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Q9Y5F9 (PCDGI_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protocadherin gamma-B6

Short name=PCDH-gamma-B6
Gene names
Name:PCDHGB6
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length930 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

Subcellular location

Cell membrane; Single-pass type I membrane protein By similarity.

Sequence similarities

Contains 6 cadherin domains.

Ontologies

Keywords
   Biological processCell adhesion
   Cellular componentCell membrane
Membrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainRepeat
Signal
Transmembrane
Transmembrane helix
   LigandCalcium
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processhomophilic cell adhesion

Inferred from electronic annotation. Source: InterPro

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9Y5F9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9Y5F9-2)

Also known as: Short;

The sequence of this isoform differs from the canonical sequence as follows:
     807-820: QAPPNTDWRFSQAQ → VSFSFLCVIYLIVY
     821-930: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3030 Potential
Chain31 – 930900Protocadherin gamma-B6
PRO_0000003981

Regions

Topological domain31 – 691661Extracellular Potential
Transmembrane692 – 71221Helical; Potential
Topological domain713 – 930218Cytoplasmic Potential
Domain31 – 133103Cadherin 1
Domain134 – 242109Cadherin 2
Domain243 – 347105Cadherin 3
Domain348 – 452105Cadherin 4
Domain453 – 562110Cadherin 5
Domain570 – 675106Cadherin 6

Amino acid modifications

Glycosylation3041N-linked (GlcNAc...) Potential
Glycosylation4191N-linked (GlcNAc...) Potential
Glycosylation5451N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence807 – 82014QAPPN…FSQAQ → VSFSFLCVIYLIVY in isoform 2.
VSP_008694
Alternative sequence821 – 930110Missing in isoform 2.
VSP_008695
Natural variant6841P → S.
Corresponds to variant rs3749768 [ dbSNP | Ensembl ].
VAR_021883
Natural variant7221A → T.
Corresponds to variant rs3749767 [ dbSNP | Ensembl ].
VAR_021884
Natural variant7751S → A.
Corresponds to variant rs6891442 [ dbSNP | Ensembl ].
VAR_048572

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 274409FD35D18E6E

FASTA930101,043
        10         20         30         40         50         60 
MGGSCAQRRR AGPRQVLFPL LLPLFYPTLS EPIRYSIPEE LAKGSVVGNL AKDLGLSVLD 

        70         80         90        100        110        120 
VSARKLRVSA EKLHFSVDAE SGDLLVKNRI DREQICKERR RCELQLEAVV ENPLNIFHVI 

       130        140        150        160        170        180 
VVIEDVNDHA PQFDKKEIHL EIFESASAGT RLSLDPATDP DININSIKDY KINSNPYFSL 

       190        200        210        220        230        240 
MVRVNSDGGK YPELSLEKLL DREEQRSHSL ILTALDGGDP PRSATAHIEI SVKDTNDNPP 

       250        260        270        280        290        300 
VFSRDEYRIS LSENLPPGSP VLQVTATDQD EGVNAEINYY FRSTAQSTKH MFSLDEKTGM 

       310        320        330        340        350        360 
IKNNQSFDFE DVERYTMEVE AKDGGGLSTQ CKVIIEILDE NDNSPEIIIT SLSDQILENS 

       370        380        390        400        410        420 
PPGMVVALFK TRDLDFGGNG EVRCNIETDI PFKIYSSSNN YYKLVTDGAL DREQTPEYNV 

       430        440        450        460        470        480 
TIVATDRGKP PLSSSRSITL YVADINDNAP VFDQTSYVVH VAENNPPGAS IAQVSASDPD 

       490        500        510        520        530        540 
LGLNGHISYS IVASDLEPLA VSSYVSVSAQ SGVVFAQRAF DHEQLRAFAL TLQARDHGSP 

       550        560        570        580        590        600 
TLSANVSLRV LVGDRNDNAP RVLYPALGPD GSAFFDMVPR SAEPGYLVTK VVAVDADSGH 

       610        620        630        640        650        660 
NAWLSYHVLQ ASEPGLFSLG LRTGEVRTAR ALGDRDAARQ RLLVAVRDGG QPPLSATATL 

       670        680        690        700        710        720 
HLVFADNLQE ILPDLSDRPV LSDPQAELQF YLVVALALIS VLFLLAVILA IALRLRRSLS 

       730        740        750        760        770        780 
PATWDCFHPG LCVKSGPVVP PNYSEGTLPY SYNLCIAHTG TKEFNFLKCS VPLHSNEDMV 

       790        800        810        820        830        840 
CSVSPGALIP PHGGEDLTSH PETLTSQAPP NTDWRFSQAQ RPGTSGSQNG DDTGTWPNNQ 

       850        860        870        880        890        900 
FDTEMLQAMI LASASEAADG SSTLGGGAGT MGLSARYGPQ FTLQHVPDYR QNVYIPGSNA 

       910        920        930 
TLTNAAGKRD GKAPAGGNGN KKKSGKKEKK 

« Hide

Isoform 2 (Short) [UniParc].

Checksum: 83370B01C3D7F883
Show »

FASTA82089,765

References

[1]"A striking organization of a large family of human neural cadherin-like cell adhesion genes."
Wu Q., Maniatis T.
Cell 97:779-790(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF152335 mRNA. Translation: AAD43729.1.
AF152522 mRNA. Translation: AAD43782.1.
CCDSCCDS54929.1. [Q9Y5F9-1]
RefSeqNP_061749.1. NM_018926.2. [Q9Y5F9-1]
NP_115271.1. NM_032100.1. [Q9Y5F9-2]
UniGeneHs.368160.

3D structure databases

ProteinModelPortalQ9Y5F9.
SMRQ9Y5F9. Positions 33-686.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ9Y5F9.

Polymorphism databases

DMDM37999829.

Proteomic databases

MaxQBQ9Y5F9.
PRIDEQ9Y5F9.

Protocols and materials databases

DNASU56100.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000520790; ENSP00000428603; ENSG00000253305. [Q9Y5F9-1]
GeneID56100.
KEGGhsa:56100.
UCSCuc003lki.1. human. [Q9Y5F9-2]
uc003lkj.2. human. [Q9Y5F9-1]

Organism-specific databases

CTD56100.
GeneCardsGC05P141333.
HGNCHGNC:8713. PCDHGB6.
HPAHPA008755.
MIM604968. gene.
606303. gene.
neXtProtNX_Q9Y5F9.
PharmGKBPA33061.
GenAtlasSearch...

Phylogenomic databases

HOGENOMHOG000220892.
HOVERGENHBG054878.
KOK16496.
OMARVNSDGG.
OrthoDBEOG7J70DX.
PhylomeDBQ9Y5F9.
TreeFamTF332299.

Gene expression databases

ArrayExpressQ9Y5F9.
BgeeQ9Y5F9.
GenevestigatorQ9Y5F9.

Family and domain databases

Gene3D2.60.40.60. 6 hits.
InterProIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
[Graphical view]
PRINTSPR00205. CADHERIN.
SMARTSM00112. CA. 6 hits.
[Graphical view]
SUPFAMSSF49313. SSF49313. 6 hits.
PROSITEPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi56100.
NextBio61511.
PROQ9Y5F9.
SOURCESearch...

Entry information

Entry namePCDGI_HUMAN
AccessionPrimary (citable) accession number: Q9Y5F9
Secondary accession number(s): Q9Y5C5
Entry history
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM