name

PCDA3_HUMAN

Accession

Primary (citable) accession number: Q9Y5H8
Secondary accession number(s): O75286

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	November 1, 1999
Last modified:	May 1, 2013
This is version 112 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.