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Q9Y5F2 (PCDBB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protocadherin beta-11

Short name=PCDH-beta-11
Gene names
Name:PCDHB11
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length797 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

Subcellular location

Cell membrane; Single-pass type I membrane protein By similarity.

Sequence similarities

Contains 6 cadherin domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Chain27 – 797771Protocadherin beta-11
PRO_0000003934

Regions

Topological domain27 – 690664Extracellular Potential
Transmembrane691 – 71121Helical; Potential
Topological domain712 – 79786Cytoplasmic Potential
Domain35 – 13399Cadherin 1
Domain138 – 242105Cadherin 2
Domain247 – 347101Cadherin 3
Domain352 – 451100Cadherin 4
Domain456 – 561106Cadherin 5
Domain568 – 671104Cadherin 6

Amino acid modifications

Glycosylation4181N-linked (GlcNAc...) Potential
Glycosylation4361N-linked (GlcNAc...) Potential
Glycosylation4871N-linked (GlcNAc...) Potential
Glycosylation5671N-linked (GlcNAc...) Potential

Natural variations

Natural variant41Q → R.
Corresponds to variant rs3756323 [ dbSNP | Ensembl ].
VAR_021881
Natural variant71R → H.
Corresponds to variant rs917535 [ dbSNP | Ensembl ].
VAR_048553
Natural variant5281D → E.
Corresponds to variant rs799834 [ dbSNP | Ensembl ].
VAR_059188

Sequences

Sequence LengthMass (Da)Tools
Q9Y5F2 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 8FBA0DBCC2858504

FASTA79787,088
        10         20         30         40         50         60 
MENQGTRTQQ IRQVLLLFVL LGMSQAGSET WSFSVAEEMQ SGSFVGNLAK DLGLKVRELS 

        70         80         90        100        110        120 
SRGARVVSND KKQRLQLDIN TGDLLLSETL DREELCGSIE PCVLHLQVLM QNPTQFLQIE 

       130        140        150        160        170        180 
LQVRDINDHS PIFSEKQMLL EIPENSPVGA VFLLESAKDL DVGINAVKSY TISPNSHFHI 

       190        200        210        220        230        240 
KMRVIPDNRK YPELVLDKAL DYEELPELSF ILSALDGGSP PRSGTALVRV VVVDINDNSP 

       250        260        270        280        290        300 
EFEQAFYEVK IRENSILGSL ILIVSAWDLD SGTNGEICYT FSHASEDIRK TFEINQKSGE 

       310        320        330        340        350        360 
ITLRAPLDFE TIESYSIIIQ ATDGGGLFGK STVIIHVIDV NDNAPEITVS SITSPIPENT 

       370        380        390        400        410        420 
PETVVMVFSI QDIDSGDNGR IVCSIPEDLP FVLKSSVENY YTLETERPLD RESTAEYNIT 

       430        440        450        460        470        480 
ITVTDLGIPR LKTEHNTTVL VSDVNDNAPT FTQTSYTLFV RENNSPALHI GSVSATDRDS 

       490        500        510        520        530        540 
GTNAQVNYSL LPPQDLHLPL ASLVSINTDN GHLFALRSLD YEALQAFDFR VGATDRGSPA 

       550        560        570        580        590        600 
LSSEALVRVL VLDANDNSPF VLYPLQNGSA PCTELVPRAA EPGYLVTKVV AVDGDSGQNA 

       610        620        630        640        650        660 
WLSYQLLKAT EPGLFGVWAH NGEVRTARLL SERDAAKHRL VVLVKDNGEP PRSATATLQV 

       670        680        690        700        710        720 
LLVDGFSQPY LPLPEAAPAQ AQADSLTVYL VVALASVSSL FLFSVLLFVA VRLCRRSRAA 

       730        740        750        760        770        780 
SVGSCSVPKG PFPGHLVDVS GTGTLSQSYQ YEVCLTGGSE TNEFKFLKPV IPNIQAKGLG 

       790 
KNSEENSTFR NSFGFNF 

« Hide

References

« Hide 'large scale' references
[1]"A striking organization of a large family of human neural cadherin-like cell adhesion genes."
Wu Q., Maniatis T.
Cell 97:779-790(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number."
Vanhalst K., Kools P., Vanden Eynde E., van Roy F.
FEBS Lett. 495:120-125(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF152490 mRNA. Translation: AAD43751.1.
AF217747 mRNA. Translation: AAK51615.1.
BC112132 mRNA. Translation: AAI12133.1.
BC113611 mRNA. Translation: AAI13612.1.
CCDSCCDS4253.1.
RefSeqNP_061754.1. NM_018931.2.
UniGeneHs.283084.

3D structure databases

ProteinModelPortalQ9Y5F2.
SMRQ9Y5F2. Positions 30-677.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121065. 1 interaction.

PTM databases

PhosphoSiteQ9Y5F2.

Polymorphism databases

DMDM13431383.

Proteomic databases

PaxDbQ9Y5F2.
PRIDEQ9Y5F2.

Protocols and materials databases

DNASU56125.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000354757; ENSP00000346802; ENSG00000197479.
ENST00000608766; ENSP00000476597; ENSG00000262565.
GeneID56125.
KEGGhsa:56125.
UCSCuc003liy.3. human.

Organism-specific databases

CTD56125.
GeneCardsGC05P140579.
HGNCHGNC:8682. PCDHB11.
HPAHPA045042.
MIM604967. gene.
606337. gene.
neXtProtNX_Q9Y5F2.
PharmGKBPA33027.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG251260.
HOVERGENHBG054878.
InParanoidQ9Y5F2.
KOK16494.
OMAKTEHNTT.
OrthoDBEOG7KSX80.
PhylomeDBQ9Y5F2.
TreeFamTF332299.

Gene expression databases

ArrayExpressQ9Y5F2.
BgeeQ9Y5F2.
CleanExHS_PCDHB11.
GenevestigatorQ9Y5F2.

Family and domain databases

Gene3D2.60.40.60. 5 hits.
InterProIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
[Graphical view]
PRINTSPR00205. CADHERIN.
SMARTSM00112. CA. 6 hits.
[Graphical view]
SUPFAMSSF49313. SSF49313. 6 hits.
PROSITEPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiPCDHB11.
GenomeRNAi56125.
NextBio61632.
PROQ9Y5F2.
SOURCESearch...

Entry information

Entry namePCDBB_HUMAN
AccessionPrimary (citable) accession number: Q9Y5F2
Secondary accession number(s): Q2M223
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM