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Protein

Protocadherin gamma-A10

Gene

PCDHGA10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin gamma-A10
Short name:
PCDH-gamma-A10
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:8697. PCDHGA10.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini33 – 696664ExtracellularSequence analysisAdd
BLAST
Transmembranei697 – 71721HelicalSequence analysisAdd
BLAST
Topological domaini718 – 936219CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33045.

Polymorphism and mutation databases

BioMutaiPCDHGA10.
DMDMi37999843.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3232Sequence analysisAdd
BLAST
Chaini33 – 936904Protocadherin gamma-A10PRO_0000003966Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi51 – 511N-linked (GlcNAc...)Sequence analysis
Glycosylationi423 – 4231N-linked (GlcNAc...)Sequence analysis
Glycosylationi549 – 5491N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9Y5H3.
MaxQBiQ9Y5H3.
PaxDbiQ9Y5H3.
PeptideAtlasiQ9Y5H3.
PRIDEiQ9Y5H3.

PTM databases

iPTMnetiQ9Y5H3.
PhosphoSiteiQ9Y5H3.

Expressioni

Gene expression databases

BgeeiQ9Y5H3.
GenevisibleiQ9Y5H3. HS.

Organism-specific databases

HPAiHPA008755.

Structurei

3D structure databases

ProteinModelPortaliQ9Y5H3.
SMRiQ9Y5H3. Positions 31-663.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 137105Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini138 – 246109Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini247 – 351105Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini352 – 456105Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Domaini457 – 566110Cadherin 5PROSITE-ProRule annotationAdd
BLAST
Domaini574 – 687114Cadherin 6PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 6 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00840000129690.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.
InParanoidiQ9Y5H3.
KOiK16495.
OMAiQHFALNV.
OrthoDBiEOG7KSX80.
PhylomeDBiQ9Y5H3.
TreeFamiTF332299.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR031904. Cadherin_CBD.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
PF15974. Cadherin_tail. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y5H3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAQRNRSKE SKDCSGLVLL CLFFGIPWEA GARQISYSIP EELEKGSFVG
60 70 80 90 100
NISKDLGLAP RELAERGVRI VSRGRTQLFS LNPRSGSLIT AGRIDREELC
110 120 130 140 150
AQSARCVVSF NILVEDRVKL FGIEIEVTDI NDNAPKFQAE NLDVKINENV
160 170 180 190 200
AAGMRFPLPE AIDPDVGVNS LQSYQLSPNK HFSLRVQSRA NGVKYPELVL
210 220 230 240 250
EHSLDREEEA IHHLVLTASD GGDPLRSGTV LVSVTVFDAN DNAPVFTLPE
260 270 280 290 300
YRVSVPENLP VGTQLLTVTA TDRDEGANGE VTYSFRKLPD TQLLKFQLNK
310 320 330 340 350
YTGEIKISEN LDYEETGFYE IEIQAEDGGA YLATAKVLIT VEDVNDNSPE
360 370 380 390 400
LTITSLFSPV TEDSPLGTVV ALLNVHDLDS EQNGQVTCSI LAYLPFKLEK
410 420 430 440 450
SIDSYYRLVI HRALDREQVS SYNITVTATD GGSPPLSTEA HFMLQVADIN
460 470 480 490 500
DNPPTFSQVS YFTYIPENNA RGASIFSVTA LDPDSKENAQ IIYSLAEDTI
510 520 530 540 550
QGVPLSSYIS INSDTGVLYA LRSFDYEQFH ELQMQVTASD SGDPPLSSNV
560 570 580 590 600
SLSLFVLDQN DNAPEILYPA LPTDGSTGVE LAPRSAEPGY LVTKVVAVDR
610 620 630 640 650
DSGQNAWLSY RLLKASEPGL FAVGEHTGEV RTARALLDRD ALKQSLVVAV
660 670 680 690 700
QDHGQPPLSA TVTLTVAVAD SIPQVLADLG SFESPANSET SDLTLYLVVA
710 720 730 740 750
VAAVSCVFLA FVIVLLAHRL RRWHKSRLLQ ASGGGLTGVS GSHFVGVDGV
760 770 780 790 800
RAFLQTYSHE VSLTADSRKS HLIFPQPNYA DTLISQESCE KNDPLSLLDD
810 820 830 840 850
SKFPIEDTPL VPQAPPNTDW RFSQAQRPGT SGSQNGDDTG TWPNNQFDTE
860 870 880 890 900
MLQAMILASA SEAADGSSTL GGGAGTMGLS ARYGPQFTLQ HVPDYRQNVY
910 920 930
IPGSNATLTN AAGKRDGKAP AGGNGNKKKS GKKEKK
Length:936
Mass (Da):101,447
Last modified:November 1, 1999 - v1
Checksum:i5F614F1934D5DC61
GO
Isoform 2 (identifier: Q9Y5H3-2) [UniParc]FASTAAdd to basket

Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     813-850: QAPPNTDWRF...TWPNNQFDTE → VSFIFIFTFV...VNAKTLMSRI
     851-936: Missing.

