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Protein

Protocadherin beta-14

Gene

PCDHB14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

GO - Molecular functioni

GO - Biological processi

  • calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
  • synapse assembly Source: UniProtKB
  • synaptic transmission Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin beta-14
Short name:
PCDH-beta-14
Gene namesi
Name:PCDHB14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:8685. PCDHB14.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 686660ExtracellularSequence analysisAdd
BLAST
Transmembranei687 – 71125HelicalSequence analysisAdd
BLAST
Topological domaini712 – 79887CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33030.

Polymorphism and mutation databases

BioMutaiPCDHB14.
DMDMi13431380.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence analysisAdd
BLAST
Chaini27 – 798772Protocadherin beta-14PRO_0000003940Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi96 ↔ 102By similarity
Glycosylationi169 – 1691N-linked (GlcNAc...)Sequence analysis
Glycosylationi359 – 3591N-linked (GlcNAc...)Sequence analysis
Glycosylationi418 – 4181N-linked (GlcNAc...)Sequence analysis
Glycosylationi436 – 4361N-linked (GlcNAc...)Sequence analysis
Glycosylationi487 – 4871N-linked (GlcNAc...)Sequence analysis
Glycosylationi567 – 5671N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ9Y5E9.
PaxDbiQ9Y5E9.
PRIDEiQ9Y5E9.

PTM databases

PhosphoSiteiQ9Y5E9.

Expressioni

Gene expression databases

BgeeiQ9Y5E9.
CleanExiHS_PCDHB14.
GenevisibleiQ9Y5E9. HS.

Organism-specific databases

HPAiHPA045248.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
HNRNPKP619783EBI-10329013,EBI-304185
HNRPKQ6IBN13EBI-10329013,EBI-3440248
PSTPIP1O435863EBI-10329013,EBI-1050964
RBMY1A1P0DJD33EBI-10329013,EBI-8638511
RBMY1JQ154153EBI-10329013,EBI-8642021

Protein-protein interaction databases

BioGridi121062. 4 interactions.
IntActiQ9Y5E9. 5 interactions.
STRINGi9606.ENSP00000239449.

Structurei

3D structure databases

ProteinModelPortaliQ9Y5E9.
SMRiQ9Y5E9. Positions 33-677.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 13399Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini138 – 242105Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini247 – 347101Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini352 – 451100Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Domaini456 – 561106Cadherin 5PROSITE-ProRule annotationAdd
BLAST
Domaini568 – 671104Cadherin 6PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 6 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00840000129690.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.
InParanoidiQ9Y5E9.
KOiK16494.
OMAiTFFHASE.
OrthoDBiEOG7KSX80.
PhylomeDBiQ9Y5E9.
TreeFamiTF332299.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y5E9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEIRGALDLR KRQVLIFLVL LGLSRAGTES AHYSVAEETE IGSFVANLAR
60 70 80 90 100
DLGLGVEELS SREARVVSDD NKKYLHLDLL TGNLLLNEKL DRDELCGSTE
110 120 130 140 150
PCVLHFQVVL ENPLQFFRFE LCVKDINDHS PTFLDKEILI KISEGTTVGA
160 170 180 190 200
TFLMESAQDL DVGSNSLQNY TISPNSHFYI KIPDSSDRKI YPELVLDRAL
210 220 230 240 250
DYEQEAELRL TLTAVDGGSP PKSGTTLVLI KVLDINDNAP EFPQSLYEVQ
260 270 280 290 300
VPEDRPLGSW IATISAKDLD AGNYGKISYT FFHASEDIRK TFEINPISGE
310 320 330 340 350
VNLRSPLDFE VIQSYTINIQ ATDGGGLSGK CTLLVKVMDI NDNPPEVTIS
360 370 380 390 400
SITKRIPENA SETLVALFSI LDQDSGDNGR MICSIQDNLP FFLKPTFKNF
410 420 430 440 450
FTLVSEKALD RESQAEYNIT ITVTDLGTPR LKTEYNITVL LSDVNDNAPT
460 470 480 490 500
FTQTSYTLFV RENNSPALHI GSVSATDRDS GTNAQVNYSL LPPQDRHLPL
510 520 530 540 550
ASLVSINADN GHLFALRSLD YEALQEFEFR VGATDRGSPA LSSEALVRVL
560 570 580 590 600
VLDANDNSPF VLYPLQNGSA PCTELVPRAA EPGYLVTKVV AVDGDSGQNA
610 620 630 640 650
WLSYQLLKAT EPGLFGVWAH NGEVRTARLL SERDAAKHRL VVLVKDNGEP
660 670 680 690 700
PRSATATLHV LLVDGFSQPY LPLPEAAPAQ AQADSLTVYL VVALASVSSL
710 720 730 740 750
FLFSVLLFVA VRLCRRSRAA SVGRCSVPEG PFPGHLVDVS GTGTLSQSYQ
760 770 780 790
YEVCLTGGSG TNEFKFLKPI IPNFQVHDTG RNMGEIENFR NSFGLNIQ
Length:798
Mass (Da):87,548
Last modified:November 1, 1999 - v1
Checksum:i65151C1A423BB52E
GO
Isoform 2 (identifier: Q9Y5E9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-153: Missing.

