Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protocadherin gamma-A3

Gene

PCDHGA3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin gamma-A3
Short name:
PCDH-gamma-A3
Gene namesi
Name:PCDHGA3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:8701. PCDHGA3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 692ExtracellularSequence analysisAdd BLAST663
Transmembranei693 – 713HelicalSequence analysisAdd BLAST21
Topological domaini714 – 932CytoplasmicSequence analysisAdd BLAST219

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi56112.
OpenTargetsiENSG00000254245.
PharmGKBiPA33049.

Polymorphism and mutation databases

BioMutaiPCDHGA3.
DMDMi296439266.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000000395230 – 932Protocadherin gamma-A3Add BLAST903

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi265N-linked (GlcNAc...)Sequence analysis1
Glycosylationi419N-linked (GlcNAc...)Sequence analysis1
Glycosylationi545N-linked (GlcNAc...)Sequence analysis1
Glycosylationi685N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9Y5H0.
PaxDbiQ9Y5H0.
PeptideAtlasiQ9Y5H0.
PRIDEiQ9Y5H0.
TopDownProteomicsiQ9Y5H0-2. [Q9Y5H0-2]

PTM databases

iPTMnetiQ9Y5H0.
PhosphoSitePlusiQ9Y5H0.

Expressioni

Gene expression databases

BgeeiENSG00000254245.
ExpressionAtlasiQ9Y5H0. baseline and differential.
GenevisibleiQ9Y5H0. HS.

Organism-specific databases

HPAiHPA008755.
HPA039295.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000253812.

Structurei

3D structure databases

ProteinModelPortaliQ9Y5H0.
SMRiQ9Y5H0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 133Cadherin 1PROSITE-ProRule annotationAdd BLAST104
Domaini134 – 242Cadherin 2PROSITE-ProRule annotationAdd BLAST109
Domaini243 – 347Cadherin 3PROSITE-ProRule annotationAdd BLAST105
Domaini348 – 452Cadherin 4PROSITE-ProRule annotationAdd BLAST105
Domaini453 – 562Cadherin 5PROSITE-ProRule annotationAdd BLAST110
Domaini570 – 682Cadherin 6PROSITE-ProRule annotationAdd BLAST113

Sequence similaritiesi

Contains 6 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00850000132246.
HOVERGENiHBG054878.
InParanoidiQ9Y5H0.
KOiK16495.
OMAiDSIENAH.
OrthoDBiEOG091G024L.
PhylomeDBiQ9Y5H0.
TreeFamiTF332299.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR031904. Cadherin_CBD.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 4 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
PF15974. Cadherin_tail. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y5H0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTNCLSFRNG RGLALLCALL GTLCETGSGQ IRYSVSEELD KGSFVGNIAN
60 70 80 90 100
DLGLEPRELA ERGVRIVSRG RTQLFSLNPQ SGSLVTAERI DREELCAQIP
110 120 130 140 150
LCLVKINILV EDKLKIFEVE IEIKDINDNA PNFPTEELEI KIGELTVPGT
160 170 180 190 200
RFPIKTAFDP DVGINSLQNY KLSPNDYFSL AVNSVSEGAK YPELVLERAL
210 220 230 240 250
DREKKEIHQL VLVASDGGDP VHSGNLHIQV IVLDANDNPP MFTQPEYRVS
260 270 280 290 300
VWENVPVGTR LLTVNATDPD EGFNAQVSYI LDKMPGKIAE IFHLNSVSGE
310 320 330 340 350
VSILKSLDYE DAMFYEIKIE AQDGPGLLSR AKILVTVLDV NDNAPEITIT
360 370 380 390 400
SLTSSVPEEG TVGREIALID VHDRDSGQNG QVEVFVLGNL PFKLEKSIDQ
410 420 430 440 450
YYRLVTATSL DREQISEYNI SLRASDGGSP PLSTETHITL HVIDINDNPP
460 470 480 490 500
TFPHLSYSAY IPENNPRGAS IFSVTAQDPD SNNNARITYA LTEDTLQGAP
510 520 530 540 550
LSSFVSINSN TGVLYALRSF DYEQFRDLKL LVTASDSGNP PLSSNVSLNL
560 570 580 590 600
FVLDQNDNAP EILYPALPTD GSTGVELAPR SAEPGYLVTK VVAVDRDSGQ
610 620 630 640 650
NAWLSYRLLK ASEPGLFSVG LHTGEVRTAR ALLDRDALKQ SLVVAVQDHG
660 670 680 690 700
QPPLSATVTL TVAVADRIPD ILADLGSLEP SAKPNDSDLT LYLVVAVAAV
710 720 730 740 750
SCVFLAFVIV LLALRLRRWH KSRLLQASGG GLASTPGSHF VGADGVRAFL
760 770 780 790 800
QTYSHEVSLT ADSRKSHLIF PQPNYADTLI SQESCEKSEP LLITQDLLEM
810 820 830 840 850
KGDSNLLQQA PPNTDWRFSQ AQRPGTSGSQ NGDDTGTWPN NQFDTEMLQA
860 870 880 890 900
MILASASEAA DGSSTLGGGA GTMGLSARYG PQFTLQHVPD YRQNVYIPGS
910 920 930
NATLTNAAGK RDGKAPAGGN GNKKKSGKKE KK
Length:932
Mass (Da):100,971
Last modified:May 18, 2010 - v2
Checksum:iFBDA8E923A12D519
GO
Isoform 2 (identifier: Q9Y5H0-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     809-829: QAPPNTDWRFSQAQRPGTSGS → VSLFISLIIKNKYENVVIIKL
     830-932: Missing.

