Q9Y5G2 (PCDGE_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protocadherin gamma-B2
Short name=PCDH-gamma-B2

Gene names

Name:

PCDHGB2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	931 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
Subcellular location	Cell membrane; Single-pass type I membrane protein By similarity.
Sequence similarities	Contains 6 cadherin domains.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Signal Transmembrane Transmembrane helix
Ligand	Calcium
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	homophilic cell adhesion Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9Y5G2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9Y5G2-2)

Also known as: Short;

The sequence of this isoform differs from the canonical sequence as follows:
     808-811: QAPP → VSFN
     812-931: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 30	30	Potential
	Chain	31 – 931	901	Protocadherin gamma-B2		PRO_0000003974
Regions
	Topological domain	31 – 691	661	Extracellular Potential
	Transmembrane	692 – 712	21	Helical; Potential
	Topological domain	713 – 931	219	Cytoplasmic Potential
	Domain	31 – 133	103	Cadherin 1
	Domain	134 – 242	109	Cadherin 2
	Domain	243 – 347	105	Cadherin 3
	Domain	348 – 452	105	Cadherin 4
	Domain	453 – 562	110	Cadherin 5
	Domain	570 – 675	106	Cadherin 6
Amino acid modifications
	Glycosylation	419	1	N-linked (GlcNAc...) Potential
	Glycosylation	545	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	808 – 811	4	QAPP → VSFN in isoform 2.		VSP_008686
	Alternative sequence	812 – 931	120	Missing in isoform 2.		VSP_008687
	Natural variant	26	1	P → R. Corresponds to variant rs17097231 [ dbSNP | Ensembl ].		VAR_048568
	Natural variant	58	1	V → I. Corresponds to variant rs13171859 [ dbSNP | Ensembl ].		VAR_061071
	Natural variant	687	1	K → E. Corresponds to variant rs57735633 [ dbSNP | Ensembl ].		VAR_061072

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 26B7518D2B632BEF	FASTA	931	100,875
	10 20 30 40 50 60 MKASSGRCGL VRWLQVLLPF LLSLFPGALP VQIRYSIPEE LAKNSVVGNL AKDLGLSVRD 70 80 90 100 110 120 LPARKLRVSA EKEYFTVNPE SGDLLVSDRI DREQICGKQP LCVLDFDTVA ENPLNIFYIA 130 140 150 160 170 180 VIVQDINDNT PLFKQTKINL KIGESTKPGT TFPLDPALDS DVGPNSLQRY HLNDNEYFDL 190 200 210 220 230 240 AEKQTPDGRK YPELILKHSL DREEHSLHQL VLTAVDGGDP PQSGTTQIRI KVTDANDNPP 250 260 270 280 290 300 VFSQDVYRVT LREDVPPGFF VLQVTATDRD EGINAEITYS FHNVDEQVKH FFNLNEKTGE 310 320 330 340 350 360 ITTKDDLDFE IASSYTLSIE AKDPGDLAAH CSIQVEILDD NDCAPEVIVT SVSTPLPEDS 370 380 390 400 410 420 PPGTVIALIK TRDRDSGENG EVYCQVLGNA KFILKSSSKN YYKLVTDGAL DREEIPEYNL 430 440 450 460 470 480 TITATDGGKP PLSSSIIVTL HISDVNDNAP VFQQTSYMVH VAENNPPGAS IAQISASDPD 490 500 510 520 530 540 LGPSGQVSYS IVASDLKPRE ILSYVSVSAQ SGVVFAQRAF DHEQLRAFEL TLQARDQGSP 550 560 570 580 590 600 ALSANVSLRV LVGDLNDNAP RVLYPALGPD GSALFDMVPR AAEPGYLVTK VVAVDADSGH 610 620 630 640 650 660 NAWLSYHVLQ ASEPGLFSLG LRTGEVRTAR ALGDRDAARQ RLLVAVRDGG QPPLSATATL 670 680 690 700 710 720 HLIFADSLQE VLPDLSDRRE PSDPQAKLQF YLVVALALIS VLFFLAVILA ISLRLRLSSR 730 740 750 760 770 780 SDAWDCFQPG LSSKPGPGVL PNYSEGTLPY SYNLCVASQS AKTEFNFLNI TPELVPAQDL 790 800 810 820 830 840 VCDNASWEQN TNHGAAGVPF ASDTILKQAP PNTDWRFSQA QRPGTSGSQN GDDTGTWPNN 850 860 870 880 890 900 QFDTEMLQAM ILASASEAAD GSSTLGGGAG TMGLSARYGP QFTLQHVPDY RQNVYIPGSN 910 920 930 ATLTNAAGKR DGKAPAGGNG NKKKSGKKEK K
	Isoform 2 (Short) [UniParc]. Checksum: AFF0BC6EF90BFAAA	FASTA	811	88,397
	10 20 30 40 50 60 MKASSGRCGL VRWLQVLLPF LLSLFPGALP VQIRYSIPEE LAKNSVVGNL AKDLGLSVRD 70 80 90 100 110 120 LPARKLRVSA EKEYFTVNPE SGDLLVSDRI DREQICGKQP LCVLDFDTVA ENPLNIFYIA 130 140 150 160 170 180 VIVQDINDNT PLFKQTKINL KIGESTKPGT TFPLDPALDS DVGPNSLQRY HLNDNEYFDL 190 200 210 220 230 240 AEKQTPDGRK YPELILKHSL DREEHSLHQL VLTAVDGGDP PQSGTTQIRI KVTDANDNPP 250 260 270 280 290 300 VFSQDVYRVT LREDVPPGFF VLQVTATDRD EGINAEITYS FHNVDEQVKH FFNLNEKTGE 310 320 330 340 350 360 ITTKDDLDFE IASSYTLSIE AKDPGDLAAH CSIQVEILDD NDCAPEVIVT SVSTPLPEDS 370 380 390 400 410 420 PPGTVIALIK TRDRDSGENG EVYCQVLGNA KFILKSSSKN YYKLVTDGAL DREEIPEYNL 430 440 450 460 470 480 TITATDGGKP PLSSSIIVTL HISDVNDNAP VFQQTSYMVH VAENNPPGAS IAQISASDPD 490 500 510 520 530 540 LGPSGQVSYS IVASDLKPRE ILSYVSVSAQ SGVVFAQRAF DHEQLRAFEL TLQARDQGSP 550 560 570 580 590 600 ALSANVSLRV LVGDLNDNAP RVLYPALGPD GSALFDMVPR AAEPGYLVTK VVAVDADSGH 610 620 630 640 650 660 NAWLSYHVLQ ASEPGLFSLG LRTGEVRTAR ALGDRDAARQ RLLVAVRDGG QPPLSATATL 670 680 690 700 710 720 HLIFADSLQE VLPDLSDRRE PSDPQAKLQF YLVVALALIS VLFFLAVILA ISLRLRLSSR 730 740 750 760 770 780 SDAWDCFQPG LSSKPGPGVL PNYSEGTLPY SYNLCVASQS AKTEFNFLNI TPELVPAQDL 790 800 810 VCDNASWEQN TNHGAAGVPF ASDTILKVSF N

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A striking organization of a large family of human neural cadherin-like cell adhesion genes." Wu Q., Maniatis T. Cell 97:779-790(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2). Tissue: Brain.
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF152331 mRNA. Translation: AAD43725.1. AF152518 mRNA. Translation: AAD43778.1. CH471062 Genomic DNA. Translation: EAW61939.1. BC101805 mRNA. Translation: AAI01806.1.
IPI	IPI00028616. IPI00215842.
RefSeq	NP_061746.1. NM_018923.2. NP_115267.1. NM_032096.1.
UniGene	Hs.368160.
3D structure databases
ProteinModelPortal	Q9Y5G2.
ModBase	Search...
PTM databases
PhosphoSite	Q9Y5G2.
Polymorphism databases
DMDM	37999832.
Proteomic databases
PRIDE	Q9Y5G2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000522605; ENSP00000429018; ENSG00000253910.
GeneID	56103.
KEGG	hsa:56103.
UCSC	uc003ljs.2. human. uc011dar.2. human.
Organism-specific databases
CTD	56103.
GeneCards	GC05P141212.
HGNC	HGNC:8709. PCDHGB2.
HPA	HPA008755.
MIM	604968. gene. 606300. gene.
neXtProt	NX_Q9Y5G2.
PharmGKB	PA33057.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HOG000220892.
HOVERGEN	HBG054878.
KO	K16496.
OMA	HENIPIN.
Gene expression databases
ArrayExpress	Q9Y5G2.
Bgee	Q9Y5G2.
Genevestigator	Q9Y5G2.
Family and domain databases
Gene3D	2.60.40.60. 6 hits.
InterPro	IPR002126. Cadherin. IPR015919. Cadherin-like. IPR020894. Cadherin_CS. IPR013164. Cadherin_N. [Graphical view]
Pfam	PF00028. Cadherin. 5 hits. PF08266. Cadherin_2. 1 hit. [Graphical view]
PRINTS	PR00205. CADHERIN.
SMART	SM00112. CA. 6 hits. [Graphical view]
SUPFAM	SSF49313. Cadherin. 6 hits.
PROSITE	PS00232. CADHERIN_1. 4 hits. PS50268. CADHERIN_2. 6 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	56103.
NextBio	61529.
SOURCE	Search...

Entry information

Entry name

PCDGE_HUMAN

Accession

Primary (citable) accession number: Q9Y5G2
Secondary accession number(s): Q3MIJ3, Q9UN65

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 24, 2003
Last sequence update:	November 1, 1999
Last modified:	May 1, 2013
This is version 97 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.