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Protein

Protocadherin gamma-B5

Gene

PCDHGB5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin gamma-B5
Short name:
PCDH-gamma-B5
Gene namesi
Name:PCDHGB5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:8712. PCDHGB5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini31 – 687ExtracellularSequence analysisAdd BLAST657
Transmembranei688 – 708HelicalSequence analysisAdd BLAST21
Topological domaini709 – 923CytoplasmicSequence analysisAdd BLAST215

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000276547.
PharmGKBiPA33060.

Polymorphism and mutation databases

BioMutaiPCDHGB5.
DMDMi37999830.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000000397931 – 923Protocadherin gamma-B5Add BLAST893

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi415N-linked (GlcNAc...)Sequence analysis1
Glycosylationi541N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9Y5G0.
PeptideAtlasiQ9Y5G0.
PRIDEiQ9Y5G0.

PTM databases

iPTMnetiQ9Y5G0.
PhosphoSitePlusiQ9Y5G0.

Expressioni

Gene expression databases

GenevisibleiQ9Y5G0. HS.

Organism-specific databases

HPAiHPA008755.

Interactioni

Protein-protein interaction databases

BioGridi121041. 2 interactors.
IntActiQ9Y5G0. 2 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ9Y5G0.
SMRiQ9Y5G0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 133Cadherin 1PROSITE-ProRule annotationAdd BLAST103
Domaini134 – 242Cadherin 2PROSITE-ProRule annotationAdd BLAST109
Domaini243 – 343Cadherin 3PROSITE-ProRule annotationAdd BLAST101
Domaini344 – 448Cadherin 4PROSITE-ProRule annotationAdd BLAST105
Domaini449 – 558Cadherin 5PROSITE-ProRule annotationAdd BLAST110
Domaini566 – 671Cadherin 6PROSITE-ProRule annotationAdd BLAST106

Sequence similaritiesi

Contains 6 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00840000129690.
HOVERGENiHBG054878.
InParanoidiQ9Y5G0.
KOiK16496.
OMAiCTVEINI.
OrthoDBiEOG091G01ZQ.
PhylomeDBiQ9Y5G0.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR031904. Cadherin_CBD.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
PF15974. Cadherin_tail. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y5G0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGSGAGELGR AERLPVLFLF LLSLFCPALC EQIRYRIPEE MPKGSVVGNL
60 70 80 90 100
ATDLGFSVQE LPTRKLRVSS EKPYFTVSAE SGELLVSSRL DREEICGKKP
110 120 130 140 150
ACALEFEAVA ENPLNFYHVN VEIEDINDHT PKFTQNSFEL QISESAQPGT
160 170 180 190 200
RFILEVAEDA DIGLNSLQKY KLSLNPSFSL IIKEKQDGSK YPELALEKTL
210 220 230 240 250
DREQQSYHRL VLTALDGGHP PLSGTTELRI QVTDANDNPP VFNRDVYRVS
260 270 280 290 300
LRENVPPGTT VLQVSATDQD EGINSEITYS FYRTGQIFSL NSKSGEITTQ
310 320 330 340 350
KKLDFEETKE YSMVVEGRDG GGLVAQCTVE INIQDENDNS PEVTFHSLLE
360 370 380 390 400
MILENAVPGT LIALIKIHDQ DSGENGEVNC QLQGEVPFKI ISSSKNSYKL
410 420 430 440 450
VTDGTLDREQ TPEYNVTITA TDRGKPPLSS SISVILHIRD VNDNAPVFHQ
460 470 480 490 500
ASYLVSVPEN NPPGASIAQV CASDLDLGLN GQVSYSIMAS DLEPLALASY
510 520 530 540 550
VSMSAQSGVV FAQRAFDYEQ LRTFELTLQA RDQGSPALSA NVSLRVLVGD
560 570 580 590 600
RNDNAPRVLY PALGPDGSAL FDMVPRAAEP GYLVTKVVAV DADSGHNAWL
610 620 630 640 650
SYHVLQASEP GLFSLGLRTG EVRTARALGD RDAARQRLLV AVRDGGQPPL
660 670 680 690 700
SATATLHLVF ADSLQEVLPD ITDRPVPSDP QAELQFYLVV ALALISVLFL
710 720 730 740 750
LAVILAVALR LRRSSSPAAW SCFQPGLCVK SGPVVPPNYS QGTLPYSYNL
760 770 780 790 800
CVAHTGKTEF NFLKCSEQLS SGQDILCGDS SGALFPLCNS SESTSHPELQ
810 820 830 840 850
APPNTDWRFS QAQRPGTSGS QNGDDTGTWP NNQFDTEMLQ AMILASASEA
860 870 880 890 900
ADGSSTLGGG AGTMGLSARY GPQFTLQHVP DYRQNVYIPG SNATLTNAAG
910 920
KRDGKAPAGG NGNKKKSGKK EKK
Length:923
Mass (Da):99,875
Last modified:November 1, 1999 - v1
Checksum:i2CC42DDF7D80CC60
GO
Isoform 2 (identifier: Q9Y5G0-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     800-818: QAPPNTDWRFSQAQRPGTS → VSFIYVYSFSLPTQFSVFT
     819-923: Missing.

