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Protein

Protocadherin gamma-C4

Gene

PCDHGC4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin gamma-C4
Short name:
PCDH-gamma-C4
Gene namesi
Name:PCDHGC4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:8717. PCDHGC4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 692ExtracellularSequence analysisAdd BLAST663
Transmembranei693 – 713HelicalSequence analysisAdd BLAST21
Topological domaini714 – 938CytoplasmicSequence analysisAdd BLAST225

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000242419.
PharmGKBiPA33065.

Polymorphism and mutation databases

BioMutaiPCDHGC4.
DMDMi37999827.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000000398730 – 938Protocadherin gamma-C4Add BLAST909

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi265N-linked (GlcNAc...)Sequence analysis1
Glycosylationi276N-linked (GlcNAc...)Sequence analysis1
Glycosylationi444N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9Y5F7.
PaxDbiQ9Y5F7.
PeptideAtlasiQ9Y5F7.
PRIDEiQ9Y5F7.

PTM databases

iPTMnetiQ9Y5F7.
PhosphoSitePlusiQ9Y5F7.

Expressioni

Gene expression databases

BgeeiENSG00000242419.
ExpressionAtlasiQ9Y5F7. baseline and differential.
GenevisibleiQ9Y5F7. HS.

Organism-specific databases

HPAiHPA008755.

Interactioni

Protein-protein interaction databases

BioGridi121038. 3 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ9Y5F7.
SMRiQ9Y5F7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 133Cadherin 1PROSITE-ProRule annotationAdd BLAST104
Domaini134 – 242Cadherin 2PROSITE-ProRule annotationAdd BLAST109
Domaini243 – 350Cadherin 3PROSITE-ProRule annotationAdd BLAST108
Domaini351 – 455Cadherin 4PROSITE-ProRule annotationAdd BLAST105
Domaini456 – 565Cadherin 5PROSITE-ProRule annotationAdd BLAST110
Domaini572 – 676Cadherin 6PROSITE-ProRule annotationAdd BLAST105

Sequence similaritiesi

Contains 6 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00850000132246.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.
InParanoidiQ9Y5F7.
KOiK16497.
OMAiHYFFLLW.
OrthoDBiEOG091G00SP.
PhylomeDBiQ9Y5F7.
TreeFamiTF332299.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR031904. Cadherin_CBD.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF15974. Cadherin_tail. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y5F7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLRKVRSWTE IWRWATLLFL FYHLGYVCGQ IRYPVPEESQ EGTFVGNVAQ
60 70 80 90 100
DFLLDTDSLS ARRLQVAGEV NQRHFRVDLD SGALLIKNPI DREALCGLSA
110 120 130 140 150
SCIVPLEFVT EGPLEMYRAE VEIVDVNDHA PRFPRQQLDL EIGEAAPPGQ
160 170 180 190 200
RFPLEKAQDA DVGSNSISSY RLSSNEHFAL DVKKRSDGSL VPELLLEKPL
210 220 230 240 250
DREKQSDYRL VLTAVDGGNP PRSGTAELRV SVLDVNDNAP AFQQSSYRIS
260 270 280 290 300
VLESAPAGMV LIQLNASDPD LGPSGNVTFY FSGHTPDRVR NLFSLHPTTG
310 320 330 340 350
KLTLLGPLDF ESENYYEFDV RARDGGSPAM EQHCSLRVDL LDVNDNAPYI
360 370 380 390 400
TVTSELGTLP ESAEPGTVVA LISVQDPDSG SNGDVSLRIP DHLPFALKSA
410 420 430 440 450
FRNQFSLVTA GPLDREAKSS YDIMVTASDA GNPPLSTHRT IFLNISDVND
460 470 480 490 500
NPPSFFQRSH EVFVPENNRP GDLLCSLAAS DPDSGLNALI SYSLLEPRNR
510 520 530 540 550
DVSASSFISL NPQTGAVHAT RSFDYEQTQT LQFEVQARDR GNPPLSSTVT
560 570 580 590 600
VRLFVLDLND NAPAVLRPRA RPGSLCPQAL PPSVGAGHLI TKVTAVDLDS
610 620 630 640 650
GYNAWVSYQL LEAPDPSLFA VSRYAGEVRT AVPIPADLPP QKLVIVVKDS
660 670 680 690 700
GSPPLSTSVT LLVSLEEDTH PVVPDLRESS APREGESRLT LYLAVSLVAI
710 720 730 740 750
CFVSFGSFVA LLSKCLRGAA CGVTCFPAGT CACLTRSRRR EGLPPSNGIL
760 770 780 790 800
RIQLGSDDPI KFVDVGGHSH GCTPLASAPT RSDSFMMVKS PSAPMAGEPV
810 820 830 840 850
RPSCPPSDLL YGLEQAPPNT DWRFSQAQRP GTSGSQNGDD TGTWPNNQFD
860 870 880 890 900
TEMLQAMILA SASEAADGSS TLGGGAGTMG LSARYGPQFT LQHVPDYRQN
910 920 930
VYIPGSNATL TNAAGKRDGK APAGGNGNKK KSGKKEKK
Length:938
Mass (Da):101,214
Last modified:November 1, 1999 - v1
Checksum:i99820B82A2F18ECC
GO
Isoform 2 (identifier: Q9Y5F7-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     815-871: QAPPNTDWRF...ASEAADGSST → VRPLQAQQML...DAVLCNCFVN
     872-938: Missing.