Note: No experimental confirmation available.
Show »
Length:645
Mass (Da):70,448
Checksum:i9F771EFF7BB91B1A
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 153153Missing in isoform 2. 1 PublicationVSP_055932Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152493 mRNA. Translation: AAD43754.1.
AF217744 mRNA. Translation: AAK51612.1.
AK298296 mRNA. Translation: BAG60554.1.
AC005752 Genomic DNA. No translation available.
BC098144 mRNA. Translation: AAH98144.1.
BC099728 mRNA. Translation: AAH99728.1.
CCDSiCCDS4256.1. [Q9Y5E9-1]
RefSeqiNP_061757.1. NM_018934.3. [Q9Y5E9-1]
UniGeneiHs.658497.

Genome annotation databases

EnsembliENST00000239449; ENSP00000239449; ENSG00000120327. [Q9Y5E9-1]
ENST00000624896; ENSP00000485055; ENSG00000120327. [Q9Y5E9-2]
GeneIDi56122.
KEGGihsa:56122.
UCSCiuc003ljb.5. human. [Q9Y5E9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152493 mRNA. Translation: AAD43754.1.
AF217744 mRNA. Translation: AAK51612.1.
AK298296 mRNA. Translation: BAG60554.1.
AC005752 Genomic DNA. No translation available.
BC098144 mRNA. Translation: AAH98144.1.
BC099728 mRNA. Translation: AAH99728.1.
CCDSiCCDS4256.1. [Q9Y5E9-1]
RefSeqiNP_061757.1. NM_018934.3. [Q9Y5E9-1]
UniGeneiHs.658497.

3D structure databases

ProteinModelPortaliQ9Y5E9.
SMRiQ9Y5E9. Positions 33-677.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121062. 4 interactions.
IntActiQ9Y5E9. 5 interactions.
STRINGi9606.ENSP00000239449.

PTM databases

PhosphoSiteiQ9Y5E9.

Polymorphism and mutation databases

BioMutaiPCDHB14.
DMDMi13431380.

Proteomic databases

EPDiQ9Y5E9.
PaxDbiQ9Y5E9.
PRIDEiQ9Y5E9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000239449; ENSP00000239449; ENSG00000120327. [Q9Y5E9-1]
ENST00000624896; ENSP00000485055; ENSG00000120327. [Q9Y5E9-2]
GeneIDi56122.
KEGGihsa:56122.
UCSCiuc003ljb.5. human. [Q9Y5E9-1]

Organism-specific databases

CTDi56122.
GeneCardsiPCDHB14.
HGNCiHGNC:8685. PCDHB14.
HPAiHPA045248.
MIMi604967. gene.
606340. gene.
neXtProtiNX_Q9Y5E9.
PharmGKBiPA33030.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00840000129690.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.
InParanoidiQ9Y5E9.
KOiK16494.
OMAiTFFHASE.
OrthoDBiEOG7KSX80.
PhylomeDBiQ9Y5E9.
TreeFamiTF332299.

Miscellaneous databases

ChiTaRSiPCDHB14. human.
GeneWikiiPCDHB14.
GenomeRNAii56122.
NextBioi35473851.
PROiQ9Y5E9.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y5E9.
CleanExiHS_PCDHB14.
GenevisibleiQ9Y5E9. HS.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A striking organization of a large family of human neural cadherin-like cell adhesion genes."
    Wu Q., Maniatis T.
    Cell 97:779-790(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number."
    Vanhalst K., Kools P., Vanden Eynde E., van Roy F.
    FEBS Lett. 495:120-125(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Kidney.
  4. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).

Entry informationi

Entry nameiPCDBE_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5E9
Secondary accession number(s): B4DPE2, Q4FZA4, Q4KN11
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1999
Last modified: May 11, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.