ID   PCDGB_HUMAN             Reviewed;         935 AA.
AC   Q9Y5H2; B7ZVY8; Q9Y5D8; Q9Y5D9;
DT   24-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   27-MAR-2024, entry version 169.
DE   RecName: Full=Protocadherin gamma-A11;
DE            Short=PCDH-gamma-A11;
DE   Flags: Precursor;
GN   Name=PCDHGA11;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3).
RC   TISSUE=Brain;
RX   PubMed=10380929; DOI=10.1016/s0092-8674(00)80789-8;
RA   Wu Q., Maniatis T.;
RT   "A striking organization of a large family of human neural cadherin-like
RT   cell adhesion genes.";
RL   Cell 97:779-790(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Brain, and Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Potential calcium-dependent cell-adhesion protein. May be
CC       involved in the establishment and maintenance of specific neuronal
CC       connections in the brain.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I
CC       membrane protein {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=Q9Y5H2-1; Sequence=Displayed;
CC       Name=2; Synonyms=Short;
CC         IsoId=Q9Y5H2-2; Sequence=VSP_008680, VSP_008681;
CC       Name=3;
CC         IsoId=Q9Y5H2-3; Sequence=VSP_008679;
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DR   EMBL; AF152320; AAD43714.1; -; mRNA.
DR   EMBL; AF152505; AAD43766.1; -; mRNA.
DR   EMBL; AF152504; AAD43765.1; -; mRNA.
DR   EMBL; CH471062; EAW61934.1; -; Genomic_DNA.
DR   EMBL; BC136781; AAI36782.1; -; mRNA.
DR   EMBL; BC171774; AAI71774.1; -; mRNA.
DR   CCDS; CCDS47294.1; -. [Q9Y5H2-1]
DR   CCDS; CCDS54930.1; -. [Q9Y5H2-3]
DR   CCDS; CCDS75345.1; -. [Q9Y5H2-2]
DR   RefSeq; NP_061737.1; NM_018914.2. [Q9Y5H2-1]
DR   RefSeq; NP_114480.1; NM_032091.1. [Q9Y5H2-2]
DR   RefSeq; NP_114481.1; NM_032092.1. [Q9Y5H2-3]
DR   AlphaFoldDB; Q9Y5H2; -.
DR   SMR; Q9Y5H2; -.
DR   BioGRID; 121045; 19.
DR   IntAct; Q9Y5H2; 9.
DR   STRING; 9606.ENSP00000381589; -.
DR   GlyCosmos; Q9Y5H2; 5 sites, No reported glycans.
DR   GlyGen; Q9Y5H2; 5 sites.
DR   iPTMnet; Q9Y5H2; -.
DR   PhosphoSitePlus; Q9Y5H2; -.
DR   BioMuta; PCDHGA11; -.
DR   DMDM; 37999842; -.
DR   jPOST; Q9Y5H2; -.
DR   MassIVE; Q9Y5H2; -.
DR   MaxQB; Q9Y5H2; -.
DR   PaxDb; 9606-ENSP00000381589; -.
DR   PeptideAtlas; Q9Y5H2; -.
DR   ProteomicsDB; 86385; -. [Q9Y5H2-1]
DR   ProteomicsDB; 86386; -. [Q9Y5H2-2]
DR   ProteomicsDB; 86387; -. [Q9Y5H2-3]
DR   Antibodypedia; 57509; 13 antibodies from 7 providers.
DR   DNASU; 56105; -.
DR   Ensembl; ENST00000398587.7; ENSP00000381589.2; ENSG00000253873.6. [Q9Y5H2-1]
DR   Ensembl; ENST00000518882.2; ENSP00000428333.1; ENSG00000253873.6. [Q9Y5H2-3]
DR   Ensembl; ENST00000622044.1; ENSP00000480917.1; ENSG00000253873.6. [Q9Y5H2-2]
DR   GeneID; 56105; -.
DR   KEGG; hsa:56105; -.
DR   MANE-Select; ENST00000398587.7; ENSP00000381589.2; NM_018914.3; NP_061737.1.
DR   UCSC; uc003lko.2; human. [Q9Y5H2-1]
DR   AGR; HGNC:8698; -.
DR   CTD; 56105; -.
DR   DisGeNET; 56105; -.
DR   GeneCards; PCDHGA11; -.
DR   HGNC; HGNC:8698; PCDHGA11.
DR   HPA; ENSG00000253873; Low tissue specificity.
DR   MalaCards; PCDHGA11; -.
DR   MIM; 604968; gene.
DR   MIM; 606298; gene.
DR   neXtProt; NX_Q9Y5H2; -.
DR   OpenTargets; ENSG00000253873; -.
DR   PharmGKB; PA33046; -.
DR   VEuPathDB; HostDB:ENSG00000253873; -.
DR   eggNOG; KOG3594; Eukaryota.
DR   GeneTree; ENSGT00940000164062; -.
DR   HOGENOM; CLU_006480_3_0_1; -.
DR   InParanoid; Q9Y5H2; -.
DR   OMA; RKMKSKA; -.
DR   OrthoDB; 5402790at2759; -.
DR   PhylomeDB; Q9Y5H2; -.
DR   TreeFam; TF332299; -.
DR   PathwayCommons; Q9Y5H2; -.
DR   SignaLink; Q9Y5H2; -.
DR   SIGNOR; Q9Y5H2; -.
DR   BioGRID-ORCS; 56105; 6 hits in 1089 CRISPR screens.
DR   GeneWiki; PCDHGA11; -.
DR   GenomeRNAi; 56105; -.
DR   Pharos; Q9Y5H2; Tdark.
DR   PRO; PR:Q9Y5H2; -.
DR   Proteomes; UP000005640; Chromosome 5.
DR   RNAct; Q9Y5H2; Protein.
DR   Bgee; ENSG00000253873; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 95 other cell types or tissues.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR   GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR   GO; GO:0007399; P:nervous system development; IEA:UniProt.
DR   CDD; cd11304; Cadherin_repeat; 6.
DR   Gene3D; 2.60.40.60; Cadherins; 6.
DR   InterPro; IPR002126; Cadherin-like_dom.
DR   InterPro; IPR015919; Cadherin-like_sf.
DR   InterPro; IPR032455; Cadherin_C.
DR   InterPro; IPR031904; Cadherin_CBD.
DR   InterPro; IPR020894; Cadherin_CS.
DR   InterPro; IPR013164; Cadherin_N.
DR   PANTHER; PTHR24028; CADHERIN-87A; 1.
DR   PANTHER; PTHR24028:SF84; PROTOCADHERIN GAMMA-A11; 1.
DR   Pfam; PF00028; Cadherin; 4.
DR   Pfam; PF08266; Cadherin_2; 1.
DR   Pfam; PF16492; Cadherin_C_2; 1.
DR   Pfam; PF15974; Cadherin_tail; 1.
DR   PRINTS; PR00205; CADHERIN.
DR   SMART; SM00112; CA; 6.
DR   SUPFAM; SSF49313; Cadherin-like; 6.
DR   PROSITE; PS00232; CADHERIN_1; 5.
DR   PROSITE; PS50268; CADHERIN_2; 6.
DR   Genevisible; Q9Y5H2; HS.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Calcium; Cell adhesion; Cell membrane; Glycoprotein;
KW   Membrane; Reference proteome; Repeat; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000255"
FT   CHAIN           30..935
FT                   /note="Protocadherin gamma-A11"
FT                   /id="PRO_0000003968"
FT   TOPO_DOM        30..693
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        694..714
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        715..935
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          30..134
FT                   /note="Cadherin 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   DOMAIN          135..243
FT                   /note="Cadherin 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   DOMAIN          244..348
FT                   /note="Cadherin 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   DOMAIN          349..453
FT                   /note="Cadherin 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   DOMAIN          454..563
FT                   /note="Cadherin 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   DOMAIN          571..677
FT                   /note="Cadherin 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   REGION          805..844
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          905..935
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        48
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        255
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        266
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        420
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        546
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         627..811
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:10380929"
FT                   /id="VSP_008679"
FT   VAR_SEQ         812..837
FT                   /note="QAPPNTDWRFSQAQRPGTSGSQNGDD -> VRFISLPPNCWCLGTSLLRRCF
FT                   LSLL (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:10380929"
FT                   /id="VSP_008680"
FT   VAR_SEQ         838..935
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:10380929"
FT                   /id="VSP_008681"
FT   VARIANT         104
FT                   /note="F -> L (in dbSNP:rs11167744)"
FT                   /id="VAR_033711"
SQ   SEQUENCE   935 AA;  101543 MW;  51296C167D62480B CRC64;
     MANRLQRGDR SRLLLLLCIF LGTLRGFRAR QIRYSVPEET EKGSFVGNIS KDLGLEPREL
     AKRGVRIVSR GKTQLFAVNP RSGSLITAGR IDREELCETV SSCFLNMELL VEDTLKIYGV
     EVEIIDINDN APSFQEDEVE IKVSEHAIPG ARFALPNARD PDVGVNSLQS YQLSPNNYFS
     LQLRGRTDGA KNPELVLEGS LDREKEAAHL LLLTALDGGD PIRKGAVPIR VVVLDVNDHI
     PMFTQSVYRV SVPENISSGT RVLMVNATDP DEGINGEVMY SFRNMESKAS EIFQLDSQTG
     EVQVRGSLDF EKYRFYEMEI QGQDGGGLFT TTTMLITVVD VNDNAPEITI TSSINSILEN
     SPPGTVIALL NVQDQDSGEN GQVSCFIPNH LPFKLEKTYG NYYKLITSRV LDRELVQSYN
     ITLTATDQGS PPLSAETHVW LNVADDNDNP PVFPHSSYSA YIPENNPRGA SIFSVTALDP
     DSKQNALVTY SLTDDTVQGV PLSSYVSINS NTGVLYALQS FDYEQFRDLE LRVIARDSGD
     PPLSSNVSLS LFVLDQNDNA PEILYPALPT DGSTGVELAP RSAEPGYLVT KVVAVDKDSG
     QNAWLSYRLL KASEPGLFAV GEHTGEVRTA RALLDRDALK QSLVVAVQDH GQPPLSATVT
     LTVAVADSIP EVLADLGSLE SLANSETSDL SLYLVVAVAA VSCIFLVFVI VLLALRLWRW
     HKSRLLQASE GGLAGMPTSH FVGVDGVQAF LQTYSHEVSL IADSQKSHLI FPQPNYGDTL
     ISQESCEKSE PLLIAEDSAI ILGKCDPTSN QQAPPNTDWR FSQAQRPGTS GSQNGDDTGT
     WPNNQFDTEM LQAMILASAS EAADGSSTLG GGAGTMGLSA RYGPQFTLQH VPDYRQNVYI
     PGSNATLTNA AGKRDGKAPA GGNGNKKKSG KKEKK
//