Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protocadherin gamma-A4

Gene

PCDHGA4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin gamma-A4
Short name:
PCDH-gamma-A4
Gene namesi
Name:PCDHGA4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:8702. PCDHGA4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini29 – 692664ExtracellularSequence analysisAdd
BLAST
Transmembranei693 – 71321HelicalSequence analysisAdd
BLAST
Topological domaini714 – 931218CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33050.

Polymorphism and mutation databases

DMDMi37999839.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence analysisAdd
BLAST
Chaini29 – 931903Protocadherin gamma-A4PRO_0000003954Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi419 – 4191N-linked (GlcNAc...)Sequence analysis
Glycosylationi545 – 5451N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9Y5G9.
PeptideAtlasiQ9Y5G9.
PRIDEiQ9Y5G9.

PTM databases

iPTMnetiQ9Y5G9.
PhosphoSiteiQ9Y5G9.

Expressioni

Gene expression databases

BgeeiENSG00000262576.

Organism-specific databases

HPAiHPA008755.

Interactioni

Protein-protein interaction databases

BioGridi121051. 1 interaction.
STRINGi9606.ENSP00000458570.

Structurei

3D structure databases

ProteinModelPortaliQ9Y5G9.
SMRiQ9Y5G9. Positions 31-690.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 133105Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini134 – 242109Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini243 – 347105Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini348 – 452105Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Domaini453 – 567115Cadherin 5PROSITE-ProRule annotationAdd
BLAST
Domaini570 – 682113Cadherin 6PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 6 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
HOVERGENiHBG054878.
InParanoidiQ9Y5G9.
KOiK16495.
PhylomeDBiQ9Y5G9.
TreeFamiTF332299.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR031904. Cadherin_CBD.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
PF15974. Cadherin_tail. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y5G9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAPPARPDH TRLLQICLLL GVLVEIRAEQ ILYSVFEEQE EGSVVGNIAK
60 70 80 90 100
DLGLAPRELA ERGVRIVSRG RTQLFALNPR SGTLVTAGRI DREELCDRSP
110 120 130 140 150
NCVTNLEILL EDTVKILRVE VEIIDVNDNP PSFGTEQREI KVAENENPGA
160 170 180 190 200
RFPLPEAFDP DVGVNSLQGY QLNSNGYFSL DVQSGADGIK YPELVLERAL
210 220 230 240 250
DREEEAVHHL VLTAFDGGDP VRSGTARILI ILVDTNDNAP VFTQPEYHVS
260 270 280 290 300
VRENVPVGTR LLTVKATDPD EGANGDVTYS FRKVRDKISQ LFQLNSLSGD
310 320 330 340 350
ITILGGLDYE DSGFYDIDVE AHDGPGLRAR SKVLVTVLDE NDNAPEVTVT
360 370 380 390 400
SLTSSVQESS SPGTVIALFN VHDSDSGGNG LVTCSIPDNL PFTLEKTYGN
410 420 430 440 450
YYRLLTHRTL DREEVSEYNI TVTATDQGTP PLSTETHISL QVMDINDNPP
460 470 480 490 500
TFPHASYSAY IPENNPRGAS ILSMTAQDPD SGDNARITYS LAEDTFQGAP
510 520 530 540 550
LSSYVSINSN TGILYALCSF DYEQFRDLQL LMTASDSGDP PLSSNVSLSL
560 570 580 590 600
FVLDQNDNVP EILYPTFPTD GSTGVELAPR SADSGYLVTK VVAVDRDSGQ
610 620 630 640 650
NAWLSYSLLK SSEPGLFAVG LHTGEVRTAR ALLDRDALKQ RLVVVVQDHG
660 670 680 690 700
QPPLSATVTL TVAVADSIPD VLADLGSLKP SADPDDSGLT LYLVVAVAAV
710 720 730 740 750
SCVFLAFVTV LLALKLRRWH KSRLLHAEGS RLAGVPASHF VGVDGVRAFL
760 770 780 790 800
QTYSHEVSLT ADSRKSHLIF SQPSYADTLI SRESCEKSEP LLITQDLLET
810 820 830 840 850
KGDPNLQQAP PNTDWRFSQA QRPGTSGSQN GDDTGTWPNN QFDTEMLQAM
860 870 880 890 900
ILASASEAAD GSSTLGGGAG TMGLSARYGP QFTLQHVPDY RQNVYIPGSN
910 920 930
ATLTNAAGKR DGKAPAGGNG NKKKSGKKEK K
Length:931
Mass (Da):100,589
Last modified:November 1, 1999 - v1
Checksum:iA575EAEC693EFB26
GO
Isoform 2 (identifier: Q9Y5G9-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     808-820: QAPPNTDWRFSQA → VSQSYNRSYHTEI
     821-931: Missing.

Show »
Length:820
Mass (Da):89,229
Checksum:iC8E13CC5C3E632EC
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti150 – 1501A → T.
Corresponds to variant rs11575949 [ dbSNP | Ensembl ].
VAR_048557
Natural varianti641 – 6411R → K.
Corresponds to variant rs4329068 [ dbSNP | Ensembl ].
VAR_048558
Natural varianti683 – 6831D → H.
Corresponds to variant rs11575951 [ dbSNP | Ensembl ].
VAR_048559

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei808 – 82013QAPPN…RFSQA → VSQSYNRSYHTEI in isoform 2. 1 PublicationVSP_008665Add
BLAST
Alternative sequencei821 – 931111Missing in isoform 2. 1 PublicationVSP_008666Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152324 mRNA. Translation: AAD43718.1.
AF152511 mRNA. Translation: AAD43771.1.
RefSeqiNP_061740.2. NM_018917.3.
NP_114442.2. NM_032053.2.
UniGeneiHs.368160.

Genome annotation databases

GeneIDi56111.
KEGGihsa:56111.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152324 mRNA. Translation: AAD43718.1.
AF152511 mRNA. Translation: AAD43771.1.
RefSeqiNP_061740.2. NM_018917.3.
NP_114442.2. NM_032053.2.
UniGeneiHs.368160.

3D structure databases

ProteinModelPortaliQ9Y5G9.
SMRiQ9Y5G9. Positions 31-690.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121051. 1 interaction.
STRINGi9606.ENSP00000458570.

PTM databases

iPTMnetiQ9Y5G9.
PhosphoSiteiQ9Y5G9.

Polymorphism and mutation databases

DMDMi37999839.

Proteomic databases

PaxDbiQ9Y5G9.
PeptideAtlasiQ9Y5G9.
PRIDEiQ9Y5G9.

Protocols and materials databases

DNASUi56111.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi56111.
KEGGihsa:56111.

Organism-specific databases

CTDi56111.
GeneCardsiPCDHGA4.
HGNCiHGNC:8702. PCDHGA4.
HPAiHPA008755.
MIMi604968. gene.
606291. gene.
neXtProtiNX_Q9Y5G9.
PharmGKBiPA33050.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
HOVERGENiHBG054878.
InParanoidiQ9Y5G9.
KOiK16495.
PhylomeDBiQ9Y5G9.
TreeFamiTF332299.

Miscellaneous databases

GenomeRNAii56111.
PROiQ9Y5G9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000262576.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR031904. Cadherin_CBD.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
PF15974. Cadherin_tail. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPCDG4_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5G9
Secondary accession number(s): Q9Y5D3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: November 1, 1999
Last modified: September 7, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.