Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9Y5F9

- PCDGI_HUMAN

UniProt

Q9Y5F9 - PCDGI_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Protocadherin gamma-B6

Gene

PCDHGB6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro

GO - Biological processi

  1. homophilic cell adhesion Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin gamma-B6
Short name:
PCDH-gamma-B6
Gene namesi
Name:PCDHGB6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:8713. PCDHGB6.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33061.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030Sequence AnalysisAdd
BLAST
Chaini31 – 930900Protocadherin gamma-B6PRO_0000003981Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi304 – 3041N-linked (GlcNAc...)Sequence Analysis
Glycosylationi419 – 4191N-linked (GlcNAc...)Sequence Analysis
Glycosylationi545 – 5451N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9Y5F9.
PRIDEiQ9Y5F9.

PTM databases

PhosphoSiteiQ9Y5F9.

Expressioni

Gene expression databases

BgeeiQ9Y5F9.
ExpressionAtlasiQ9Y5F9. baseline.
GenevestigatoriQ9Y5F9.

Organism-specific databases

HPAiHPA008755.

Structurei

3D structure databases

ProteinModelPortaliQ9Y5F9.
SMRiQ9Y5F9. Positions 33-686.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini31 – 691661ExtracellularSequence AnalysisAdd
BLAST
Topological domaini713 – 930218CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei692 – 71221HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 133103Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini134 – 242109Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini243 – 347105Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini348 – 452105Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Domaini453 – 562110Cadherin 5PROSITE-ProRule annotationAdd
BLAST
Domaini570 – 675106Cadherin 6PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 6 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00760000118847.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.
InParanoidiQ9Y5F9.
KOiK16496.
OMAiRVNSDGG.
OrthoDBiEOG7J70DX.
PhylomeDBiQ9Y5F9.
TreeFamiTF332299.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9Y5F9) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGGSCAQRRR AGPRQVLFPL LLPLFYPTLS EPIRYSIPEE LAKGSVVGNL
60 70 80 90 100
AKDLGLSVLD VSARKLRVSA EKLHFSVDAE SGDLLVKNRI DREQICKERR
110 120 130 140 150
RCELQLEAVV ENPLNIFHVI VVIEDVNDHA PQFDKKEIHL EIFESASAGT
160 170 180 190 200
RLSLDPATDP DININSIKDY KINSNPYFSL MVRVNSDGGK YPELSLEKLL
210 220 230 240 250
DREEQRSHSL ILTALDGGDP PRSATAHIEI SVKDTNDNPP VFSRDEYRIS
260 270 280 290 300
LSENLPPGSP VLQVTATDQD EGVNAEINYY FRSTAQSTKH MFSLDEKTGM
310 320 330 340 350
IKNNQSFDFE DVERYTMEVE AKDGGGLSTQ CKVIIEILDE NDNSPEIIIT
360 370 380 390 400
SLSDQILENS PPGMVVALFK TRDLDFGGNG EVRCNIETDI PFKIYSSSNN
410 420 430 440 450
YYKLVTDGAL DREQTPEYNV TIVATDRGKP PLSSSRSITL YVADINDNAP
460 470 480 490 500
VFDQTSYVVH VAENNPPGAS IAQVSASDPD LGLNGHISYS IVASDLEPLA
510 520 530 540 550
VSSYVSVSAQ SGVVFAQRAF DHEQLRAFAL TLQARDHGSP TLSANVSLRV
560 570 580 590 600
LVGDRNDNAP RVLYPALGPD GSAFFDMVPR SAEPGYLVTK VVAVDADSGH
610 620 630 640 650
NAWLSYHVLQ ASEPGLFSLG LRTGEVRTAR ALGDRDAARQ RLLVAVRDGG
660 670 680 690 700
QPPLSATATL HLVFADNLQE ILPDLSDRPV LSDPQAELQF YLVVALALIS
710 720 730 740 750
VLFLLAVILA IALRLRRSLS PATWDCFHPG LCVKSGPVVP PNYSEGTLPY
760 770 780 790 800
SYNLCIAHTG TKEFNFLKCS VPLHSNEDMV CSVSPGALIP PHGGEDLTSH
810 820 830 840 850
PETLTSQAPP NTDWRFSQAQ RPGTSGSQNG DDTGTWPNNQ FDTEMLQAMI
860 870 880 890 900
LASASEAADG SSTLGGGAGT MGLSARYGPQ FTLQHVPDYR QNVYIPGSNA
910 920 930
TLTNAAGKRD GKAPAGGNGN KKKSGKKEKK
Length:930
Mass (Da):101,043
Last modified:November 1, 1999 - v1
Checksum:i274409FD35D18E6E
GO
Isoform 2 (identifier: Q9Y5F9-2) [UniParc]FASTAAdd to Basket

Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     807-820: QAPPNTDWRFSQAQ → VSFSFLCVIYLIVY
     821-930: Missing.

Show »
Length:820
Mass (Da):89,765
Checksum:i83370B01C3D7F883
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti684 – 6841P → S.
Corresponds to variant rs3749768 [ dbSNP | Ensembl ].
VAR_021883
Natural varianti722 – 7221A → T.
Corresponds to variant rs3749767 [ dbSNP | Ensembl ].
VAR_021884
Natural varianti775 – 7751S → A.
Corresponds to variant rs6891442 [ dbSNP | Ensembl ].
VAR_048572

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei807 – 82014QAPPN…FSQAQ → VSFSFLCVIYLIVY in isoform 2. 1 PublicationVSP_008694Add
BLAST
Alternative sequencei821 – 930110Missing in isoform 2. 1 PublicationVSP_008695Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF152335 mRNA. Translation: AAD43729.1.
AF152522 mRNA. Translation: AAD43782.1.
CCDSiCCDS54929.1. [Q9Y5F9-1]
CCDS75342.1. [Q9Y5F9-2]
RefSeqiNP_061749.1. NM_018926.2. [Q9Y5F9-1]
NP_115271.1. NM_032100.1. [Q9Y5F9-2]
UniGeneiHs.368160.

Genome annotation databases

EnsembliENST00000520790; ENSP00000428603; ENSG00000253305. [Q9Y5F9-1]
ENST00000616430; ENSP00000479143; ENSG00000253305. [Q9Y5F9-2]
GeneIDi56100.
KEGGihsa:56100.
UCSCiuc003lki.1. human. [Q9Y5F9-2]
uc003lkj.2. human. [Q9Y5F9-1]

Polymorphism databases

DMDMi37999829.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF152335 mRNA. Translation: AAD43729.1 .
AF152522 mRNA. Translation: AAD43782.1 .
CCDSi CCDS54929.1. [Q9Y5F9-1 ]
CCDS75342.1. [Q9Y5F9-2 ]
RefSeqi NP_061749.1. NM_018926.2. [Q9Y5F9-1 ]
NP_115271.1. NM_032100.1. [Q9Y5F9-2 ]
UniGenei Hs.368160.

3D structure databases

ProteinModelPortali Q9Y5F9.
SMRi Q9Y5F9. Positions 33-686.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9Y5F9.

Polymorphism databases

DMDMi 37999829.

Proteomic databases

MaxQBi Q9Y5F9.
PRIDEi Q9Y5F9.

Protocols and materials databases

DNASUi 56100.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000520790 ; ENSP00000428603 ; ENSG00000253305 . [Q9Y5F9-1 ]
ENST00000616430 ; ENSP00000479143 ; ENSG00000253305 . [Q9Y5F9-2 ]
GeneIDi 56100.
KEGGi hsa:56100.
UCSCi uc003lki.1. human. [Q9Y5F9-2 ]
uc003lkj.2. human. [Q9Y5F9-1 ]

Organism-specific databases

CTDi 56100.
GeneCardsi GC05P141389.
HGNCi HGNC:8713. PCDHGB6.
HPAi HPA008755.
MIMi 604968. gene.
606303. gene.
neXtProti NX_Q9Y5F9.
PharmGKBi PA33061.
GenAtlasi Search...

Phylogenomic databases

GeneTreei ENSGT00760000118847.
HOGENOMi HOG000220892.
HOVERGENi HBG054878.
InParanoidi Q9Y5F9.
KOi K16496.
OMAi RVNSDGG.
OrthoDBi EOG7J70DX.
PhylomeDBi Q9Y5F9.
TreeFami TF332299.

Miscellaneous databases

GenomeRNAii 56100.
NextBioi 61511.
PROi Q9Y5F9.
SOURCEi Search...

Gene expression databases

Bgeei Q9Y5F9.
ExpressionAtlasi Q9Y5F9. baseline.
Genevestigatori Q9Y5F9.

Family and domain databases

Gene3Di 2.60.40.60. 6 hits.
InterProi IPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view ]
Pfami PF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
[Graphical view ]
PRINTSi PR00205. CADHERIN.
SMARTi SM00112. CA. 6 hits.
[Graphical view ]
SUPFAMi SSF49313. SSF49313. 6 hits.
PROSITEi PS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A striking organization of a large family of human neural cadherin-like cell adhesion genes."
    Wu Q., Maniatis T.
    Cell 97:779-790(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain.

Entry informationi

Entry nameiPCDGI_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5F9
Secondary accession number(s): Q9Y5C5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: November 1, 1999
Last modified: October 29, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3