Show »
Length:818
Mass (Da):89,164
Checksum:i8F409ABC01FD21EA
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048571188G → S.Corresponds to variant rs6867460dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_008692800 – 818QAPPN…RPGTS → VSFIYVYSFSLPTQFSVFT in isoform 2. 2 PublicationsAdd BLAST19
Alternative sequenceiVSP_008693819 – 923Missing in isoform 2. 2 PublicationsAdd BLAST105

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152334 mRNA. Translation: AAD43728.1.
AF152521 mRNA. Translation: AAD43781.1.
CH471062 Genomic DNA. Translation: EAW61948.1.
BC093877 mRNA. Translation: AAH93877.1.
BC093879 mRNA. Translation: AAH93879.1.
CCDSiCCDS75339.1. [Q9Y5G0-1]
CCDS75340.1. [Q9Y5G0-2]
RefSeqiNP_061748.1. NM_018925.2. [Q9Y5G0-1]
NP_115270.1. NM_032099.1. [Q9Y5G0-2]
UniGeneiHs.368160.

Genome annotation databases

EnsembliENST00000617380; ENSP00000478258; ENSG00000276547. [Q9Y5G0-1]
ENST00000621169; ENSP00000484888; ENSG00000276547. [Q9Y5G0-2]
GeneIDi56101.
KEGGihsa:56101.
UCSCiuc003lkf.3. human. [Q9Y5G0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152334 mRNA. Translation: AAD43728.1.
AF152521 mRNA. Translation: AAD43781.1.
CH471062 Genomic DNA. Translation: EAW61948.1.
BC093877 mRNA. Translation: AAH93877.1.
BC093879 mRNA. Translation: AAH93879.1.
CCDSiCCDS75339.1. [Q9Y5G0-1]
CCDS75340.1. [Q9Y5G0-2]
RefSeqiNP_061748.1. NM_018925.2. [Q9Y5G0-1]
NP_115270.1. NM_032099.1. [Q9Y5G0-2]
UniGeneiHs.368160.

3D structure databases

ProteinModelPortaliQ9Y5G0.
SMRiQ9Y5G0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121041. 2 interactors.
IntActiQ9Y5G0. 2 interactors.

PTM databases

iPTMnetiQ9Y5G0.
PhosphoSitePlusiQ9Y5G0.

Polymorphism and mutation databases

BioMutaiPCDHGB5.
DMDMi37999830.

Proteomic databases

EPDiQ9Y5G0.
PeptideAtlasiQ9Y5G0.
PRIDEiQ9Y5G0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000617380; ENSP00000478258; ENSG00000276547. [Q9Y5G0-1]
ENST00000621169; ENSP00000484888; ENSG00000276547. [Q9Y5G0-2]
GeneIDi56101.
KEGGihsa:56101.
UCSCiuc003lkf.3. human. [Q9Y5G0-1]

Organism-specific databases

CTDi56101.
GeneCardsiPCDHGB5.
HGNCiHGNC:8712. PCDHGB5.
HPAiHPA008755.
MIMi604968. gene.
606302. gene.
neXtProtiNX_Q9Y5G0.
OpenTargetsiENSG00000276547.
PharmGKBiPA33060.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00840000129690.
HOVERGENiHBG054878.
InParanoidiQ9Y5G0.
KOiK16496.
OMAiCTVEINI.
OrthoDBiEOG091G01ZQ.
PhylomeDBiQ9Y5G0.

Miscellaneous databases

GenomeRNAii56101.
PROiQ9Y5G0.
SOURCEiSearch...

Gene expression databases

GenevisibleiQ9Y5G0. HS.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR031904. Cadherin_CBD.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
PF15974. Cadherin_tail. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPCDGH_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5G0
Secondary accession number(s): Q52LK8, Q9Y5C6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: November 1, 1999
Last modified: November 30, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.