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Protein

Protocadherin gamma-A11

Gene

PCDHGA11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin gamma-A11
Short name:
PCDH-gamma-A11
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:8698. PCDHGA11.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 693ExtracellularSequence analysisAdd BLAST664
Transmembranei694 – 714HelicalSequence analysisAdd BLAST21
Topological domaini715 – 935CytoplasmicSequence analysisAdd BLAST221

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi56105.
OpenTargetsiENSG00000253873.
PharmGKBiPA33046.

Polymorphism and mutation databases

BioMutaiPCDHGA11.
DMDMi37999842.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000000396830 – 935Protocadherin gamma-A11Add BLAST906

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi48N-linked (GlcNAc...)Sequence analysis1
Glycosylationi255N-linked (GlcNAc...)Sequence analysis1
Glycosylationi266N-linked (GlcNAc...)Sequence analysis1
Glycosylationi420N-linked (GlcNAc...)Sequence analysis1
Glycosylationi546N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9Y5H2.
PeptideAtlasiQ9Y5H2.
PRIDEiQ9Y5H2.

PTM databases

iPTMnetiQ9Y5H2.
PhosphoSitePlusiQ9Y5H2.

Expressioni

Gene expression databases

BgeeiENSG00000253873.
GenevisibleiQ9Y5H2. HS.

Organism-specific databases

HPAiHPA008755.

Interactioni

Protein-protein interaction databases

BioGridi121045. 10 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ9Y5H2.
SMRiQ9Y5H2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 134Cadherin 1PROSITE-ProRule annotationAdd BLAST105
Domaini135 – 243Cadherin 2PROSITE-ProRule annotationAdd BLAST109
Domaini244 – 348Cadherin 3PROSITE-ProRule annotationAdd BLAST105
Domaini349 – 453Cadherin 4PROSITE-ProRule annotationAdd BLAST105
Domaini454 – 563Cadherin 5PROSITE-ProRule annotationAdd BLAST110
Domaini571 – 677Cadherin 6PROSITE-ProRule annotationAdd BLAST107

Sequence similaritiesi

Contains 6 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00840000129690.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.
InParanoidiQ9Y5H2.
KOiK16495.
OMAiSYNITLI.
OrthoDBiEOG091G00SP.
PhylomeDBiQ9Y5H2.
TreeFamiTF332299.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR031904. Cadherin_CBD.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 4 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
PF15974. Cadherin_tail. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y5H2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MANRLQRGDR SRLLLLLCIF LGTLRGFRAR QIRYSVPEET EKGSFVGNIS
60 70 80 90 100
KDLGLEPREL AKRGVRIVSR GKTQLFAVNP RSGSLITAGR IDREELCETV
110 120 130 140 150
SSCFLNMELL VEDTLKIYGV EVEIIDINDN APSFQEDEVE IKVSEHAIPG
160 170 180 190 200
ARFALPNARD PDVGVNSLQS YQLSPNNYFS LQLRGRTDGA KNPELVLEGS
210 220 230 240 250
LDREKEAAHL LLLTALDGGD PIRKGAVPIR VVVLDVNDHI PMFTQSVYRV
260 270 280 290 300
SVPENISSGT RVLMVNATDP DEGINGEVMY SFRNMESKAS EIFQLDSQTG
310 320 330 340 350
EVQVRGSLDF EKYRFYEMEI QGQDGGGLFT TTTMLITVVD VNDNAPEITI
360 370 380 390 400
TSSINSILEN SPPGTVIALL NVQDQDSGEN GQVSCFIPNH LPFKLEKTYG
410 420 430 440 450
NYYKLITSRV LDRELVQSYN ITLTATDQGS PPLSAETHVW LNVADDNDNP
460 470 480 490 500
PVFPHSSYSA YIPENNPRGA SIFSVTALDP DSKQNALVTY SLTDDTVQGV
510 520 530 540 550
PLSSYVSINS NTGVLYALQS FDYEQFRDLE LRVIARDSGD PPLSSNVSLS
560 570 580 590 600
LFVLDQNDNA PEILYPALPT DGSTGVELAP RSAEPGYLVT KVVAVDKDSG
610 620 630 640 650
QNAWLSYRLL KASEPGLFAV GEHTGEVRTA RALLDRDALK QSLVVAVQDH
660 670 680 690 700
GQPPLSATVT LTVAVADSIP EVLADLGSLE SLANSETSDL SLYLVVAVAA
710 720 730 740 750
VSCIFLVFVI VLLALRLWRW HKSRLLQASE GGLAGMPTSH FVGVDGVQAF
760 770 780 790 800
LQTYSHEVSL IADSQKSHLI FPQPNYGDTL ISQESCEKSE PLLIAEDSAI
810 820 830 840 850
ILGKCDPTSN QQAPPNTDWR FSQAQRPGTS GSQNGDDTGT WPNNQFDTEM
860 870 880 890 900
LQAMILASAS EAADGSSTLG GGAGTMGLSA RYGPQFTLQH VPDYRQNVYI
910 920 930
PGSNATLTNA AGKRDGKAPA GGNGNKKKSG KKEKK
Length:935
Mass (Da):101,543
Last modified:November 1, 1999 - v1
Checksum:i51296C167D62480B
GO
Isoform 2 (identifier: Q9Y5H2-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     812-837: QAPPNTDWRFSQAQRPGTSGSQNGDD → VRFISLPPNCWCLGTSLLRRCFLSLL
     838-935: Missing.

Show »
Length:837
Mass (Da):91,608
Checksum:i8A5EABB07F5794B7
GO
Isoform 3 (identifier: Q9Y5H2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     627-811: Missing.

Show »
Length:750
Mass (Da):81,739
Checksum:i817DB54A0F1A446B
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033711104F → L.Corresponds to variant rs11167744dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_008679627 – 811Missing in isoform 3. 1 PublicationAdd BLAST185
Alternative sequenceiVSP_008680812 – 837QAPPN…QNGDD → VRFISLPPNCWCLGTSLLRR CFLSLL in isoform 2. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_008681838 – 935Missing in isoform 2. 1 PublicationAdd BLAST98

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152320 mRNA. Translation: AAD43714.1.
AF152505 mRNA. Translation: AAD43766.1.
AF152504 mRNA. Translation: AAD43765.1.
CH471062 Genomic DNA. Translation: EAW61934.1.
BC136781 mRNA. Translation: AAI36782.1.
BC171774 mRNA. Translation: AAI71774.1.
CCDSiCCDS47294.1. [Q9Y5H2-1]
CCDS54930.1. [Q9Y5H2-3]
CCDS75345.1. [Q9Y5H2-2]
RefSeqiNP_061737.1. NM_018914.2. [Q9Y5H2-1]
NP_114480.1. NM_032091.1. [Q9Y5H2-2]
NP_114481.1. NM_032092.1. [Q9Y5H2-3]
UniGeneiHs.368160.

Genome annotation databases

EnsembliENST00000398587; ENSP00000381589; ENSG00000253873. [Q9Y5H2-1]
ENST00000518882; ENSP00000428333; ENSG00000253873. [Q9Y5H2-3]
ENST00000622044; ENSP00000480917; ENSG00000253873. [Q9Y5H2-2]
GeneIDi56105.
KEGGihsa:56105.
UCSCiuc003lko.2. human. [Q9Y5H2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152320 mRNA. Translation: AAD43714.1.
AF152505 mRNA. Translation: AAD43766.1.
AF152504 mRNA. Translation: AAD43765.1.
CH471062 Genomic DNA. Translation: EAW61934.1.
BC136781 mRNA. Translation: AAI36782.1.
BC171774 mRNA. Translation: AAI71774.1.
CCDSiCCDS47294.1. [Q9Y5H2-1]
CCDS54930.1. [Q9Y5H2-3]
CCDS75345.1. [Q9Y5H2-2]
RefSeqiNP_061737.1. NM_018914.2. [Q9Y5H2-1]
NP_114480.1. NM_032091.1. [Q9Y5H2-2]
NP_114481.1. NM_032092.1. [Q9Y5H2-3]
UniGeneiHs.368160.

3D structure databases

ProteinModelPortaliQ9Y5H2.
SMRiQ9Y5H2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121045. 10 interactors.

PTM databases

iPTMnetiQ9Y5H2.
PhosphoSitePlusiQ9Y5H2.

Polymorphism and mutation databases

BioMutaiPCDHGA11.
DMDMi37999842.

Proteomic databases

PaxDbiQ9Y5H2.
PeptideAtlasiQ9Y5H2.
PRIDEiQ9Y5H2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000398587; ENSP00000381589; ENSG00000253873. [Q9Y5H2-1]
ENST00000518882; ENSP00000428333; ENSG00000253873. [Q9Y5H2-3]
ENST00000622044; ENSP00000480917; ENSG00000253873. [Q9Y5H2-2]
GeneIDi56105.
KEGGihsa:56105.
UCSCiuc003lko.2. human. [Q9Y5H2-1]

Organism-specific databases

CTDi56105.
DisGeNETi56105.
GeneCardsiPCDHGA11.
HGNCiHGNC:8698. PCDHGA11.
HPAiHPA008755.
MIMi604968. gene.
606298. gene.
neXtProtiNX_Q9Y5H2.
OpenTargetsiENSG00000253873.
PharmGKBiPA33046.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00840000129690.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.
InParanoidiQ9Y5H2.
KOiK16495.
OMAiSYNITLI.
OrthoDBiEOG091G00SP.
PhylomeDBiQ9Y5H2.
TreeFamiTF332299.

Miscellaneous databases

GeneWikiiPCDHGA11.
GenomeRNAii56105.
PROiQ9Y5H2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000253873.
GenevisibleiQ9Y5H2. HS.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR031904. Cadherin_CBD.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 4 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
PF15974. Cadherin_tail. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPCDGB_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5H2
Secondary accession number(s): B7ZVY8, Q9Y5D8, Q9Y5D9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.