Q9Y5H7 (PCDA5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protocadherin alpha-5
Short name=PCDH-alpha-5

Gene names

Name:	PCDHA5
Synonyms:	CNRS6

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	936 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
Subcellular location	Cell membrane; Single-pass type I membrane protein By similarity.
Sequence similarities	Contains 6 cadherin domains.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Signal Transmembrane Transmembrane helix
Ligand	Calcium
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell adhesion Traceable author statement Ref.1. Source: ProtInc homophilic cell adhesion Inferred from electronic annotation. Source: InterPro nervous system development Traceable author statement Ref.1. Source: ProtInc
Cellular_component	integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9Y5H7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9Y5H7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     785-816: PRQPNPDWRYSASLRAGMHSSVHLEEAGILRA → VSFLILTSIFPSQFSNIKCHIHPLFLYLKIMS
     817-936: Missing.

Isoform 3 (identifier: Q9Y5H7-3)

The sequence of this isoform differs from the canonical sequence as follows:
     868-890: GELPDKFIIPGSPAIISIRQEPT → EPKKQTQVSFLLRRKGEASQPRQ
     891-936: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 28	28	Potential
	Chain	29 – 936	908	Protocadherin alpha-5		PRO_0000003892
Regions
	Topological domain	29 – 696	668	Extracellular Potential
	Transmembrane	697 – 717	21	Helical; Potential
	Topological domain	718 – 936	219	Cytoplasmic Potential
	Domain	33 – 132	100	Cadherin 1
	Domain	156 – 241	86	Cadherin 2
	Domain	242 – 349	108	Cadherin 3
	Domain	350 – 454	105	Cadherin 4
	Domain	455 – 564	110	Cadherin 5
	Domain	580 – 677	98	Cadherin 6
	Repeat	773 – 776	4	PXXP 1
	Repeat	785 – 788	4	PXXP 2
	Repeat	818 – 821	4	PXXP 3
	Repeat	873 – 876	4	PXXP 4
	Repeat	877 – 890	14	PXXP 5
	Region	773 – 890	118	5 X 4 AA repeats of P-X-X-P
	Compositional bias	909 – 916	8	Poly-Lys
Amino acid modifications
	Glycosylation	264	1	N-linked (GlcNAc...) Potential
	Glycosylation	547	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	785 – 816	32	PRQPN…GILRA → VSFLILTSIFPSQFSNIKCH IHPLFLYLKIMS in isoform 2.		VSP_000679
	Alternative sequence	817 – 936	120	Missing in isoform 2.		VSP_000680
	Alternative sequence	868 – 890	23	GELPD…RQEPT → EPKKQTQVSFLLRRKGEASQ PRQ in isoform 3.		VSP_008704
	Alternative sequence	891 – 936	46	Missing in isoform 3.		VSP_008705
	Natural variant	691	1	A → V. Corresponds to variant rs4141841 [ dbSNP | Ensembl ].		VAR_048526
Experimental info
	Sequence conflict	237	1	N → S in AAH33735. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 7143EECE1A357CD6	FASTA	936	102,048
	10 20 30 40 50 60 MVYSRRGSLG SRLLLLWLLL AYWKAGSGQL HYSIPEEAKH GTFVGRIAQD LGLELAELVP 70 80 90 100 110 120 RLFRVASKGR GDLLEVNLQN GILFVNSRID REELCRRRAE CSIHLEVIVD RPLQVFHVEV 130 140 150 160 170 180 AVKDINDNPP RFSRQEQRLF ILESRMPDSR FPLEGASDLD IGANAQLRYR LNPNEYFDLD 190 200 210 220 230 240 VKTNEEETNF LELVLRKSLD REETQEHRLL VIATDGGKPE LTGTVQLLIN VLDANDNAPE 250 260 270 280 290 300 FDKSIYNVRL LENAPSGTLV IKLNASDADE GINKEIVYFF SNLVLDDVKS KFIINSNTGE 310 320 330 340 350 360 IKVNGELDYE DYNSYEINID AMDKSTFPLS GHCKVVVKLL DVNDNTPEMA ITTLFLPVKE 370 380 390 400 410 420 DAPLSTVIAL ISVSDRDSGA NGQVTCSLMP HVPFKLVSTF KNYYSLVLDS ALDRESVSVY 430 440 450 460 470 480 ELVVTARDGG SPSLWATASV SVEVADVNDN APAFAQPQYT VFVKENNPPG CHIFTVSARD 490 500 510 520 530 540 ADAQENALVS YSLVERRVGE RPLSSYVSVH AESGKVYALQ PLDHEEVELL QFQVSARDAG 550 560 570 580 590 600 VPPLGSNVTL QVFVLDENDN APALLVPRVG GTGGAVSELV PRSVGAGHVV AKVRAVDPDS 610 620 630 640 650 660 GYNAWLSYEL QPAPGSARIP FRVGLYTGEI STTRSLDETE APRHRLLVLV KDHGEPPLTA 670 680 690 700 710 720 TATVLVSLVE SGQAPKASSR ASAGAVGPEA ALVDVNVYLI IAICAVSSLL VLTLLLYTAL 730 740 750 760 770 780 RCSAQPTEAV CTRGKPTLLC SSAVGSWSYS QQRRQRVCSG EAPPKTDLMA FSPSLPQGPT 790 800 810 820 830 840 STDNPRQPNP DWRYSASLRA GMHSSVHLEE AGILRAGPGG PDQQWPTVSS ATPEPEAGEV 850 860 870 880 890 900 SPPVGAGVNS NSWTFKYGPG NPKQSGPGEL PDKFIIPGSP AIISIRQEPT NSQIDKSDFI 910 920 930 TFGKKEETKK KKKKKKGNKT QEKKEKGNST TDNSDQ
	Isoform 2 [UniParc]. Checksum: 3866970F5657BF16	FASTA	816	89,349
	10 20 30 40 50 60 MVYSRRGSLG SRLLLLWLLL AYWKAGSGQL HYSIPEEAKH GTFVGRIAQD LGLELAELVP 70 80 90 100 110 120 RLFRVASKGR GDLLEVNLQN GILFVNSRID REELCRRRAE CSIHLEVIVD RPLQVFHVEV 130 140 150 160 170 180 AVKDINDNPP RFSRQEQRLF ILESRMPDSR FPLEGASDLD IGANAQLRYR LNPNEYFDLD 190 200 210 220 230 240 VKTNEEETNF LELVLRKSLD REETQEHRLL VIATDGGKPE LTGTVQLLIN VLDANDNAPE 250 260 270 280 290 300 FDKSIYNVRL LENAPSGTLV IKLNASDADE GINKEIVYFF SNLVLDDVKS KFIINSNTGE 310 320 330 340 350 360 IKVNGELDYE DYNSYEINID AMDKSTFPLS GHCKVVVKLL DVNDNTPEMA ITTLFLPVKE 370 380 390 400 410 420 DAPLSTVIAL ISVSDRDSGA NGQVTCSLMP HVPFKLVSTF KNYYSLVLDS ALDRESVSVY 430 440 450 460 470 480 ELVVTARDGG SPSLWATASV SVEVADVNDN APAFAQPQYT VFVKENNPPG CHIFTVSARD 490 500 510 520 530 540 ADAQENALVS YSLVERRVGE RPLSSYVSVH AESGKVYALQ PLDHEEVELL QFQVSARDAG 550 560 570 580 590 600 VPPLGSNVTL QVFVLDENDN APALLVPRVG GTGGAVSELV PRSVGAGHVV AKVRAVDPDS 610 620 630 640 650 660 GYNAWLSYEL QPAPGSARIP FRVGLYTGEI STTRSLDETE APRHRLLVLV KDHGEPPLTA 670 680 690 700 710 720 TATVLVSLVE SGQAPKASSR ASAGAVGPEA ALVDVNVYLI IAICAVSSLL VLTLLLYTAL 730 740 750 760 770 780 RCSAQPTEAV CTRGKPTLLC SSAVGSWSYS QQRRQRVCSG EAPPKTDLMA FSPSLPQGPT 790 800 810 STDNVSFLIL TSIFPSQFSN IKCHIHPLFL YLKIMS
	Isoform 3 [UniParc]. Checksum: FD9B5EA33572A7E3	FASTA	890	96,996
	10 20 30 40 50 60 MVYSRRGSLG SRLLLLWLLL AYWKAGSGQL HYSIPEEAKH GTFVGRIAQD LGLELAELVP 70 80 90 100 110 120 RLFRVASKGR GDLLEVNLQN GILFVNSRID REELCRRRAE CSIHLEVIVD RPLQVFHVEV 130 140 150 160 170 180 AVKDINDNPP RFSRQEQRLF ILESRMPDSR FPLEGASDLD IGANAQLRYR LNPNEYFDLD 190 200 210 220 230 240 VKTNEEETNF LELVLRKSLD REETQEHRLL VIATDGGKPE LTGTVQLLIN VLDANDNAPE 250 260 270 280 290 300 FDKSIYNVRL LENAPSGTLV IKLNASDADE GINKEIVYFF SNLVLDDVKS KFIINSNTGE 310 320 330 340 350 360 IKVNGELDYE DYNSYEINID AMDKSTFPLS GHCKVVVKLL DVNDNTPEMA ITTLFLPVKE 370 380 390 400 410 420 DAPLSTVIAL ISVSDRDSGA NGQVTCSLMP HVPFKLVSTF KNYYSLVLDS ALDRESVSVY 430 440 450 460 470 480 ELVVTARDGG SPSLWATASV SVEVADVNDN APAFAQPQYT VFVKENNPPG CHIFTVSARD 490 500 510 520 530 540 ADAQENALVS YSLVERRVGE RPLSSYVSVH AESGKVYALQ PLDHEEVELL QFQVSARDAG 550 560 570 580 590 600 VPPLGSNVTL QVFVLDENDN APALLVPRVG GTGGAVSELV PRSVGAGHVV AKVRAVDPDS 610 620 630 640 650 660 GYNAWLSYEL QPAPGSARIP FRVGLYTGEI STTRSLDETE APRHRLLVLV KDHGEPPLTA 670 680 690 700 710 720 TATVLVSLVE SGQAPKASSR ASAGAVGPEA ALVDVNVYLI IAICAVSSLL VLTLLLYTAL 730 740 750 760 770 780 RCSAQPTEAV CTRGKPTLLC SSAVGSWSYS QQRRQRVCSG EAPPKTDLMA FSPSLPQGPT 790 800 810 820 830 840 STDNPRQPNP DWRYSASLRA GMHSSVHLEE AGILRAGPGG PDQQWPTVSS ATPEPEAGEV 850 860 870 880 890 SPPVGAGVNS NSWTFKYGPG NPKQSGPEPK KQTQVSFLLR RKGEASQPRQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A striking organization of a large family of human neural cadherin-like cell adhesion genes." Wu Q., Maniatis T. Cell 97:779-790(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2). Tissue: Brain.
[2]	"The DNA sequence and comparative analysis of human chromosome 5." Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M. Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Brain and Lung.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF152313 mRNA. Translation: AAD43707.1. AF152483 mRNA. Translation: AAD43744.1. AC005609 Genomic DNA. Translation: AAC34321.1. BC033735 mRNA. Translation: AAH33735.1.
IPI	IPI00001496. IPI00221113. IPI00377226.
RefSeq	NP_061731.1. NM_018908.2. NP_113689.1. NM_031501.1.
UniGene	Hs.199343.
3D structure databases
ProteinModelPortal	Q9Y5H7.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9Y5H7. 1 interaction.
MINT	MINT-7242520.
PTM databases
PhosphoSite	Q9Y5H7.
Polymorphism databases
DMDM	13878428.
Proteomic databases
PaxDb	Q9Y5H7.
PRIDE	Q9Y5H7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000378126; ENSP00000367366; ENSG00000204965. ENST00000529619; ENSP00000433416; ENSG00000204965. ENST00000529859; ENSP00000436557; ENSG00000204965.
GeneID	56143.
KEGG	hsa:56143.
UCSC	uc003lhj.1. human. uc003lhk.1. human. uc003lhl.2. human.
Organism-specific databases
CTD	56143.
GeneCards	GC05P140405.
H-InvDB	HIX0164437.
HGNC	HGNC:8671. PCDHA5.
HPA	HPA008712. HPA044557.
MIM	604966. gene. 606311. gene.
neXtProt	NX_Q9Y5H7.
PharmGKB	PA33017.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG294765.
HOGENOM	HOG000220892.
HOVERGEN	HBG054878.
InParanoid	Q9Y5H7.
KO	K16493.
OMA	SLFLPVK.
OrthoDB	EOG4QVCBC.
Gene expression databases
Bgee	Q9Y5H7.
Genevestigator	Q9Y5H7.
GermOnline	ENSG00000204965. Homo sapiens.
Family and domain databases
Gene3D	2.60.40.60. 6 hits.
InterPro	IPR002126. Cadherin. IPR015919. Cadherin-like. IPR020894. Cadherin_CS. IPR013164. Cadherin_N. [Graphical view]
Pfam	PF00028. Cadherin. 5 hits. PF08266. Cadherin_2. 1 hit. [Graphical view]
PRINTS	PR00205. CADHERIN.
SMART	SM00112. CA. 6 hits. [Graphical view]
SUPFAM	SSF49313. Cadherin. 6 hits.
PROSITE	PS00232. CADHERIN_1. 5 hits. PS50268. CADHERIN_2. 6 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	56143.
NextBio	61726.
SOURCE	Search...

Entry information

Entry name

PCDA5_HUMAN

Accession

Primary (citable) accession number: Q9Y5H7
Secondary accession number(s): O75284, Q8N4R3

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	November 1, 1999
Last modified:	May 1, 2013
This is version 114 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.