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Protein

Protocadherin gamma-A5

Gene

PCDHGA5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin gamma-A5
Short name:
PCDH-gamma-A5
Gene namesi
Name:PCDHGA5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:8703. PCDHGA5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini30 – 692663ExtracellularSequence analysisAdd
BLAST
Transmembranei693 – 71321HelicalSequence analysisAdd
BLAST
Topological domaini714 – 931218CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33051.

Polymorphism and mutation databases

BioMutaiPCDHGA5.
DMDMi37999838.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence analysisAdd
BLAST
Chaini30 – 931902Protocadherin gamma-A5PRO_0000003956Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi419 – 4191N-linked (GlcNAc...)Sequence analysis
Glycosylationi545 – 5451N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9Y5G8.
PeptideAtlasiQ9Y5G8.
PRIDEiQ9Y5G8.

PTM databases

iPTMnetiQ9Y5G8.
PhosphoSiteiQ9Y5G8.

Expressioni

Gene expression databases

BgeeiQ9Y5G8.
GenevisibleiQ9Y5G8. HS.

Organism-specific databases

HPAiHPA008755.

Interactioni

Protein-protein interaction databases

BioGridi121050. 51 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9Y5G8.
SMRiQ9Y5G8. Positions 27-666.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 133104Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini134 – 242109Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini243 – 347105Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini348 – 452105Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Domaini453 – 562110Cadherin 5PROSITE-ProRule annotationAdd
BLAST
Domaini570 – 683114Cadherin 6PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 6 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00840000129695.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.
InParanoidiQ9Y5G8.
KOiK16495.
OMAiLSTENHI.
OrthoDBiEOG7KSX80.
PhylomeDBiQ9Y5G8.
TreeFamiTF332299.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR031904. Cadherin_CBD.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
PF15974. Cadherin_tail. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y5G8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASPPRGWGC GELLLPFMLL GTLCEPGSGQ IRYSMPEELD KGSFVGNIAK
60 70 80 90 100
DLGLEPQELA ERGVRIVSRG RTQLFALNPR SGSLVTAGRI DREELCAQSP
110 120 130 140 150
LCVVNFNILV ENKMKIYGVE VEIIDINDNF PRFRDEELKV KVNENAAAGT
160 170 180 190 200
RLVLPFARDA DVGVNSLRSY QLSSNLHFSL DVVSGTDGQK YPELVLEQPL
210 220 230 240 250
DREKETVHDL LLTALDGGDP VLSGTTHIRV TVLDANDNAP LFTPSEYSVS
260 270 280 290 300
VPENIPVGTR LLMLTATDPD EGINGKLTYS FRNEEEKISE TFQLDSNLGE
310 320 330 340 350
ISTLQSLDYE ESRFYLMEVV AQDGGALVAS AKVVVTVQDV NDNAPEVILT
360 370 380 390 400
SLTSSISEDC LPGTVIALFS VHDGDSGENG EIACSIPRNL PFKLEKSVDN
410 420 430 440 450
YYHLLTTRDL DREETSDYNI TLTVMDHGTP PLSTESHIPL KVADVNDNPP
460 470 480 490 500
NFPQASYSTS VTENNPRGVS IFSVTAHDPD SGDNARVTYS LAEDTFQGAP
510 520 530 540 550
LSSYVSINSD TGVLYALRSF DYEQLRDLQL WVTASDSGNP PLSSNVSLSL
560 570 580 590 600
FVLDQNDNTP EILYPALPTD GSTGVELAPR SAEPGYLVTK VVAVDKDSGQ
610 620 630 640 650
NAWLSYRLLK ASEPGLFAVG LHTGEVRTAR ALLDRDALKQ SLVVAVEDHG
660 670 680 690 700
QPPLSATFTV TVAVADRIPD ILADLGSIKT PIDPEDLDLT LYLVVAVAAV
710 720 730 740 750
SCVFLAFVIV LLVLRLRRWH KSRLLQAEGS RLAGVPASHF VGVDGVRAFL
760 770 780 790 800
QTYSHEVSLT ADSRKSHLIF PQPNYADTLL SEESCEKSEP LLMSDKVDAN
810 820 830 840 850
KEERRVQQAP PNTDWRFSQA QRPGTSGSQN GDDTGTWPNN QFDTEMLQAM
860 870 880 890 900
ILASASEAAD GSSTLGGGAG TMGLSARYGP QFTLQHVPDY RQNVYIPGSN
910 920 930
ATLTNAAGKR DGKAPAGGNG NKKKSGKKEK K
Length:931
Mass (Da):100,935
Last modified:November 1, 1999 - v1
Checksum:i65B854089A52A7AA
GO
Isoform 2 (identifier: Q9Y5G8-2) [UniParc]FASTAAdd to basket

Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     808-813: QAPPNT → VSFLFR
     814-931: Missing.

Show »
Length:813
Mass (Da):88,759
Checksum:iD96148835046FD38
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei808 – 8136QAPPNT → VSFLFR in isoform 2. 2 PublicationsVSP_008667
Alternative sequencei814 – 931118Missing in isoform 2. 2 PublicationsVSP_008668Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152325 mRNA. Translation: AAD43719.1.
AF152512 mRNA. Translation: AAD43772.1.
CH471062 Genomic DNA. Translation: EAW61938.1.
BC104926 mRNA. Translation: AAI04927.1.
BC113460 mRNA. Translation: AAI13461.1.
CCDSiCCDS54925.1. [Q9Y5G8-1]
CCDS75333.1. [Q9Y5G8-2]
RefSeqiNP_061741.1. NM_018918.2. [Q9Y5G8-1]
NP_114443.1. NM_032054.1. [Q9Y5G8-2]
UniGeneiHs.368160.

Genome annotation databases

EnsembliENST00000518069; ENSP00000429834; ENSG00000253485. [Q9Y5G8-1]
ENST00000611914; ENSP00000480337; ENSG00000253485. [Q9Y5G8-2]
GeneIDi56110.
KEGGihsa:56110.
UCSCiuc003lju.3. human. [Q9Y5G8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152325 mRNA. Translation: AAD43719.1.
AF152512 mRNA. Translation: AAD43772.1.
CH471062 Genomic DNA. Translation: EAW61938.1.
BC104926 mRNA. Translation: AAI04927.1.
BC113460 mRNA. Translation: AAI13461.1.
CCDSiCCDS54925.1. [Q9Y5G8-1]
CCDS75333.1. [Q9Y5G8-2]
RefSeqiNP_061741.1. NM_018918.2. [Q9Y5G8-1]
NP_114443.1. NM_032054.1. [Q9Y5G8-2]
UniGeneiHs.368160.

3D structure databases

ProteinModelPortaliQ9Y5G8.
SMRiQ9Y5G8. Positions 27-666.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121050. 51 interactions.

PTM databases

iPTMnetiQ9Y5G8.
PhosphoSiteiQ9Y5G8.

Polymorphism and mutation databases

BioMutaiPCDHGA5.
DMDMi37999838.

Proteomic databases

PaxDbiQ9Y5G8.
PeptideAtlasiQ9Y5G8.
PRIDEiQ9Y5G8.

Protocols and materials databases

DNASUi56110.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000518069; ENSP00000429834; ENSG00000253485. [Q9Y5G8-1]
ENST00000611914; ENSP00000480337; ENSG00000253485. [Q9Y5G8-2]
GeneIDi56110.
KEGGihsa:56110.
UCSCiuc003lju.3. human. [Q9Y5G8-1]

Organism-specific databases

CTDi56110.
GeneCardsiPCDHGA5.
HGNCiHGNC:8703. PCDHGA5.
HPAiHPA008755.
MIMi604968. gene.
606292. gene.
neXtProtiNX_Q9Y5G8.
PharmGKBiPA33051.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00840000129695.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.
InParanoidiQ9Y5G8.
KOiK16495.
OMAiLSTENHI.
OrthoDBiEOG7KSX80.
PhylomeDBiQ9Y5G8.
TreeFamiTF332299.

Miscellaneous databases

GenomeRNAii56110.
PROiQ9Y5G8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y5G8.
GenevisibleiQ9Y5G8. HS.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR031904. Cadherin_CBD.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
PF15974. Cadherin_tail. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A striking organization of a large family of human neural cadherin-like cell adhesion genes."
    Wu Q., Maniatis T.
    Cell 97:779-790(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.

Entry informationi

Entry nameiPCDG5_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5G8
Secondary accession number(s): Q2M3F5, Q9Y5D2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: November 1, 1999
Last modified: July 6, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.