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Q9Y5F2

- PCDBB_HUMAN

UniProt

Q9Y5F2 - PCDBB_HUMAN

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Protein

Protocadherin beta-11

Gene
PCDHB11
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro

GO - Biological processi

  1. calcium-dependent cell-cell adhesion Source: UniProtKB
  2. cell adhesion Source: ProtInc
  3. homophilic cell adhesion Source: InterPro
  4. nervous system development Source: ProtInc
  5. synapse assembly Source: UniProtKB
  6. synaptic transmission Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin beta-11
Short name:
PCDH-beta-11
Gene namesi
Name:PCDHB11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:8682. PCDHB11.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 690664Extracellular Reviewed predictionAdd
BLAST
Transmembranei691 – 71121Helical; Reviewed predictionAdd
BLAST
Topological domaini712 – 79786Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB
  2. integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33027.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626 Reviewed predictionAdd
BLAST
Chaini27 – 797771Protocadherin beta-11PRO_0000003934Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi418 – 4181N-linked (GlcNAc...) Reviewed prediction
Glycosylationi436 – 4361N-linked (GlcNAc...) Reviewed prediction
Glycosylationi487 – 4871N-linked (GlcNAc...) Reviewed prediction
Glycosylationi567 – 5671N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9Y5F2.
PRIDEiQ9Y5F2.

PTM databases

PhosphoSiteiQ9Y5F2.

Expressioni

Gene expression databases

ArrayExpressiQ9Y5F2.
BgeeiQ9Y5F2.
CleanExiHS_PCDHB11.
GenevestigatoriQ9Y5F2.

Organism-specific databases

HPAiHPA045042.

Interactioni

Protein-protein interaction databases

BioGridi121065. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9Y5F2.
SMRiQ9Y5F2. Positions 30-677.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 13399Cadherin 1Add
BLAST
Domaini138 – 242105Cadherin 2Add
BLAST
Domaini247 – 347101Cadherin 3Add
BLAST
Domaini352 – 451100Cadherin 4Add
BLAST
Domaini456 – 561106Cadherin 5Add
BLAST
Domaini568 – 671104Cadherin 6Add
BLAST

Sequence similaritiesi

Contains 6 cadherin domains.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG251260.
HOVERGENiHBG054878.
InParanoidiQ9Y5F2.
KOiK16494.
OMAiKTEHNTT.
OrthoDBiEOG7KSX80.
PhylomeDBiQ9Y5F2.
TreeFamiTF332299.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y5F2-1 [UniParc]FASTAAdd to Basket

« Hide

MENQGTRTQQ IRQVLLLFVL LGMSQAGSET WSFSVAEEMQ SGSFVGNLAK    50
DLGLKVRELS SRGARVVSND KKQRLQLDIN TGDLLLSETL DREELCGSIE 100
PCVLHLQVLM QNPTQFLQIE LQVRDINDHS PIFSEKQMLL EIPENSPVGA 150
VFLLESAKDL DVGINAVKSY TISPNSHFHI KMRVIPDNRK YPELVLDKAL 200
DYEELPELSF ILSALDGGSP PRSGTALVRV VVVDINDNSP EFEQAFYEVK 250
IRENSILGSL ILIVSAWDLD SGTNGEICYT FSHASEDIRK TFEINQKSGE 300
ITLRAPLDFE TIESYSIIIQ ATDGGGLFGK STVIIHVIDV NDNAPEITVS 350
SITSPIPENT PETVVMVFSI QDIDSGDNGR IVCSIPEDLP FVLKSSVENY 400
YTLETERPLD RESTAEYNIT ITVTDLGIPR LKTEHNTTVL VSDVNDNAPT 450
FTQTSYTLFV RENNSPALHI GSVSATDRDS GTNAQVNYSL LPPQDLHLPL 500
ASLVSINTDN GHLFALRSLD YEALQAFDFR VGATDRGSPA LSSEALVRVL 550
VLDANDNSPF VLYPLQNGSA PCTELVPRAA EPGYLVTKVV AVDGDSGQNA 600
WLSYQLLKAT EPGLFGVWAH NGEVRTARLL SERDAAKHRL VVLVKDNGEP 650
PRSATATLQV LLVDGFSQPY LPLPEAAPAQ AQADSLTVYL VVALASVSSL 700
FLFSVLLFVA VRLCRRSRAA SVGSCSVPKG PFPGHLVDVS GTGTLSQSYQ 750
YEVCLTGGSE TNEFKFLKPV IPNIQAKGLG KNSEENSTFR NSFGFNF 797
Length:797
Mass (Da):87,088
Last modified:November 1, 1999 - v1
Checksum:i8FBA0DBCC2858504
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti4 – 41Q → R.
Corresponds to variant rs3756323 [ dbSNP | Ensembl ].
VAR_021881
Natural varianti7 – 71R → H.
Corresponds to variant rs917535 [ dbSNP | Ensembl ].
VAR_048553
Natural varianti528 – 5281D → E.
Corresponds to variant rs799834 [ dbSNP | Ensembl ].
VAR_059188

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF152490 mRNA. Translation: AAD43751.1.
AF217747 mRNA. Translation: AAK51615.1.
BC112132 mRNA. Translation: AAI12133.1.
BC113611 mRNA. Translation: AAI13612.1.
CCDSiCCDS4253.1.
RefSeqiNP_061754.1. NM_018931.2.
UniGeneiHs.283084.

Genome annotation databases

EnsembliENST00000354757; ENSP00000346802; ENSG00000197479.
ENST00000608766; ENSP00000476597; ENSG00000262565.
GeneIDi56125.
KEGGihsa:56125.
UCSCiuc003liy.3. human.

Polymorphism databases

DMDMi13431383.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF152490 mRNA. Translation: AAD43751.1 .
AF217747 mRNA. Translation: AAK51615.1 .
BC112132 mRNA. Translation: AAI12133.1 .
BC113611 mRNA. Translation: AAI13612.1 .
CCDSi CCDS4253.1.
RefSeqi NP_061754.1. NM_018931.2.
UniGenei Hs.283084.

3D structure databases

ProteinModelPortali Q9Y5F2.
SMRi Q9Y5F2. Positions 30-677.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121065. 1 interaction.

PTM databases

PhosphoSitei Q9Y5F2.

Polymorphism databases

DMDMi 13431383.

Proteomic databases

PaxDbi Q9Y5F2.
PRIDEi Q9Y5F2.

Protocols and materials databases

DNASUi 56125.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000354757 ; ENSP00000346802 ; ENSG00000197479 .
ENST00000608766 ; ENSP00000476597 ; ENSG00000262565 .
GeneIDi 56125.
KEGGi hsa:56125.
UCSCi uc003liy.3. human.

Organism-specific databases

CTDi 56125.
GeneCardsi GC05P140579.
HGNCi HGNC:8682. PCDHB11.
HPAi HPA045042.
MIMi 604967. gene.
606337. gene.
neXtProti NX_Q9Y5F2.
PharmGKBi PA33027.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG251260.
HOVERGENi HBG054878.
InParanoidi Q9Y5F2.
KOi K16494.
OMAi KTEHNTT.
OrthoDBi EOG7KSX80.
PhylomeDBi Q9Y5F2.
TreeFami TF332299.

Miscellaneous databases

GeneWikii PCDHB11.
GenomeRNAii 56125.
NextBioi 61632.
PROi Q9Y5F2.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9Y5F2.
Bgeei Q9Y5F2.
CleanExi HS_PCDHB11.
Genevestigatori Q9Y5F2.

Family and domain databases

Gene3Di 2.60.40.60. 5 hits.
InterProi IPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view ]
Pfami PF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
[Graphical view ]
PRINTSi PR00205. CADHERIN.
SMARTi SM00112. CA. 6 hits.
[Graphical view ]
SUPFAMi SSF49313. SSF49313. 6 hits.
PROSITEi PS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A striking organization of a large family of human neural cadherin-like cell adhesion genes."
    Wu Q., Maniatis T.
    Cell 97:779-790(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number."
    Vanhalst K., Kools P., Vanden Eynde E., van Roy F.
    FEBS Lett. 495:120-125(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.

Entry informationi

Entry nameiPCDBB_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5F2
Secondary accession number(s): Q2M223
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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