Show »
Length:829
Mass (Da):90,473
Checksum:i613C362D28CBD750
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti29G → S in AAD43717 (PubMed:10380929).Curated1
Sequence conflicti646V → I in AAD43717 (PubMed:10380929).Curated1
Sequence conflicti661T → I in AAD43717 (PubMed:10380929).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05558879P → S.Corresponds to variant rs11575947dbSNPEnsembl.1
Natural variantiVAR_055589154I → L.Corresponds to variant rs11575948dbSNPEnsembl.1
Natural variantiVAR_059190743A → V.Corresponds to variant rs7736541dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_008663809 – 829QAPPN…GTSGS → VSLFISLIIKNKYENVVIIK L in isoform 2. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_008664830 – 932Missing in isoform 2. 1 PublicationAdd BLAST103

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152323 mRNA. Translation: AAD43717.1.
AF152510 mRNA. Translation: AAD43770.1.
AC005366 Genomic DNA. No translation available.
AC005618 Genomic DNA. No translation available.
AC008781 Genomic DNA. No translation available.
CCDSiCCDS47290.1. [Q9Y5H0-1]
CCDS75329.1. [Q9Y5H0-2]
RefSeqiNP_061739.2. NM_018916.3. [Q9Y5H0-1]
NP_114400.1. NM_032011.1. [Q9Y5H0-2]
UniGeneiHs.368160.

Genome annotation databases

EnsembliENST00000253812; ENSP00000253812; ENSG00000254245. [Q9Y5H0-1]
ENST00000619750; ENSP00000479265; ENSG00000254245. [Q9Y5H0-2]
GeneIDi56112.
KEGGihsa:56112.
UCSCiuc003ljm.3. human. [Q9Y5H0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152323 mRNA. Translation: AAD43717.1.
AF152510 mRNA. Translation: AAD43770.1.
AC005366 Genomic DNA. No translation available.
AC005618 Genomic DNA. No translation available.
AC008781 Genomic DNA. No translation available.
CCDSiCCDS47290.1. [Q9Y5H0-1]
CCDS75329.1. [Q9Y5H0-2]
RefSeqiNP_061739.2. NM_018916.3. [Q9Y5H0-1]
NP_114400.1. NM_032011.1. [Q9Y5H0-2]
UniGeneiHs.368160.

3D structure databases

ProteinModelPortaliQ9Y5H0.
SMRiQ9Y5H0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000253812.

PTM databases

iPTMnetiQ9Y5H0.
PhosphoSitePlusiQ9Y5H0.

Polymorphism and mutation databases

BioMutaiPCDHGA3.
DMDMi296439266.

Proteomic databases

EPDiQ9Y5H0.
PaxDbiQ9Y5H0.
PeptideAtlasiQ9Y5H0.
PRIDEiQ9Y5H0.
TopDownProteomicsiQ9Y5H0-2. [Q9Y5H0-2]

Protocols and materials databases

DNASUi56112.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000253812; ENSP00000253812; ENSG00000254245. [Q9Y5H0-1]
ENST00000619750; ENSP00000479265; ENSG00000254245. [Q9Y5H0-2]
GeneIDi56112.
KEGGihsa:56112.
UCSCiuc003ljm.3. human. [Q9Y5H0-1]

Organism-specific databases

CTDi56112.
DisGeNETi56112.
GeneCardsiPCDHGA3.
H-InvDBHIX0164292.
HGNCiHGNC:8701. PCDHGA3.
HPAiHPA008755.
HPA039295.
MIMi604968. gene.
606290. gene.
neXtProtiNX_Q9Y5H0.
OpenTargetsiENSG00000254245.
PharmGKBiPA33049.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00850000132246.
HOVERGENiHBG054878.
InParanoidiQ9Y5H0.
KOiK16495.
OMAiDSIENAH.
OrthoDBiEOG091G024L.
PhylomeDBiQ9Y5H0.
TreeFamiTF332299.

Miscellaneous databases

GenomeRNAii56112.
PROiQ9Y5H0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000254245.
ExpressionAtlasiQ9Y5H0. baseline and differential.
GenevisibleiQ9Y5H0. HS.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR031904. Cadherin_CBD.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 4 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
PF15974. Cadherin_tail. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPCDG3_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5H0
Secondary accession number(s): Q9Y5D4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: May 18, 2010
Last modified: November 30, 2016
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.