Show »
Length:850
Mass (Da):92,943
Checksum:i1F5489040E08FBC6
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti89 – 891I → V.
Corresponds to variant rs4912751 [ dbSNP | Ensembl ].
VAR_048566
Natural varianti796 – 7961S → P.
Corresponds to variant rs11575963 [ dbSNP | Ensembl ].
VAR_048567

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei813 – 85038QAPPN…QFDTE → VSFIFIFTFVKKKKIGFYFE VCGMMVESVNAKTLMSRI in isoform 2. 1 PublicationVSP_008677Add
BLAST
Alternative sequencei851 – 93686Missing in isoform 2. 1 PublicationVSP_008678Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152319 mRNA. Translation: AAD43713.1.
AF152503 mRNA. Translation: AAD43764.1.
CCDSiCCDS47292.1. [Q9Y5H3-1]
CCDS75343.1. [Q9Y5H3-2]
RefSeqiNP_061736.1. NM_018913.2. [Q9Y5H3-1]
NP_114479.1. NM_032090.1. [Q9Y5H3-2]
UniGeneiHs.368160.

Genome annotation databases

EnsembliENST00000398610; ENSP00000381611; ENSG00000253846. [Q9Y5H3-1]
ENST00000612503; ENSP00000481157; ENSG00000253846. [Q9Y5H3-2]
GeneIDi56106.
KEGGihsa:56106.
UCSCiuc003lkl.3. human. [Q9Y5H3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152319 mRNA. Translation: AAD43713.1.
AF152503 mRNA. Translation: AAD43764.1.
CCDSiCCDS47292.1. [Q9Y5H3-1]
CCDS75343.1. [Q9Y5H3-2]
RefSeqiNP_061736.1. NM_018913.2. [Q9Y5H3-1]
NP_114479.1. NM_032090.1. [Q9Y5H3-2]
UniGeneiHs.368160.

3D structure databases

ProteinModelPortaliQ9Y5H3.
SMRiQ9Y5H3. Positions 31-663.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ9Y5H3.
PhosphoSiteiQ9Y5H3.

Polymorphism and mutation databases

BioMutaiPCDHGA10.
DMDMi37999843.

Proteomic databases

EPDiQ9Y5H3.
MaxQBiQ9Y5H3.
PaxDbiQ9Y5H3.
PeptideAtlasiQ9Y5H3.
PRIDEiQ9Y5H3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000398610; ENSP00000381611; ENSG00000253846. [Q9Y5H3-1]
ENST00000612503; ENSP00000481157; ENSG00000253846. [Q9Y5H3-2]
GeneIDi56106.
KEGGihsa:56106.
UCSCiuc003lkl.3. human. [Q9Y5H3-1]

Organism-specific databases

CTDi56106.
GeneCardsiPCDHGA10.
HGNCiHGNC:8697. PCDHGA10.
HPAiHPA008755.
MIMi604968. gene.
606297. gene.
neXtProtiNX_Q9Y5H3.
PharmGKBiPA33045.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00840000129690.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.
InParanoidiQ9Y5H3.
KOiK16495.
OMAiQHFALNV.
OrthoDBiEOG7KSX80.
PhylomeDBiQ9Y5H3.
TreeFamiTF332299.

Miscellaneous databases

GenomeRNAii56106.
PROiQ9Y5H3.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y5H3.
GenevisibleiQ9Y5H3. HS.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR031904. Cadherin_CBD.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
PF15974. Cadherin_tail. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A striking organization of a large family of human neural cadherin-like cell adhesion genes."
    Wu Q., Maniatis T.
    Cell 97:779-790(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain.

Entry informationi

Entry nameiPCDGA_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5H3
Secondary accession number(s): Q9Y5E0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: November 1, 1999
Last modified: July 6, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.