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Protein

Protocadherin gamma-A8

Gene

PCDHGA8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin gamma-A8
Short name:
PCDH-gamma-A8
Gene namesi
Name:PCDHGA8
Synonyms:KIAA0327
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:8706. PCDHGA8.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini30 – 692663ExtracellularSequence analysisAdd
BLAST
Transmembranei693 – 71321HelicalSequence analysisAdd
BLAST
Topological domaini714 – 932219CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33054.

Polymorphism and mutation databases

BioMutaiPCDHGA8.
DMDMi37999835.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence analysisAdd
BLAST
Chaini30 – 932903Protocadherin gamma-A8PRO_0000003962Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi47 – 471N-linked (GlcNAc...)Sequence analysis
Glycosylationi414 – 4141N-linked (GlcNAc...)Sequence analysis
Glycosylationi419 – 4191N-linked (GlcNAc...)Sequence analysis
Glycosylationi545 – 5451N-linked (GlcNAc...)Sequence analysis
Glycosylationi685 – 6851N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9Y5G5.
PaxDbiQ9Y5G5.
PRIDEiQ9Y5G5.

PTM databases

iPTMnetiQ9Y5G5.
PhosphoSiteiQ9Y5G5.

Expressioni

Gene expression databases

BgeeiQ9Y5G5.
GenevisibleiQ9Y5G5. HS.

Organism-specific databases

HPAiHPA008755.

Interactioni

Protein-protein interaction databases

BioGridi115059. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9Y5G5.
SMRiQ9Y5G5. Positions 27-690.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 133104Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini134 – 242109Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini243 – 347105Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini348 – 452105Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Domaini453 – 562110Cadherin 5PROSITE-ProRule annotationAdd
BLAST
Domaini570 – 682113Cadherin 6PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 6 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00840000129695.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.
InParanoidiQ9Y5G5.
KOiK16495.
OMAiAFLSVHD.
OrthoDBiEOG7KSX80.
PhylomeDBiQ9Y5G5.
TreeFamiTF332299.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR031904. Cadherin_CBD.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
PF15974. Cadherin_tail. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y5G5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAPQSRPRR GELILLCALL GTLWEIGRGQ IRYSVPEETD KGSFVGNISK
60 70 80 90 100
DLGLDPRKLA KHGVRIVSRG RTQLFALNPR SGSLITAGRI DREELCAQSP
110 120 130 140 150
RCLININTLV EDKGKLFGVE IEIIDINDNN PKFQVEDLEV KINEIAVPGA
160 170 180 190 200
RYPLPEAVDP DVGVNSLQSY QLSPNHHFSL DVQTGDNGAI NPELVLERAL
210 220 230 240 250
DREEEAAHHL VLTASDGGKP PRSSTVRIHV TVLDTNDNAP VFPHPIYRVK
260 270 280 290 300
VLENMPPGTR LLTVTASDPD EGINGKVAYK FRKINEKQTP LFQLNENTGE
310 320 330 340 350
ISIAKSLDYE ECSFYEMEIQ AEDVGALLGR TKLLISVEDV NDNRPEVIIT
360 370 380 390 400
SLFSPVLENS LPGTVIAFLS VHDQDSGKNG QVVCYTRDNL PFKLEKSIGN
410 420 430 440 450
YYRLVTRKYL DRENVSIYNI TVMASDLGTP PLSTETQIAL HVADINDNPP
460 470 480 490 500
TFPHASYSAY ILENNLRGAS IFSLTAHDPD SQENAQVTYS VTEDTLQGAP
510 520 530 540 550
LSSYISINSD TGVLYALQSF DYEQIRDLQL LVTASDSGDP PLSSNMSLSL
560 570 580 590 600
FVLDQNDNAP EILYPALPTD GSTGVELAPR SAERGYLVTK VVAVDRDSGQ
610 620 630 640 650
NAWLSYRLLK ASEPGLFSVG LHTGEVRTAR ALLDRDALKQ SLVVAVQDHG
660 670 680 690 700
QPPLSATVTL TVAVADSIPE VLTELGSLKP SVDPNDSSLT LYLVVAVAAI
710 720 730 740 750
SCVFLAFVAV LLGLRLRRWH KSRLLQDSGG RLVGVPASHF VGVEEVQAFL
760 770 780 790 800
QTYSQEVSLT ADSRKSHLIF PQPNYADMLI SQEGCEKNDS LLTSVDFHEY
810 820 830 840 850
KNEADHGQQA PPNTDWRFSQ AQRPGTSGSQ NGDDTGTWPN NQFDTEMLQA
860 870 880 890 900
MILASASEAA DGSSTLGGGA GTMGLSARYG PQFTLQHVPD YRQNVYIPGS
910 920 930
NATLTNAAGK RDGKAPAGGN GNKKKSGKKE KK
Length:932
Mass (Da):101,480
Last modified:November 1, 1999 - v1
Checksum:i6234C316CD770337
GO
Isoform 2 (identifier: Q9Y5G5-2) [UniParc]FASTAAdd to basket

Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     809-820: QAPPNTDWRFSQ → VSLVLCLLLISR
     821-932: Missing.

Show »
Length:820
Mass (Da):89,865
Checksum:i8A6CA78E4457FC33
GO

Sequence cautioni

The sequence BAA20785.2 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti16 – 161L → R.
Corresponds to variant rs726684 [ dbSNP | Ensembl ].
VAR_048564
Natural varianti187 – 1871N → K.
Corresponds to variant rs11575958 [ dbSNP | Ensembl ].
VAR_061070

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei809 – 82012QAPPN…WRFSQ → VSLVLCLLLISR in isoform 2. 3 PublicationsVSP_008673Add
BLAST
Alternative sequencei821 – 932112Missing in isoform 2. 3 PublicationsVSP_008674Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152328 mRNA. Translation: AAD43722.1.
AF152515 mRNA. Translation: AAD43775.1.
AB002325 mRNA. Translation: BAA20785.2. Different initiation.
CH471062 Genomic DNA. Translation: EAW61942.1.
BC152415 mRNA. Translation: AAI52416.1.
CCDSiCCDS47291.1. [Q9Y5G5-1]
CCDS75338.1. [Q9Y5G5-2]
RefSeqiNP_054723.1. NM_014004.2. [Q9Y5G5-2]
NP_114477.1. NM_032088.1. [Q9Y5G5-1]
UniGeneiHs.368160.

Genome annotation databases

EnsembliENST00000398604; ENSP00000381605; ENSG00000253767. [Q9Y5G5-1]
ENST00000610569; ENSP00000483161; ENSG00000253767. [Q9Y5G5-2]
GeneIDi9708.
KEGGihsa:9708.
UCSCiuc003lkb.5. human. [Q9Y5G5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152328 mRNA. Translation: AAD43722.1.
AF152515 mRNA. Translation: AAD43775.1.
AB002325 mRNA. Translation: BAA20785.2. Different initiation.
CH471062 Genomic DNA. Translation: EAW61942.1.
BC152415 mRNA. Translation: AAI52416.1.
CCDSiCCDS47291.1. [Q9Y5G5-1]
CCDS75338.1. [Q9Y5G5-2]
RefSeqiNP_054723.1. NM_014004.2. [Q9Y5G5-2]
NP_114477.1. NM_032088.1. [Q9Y5G5-1]
UniGeneiHs.368160.

3D structure databases

ProteinModelPortaliQ9Y5G5.
SMRiQ9Y5G5. Positions 27-690.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115059. 1 interaction.

PTM databases

iPTMnetiQ9Y5G5.
PhosphoSiteiQ9Y5G5.

Polymorphism and mutation databases

BioMutaiPCDHGA8.
DMDMi37999835.

Proteomic databases

EPDiQ9Y5G5.
PaxDbiQ9Y5G5.
PRIDEiQ9Y5G5.

Protocols and materials databases

DNASUi9708.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000398604; ENSP00000381605; ENSG00000253767. [Q9Y5G5-1]
ENST00000610569; ENSP00000483161; ENSG00000253767. [Q9Y5G5-2]
GeneIDi9708.
KEGGihsa:9708.
UCSCiuc003lkb.5. human. [Q9Y5G5-1]

Organism-specific databases

CTDi9708.
GeneCardsiPCDHGA8.
HGNCiHGNC:8706. PCDHGA8.
HPAiHPA008755.
MIMi604968. gene.
606295. gene.
neXtProtiNX_Q9Y5G5.
PharmGKBiPA33054.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00840000129695.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.
InParanoidiQ9Y5G5.
KOiK16495.
OMAiAFLSVHD.
OrthoDBiEOG7KSX80.
PhylomeDBiQ9Y5G5.
TreeFamiTF332299.

Miscellaneous databases

GenomeRNAii9708.
PROiQ9Y5G5.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y5G5.
GenevisibleiQ9Y5G5. HS.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR031904. Cadherin_CBD.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
PF15974. Cadherin_tail. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A striking organization of a large family of human neural cadherin-like cell adhesion genes."
    Wu Q., Maniatis T.
    Cell 97:779-790(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain.
  2. "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).

Entry informationi

Entry nameiPCDG8_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5G5
Secondary accession number(s): A7MCZ4, O15039
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: November 1, 1999
Last modified: June 8, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.