Show »
Length:871
Mass (Da):94,477
Checksum:i7ECD96F291D15B11
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_008700815 – 871QAPPN…DGSST → VRPLQAQQMLEGYSDPGIWL GHVLESTGLSVSAHSDVTIF VRGNYVVDAVLCNCFVN in isoform 2. 2 PublicationsAdd BLAST57
Alternative sequenceiVSP_008701872 – 938Missing in isoform 2. 2 PublicationsAdd BLAST67

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152338 mRNA. Translation: AAD43732.1.
AF152525 mRNA. Translation: AAD43785.1.
CH471062 Genomic DNA. Translation: EAW61946.1.
BC101035 mRNA. Translation: AAI01036.1.
BC101038 mRNA. Translation: AAI01039.1.
CCDSiCCDS4262.1. [Q9Y5F7-1]
CCDS75349.1. [Q9Y5F7-2]
RefSeqiNP_061751.1. NM_018928.2. [Q9Y5F7-1]
NP_115782.1. NM_032406.1. [Q9Y5F7-2]
UniGeneiHs.368160.

Genome annotation databases

EnsembliENST00000306593; ENSP00000306918; ENSG00000242419. [Q9Y5F7-1]
ENST00000617094; ENSP00000483845; ENSG00000242419. [Q9Y5F7-2]
GeneIDi56098.
KEGGihsa:56098.
UCSCiuc003lky.3. human. [Q9Y5F7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152338 mRNA. Translation: AAD43732.1.
AF152525 mRNA. Translation: AAD43785.1.
CH471062 Genomic DNA. Translation: EAW61946.1.
BC101035 mRNA. Translation: AAI01036.1.
BC101038 mRNA. Translation: AAI01039.1.
CCDSiCCDS4262.1. [Q9Y5F7-1]
CCDS75349.1. [Q9Y5F7-2]
RefSeqiNP_061751.1. NM_018928.2. [Q9Y5F7-1]
NP_115782.1. NM_032406.1. [Q9Y5F7-2]
UniGeneiHs.368160.

3D structure databases

ProteinModelPortaliQ9Y5F7.
SMRiQ9Y5F7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121038. 3 interactors.

PTM databases

iPTMnetiQ9Y5F7.
PhosphoSitePlusiQ9Y5F7.

Polymorphism and mutation databases

BioMutaiPCDHGC4.
DMDMi37999827.

Proteomic databases

EPDiQ9Y5F7.
PaxDbiQ9Y5F7.
PeptideAtlasiQ9Y5F7.
PRIDEiQ9Y5F7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306593; ENSP00000306918; ENSG00000242419. [Q9Y5F7-1]
ENST00000617094; ENSP00000483845; ENSG00000242419. [Q9Y5F7-2]
GeneIDi56098.
KEGGihsa:56098.
UCSCiuc003lky.3. human. [Q9Y5F7-1]

Organism-specific databases

CTDi56098.
GeneCardsiPCDHGC4.
HGNCiHGNC:8717. PCDHGC4.
HPAiHPA008755.
MIMi604968. gene.
606305. gene.
neXtProtiNX_Q9Y5F7.
OpenTargetsiENSG00000242419.
PharmGKBiPA33065.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00850000132246.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.
InParanoidiQ9Y5F7.
KOiK16497.
OMAiHYFFLLW.
OrthoDBiEOG091G00SP.
PhylomeDBiQ9Y5F7.
TreeFamiTF332299.

Miscellaneous databases

GenomeRNAii56098.
PROiQ9Y5F7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000242419.
ExpressionAtlasiQ9Y5F7. baseline and differential.
GenevisibleiQ9Y5F7. HS.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR031904. Cadherin_CBD.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF15974. Cadherin_tail. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPCDGL_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5F7
Secondary accession number(s): Q495T2, Q9Y5C3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: November 1, 1999
Last modified: November 30, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.