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Q9Y5H1 (PCDG2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protocadherin gamma-A2

Short name=PCDH-gamma-A2
Gene names
Name:PCDHGA2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length932 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

Subcellular location

Cell membrane; Single-pass type I membrane protein By similarity.

Sequence similarities

Contains 6 cadherin domains.

Ontologies

Keywords
   Biological processCell adhesion
   Cellular componentCell membrane
Membrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainRepeat
Signal
Transmembrane
Transmembrane helix
   LigandCalcium
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processhomophilic cell adhesion

Inferred from electronic annotation. Source: InterPro

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9Y5H1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9Y5H1-2)

Also known as: Short;

The sequence of this isoform differs from the canonical sequence as follows:
     809-823: QAPPNTDWRFSQAQR → VIYLFTTYVLASLLK
     824-932: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2828 Potential
Chain29 – 932904Protocadherin gamma-A2
PRO_0000003950

Regions

Topological domain29 – 692664Extracellular Potential
Transmembrane693 – 71321Helical; Potential
Topological domain714 – 932219Cytoplasmic Potential
Domain29 – 133105Cadherin 1
Domain134 – 242109Cadherin 2
Domain243 – 347105Cadherin 3
Domain348 – 452105Cadherin 4
Domain453 – 562110Cadherin 5
Domain570 – 682113Cadherin 6

Amino acid modifications

Glycosylation4191N-linked (GlcNAc...) Potential
Glycosylation5451N-linked (GlcNAc...) Potential
Glycosylation6851N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence809 – 82315QAPPN…SQAQR → VIYLFTTYVLASLLK in isoform 2.
VSP_008661
Alternative sequence824 – 932109Missing in isoform 2.
VSP_008662
Natural variant51Q → R.
Corresponds to variant rs6878145 [ dbSNP | Ensembl ].
VAR_048556

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 19FE96244C0AB248

FASTA932101,484
        10         20         30         40         50         60 
MAALQKLPHC RKLVLLCFLL ATLWEARAGQ IRYSVREEID RGSFVGNIAK DLGLEPLALA 

        70         80         90        100        110        120 
EQGVRIVSRG RSQLFALNPR SGSLVTANRI DREELCAQSA PCLLNFNILL EDKLTIYSVE 

       130        140        150        160        170        180 
VEITDINDNA PRFGVEELEL KISETTTPGF RIPLKNAHDA DVGENALQKY ALNPNDHFSL 

       190        200        210        220        230        240 
DVRRGADGNK YPELVLERSL DREEEAVHHL VLVASDGGDP VLSGTSRICV KVLDANDNAP 

       250        260        270        280        290        300 
VFTQPEYRIS IPENTLVGTR ILTVTATDAD EGYYAQVVYF LEKSPGETSE VFELKSTSGE 

       310        320        330        340        350        360 
LTIIKDLDYE DATFHEIDIE AQDGPGLLTR AKVIVTVLDV NDNAPEFYMT SATSSVSEDS 

       370        380        390        400        410        420 
LPGTIIGLFN VHDRDSGQNA FTTCSLPEDL PFKLEKSVDN YYRLVTTRAL DREQFSFYNI 

       430        440        450        460        470        480 
TLTAKDGGNP SLSTDAHILL QVADINDNAP AFSRTSYSTY IPENNPRGAS VFSVTAHDPD 

       490        500        510        520        530        540 
SNDNAHVTYS FAEDTVQGAP LSSYISINSD TGVLYALRSF DYEQLRDLQV WVIARDSGNP 

       550        560        570        580        590        600 
PLSSNVSLSL FVLDQNDNAP EILYPAFPTD GSTGVELAPR SAEPGYLVTK VVAVDRDSGQ 

       610        620        630        640        650        660 
NAWLSYHLLK ASEPGLFSVG LHTGEVRTAR ALLDRDALKQ SLVVAIQDHG QPPLSATVTL 

       670        680        690        700        710        720 
TVAVADRIPD ILADLGSLEP SAIPNDSDLT LYLVVAVAAV SCVFLAFVIV LLAHRLRRWH 

       730        740        750        760        770        780 
KSRLLQASGG SLTGMQSSHF VGVDGVRAFL QTYSHEVSLT ADSRKSHLIF PQPNYADTLI 

       790        800        810        820        830        840 
SQESCEKKDF LSAPQSLLEE EREETFSQQA PPNTDWRFSQ AQRPGTSGSQ NGDDTGTWPN 

       850        860        870        880        890        900 
NQFDTEMLQA MILASASEAA DGSSTLGGGA GTMGLSARYG PQFTLQHVPD YRQNVYIPGS 

       910        920        930 
NATLTNAAGK RDGKAPAGGN GNKKKSGKKE KK 

« Hide

Isoform 2 (Short) [UniParc].

Checksum: 9149FDC3C4004377
Show »

FASTA82390,284

References

« Hide 'large scale' references
[1]"A striking organization of a large family of human neural cadherin-like cell adhesion genes."
Wu Q., Maniatis T.
Cell 97:779-790(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
Tissue: Brain.
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF152322 mRNA. Translation: AAD43716.1.
AF152508 mRNA. Translation: AAD43769.1.
CH471062 Genomic DNA. Translation: EAW61941.1.
BC093871 mRNA. Translation: AAH93871.1.
BC104950 mRNA. Translation: AAI04951.1.
RefSeqNP_061738.1. NM_018915.3.
NP_114398.1. NM_032009.2.
UniGeneHs.368160.

3D structure databases

ProteinModelPortalQ9Y5H1.
SMRQ9Y5H1. Positions 31-690.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ9Y5H1.

Polymorphism databases

DMDM37999841.

Proteomic databases

PaxDbQ9Y5H1.
PRIDEQ9Y5H1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000394576; ENSP00000378077; ENSG00000081853. [Q9Y5H1-1]
GeneID56113.
KEGGhsa:56113.
UCSCuc003ljk.2. human. [Q9Y5H1-1]
uc011dao.2. human. [Q9Y5H1-2]

Organism-specific databases

CTD56113.
GeneCardsGC05P141287.
HGNCHGNC:8700. PCDHGA2.
HPAHPA008755.
MIM604968. gene.
606289. gene.
neXtProtNX_Q9Y5H1.
PharmGKBPA33048.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG256872.
HOGENOMHOG000220892.
HOVERGENHBG054878.
InParanoidQ9Y5H1.
KOK16495.
OMAHTSYSAY.
OrthoDBEOG7KSX80.
PhylomeDBQ9Y5H1.
TreeFamTF332299.

Gene expression databases

BgeeQ9Y5H1.
GenevestigatorQ9Y5H1.

Family and domain databases

Gene3D2.60.40.60. 6 hits.
InterProIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
[Graphical view]
PRINTSPR00205. CADHERIN.
SMARTSM00112. CA. 6 hits.
[Graphical view]
SUPFAMSSF49313. SSF49313. 6 hits.
PROSITEPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi56113.
NextBio61591.
PROQ9Y5H1.
SOURCESearch...

Entry information

Entry namePCDG2_HUMAN
AccessionPrimary (citable) accession number: Q9Y5H1
Secondary accession number(s): Q52LL6, Q9Y5D5
Entry history
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: November 1, 1999
Last modified: April 16, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM