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Protein

Protocadherin gamma-A9

Gene

PCDHGA9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin gamma-A9
Short name:
PCDH-gamma-A9
Gene namesi
Name:PCDHGA9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:8707. PCDHGA9.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini29 – 692664ExtracellularSequence analysisAdd
BLAST
Transmembranei693 – 71321HelicalSequence analysisAdd
BLAST
Topological domaini714 – 932219CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33055.

Polymorphism and mutation databases

BioMutaiPCDHGA9.
DMDMi37999834.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence analysisAdd
BLAST
Chaini29 – 932904Protocadherin gamma-A9PRO_0000003964Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi47 – 471N-linked (GlcNAc...)Sequence analysis
Glycosylationi127 – 1271N-linked (GlcNAc...)Sequence analysis
Glycosylationi389 – 3891N-linked (GlcNAc...)Sequence analysis
Glycosylationi419 – 4191N-linked (GlcNAc...)Sequence analysis
Glycosylationi545 – 5451N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9Y5G4.
PaxDbiQ9Y5G4.
PRIDEiQ9Y5G4.

PTM databases

iPTMnetiQ9Y5G4.
PhosphoSiteiQ9Y5G4.

Expressioni

Gene expression databases

BgeeiQ9Y5G4.
GenevisibleiQ9Y5G4. HS.

Organism-specific databases

HPAiHPA008755.

Interactioni

Protein-protein interaction databases

BioGridi121047. 2 interactions.
STRINGi9606.ENSP00000460274.

Structurei

3D structure databases

ProteinModelPortaliQ9Y5G4.
SMRiQ9Y5G4. Positions 31-666.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 133105Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini134 – 242109Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini243 – 347105Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini348 – 452105Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Domaini453 – 562110Cadherin 5PROSITE-ProRule annotationAdd
BLAST
Domaini570 – 683114Cadherin 6PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 6 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00840000129695.
HOVERGENiHBG054878.
InParanoidiQ9Y5G4.
KOiK16495.
OMAiGKSEPLC.
OrthoDBiEOG7KSX80.
PhylomeDBiQ9Y5G4.
TreeFamiTF332299.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR031904. Cadherin_CBD.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
PF15974. Cadherin_tail. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 4 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y5G4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAPTKCQLR GRLVLLCSLL GMLWEARASQ IRYSVPEETE KGYIVGNISK
60 70 80 90 100
DLALEPRELA ERRVRIVSRG RTQLFSLNPR SGTLVTAGRI DREELCAQSP
110 120 130 140 150
RCLVNFKVLV EDRVKLYGIE IEVTDINDSA PKFQAESLEV KINEIAVPGA
160 170 180 190 200
RYPLPEAIDP DVGVNSLQSY QLSPNHHFSL NVQTGDNGAI NPELVLERAL
210 220 230 240 250
DREEATAHHL VLTASDGGEP RRSSTVRIHV TVLDTNDNAP VFAQRIYRVK
260 270 280 290 300
VLENVPPGTW LLTATASDLD EGINGKVAYK FWKINEKQSL LFQLNENTGE
310 320 330 340 350
ISTAKSLDYE ECSFYEMEIQ AEDGGGLKGW TKVLISVEDV NDNRPEVTIT
360 370 380 390 400
SLFSPVREDA PQGTVILLFN AHDRDSGKNG QVVCSIQENL SFTLENSEED
410 420 430 440 450
YYRLLTAQIL DREKASEYNI TVTATDRGTP PLSTEIHITL QVTDINDNPP
460 470 480 490 500
AFSQASYSVY LPENNARGTS IFSVIAYDPD SNENSRVIYS LAEDTIQGSP
510 520 530 540 550
LSTYVSINSD TGVLYALCSF DYEQFRDLQM QVTASDSGSP PLSSNVSLRL
560 570 580 590 600
FVLDQNDNAP EILYPALPTD GSTGVELAPR SAEPGYLVTK VVAVDRDSGQ
610 620 630 640 650
NAWLSYRLFK ASEPGLFSVG LHTGEVRTAR ALLDRDALKQ SLVVAVQDHG
660 670 680 690 700
QPPLSATVTL TVAIADSIPD ILADLGSLQI PADLEASDLT LYLVVAVAVV
710 720 730 740 750
SCVFLTFVIT LLALRLRHWH SSHLLRATSD GLAGVPTSHF VGVDGVRAFL
760 770 780 790 800
QTYSQEFSLT ADSRKSHLIF PQPNYADTLI SQQSCEKNEP LCVSVDSKFP
810 820 830 840 850
IEDTPLVPQA PPNTDWRFSQ AQRPGTSGSQ NGDDTGTWPN NQFDTEMLQA
860 870 880 890 900
MILASASEAA DGSSTLGGGA GTMGLSARYG PQFTLQHVPD YRQNVYIPGS
910 920 930
NATLTNAAGK RDGKAPAGGN GNKKKSGKKE KK
Length:932
Mass (Da):101,687
Last modified:November 1, 1999 - v1
Checksum:i6FF22C104BE91FAD
GO
Isoform 2 (identifier: Q9Y5G4-2) [UniParc]FASTAAdd to basket

Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     809-828: QAPPNTDWRFSQAQRPGTSG → VSSFFFFLSFLFLFFVLFCF
     829-932: Missing.

Show »
Length:828
Mass (Da):91,248
Checksum:iE8D1F233FBA9F588
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti791 – 7911L → F.
Corresponds to variant rs17097274 [ dbSNP | Ensembl ].
VAR_048565

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei809 – 82820QAPPN…PGTSG → VSSFFFFLSFLFLFFVLFCF in isoform 2. 2 PublicationsVSP_008675Add
BLAST
Alternative sequencei829 – 932104Missing in isoform 2. 2 PublicationsVSP_008676Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152329 mRNA. Translation: AAD43723.1.
AF152516 mRNA. Translation: AAD43776.1.
CH471062 Genomic DNA. Translation: EAW61958.1.
BC132769 mRNA. Translation: AAI32770.1.
CCDSiCCDS58981.1. [Q9Y5G4-1]
CCDS75341.1. [Q9Y5G4-2]
RefSeqiNP_061744.1. NM_018921.2. [Q9Y5G4-1]
NP_114478.1. NM_032089.1. [Q9Y5G4-2]
UniGeneiHs.368160.

Genome annotation databases

EnsembliENST00000573521; ENSP00000460274; ENSG00000261934. [Q9Y5G4-1]
ENST00000616887; ENSP00000480862; ENSG00000261934. [Q9Y5G4-2]
GeneIDi56107.
KEGGihsa:56107.
UCSCiuc003lkh.3. human. [Q9Y5G4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152329 mRNA. Translation: AAD43723.1.
AF152516 mRNA. Translation: AAD43776.1.
CH471062 Genomic DNA. Translation: EAW61958.1.
BC132769 mRNA. Translation: AAI32770.1.
CCDSiCCDS58981.1. [Q9Y5G4-1]
CCDS75341.1. [Q9Y5G4-2]
RefSeqiNP_061744.1. NM_018921.2. [Q9Y5G4-1]
NP_114478.1. NM_032089.1. [Q9Y5G4-2]
UniGeneiHs.368160.

3D structure databases

ProteinModelPortaliQ9Y5G4.
SMRiQ9Y5G4. Positions 31-666.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121047. 2 interactions.
STRINGi9606.ENSP00000460274.

PTM databases

iPTMnetiQ9Y5G4.
PhosphoSiteiQ9Y5G4.

Polymorphism and mutation databases

BioMutaiPCDHGA9.
DMDMi37999834.

Proteomic databases

MaxQBiQ9Y5G4.
PaxDbiQ9Y5G4.
PRIDEiQ9Y5G4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000573521; ENSP00000460274; ENSG00000261934. [Q9Y5G4-1]
ENST00000616887; ENSP00000480862; ENSG00000261934. [Q9Y5G4-2]
GeneIDi56107.
KEGGihsa:56107.
UCSCiuc003lkh.3. human. [Q9Y5G4-1]

Organism-specific databases

CTDi56107.
GeneCardsiPCDHGA9.
HGNCiHGNC:8707. PCDHGA9.
HPAiHPA008755.
MIMi604968. gene.
606296. gene.
neXtProtiNX_Q9Y5G4.
PharmGKBiPA33055.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00840000129695.
HOVERGENiHBG054878.
InParanoidiQ9Y5G4.
KOiK16495.
OMAiGKSEPLC.
OrthoDBiEOG7KSX80.
PhylomeDBiQ9Y5G4.
TreeFamiTF332299.

Miscellaneous databases

GenomeRNAii56107.
PROiQ9Y5G4.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y5G4.
GenevisibleiQ9Y5G4. HS.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR031904. Cadherin_CBD.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
PF15974. Cadherin_tail. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 4 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A striking organization of a large family of human neural cadherin-like cell adhesion genes."
    Wu Q., Maniatis T.
    Cell 97:779-790(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.

Entry informationi

Entry nameiPCDG9_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5G4
Secondary accession number(s): A2RU65, Q9Y5C9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: November 1, 1999
Last modified: June 8, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.