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Protein

Protocadherin beta-11

Gene

PCDHB11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

GO - Molecular functioni

GO - Biological processi

  • calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
  • cell adhesion Source: ProtInc
  • chemical synaptic transmission Source: UniProtKB
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
  • nervous system development Source: ProtInc
  • synapse assembly Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin beta-11
Short name:
PCDH-beta-11
Gene namesi
Name:PCDHB11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:8682. PCDHB11.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 690ExtracellularSequence analysisAdd BLAST664
Transmembranei691 – 711HelicalSequence analysisAdd BLAST21
Topological domaini712 – 797CytoplasmicSequence analysisAdd BLAST86

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
  • integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi56125.
OpenTargetsiENSG00000197479.
PharmGKBiPA33027.

Polymorphism and mutation databases

BioMutaiPCDHB11.
DMDMi13431383.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000000393427 – 797Protocadherin beta-11Add BLAST771

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei297N6-acetyllysineBy similarity1
Glycosylationi418N-linked (GlcNAc...)Sequence analysis1
Glycosylationi436N-linked (GlcNAc...)Sequence analysis1
Glycosylationi487N-linked (GlcNAc...)Sequence analysis1
Glycosylationi567N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Acetylation, Glycoprotein

Proteomic databases

EPDiQ9Y5F2.
PaxDbiQ9Y5F2.
PeptideAtlasiQ9Y5F2.
PRIDEiQ9Y5F2.

PTM databases

iPTMnetiQ9Y5F2.
PhosphoSitePlusiQ9Y5F2.

Expressioni

Gene expression databases

BgeeiENSG00000197479.
CleanExiHS_PCDHB11.
GenevisibleiQ9Y5F2. HS.

Organism-specific databases

HPAiHPA045042.

Interactioni

Protein-protein interaction databases

BioGridi121065. 48 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ9Y5F2.
SMRiQ9Y5F2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 133Cadherin 1PROSITE-ProRule annotationAdd BLAST99
Domaini138 – 242Cadherin 2PROSITE-ProRule annotationAdd BLAST105
Domaini247 – 347Cadherin 3PROSITE-ProRule annotationAdd BLAST101
Domaini352 – 451Cadherin 4PROSITE-ProRule annotationAdd BLAST100
Domaini456 – 561Cadherin 5PROSITE-ProRule annotationAdd BLAST106
Domaini568 – 671Cadherin 6PROSITE-ProRule annotationAdd BLAST104

Sequence similaritiesi

Contains 6 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00840000129690.
HOVERGENiHBG054878.
InParanoidiQ9Y5F2.
KOiK16494.
OMAiKTEHNTT.
OrthoDBiEOG091G024L.
PhylomeDBiQ9Y5F2.
TreeFamiTF332299.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
IPR030734. PCDHB11.
[Graphical view]
PANTHERiPTHR24028:SF91. PTHR24028:SF91. 1 hit.
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y5F2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MENQGTRTQQ IRQVLLLFVL LGMSQAGSET WSFSVAEEMQ SGSFVGNLAK
60 70 80 90 100
DLGLKVRELS SRGARVVSND KKQRLQLDIN TGDLLLSETL DREELCGSIE
110 120 130 140 150
PCVLHLQVLM QNPTQFLQIE LQVRDINDHS PIFSEKQMLL EIPENSPVGA
160 170 180 190 200
VFLLESAKDL DVGINAVKSY TISPNSHFHI KMRVIPDNRK YPELVLDKAL
210 220 230 240 250
DYEELPELSF ILSALDGGSP PRSGTALVRV VVVDINDNSP EFEQAFYEVK
260 270 280 290 300
IRENSILGSL ILIVSAWDLD SGTNGEICYT FSHASEDIRK TFEINQKSGE
310 320 330 340 350
ITLRAPLDFE TIESYSIIIQ ATDGGGLFGK STVIIHVIDV NDNAPEITVS
360 370 380 390 400
SITSPIPENT PETVVMVFSI QDIDSGDNGR IVCSIPEDLP FVLKSSVENY
410 420 430 440 450
YTLETERPLD RESTAEYNIT ITVTDLGIPR LKTEHNTTVL VSDVNDNAPT
460 470 480 490 500
FTQTSYTLFV RENNSPALHI GSVSATDRDS GTNAQVNYSL LPPQDLHLPL
510 520 530 540 550
ASLVSINTDN GHLFALRSLD YEALQAFDFR VGATDRGSPA LSSEALVRVL
560 570 580 590 600
VLDANDNSPF VLYPLQNGSA PCTELVPRAA EPGYLVTKVV AVDGDSGQNA
610 620 630 640 650
WLSYQLLKAT EPGLFGVWAH NGEVRTARLL SERDAAKHRL VVLVKDNGEP
660 670 680 690 700
PRSATATLQV LLVDGFSQPY LPLPEAAPAQ AQADSLTVYL VVALASVSSL
710 720 730 740 750
FLFSVLLFVA VRLCRRSRAA SVGSCSVPKG PFPGHLVDVS GTGTLSQSYQ
760 770 780 790
YEVCLTGGSE TNEFKFLKPV IPNIQAKGLG KNSEENSTFR NSFGFNF
Length:797
Mass (Da):87,088
Last modified:November 1, 1999 - v1
Checksum:i8FBA0DBCC2858504
GO
Isoform 2 (identifier: Q9Y5F2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-365: Missing.

Note: No experimental confirmation available.
Show »
Length:432
Mass (Da):46,732
Checksum:i3EE3340AF7EE89BB
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0218814Q → R.Corresponds to variant rs3756323dbSNPEnsembl.1
Natural variantiVAR_0485537R → H.Corresponds to variant rs917535dbSNPEnsembl.1
Natural variantiVAR_059188528D → E.Corresponds to variant rs799834dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0559311 – 365Missing in isoform 2. 1 PublicationAdd BLAST365

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152490 mRNA. Translation: AAD43751.1.
AF217747 mRNA. Translation: AAK51615.1.
AK299719 mRNA. Translation: BAG61619.1.
AC005752 Genomic DNA. No translation available.
BC112132 mRNA. Translation: AAI12133.1.
BC113611 mRNA. Translation: AAI13612.1.
CCDSiCCDS4253.1. [Q9Y5F2-1]
RefSeqiNP_061754.1. NM_018931.2. [Q9Y5F2-1]
UniGeneiHs.283084.

Genome annotation databases

EnsembliENST00000354757; ENSP00000346802; ENSG00000197479. [Q9Y5F2-1]
ENST00000624887; ENSP00000485553; ENSG00000197479. [Q9Y5F2-2]
GeneIDi56125.
KEGGihsa:56125.
UCSCiuc003liy.4. human. [Q9Y5F2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152490 mRNA. Translation: AAD43751.1.
AF217747 mRNA. Translation: AAK51615.1.
AK299719 mRNA. Translation: BAG61619.1.
AC005752 Genomic DNA. No translation available.
BC112132 mRNA. Translation: AAI12133.1.
BC113611 mRNA. Translation: AAI13612.1.
CCDSiCCDS4253.1. [Q9Y5F2-1]
RefSeqiNP_061754.1. NM_018931.2. [Q9Y5F2-1]
UniGeneiHs.283084.

3D structure databases

ProteinModelPortaliQ9Y5F2.
SMRiQ9Y5F2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121065. 48 interactors.

PTM databases

iPTMnetiQ9Y5F2.
PhosphoSitePlusiQ9Y5F2.

Polymorphism and mutation databases

BioMutaiPCDHB11.
DMDMi13431383.

Proteomic databases

EPDiQ9Y5F2.
PaxDbiQ9Y5F2.
PeptideAtlasiQ9Y5F2.
PRIDEiQ9Y5F2.

Protocols and materials databases

DNASUi56125.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354757; ENSP00000346802; ENSG00000197479. [Q9Y5F2-1]
ENST00000624887; ENSP00000485553; ENSG00000197479. [Q9Y5F2-2]
GeneIDi56125.
KEGGihsa:56125.
UCSCiuc003liy.4. human. [Q9Y5F2-1]

Organism-specific databases

CTDi56125.
DisGeNETi56125.
GeneCardsiPCDHB11.
HGNCiHGNC:8682. PCDHB11.
HPAiHPA045042.
MIMi604967. gene.
606337. gene.
neXtProtiNX_Q9Y5F2.
OpenTargetsiENSG00000197479.
PharmGKBiPA33027.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00840000129690.
HOVERGENiHBG054878.
InParanoidiQ9Y5F2.
KOiK16494.
OMAiKTEHNTT.
OrthoDBiEOG091G024L.
PhylomeDBiQ9Y5F2.
TreeFamiTF332299.

Miscellaneous databases

GeneWikiiPCDHB11.
GenomeRNAii56125.
PROiQ9Y5F2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000197479.
CleanExiHS_PCDHB11.
GenevisibleiQ9Y5F2. HS.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
IPR030734. PCDHB11.
[Graphical view]
PANTHERiPTHR24028:SF91. PTHR24028:SF91. 1 hit.
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPCDBB_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5F2
Secondary accession number(s): B4DSF7, Q2M223
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1999
Last modified: November 30, 2016
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.