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Protein

Protocadherin alpha-8

Gene

PCDHA8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

GO - Molecular functioni

GO - Biological processi

  • cell adhesion Source: ProtInc
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
  • nervous system development Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin alpha-8
Short name:
PCDH-alpha-8
Gene namesi
Name:PCDHA8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:8674. PCDHA8.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 697ExtracellularSequence analysisAdd BLAST668
Transmembranei698 – 718HelicalSequence analysisAdd BLAST21
Topological domaini719 – 950CytoplasmicSequence analysisAdd BLAST232

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000204962.
PharmGKBiPA33020.

Polymorphism and mutation databases

BioMutaiPCDHA8.
DMDMi13878427.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000000389830 – 950Protocadherin alpha-8Add BLAST921

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi257N-linked (GlcNAc...)Sequence analysis1
Glycosylationi265N-linked (GlcNAc...)Sequence analysis1
Glycosylationi548N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9Y5H6.
PaxDbiQ9Y5H6.
PeptideAtlasiQ9Y5H6.
PRIDEiQ9Y5H6.

PTM databases

iPTMnetiQ9Y5H6.
PhosphoSitePlusiQ9Y5H6.

Expressioni

Gene expression databases

BgeeiENSG00000204962.
GenevisibleiQ9Y5H6. HS.

Organism-specific databases

HPAiHPA044585.

Interactioni

Protein-protein interaction databases

BioGridi121080. 1 interactor.
IntActiQ9Y5H6. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliQ9Y5H6.
SMRiQ9Y5H6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 133Cadherin 1PROSITE-ProRule annotationAdd BLAST104
Domaini157 – 242Cadherin 2PROSITE-ProRule annotationAdd BLAST86
Domaini243 – 350Cadherin 3PROSITE-ProRule annotationAdd BLAST108
Domaini351 – 455Cadherin 4PROSITE-ProRule annotationAdd BLAST105
Domaini456 – 565Cadherin 5PROSITE-ProRule annotationAdd BLAST110
Domaini581 – 678Cadherin 6PROSITE-ProRule annotationAdd BLAST98
Repeati774 – 777PXXP 14
Repeati799 – 802PXXP 24
Repeati832 – 835PXXP 34
Repeati873 – 876PXXP 44
Repeati891 – 894PXXP 54

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni774 – 8945 X 4 AA repeats of P-X-X-PAdd BLAST121

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi923 – 930Poly-Lys8

Sequence similaritiesi

Contains 6 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00850000132246.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.
InParanoidiQ9Y5H6.
KOiK16493.
OMAiRLSSHDY.
OrthoDBiEOG091G00KR.
PhylomeDBiQ9Y5H6.
TreeFamiTF332299.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR031904. Cadherin_CBD.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF15974. Cadherin_tail. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y5H6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDYHWRGELG SWRLLLLLLL LAAWKVGSGQ LHYSVPEEAK HGTFVGRIAQ
60 70 80 90 100
DLGLELAELV PRLFRVASKR HRDLLEVSLQ NGILFVNSRI DREELCGRSA
110 120 130 140 150
ECSIHLEVIV DRPLQVFHVD VEVKDVNDNP PVFRVKDQKL FVSESRMPDS
160 170 180 190 200
RFPLEGASDA DVGANSVLTY RLSSHDYFML DVNSKNDENK LVELVLRKSL
210 220 230 240 250
DREDAPAHHL FLTATDGGKP ELTGTVQLLV TVLDVNDNAP TFEQSEYEVR
260 270 280 290 300
IFENADNGTT VIKLNASDPD EGANGAISYS FNSLVETMVI DHFSIDRNTG
310 320 330 340 350
EIVIRGNLDF EQENLYKILI DATDKGHPPM AGHCTVLVRI LDKNDNVPEI
360 370 380 390 400
ALTSLSLPVR EDAQFGTVIA LISVNDLDSG ANGQVTCSLM PHVPFKLVST
410 420 430 440 450
FKNYYSLVLD SALDRERVSA YELVVTARDG GSPSLWATAS LSVEVADVND
460 470 480 490 500
NAPAFAQPEY TVFVKENNPP GCHIFTVSAR DADAQENALV SYSLVERRVG
510 520 530 540 550
ERSLSSYISV HTESGKVYAL QPLDHEELEL LQFQVSARDA GVPPLGSNVT
560 570 580 590 600
LQVFVLDEND NAPALLEPRV GGTGGAASKL VPRSVGAGHV VAKVRAVDAD
610 620 630 640 650
SGYNAWLSYE LQPAASSPRI PFRVGLYTGE ISTTRVLDEA DSPRHRLLVL
660 670 680 690 700
VKDHGEPALT ATATVLVSLV ESGQAPKASS RQSAGVLGPE AALVDVNVYL
710 720 730 740 750
IIAICAVSSL LVLTLLLYTA LRCSALPTEG GCRAGKPTLV CSSAVGSWSY
760 770 780 790 800
SQQQPQRVCS GEGPPKTDLM AFSPCLPPDL GSVDVGEEQD LNVDHGLKPR
810 820 830 840 850
QPNPDWRYSA SLRAGMHSSV HLEEAGILRA GPGGPDQQWP TVSSATPEPE
860 870 880 890 900
AGEVSPPVGA GVNSNSWTFK YGPGNPKQSG PGELPDKFII PGSPAIISIR
910 920 930 940 950
QEPTNSQIDK SDFITFGKKE ETKKKKKKKK GNKTQEKKEK GNSTTDNSDQ
Length:950
Mass (Da):103,051
Last modified:November 1, 1999 - v1
Checksum:iFABCBDA29118B63E
GO
Isoform 2 (identifier: Q9Y5H6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     799-814: PRQPNPDWRYSASLRA → VSPFKFRTHKFYLWKL
     815-950: Missing.

