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Protein

Protocadherin gamma-A4

Gene

PCDHGA4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell adhesion
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin gamma-A4
Short name:
PCDH-gamma-A4
Gene namesi
Name:PCDHGA4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componentsi: Chromosome 5, Unplaced

Organism-specific databases

EuPathDBiHostDB:ENSG00000262576.2.
HGNCiHGNC:8702. PCDHGA4.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini60 – 723ExtracellularSequence analysisAdd BLAST664
Transmembranei724 – 744HelicalSequence analysisAdd BLAST21
Topological domaini745 – 962CytoplasmicSequence analysisAdd BLAST218

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000262576.
PharmGKBiPA33050.

Polymorphism and mutation databases

DMDMi37999839.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 59CuratedAdd BLAST59
ChainiPRO_000000395460 – 962Protocadherin gamma-A4Add BLAST903

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi450N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi576N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9Y5G9.
PeptideAtlasiQ9Y5G9.
PRIDEiQ9Y5G9.

PTM databases

iPTMnetiQ9Y5G9.
PhosphoSitePlusiQ9Y5G9.

Expressioni

Gene expression databases

ExpressionAtlasiA0A087WT05. baseline and differential.

Organism-specific databases

HPAiHPA008755.

Interactioni

Protein-protein interaction databases

BioGridi121051. 1 interactor.
IntActiQ9Y5G9. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliQ9Y5G9.
SMRiQ9Y5G9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini60 – 164Cadherin 1PROSITE-ProRule annotationAdd BLAST105
Domaini165 – 273Cadherin 2PROSITE-ProRule annotationAdd BLAST109
Domaini274 – 378Cadherin 3PROSITE-ProRule annotationAdd BLAST105
Domaini379 – 483Cadherin 4PROSITE-ProRule annotationAdd BLAST105
Domaini484 – 598Cadherin 5PROSITE-ProRule annotationAdd BLAST115
Domaini601 – 713Cadherin 6PROSITE-ProRule annotationAdd BLAST113

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00840000129690.
HOVERGENiHBG054878.
InParanoidiQ9Y5G9.
KOiK16495.
OMAiQPEYHIS.
OrthoDBiEOG091G024L.
PhylomeDBiQ9Y5G9.
TreeFamiTF332299.

Family and domain databases

InterProiView protein in InterPro
IPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR031904. Cadherin_CBD.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
PfamiView protein in Pfam
PF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
PF15974. Cadherin_tail. 1 hit.
PRINTSiPR00205. CADHERIN.
SMARTiView protein in SMART
SM00112. CA. 6 hits.
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiView protein in PROSITE
PS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y5G9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHFILDPEDP GAPQASTEGK PKHRRLRGGV VMAAPPARPD HTRLLQICLL
60 70 80 90 100
LGVLVEIRAE QILYSVFEEQ EEGSVVGNIA KDLGLAPREL AERGVRIVSR
110 120 130 140 150
GRTQLFALNP RSGTLVTAGR IDREELCDRS PNCVTNLEIL LEDTVKILRV
160 170 180 190 200
EVEIIDVNDN PPSFGTEQRE IKVAENENPG ARFPLPEAFD PDVGVNSLQG
210 220 230 240 250
YQLNSNGYFS LDVQSGADGI KYPELVLERA LDREEEAVHH LVLTAFDGGD
260 270 280 290 300
PVRSGTARIL IILVDTNDNA PVFTQPEYHV SVRENVPVGT RLLTVKATDP
310 320 330 340 350
DEGANGDVTY SFRKVRDKIS QLFQLNSLSG DITILGGLDY EDSGFYDIDV
360 370 380 390 400
EAHDGPGLRA RSKVLVTVLD ENDNAPEVTV TSLTSSVQES SSPGTVIALF
410 420 430 440 450
NVHDSDSGGN GLVTCSIPDN LPFTLEKTYG NYYRLLTHRT LDREEVSEYN
460 470 480 490 500
ITVTATDQGT PPLSTETHIS LQVMDINDNP PTFPHASYSA YIPENNPRGA
510 520 530 540 550
SILSMTAQDP DSGDNARITY SLAEDTFQGA PLSSYVSINS NTGILYALCS
560 570 580 590 600
FDYEQFRDLQ LLMTASDSGD PPLSSNVSLS LFVLDQNDNV PEILYPTFPT
610 620 630 640 650
DGSTGVELAP RSADSGYLVT KVVAVDRDSG QNAWLSYSLL KSSEPGLFAV
660 670 680 690 700
GLHTGEVRTA RALLDRDALK QRLVVVVQDH GQPPLSATVT LTVAVADSIP
710 720 730 740 750
DVLADLGSLK PSADPDDSGL TLYLVVAVAA VSCVFLAFVT VLLALKLRRW
760 770 780 790 800
HKSRLLHAEG SRLAGVPASH FVGVDGVRAF LQTYSHEVSL TADSRKSHLI
810 820 830 840 850
FSQPSYADTL ISRESCEKSE PLLITQDLLE TKGDPNLQQA PPNTDWRFSQ
860 870 880 890 900
AQRPGTSGSQ NGDDTGTWPN NQFDTEMLQA MILASASEAA DGSSTLGGGA
910 920 930 940 950
GTMGLSARYG PQFTLQHVPD YRQNVYIPGS NATLTNAAGK RDGKAPAGGN
960
GNKKKSGKKE KK
Length:962
Mass (Da):103,968
Last modified:September 27, 2017 - v2
Checksum:i6A2AE19550423EC6
GO
Isoform 2 (identifier: Q9Y5G9-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     839-851: QAPPNTDWRFSQA → VSQSYNRSYHTEI
     852-962: Missing.

Show »
Length:851
Mass (Da):92,608
Checksum:i95348ADC8BFBB620
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048557181A → T. Corresponds to variant dbSNP:rs11575949Ensembl.1
Natural variantiVAR_048558672R → K. Corresponds to variant dbSNP:rs4329068Ensembl.1
Natural variantiVAR_048559714D → H. Corresponds to variant dbSNP:rs11575951Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_008665839 – 851QAPPN…RFSQA → VSQSYNRSYHTEI in isoform 2. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_008666852 – 962Missing in isoform 2. 1 PublicationAdd BLAST111

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005618 Genomic DNA. No translation available.
AC008781 Genomic DNA. No translation available.
KC877131 Genomic DNA. No translation available.
AF152324 mRNA. Translation: AAD43718.1.
AF152511 mRNA. Translation: AAD43771.1.
RefSeqiNP_061740.2. NM_018917.3.
NP_114442.2. NM_032053.2.
UniGeneiHs.368160.

Genome annotation databases

GeneIDi56111.
KEGGihsa:56111.
UCSCiuc003ljp.3. human.
uc003ljq.4. human.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPCDG4_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5G9
Secondary accession number(s): A0A087WT05, A0A087WTI2, Q9Y5D3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: September 27, 2017
Last modified: September 27, 2017
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-32 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot