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Protein

Protocadherin gamma-A5

Gene

PCDHGA5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin gamma-A5
Short name:
PCDH-gamma-A5
Gene namesi
Name:PCDHGA5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:8703. PCDHGA5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 692ExtracellularSequence analysisAdd BLAST663
Transmembranei693 – 713HelicalSequence analysisAdd BLAST21
Topological domaini714 – 931CytoplasmicSequence analysisAdd BLAST218

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000253485.
PharmGKBiPA33051.

Polymorphism and mutation databases

BioMutaiPCDHGA5.
DMDMi37999838.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000000395630 – 931Protocadherin gamma-A5Add BLAST902

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi419N-linked (GlcNAc...)Sequence analysis1
Glycosylationi545N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9Y5G8.
PeptideAtlasiQ9Y5G8.
PRIDEiQ9Y5G8.

PTM databases

iPTMnetiQ9Y5G8.
PhosphoSitePlusiQ9Y5G8.

Expressioni

Gene expression databases

BgeeiENSG00000253485.
GenevisibleiQ9Y5G8. HS.

Organism-specific databases

HPAiHPA008755.

Interactioni

Protein-protein interaction databases

BioGridi121050. 51 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ9Y5G8.
SMRiQ9Y5G8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 133Cadherin 1PROSITE-ProRule annotationAdd BLAST104
Domaini134 – 242Cadherin 2PROSITE-ProRule annotationAdd BLAST109
Domaini243 – 347Cadherin 3PROSITE-ProRule annotationAdd BLAST105
Domaini348 – 452Cadherin 4PROSITE-ProRule annotationAdd BLAST105
Domaini453 – 562Cadherin 5PROSITE-ProRule annotationAdd BLAST110
Domaini570 – 683Cadherin 6PROSITE-ProRule annotationAdd BLAST114

Sequence similaritiesi

Contains 6 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00840000129690.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.
InParanoidiQ9Y5G8.
KOiK16495.
OMAiLSTENHI.
OrthoDBiEOG091G024L.
PhylomeDBiQ9Y5G8.
TreeFamiTF332299.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR031904. Cadherin_CBD.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
PF15974. Cadherin_tail. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y5G8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASPPRGWGC GELLLPFMLL GTLCEPGSGQ IRYSMPEELD KGSFVGNIAK
60 70 80 90 100
DLGLEPQELA ERGVRIVSRG RTQLFALNPR SGSLVTAGRI DREELCAQSP
110 120 130 140 150
LCVVNFNILV ENKMKIYGVE VEIIDINDNF PRFRDEELKV KVNENAAAGT
160 170 180 190 200
RLVLPFARDA DVGVNSLRSY QLSSNLHFSL DVVSGTDGQK YPELVLEQPL
210 220 230 240 250
DREKETVHDL LLTALDGGDP VLSGTTHIRV TVLDANDNAP LFTPSEYSVS
260 270 280 290 300
VPENIPVGTR LLMLTATDPD EGINGKLTYS FRNEEEKISE TFQLDSNLGE
310 320 330 340 350
ISTLQSLDYE ESRFYLMEVV AQDGGALVAS AKVVVTVQDV NDNAPEVILT
360 370 380 390 400
SLTSSISEDC LPGTVIALFS VHDGDSGENG EIACSIPRNL PFKLEKSVDN
410 420 430 440 450
YYHLLTTRDL DREETSDYNI TLTVMDHGTP PLSTESHIPL KVADVNDNPP
460 470 480 490 500
NFPQASYSTS VTENNPRGVS IFSVTAHDPD SGDNARVTYS LAEDTFQGAP
510 520 530 540 550
LSSYVSINSD TGVLYALRSF DYEQLRDLQL WVTASDSGNP PLSSNVSLSL
560 570 580 590 600
FVLDQNDNTP EILYPALPTD GSTGVELAPR SAEPGYLVTK VVAVDKDSGQ
610 620 630 640 650
NAWLSYRLLK ASEPGLFAVG LHTGEVRTAR ALLDRDALKQ SLVVAVEDHG
660 670 680 690 700
QPPLSATFTV TVAVADRIPD ILADLGSIKT PIDPEDLDLT LYLVVAVAAV
710 720 730 740 750
SCVFLAFVIV LLVLRLRRWH KSRLLQAEGS RLAGVPASHF VGVDGVRAFL
760 770 780 790 800
QTYSHEVSLT ADSRKSHLIF PQPNYADTLL SEESCEKSEP LLMSDKVDAN
810 820 830 840 850
KEERRVQQAP PNTDWRFSQA QRPGTSGSQN GDDTGTWPNN QFDTEMLQAM
860 870 880 890 900
ILASASEAAD GSSTLGGGAG TMGLSARYGP QFTLQHVPDY RQNVYIPGSN
910 920 930
ATLTNAAGKR DGKAPAGGNG NKKKSGKKEK K
Length:931
Mass (Da):100,935
Last modified:November 1, 1999 - v1
Checksum:i65B854089A52A7AA
GO
Isoform 2 (identifier: Q9Y5G8-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     808-813: QAPPNT → VSFLFR
     814-931: Missing.