Show »
Length:814
Mass (Da):88,710
Checksum:iBFEE876BF62E0B01
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02187678S → N.Corresponds to variant rs3756331dbSNPEnsembl.1
Natural variantiVAR_048529269P → R.Corresponds to variant rs525886dbSNPEnsembl.1
Natural variantiVAR_021877403N → T.Corresponds to variant rs3733706dbSNPEnsembl.1
Natural variantiVAR_059181579K → E.Corresponds to variant rs6580012dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_000686799 – 814PRQPN…ASLRA → VSPFKFRTHKFYLWKL in isoform 2. 2 PublicationsAdd BLAST16
Alternative sequenceiVSP_000687815 – 950Missing in isoform 2. 2 PublicationsAdd BLAST136

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152316 mRNA. Translation: AAD43710.1.
AF152486 mRNA. Translation: AAD43747.1.
AC005609 Genomic DNA. Translation: AAC34318.1.
BC136750 mRNA. Translation: AAI36751.1.
CCDSiCCDS54919.1. [Q9Y5H6-1]
RefSeqiNP_061734.1. NM_018911.2. [Q9Y5H6-1]
NP_114062.1. NM_031856.1. [Q9Y5H6-2]
UniGeneiHs.199343.

Genome annotation databases

EnsembliENST00000378123; ENSP00000367363; ENSG00000204962. [Q9Y5H6-2]
ENST00000531613; ENSP00000434655; ENSG00000204962. [Q9Y5H6-1]
GeneIDi56140.
KEGGihsa:56140.
UCSCiuc003lhr.2. human. [Q9Y5H6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152316 mRNA. Translation: AAD43710.1.
AF152486 mRNA. Translation: AAD43747.1.
AC005609 Genomic DNA. Translation: AAC34318.1.
BC136750 mRNA. Translation: AAI36751.1.
CCDSiCCDS54919.1. [Q9Y5H6-1]
RefSeqiNP_061734.1. NM_018911.2. [Q9Y5H6-1]
NP_114062.1. NM_031856.1. [Q9Y5H6-2]
UniGeneiHs.199343.

3D structure databases

ProteinModelPortaliQ9Y5H6.
SMRiQ9Y5H6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121080. 1 interactor.
IntActiQ9Y5H6. 1 interactor.

PTM databases

iPTMnetiQ9Y5H6.
PhosphoSitePlusiQ9Y5H6.

Polymorphism and mutation databases

BioMutaiPCDHA8.
DMDMi13878427.

Proteomic databases

EPDiQ9Y5H6.
PaxDbiQ9Y5H6.
PeptideAtlasiQ9Y5H6.
PRIDEiQ9Y5H6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378123; ENSP00000367363; ENSG00000204962. [Q9Y5H6-2]
ENST00000531613; ENSP00000434655; ENSG00000204962. [Q9Y5H6-1]
GeneIDi56140.
KEGGihsa:56140.
UCSCiuc003lhr.2. human. [Q9Y5H6-1]

Organism-specific databases

CTDi56140.
GeneCardsiPCDHA8.
HGNCiHGNC:8674. PCDHA8.
HPAiHPA044585.
MIMi604966. gene.
606314. gene.
neXtProtiNX_Q9Y5H6.
OpenTargetsiENSG00000204962.
PharmGKBiPA33020.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00850000132246.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.
InParanoidiQ9Y5H6.
KOiK16493.
OMAiRLSSHDY.
OrthoDBiEOG091G00KR.
PhylomeDBiQ9Y5H6.
TreeFamiTF332299.

Miscellaneous databases

GenomeRNAii56140.
PROiQ9Y5H6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000204962.
GenevisibleiQ9Y5H6. HS.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR031904. Cadherin_CBD.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF15974. Cadherin_tail. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPCDA8_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5H6
Secondary accession number(s): B9EGT7, O75281
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1999
Last modified: November 30, 2016
This is version 144 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.