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Protein

Protocadherin gamma-C5

Gene

PCDHGC5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin gamma-C5
Short name:
PCDH-gamma-C5
Gene namesi
Name:PCDHGC5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:8718. PCDHGC5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini30 – 693664ExtracellularSequence analysisAdd
BLAST
Transmembranei694 – 71421HelicalSequence analysisAdd
BLAST
Topological domaini715 – 944230CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33066.

Polymorphism and mutation databases

BioMutaiPCDHGC5.
DMDMi37999826.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence analysisAdd
BLAST
Chaini30 – 944915Protocadherin gamma-C5PRO_0000003989Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi265 – 2651N-linked (GlcNAc...)Sequence analysis
Glycosylationi443 – 4431N-linked (GlcNAc...)Sequence analysis
Glycosylationi547 – 5471N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9Y5F6.
PRIDEiQ9Y5F6.

PTM databases

PhosphoSiteiQ9Y5F6.

Expressioni

Gene expression databases

BgeeiQ9Y5F6.
GenevisibleiQ9Y5F6. HS.

Organism-specific databases

HPAiHPA008755.

Interactioni

Protein-protein interaction databases

BioGridi121037. 1 interaction.
STRINGi9606.ENSP00000252087.

Structurei

3D structure databases

ProteinModelPortaliQ9Y5F6.
SMRiQ9Y5F6. Positions 28-692.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 133104Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini134 – 242109Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini243 – 350108Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini351 – 454104Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Domaini455 – 564110Cadherin 5PROSITE-ProRule annotationAdd
BLAST
Domaini571 – 677107Cadherin 6PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 6 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00840000129690.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.
InParanoidiQ9Y5F6.
KOiK16497.
OMAiCCGRQDS.
OrthoDBiEOG7J445X.
PhylomeDBiQ9Y5F6.
TreeFamiTF332299.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR031904. Cadherin_CBD.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
PF15974. Cadherin_tail. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y5F6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGPKTLPQLA GKWQVLCMLS LCCWGWVSGQ LRYSVVEESE PGTLVGNVAQ
60 70 80 90 100
DLGLKMTDLL SRRLQLGSEE NGRYFSLSLM SGALAVNQKI DRESLCGAST
110 120 130 140 150
SCLLPVQVVT EHPLELIRVE VEILDLNDNS PSFATPEREM RISESAASGA
160 170 180 190 200
RFPLDSAQDP DVGTNTVSFY TLSPNSHFSL NVKTLKDGKP FPELVLEQQL
210 220 230 240 250
DREAQARHQL VLTAVDGGTP ARSGTTLISV IVLDINDNAP TFQSSVLRVG
260 270 280 290 300
IPENAPIGTL LLRLNATDPD EGTNGQLDYS FGDHTSEAVR NLFGLDPSSG
310 320 330 340 350
AIHVLGPIDF EESRFYEIHA RARDQGQPAM EGHCVIQVDV GDVNDNAPEV
360 370 380 390 400
LLASLANPVL ESTPVGTVVG LFNVRDRDSG RNGEVSLDIS PDLPFQIKPS
410 420 430 440 450
ENHYSLLTSQ PLDREATSHY IIELLASDAG SPSLHKHLTI RLNISDVNDN
460 470 480 490 500
APRFNQQLYT AYILENRPPG SLLCTVAASD PDTGDNARLT YSIVGNQVQG
510 520 530 540 550
APASSFVYVN PEDGRIFAQR TFDYELLQML QIVVGVRDSG SPPLHANTSL
560 570 580 590 600
HVFVLDENDN APAVLHPRPD WEHSAPQRLP RSAPPGSLVT KVTAVDADAG
610 620 630 640 650
HNAWLSYSLL PQSTAPGLFL VSTHTGEVRT ARALLEDDSD TQQVVVLVRD
660 670 680 690 700
NGDPSLSSTA TVLLVLEDED PEEMPKSSDF LIHPPERSDL TLYLIVALAT
710 720 730 740 750
VSLLSLVTFT FLSAKCLQGN ADGDGGGGQC CRRQDSPSPD FYKQSSPNLQ
760 770 780 790 800
VSSDGTLKYM EVTLRPTDSQ SHCYRTCFSP ASDGSDFTFL RPLSVQQPTA
810 820 830 840 850
LALEPDAIRS RSNTLRERSQ QAPPNTDWRF SQAQRPGTSG SQNGDDTGTW
860 870 880 890 900
PNNQFDTEML QAMILASASE AADGSSTLGG GAGTMGLSAR YGPQFTLQHV
910 920 930 940
PDYRQNVYIP GSNATLTNAA GKRDGKAPAG GNGNKKKSGK KEKK
Length:944
Mass (Da):101,921
Last modified:November 1, 1999 - v1
Checksum:i10B8E7D60DC9497A
GO
Isoform 2 (identifier: Q9Y5F6-2) [UniParc]FASTAAdd to basket

Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     821-878: QAPPNTDWRF...SEAADGSSTL → VRGSAPPRAT...DRLRETRVAD
     879-944: Missing.

Show »
Length:878
Mass (Da):95,193
Checksum:iE7964C6A42CB1EA4
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti275 – 2751G → S.
Corresponds to variant rs2233603 [ dbSNP | Ensembl ].
VAR_048574
Natural varianti570 – 5701D → G.
Corresponds to variant rs2074912 [ dbSNP | Ensembl ].
VAR_024394

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei821 – 87858QAPPN…GSSTL → VRGSAPPRATPGGGTGEAAR PHKGLNLHPLLSGRLGRWLR STRFSGSLDRLRETRVAD in isoform 2. 1 PublicationVSP_008702Add
BLAST
Alternative sequencei879 – 94466Missing in isoform 2. 1 PublicationVSP_008703Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152339 mRNA. Translation: AAD43733.1.
AF152526 mRNA. Translation: AAD43786.1.
CCDSiCCDS4263.1. [Q9Y5F6-1]
CCDS75350.1. [Q9Y5F6-2]
RefSeqiNP_061752.1. NM_018929.2. [Q9Y5F6-1]
NP_115783.1. NM_032407.1. [Q9Y5F6-2]
UniGeneiHs.368160.

Genome annotation databases

EnsembliENST00000252087; ENSP00000252087; ENSG00000240764. [Q9Y5F6-1]
ENST00000610789; ENSP00000482569; ENSG00000240764. [Q9Y5F6-2]
GeneIDi56097.
KEGGihsa:56097.
UCSCiuc003lla.3. human. [Q9Y5F6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152339 mRNA. Translation: AAD43733.1.
AF152526 mRNA. Translation: AAD43786.1.
CCDSiCCDS4263.1. [Q9Y5F6-1]
CCDS75350.1. [Q9Y5F6-2]
RefSeqiNP_061752.1. NM_018929.2. [Q9Y5F6-1]
NP_115783.1. NM_032407.1. [Q9Y5F6-2]
UniGeneiHs.368160.

3D structure databases

ProteinModelPortaliQ9Y5F6.
SMRiQ9Y5F6. Positions 28-692.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121037. 1 interaction.
STRINGi9606.ENSP00000252087.

PTM databases

PhosphoSiteiQ9Y5F6.

Polymorphism and mutation databases

BioMutaiPCDHGC5.
DMDMi37999826.

Proteomic databases

PaxDbiQ9Y5F6.
PRIDEiQ9Y5F6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000252087; ENSP00000252087; ENSG00000240764. [Q9Y5F6-1]
ENST00000610789; ENSP00000482569; ENSG00000240764. [Q9Y5F6-2]
GeneIDi56097.
KEGGihsa:56097.
UCSCiuc003lla.3. human. [Q9Y5F6-1]

Organism-specific databases

CTDi56097.
GeneCardsiPCDHGC5.
HGNCiHGNC:8718. PCDHGC5.
HPAiHPA008755.
MIMi604968. gene.
606306. gene.
neXtProtiNX_Q9Y5F6.
PharmGKBiPA33066.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00840000129690.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.
InParanoidiQ9Y5F6.
KOiK16497.
OMAiCCGRQDS.
OrthoDBiEOG7J445X.
PhylomeDBiQ9Y5F6.
TreeFamiTF332299.

Miscellaneous databases

GenomeRNAii56097.
NextBioi61493.
PROiQ9Y5F6.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y5F6.
GenevisibleiQ9Y5F6. HS.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR031904. Cadherin_CBD.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
PF15974. Cadherin_tail. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A striking organization of a large family of human neural cadherin-like cell adhesion genes."
    Wu Q., Maniatis T.
    Cell 97:779-790(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain.

Entry informationi

Entry nameiPCDGM_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5F6
Secondary accession number(s): Q9Y5C2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: November 1, 1999
Last modified: May 11, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.