Show »
Length:813
Mass (Da):88,759
Checksum:iD96148835046FD38
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_008667808 – 813QAPPNT → VSFLFR in isoform 2. 2 Publications6
Alternative sequenceiVSP_008668814 – 931Missing in isoform 2. 2 PublicationsAdd BLAST118

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152325 mRNA. Translation: AAD43719.1.
AF152512 mRNA. Translation: AAD43772.1.
CH471062 Genomic DNA. Translation: EAW61938.1.
BC104926 mRNA. Translation: AAI04927.1.
BC113460 mRNA. Translation: AAI13461.1.
CCDSiCCDS54925.1. [Q9Y5G8-1]
CCDS75333.1. [Q9Y5G8-2]
RefSeqiNP_061741.1. NM_018918.2. [Q9Y5G8-1]
NP_114443.1. NM_032054.1. [Q9Y5G8-2]
UniGeneiHs.368160.

Genome annotation databases

EnsembliENST00000518069; ENSP00000429834; ENSG00000253485. [Q9Y5G8-1]
ENST00000611914; ENSP00000480337; ENSG00000253485. [Q9Y5G8-2]
GeneIDi56110.
KEGGihsa:56110.
UCSCiuc003lju.3. human. [Q9Y5G8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152325 mRNA. Translation: AAD43719.1.
AF152512 mRNA. Translation: AAD43772.1.
CH471062 Genomic DNA. Translation: EAW61938.1.
BC104926 mRNA. Translation: AAI04927.1.
BC113460 mRNA. Translation: AAI13461.1.
CCDSiCCDS54925.1. [Q9Y5G8-1]
CCDS75333.1. [Q9Y5G8-2]
RefSeqiNP_061741.1. NM_018918.2. [Q9Y5G8-1]
NP_114443.1. NM_032054.1. [Q9Y5G8-2]
UniGeneiHs.368160.

3D structure databases

ProteinModelPortaliQ9Y5G8.
SMRiQ9Y5G8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121050. 51 interactors.

PTM databases

iPTMnetiQ9Y5G8.
PhosphoSitePlusiQ9Y5G8.

Polymorphism and mutation databases

BioMutaiPCDHGA5.
DMDMi37999838.

Proteomic databases

PaxDbiQ9Y5G8.
PeptideAtlasiQ9Y5G8.
PRIDEiQ9Y5G8.

Protocols and materials databases

DNASUi56110.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000518069; ENSP00000429834; ENSG00000253485. [Q9Y5G8-1]
ENST00000611914; ENSP00000480337; ENSG00000253485. [Q9Y5G8-2]
GeneIDi56110.
KEGGihsa:56110.
UCSCiuc003lju.3. human. [Q9Y5G8-1]

Organism-specific databases

CTDi56110.
GeneCardsiPCDHGA5.
HGNCiHGNC:8703. PCDHGA5.
HPAiHPA008755.
MIMi604968. gene.
606292. gene.
neXtProtiNX_Q9Y5G8.
OpenTargetsiENSG00000253485.
PharmGKBiPA33051.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00840000129690.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.
InParanoidiQ9Y5G8.
KOiK16495.
OMAiLSTENHI.
OrthoDBiEOG091G024L.
PhylomeDBiQ9Y5G8.
TreeFamiTF332299.

Miscellaneous databases

GenomeRNAii56110.
PROiQ9Y5G8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000253485.
GenevisibleiQ9Y5G8. HS.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR031904. Cadherin_CBD.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
PF15974. Cadherin_tail. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPCDG5_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5G8
Secondary accession number(s): Q2M3F5, Q9Y5D2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.