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Q9Y5H2 (PCDGB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protocadherin gamma-A11

Short name=PCDH-gamma-A11
Gene names
Name:PCDHGA11
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length935 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

Subcellular location

Cell membrane; Single-pass type I membrane protein By similarity.

Sequence similarities

Contains 6 cadherin domains.

Ontologies

Keywords
   Biological processCell adhesion
   Cellular componentCell membrane
Membrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainRepeat
Signal
Transmembrane
Transmembrane helix
   LigandCalcium
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processhomophilic cell adhesion

Inferred from electronic annotation. Source: InterPro

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9Y5H2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9Y5H2-2)

Also known as: Short;

The sequence of this isoform differs from the canonical sequence as follows:
     812-837: QAPPNTDWRFSQAQRPGTSGSQNGDD → VRFISLPPNCWCLGTSLLRRCFLSLL
     838-935: Missing.
Isoform 3 (identifier: Q9Y5H2-3)

The sequence of this isoform differs from the canonical sequence as follows:
     627-811: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2929 Potential
Chain30 – 935906Protocadherin gamma-A11
PRO_0000003968

Regions

Topological domain30 – 693664Extracellular Potential
Transmembrane694 – 71421Helical; Potential
Topological domain715 – 935221Cytoplasmic Potential
Domain30 – 134105Cadherin 1
Domain135 – 243109Cadherin 2
Domain244 – 348105Cadherin 3
Domain349 – 453105Cadherin 4
Domain454 – 563110Cadherin 5
Domain571 – 677107Cadherin 6

Amino acid modifications

Glycosylation481N-linked (GlcNAc...) Potential
Glycosylation2551N-linked (GlcNAc...) Potential
Glycosylation2661N-linked (GlcNAc...) Potential
Glycosylation4201N-linked (GlcNAc...) Potential
Glycosylation5461N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence627 – 811185Missing in isoform 3.
VSP_008679
Alternative sequence812 – 83726QAPPN…QNGDD → VRFISLPPNCWCLGTSLLRR CFLSLL in isoform 2.
VSP_008680
Alternative sequence838 – 93598Missing in isoform 2.
VSP_008681
Natural variant1041F → L.
Corresponds to variant rs11167744 [ dbSNP | Ensembl ].
VAR_033711

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 51296C167D62480B

FASTA935101,543
        10         20         30         40         50         60 
MANRLQRGDR SRLLLLLCIF LGTLRGFRAR QIRYSVPEET EKGSFVGNIS KDLGLEPREL 

        70         80         90        100        110        120 
AKRGVRIVSR GKTQLFAVNP RSGSLITAGR IDREELCETV SSCFLNMELL VEDTLKIYGV 

       130        140        150        160        170        180 
EVEIIDINDN APSFQEDEVE IKVSEHAIPG ARFALPNARD PDVGVNSLQS YQLSPNNYFS 

       190        200        210        220        230        240 
LQLRGRTDGA KNPELVLEGS LDREKEAAHL LLLTALDGGD PIRKGAVPIR VVVLDVNDHI 

       250        260        270        280        290        300 
PMFTQSVYRV SVPENISSGT RVLMVNATDP DEGINGEVMY SFRNMESKAS EIFQLDSQTG 

       310        320        330        340        350        360 
EVQVRGSLDF EKYRFYEMEI QGQDGGGLFT TTTMLITVVD VNDNAPEITI TSSINSILEN 

       370        380        390        400        410        420 
SPPGTVIALL NVQDQDSGEN GQVSCFIPNH LPFKLEKTYG NYYKLITSRV LDRELVQSYN 

       430        440        450        460        470        480 
ITLTATDQGS PPLSAETHVW LNVADDNDNP PVFPHSSYSA YIPENNPRGA SIFSVTALDP 

       490        500        510        520        530        540 
DSKQNALVTY SLTDDTVQGV PLSSYVSINS NTGVLYALQS FDYEQFRDLE LRVIARDSGD 

       550        560        570        580        590        600 
PPLSSNVSLS LFVLDQNDNA PEILYPALPT DGSTGVELAP RSAEPGYLVT KVVAVDKDSG 

       610        620        630        640        650        660 
QNAWLSYRLL KASEPGLFAV GEHTGEVRTA RALLDRDALK QSLVVAVQDH GQPPLSATVT 

       670        680        690        700        710        720 
LTVAVADSIP EVLADLGSLE SLANSETSDL SLYLVVAVAA VSCIFLVFVI VLLALRLWRW 

       730        740        750        760        770        780 
HKSRLLQASE GGLAGMPTSH FVGVDGVQAF LQTYSHEVSL IADSQKSHLI FPQPNYGDTL 

       790        800        810        820        830        840 
ISQESCEKSE PLLIAEDSAI ILGKCDPTSN QQAPPNTDWR FSQAQRPGTS GSQNGDDTGT 

       850        860        870        880        890        900 
WPNNQFDTEM LQAMILASAS EAADGSSTLG GGAGTMGLSA RYGPQFTLQH VPDYRQNVYI 

       910        920        930 
PGSNATLTNA AGKRDGKAPA GGNGNKKKSG KKEKK 

« Hide

Isoform 2 (Short) [UniParc].

Checksum: 8A5EABB07F5794B7
Show »

FASTA83791,608
Isoform 3 [UniParc].

Checksum: 817DB54A0F1A446B
Show »

FASTA75081,739

References

« Hide 'large scale' references
[1]"A striking organization of a large family of human neural cadherin-like cell adhesion genes."
Wu Q., Maniatis T.
Cell 97:779-790(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3).
Tissue: Brain.
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain and Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF152320 mRNA. Translation: AAD43714.1.
AF152505 mRNA. Translation: AAD43766.1.
AF152504 mRNA. Translation: AAD43765.1.
CH471062 Genomic DNA. Translation: EAW61934.1.
BC136781 mRNA. Translation: AAI36782.1.
BC171774 mRNA. Translation: AAI71774.1.
RefSeqNP_061737.1. NM_018914.2.
NP_114480.1. NM_032091.1.
NP_114481.1. NM_032092.1.
UniGeneHs.368160.

3D structure databases

ProteinModelPortalQ9Y5H2.
SMRQ9Y5H2. Positions 31-668.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121045. 1 interaction.

PTM databases

PhosphoSiteQ9Y5H2.

Polymorphism databases

DMDM37999842.

Proteomic databases

PaxDbQ9Y5H2.
PRIDEQ9Y5H2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000398587; ENSP00000381589; ENSG00000253873. [Q9Y5H2-1]
ENST00000518882; ENSP00000428333; ENSG00000253873. [Q9Y5H2-3]
GeneID56105.
KEGGhsa:56105.
UCSCuc003lko.1. human. [Q9Y5H2-2]
uc003lkp.2. human. [Q9Y5H2-3]
uc003lkq.2. human. [Q9Y5H2-1]

Organism-specific databases

CTD56105.
GeneCardsGC05P141335.
HGNCHGNC:8698. PCDHGA11.
HPAHPA008755.
MIM604968. gene.
606298. gene.
neXtProtNX_Q9Y5H2.
PharmGKBPA33046.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG256872.
HOGENOMHOG000220892.
HOVERGENHBG054878.
InParanoidQ9Y5H2.
KOK16495.
OMAREELCEA.
OrthoDBEOG7KSX80.
PhylomeDBQ9Y5H2.
TreeFamTF332299.

Gene expression databases

BgeeQ9Y5H2.
GenevestigatorQ9Y5H2.

Family and domain databases

Gene3D2.60.40.60. 6 hits.
InterProIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamPF00028. Cadherin. 4 hits.
PF08266. Cadherin_2. 1 hit.
[Graphical view]
PRINTSPR00205. CADHERIN.
SMARTSM00112. CA. 6 hits.
[Graphical view]
SUPFAMSSF49313. SSF49313. 6 hits.
PROSITEPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiPCDHGA11.
GenomeRNAi56105.
NextBio61541.
PROQ9Y5H2.
SOURCESearch...

Entry information

Entry namePCDGB_HUMAN
AccessionPrimary (citable) accession number: Q9Y5H2
Secondary accession number(s): B7ZVY8, Q9Y5D8, Q9Y5D9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: November 1, 1999
Last modified: April 16, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM