Q9Y5F2 (PCDBB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protocadherin beta-11
Short name=PCDH-beta-11

Gene names

Name:

PCDHB11

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	797 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
Subcellular location	Cell membrane; Single-pass type I membrane protein By similarity.
Sequence similarities	Contains 6 cadherin domains.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Repeat Signal Transmembrane Transmembrane helix
Ligand	Calcium
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	calcium-dependent cell-cell adhesion Non-traceable author statement Ref.2. Source: UniProtKB homophilic cell adhesion Inferred from electronic annotation. Source: InterPro synapse assembly Traceable author statement PubMed 12231349. Source: UniProtKB synaptic transmission Traceable author statement PubMed 12231349. Source: UniProtKB
Cellular_component	integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 26	26	Potential
	Chain	27 – 797	771	Protocadherin beta-11		PRO_0000003934
Regions
	Topological domain	27 – 690	664	Extracellular Potential
	Transmembrane	691 – 711	21	Helical; Potential
	Topological domain	712 – 797	86	Cytoplasmic Potential
	Domain	35 – 133	99	Cadherin 1
	Domain	138 – 242	105	Cadherin 2
	Domain	247 – 347	101	Cadherin 3
	Domain	352 – 451	100	Cadherin 4
	Domain	456 – 561	106	Cadherin 5
	Domain	568 – 671	104	Cadherin 6
Amino acid modifications
	Glycosylation	418	1	N-linked (GlcNAc...) Potential
	Glycosylation	436	1	N-linked (GlcNAc...) Potential
	Glycosylation	487	1	N-linked (GlcNAc...) Potential
	Glycosylation	567	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	4	1	Q → R. Corresponds to variant rs3756323 [ dbSNP | Ensembl ].		VAR_021881
	Natural variant	7	1	R → H. Corresponds to variant rs917535 [ dbSNP | Ensembl ].		VAR_048553
	Natural variant	528	1	D → E. Corresponds to variant rs799834 [ dbSNP | Ensembl ].		VAR_059188

Sequences

	Sequence		Length	Mass (Da)
	Q9Y5F2 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 8FBA0DBCC2858504	FASTA	797	87,088
	10 20 30 40 50 60 MENQGTRTQQ IRQVLLLFVL LGMSQAGSET WSFSVAEEMQ SGSFVGNLAK DLGLKVRELS 70 80 90 100 110 120 SRGARVVSND KKQRLQLDIN TGDLLLSETL DREELCGSIE PCVLHLQVLM QNPTQFLQIE 130 140 150 160 170 180 LQVRDINDHS PIFSEKQMLL EIPENSPVGA VFLLESAKDL DVGINAVKSY TISPNSHFHI 190 200 210 220 230 240 KMRVIPDNRK YPELVLDKAL DYEELPELSF ILSALDGGSP PRSGTALVRV VVVDINDNSP 250 260 270 280 290 300 EFEQAFYEVK IRENSILGSL ILIVSAWDLD SGTNGEICYT FSHASEDIRK TFEINQKSGE 310 320 330 340 350 360 ITLRAPLDFE TIESYSIIIQ ATDGGGLFGK STVIIHVIDV NDNAPEITVS SITSPIPENT 370 380 390 400 410 420 PETVVMVFSI QDIDSGDNGR IVCSIPEDLP FVLKSSVENY YTLETERPLD RESTAEYNIT 430 440 450 460 470 480 ITVTDLGIPR LKTEHNTTVL VSDVNDNAPT FTQTSYTLFV RENNSPALHI GSVSATDRDS 490 500 510 520 530 540 GTNAQVNYSL LPPQDLHLPL ASLVSINTDN GHLFALRSLD YEALQAFDFR VGATDRGSPA 550 560 570 580 590 600 LSSEALVRVL VLDANDNSPF VLYPLQNGSA PCTELVPRAA EPGYLVTKVV AVDGDSGQNA 610 620 630 640 650 660 WLSYQLLKAT EPGLFGVWAH NGEVRTARLL SERDAAKHRL VVLVKDNGEP PRSATATLQV 670 680 690 700 710 720 LLVDGFSQPY LPLPEAAPAQ AQADSLTVYL VVALASVSSL FLFSVLLFVA VRLCRRSRAA 730 740 750 760 770 780 SVGSCSVPKG PFPGHLVDVS GTGTLSQSYQ YEVCLTGGSE TNEFKFLKPV IPNIQAKGLG 790 KNSEENSTFR NSFGFNF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A striking organization of a large family of human neural cadherin-like cell adhesion genes." Wu Q., Maniatis T. Cell 97:779-790(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number." Vanhalst K., Kools P., Vanden Eynde E., van Roy F. FEBS Lett. 495:120-125(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF152490 mRNA. Translation: AAD43751.1. AF217747 mRNA. Translation: AAK51615.1. BC112132 mRNA. Translation: AAI12133.1. BC113611 mRNA. Translation: AAI13612.1.
IPI	IPI00001451.
RefSeq	NP_061754.1. NM_018931.2.
UniGene	Hs.283084.
3D structure databases
ProteinModelPortal	Q9Y5F2.
ModBase	Search...
PTM databases
PhosphoSite	Q9Y5F2.
Polymorphism databases
DMDM	13431383.
Proteomic databases
PaxDb	Q9Y5F2.
PRIDE	Q9Y5F2.
Protocols and materials databases
DNASU	56125.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000354757; ENSP00000346802; ENSG00000197479.
GeneID	56125.
KEGG	hsa:56125.
UCSC	uc003liy.3. human.
Organism-specific databases
CTD	56125.
GeneCards	GC05P140579.
HGNC	HGNC:8682. PCDHB11.
HPA	HPA045042.
MIM	604967. gene. 606337. gene.
neXtProt	NX_Q9Y5F2.
PharmGKB	PA33027.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG251260.
HOVERGEN	HBG054878.
InParanoid	Q9Y5F2.
KO	K16494.
OMA	QAGSETW.
OrthoDB	EOG4SXNBX.
PhylomeDB	Q9Y5F2.
Gene expression databases
ArrayExpress	Q9Y5F2.
Bgee	Q9Y5F2.
CleanEx	HS_PCDHB11.
Genevestigator	Q9Y5F2.
GermOnline	ENSG00000197479. Homo sapiens.
Family and domain databases
Gene3D	2.60.40.60. 5 hits.
InterPro	IPR002126. Cadherin. IPR015919. Cadherin-like. IPR020894. Cadherin_CS. IPR013164. Cadherin_N. [Graphical view]
Pfam	PF00028. Cadherin. 5 hits. PF08266. Cadherin_2. 1 hit. [Graphical view]
PRINTS	PR00205. CADHERIN.
SMART	SM00112. CA. 6 hits. [Graphical view]
SUPFAM	SSF49313. Cadherin. 6 hits.
PROSITE	PS00232. CADHERIN_1. 5 hits. PS50268. CADHERIN_2. 6 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	56125.
NextBio	61632.
SOURCE	Search...

Entry information

Entry name

PCDBB_HUMAN

Accession

Primary (citable) accession number: Q9Y5F2
Secondary accession number(s): Q2M223

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	November 1, 1999
Last modified:	May 1, 2013
This is version 107 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.