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Protein

Protocadherin beta-15

Gene

PCDHB15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

GO - Molecular functioni

GO - Biological processi

  • cell adhesion Source: ProtInc
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
  • nervous system development Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Enzyme and pathway databases

BioCyciZFISH:ENSG00000113248-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin beta-15
Short name:
PCDH-beta-15
Gene namesi
Name:PCDHB15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:8686. PCDHB15.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 690ExtracellularSequence analysisAdd BLAST664
Transmembranei691 – 711HelicalSequence analysisAdd BLAST21
Topological domaini712 – 787CytoplasmicSequence analysisAdd BLAST76

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • photoreceptor connecting cilium Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000113248.
PharmGKBiPA33031.

Polymorphism and mutation databases

BioMutaiPCDHB15.
DMDMi13431379.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000000394227 – 787Protocadherin beta-15Add BLAST761

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi418N-linked (GlcNAc...)Sequence analysis1
Glycosylationi567N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9Y5E8.
PaxDbiQ9Y5E8.
PeptideAtlasiQ9Y5E8.
PRIDEiQ9Y5E8.

PTM databases

iPTMnetiQ9Y5E8.
PhosphoSitePlusiQ9Y5E8.

Expressioni

Gene expression databases

BgeeiENSG00000113248.
CleanExiHS_PCDHB15.
ExpressionAtlasiQ9Y5E8. baseline and differential.
GenevisibleiQ9Y5E8. HS.

Organism-specific databases

HPAiCAB026471.
HPA007172.

Interactioni

Protein-protein interaction databases

BioGridi121061. 25 interactors.
IntActiQ9Y5E8. 25 interactors.
STRINGi9606.ENSP00000231173.

Structurei

3D structure databases

ProteinModelPortaliQ9Y5E8.
SMRiQ9Y5E8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 133Cadherin 1PROSITE-ProRule annotationAdd BLAST99
Domaini138 – 242Cadherin 2PROSITE-ProRule annotationAdd BLAST105
Domaini247 – 347Cadherin 3PROSITE-ProRule annotationAdd BLAST101
Domaini352 – 451Cadherin 4PROSITE-ProRule annotationAdd BLAST100
Domaini456 – 561Cadherin 5PROSITE-ProRule annotationAdd BLAST106
Domaini568 – 671Cadherin 6PROSITE-ProRule annotationAdd BLAST104

Sequence similaritiesi

Contains 6 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00840000129690.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.
InParanoidiQ9Y5E8.
KOiK16494.
OMAiWEPRRYS.
OrthoDBiEOG091G024L.
PhylomeDBiQ9Y5E8.
TreeFamiTF332299.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
IPR030733. PCDHB15.
[Graphical view]
PANTHERiPTHR24028:SF97. PTHR24028:SF97. 1 hit.
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y5E8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPAGERFPE QRQVLILLLL LEVTLAGWEP RRYSVMEETE RGSFVANLAN
60 70 80 90 100
DLGLGVGELA ERGARVVSED NEQGLQLDLQ TGQLILNEKL DREKLCGPTE
110 120 130 140 150
PCIMHFQVLL KKPLEVFRAE LLVTDINDHS PEFPEREMTL KIPETSSLGT
160 170 180 190 200
VFPLKKARDL DVGSNNVQNY NISPNSHFHV STRTRGDGRK YPELVLDTEL
210 220 230 240 250
DREEQAELRL TLTAVDGGSP PRSGTVQILI LVLDANDNAP EFVQALYEVQ
260 270 280 290 300
VPENSPVGSL VVKVSARDLD TGTNGEISYS LYYSSQEIDK PFELSSLSGE
310 320 330 340 350
IRLIKKLDFE TMSSYDLDIE ASDGGGLSGK CSVSVKVLDV NDNFPELSIS
360 370 380 390 400
SLTSPIPENS PETEVALFRI RDRDSGENGK MICSIQDDVP FKLKPSVENF
410 420 430 440 450
YRLVTEGALD RETRAEYNIT ITITDLGTPR LKTEQSITVL VSDVNDNAPA
460 470 480 490 500
FTQTSYTLFV RENNSPALHI GSVSATDRDS GTNAQVTYSL LPPRDPHLPL
510 520 530 540 550
TSLVSINTDN GHLFALQSLD YEALQAFEFR VGATDRGFPA LSSEALVRVL
560 570 580 590 600
VLDANDNSPF VLYPLQNGSA PCTELVPRAA EPGYLVTKVV AVDGDSGQNA
610 620 630 640 650
WLSYQLLKAT EPGLFGVWAH NGEVRTARLL SERDVAKHRL VVLVKDNGEP
660 670 680 690 700
PRSATATLQV LLVDGFSQPY LPLPEAAPAQ AQADSLTVYL VVALASVSSL
710 720 730 740 750
FLFSVFLFVA VRLCRRSRAA SVGRCSVPEG PFPGHLVDVS GTGTLSQSYQ
760 770 780
YEVCLTGGSE SNDFKFLKPI FPNIVSQDSR RKSEFLE
Length:787
Mass (Da):86,329
Last modified:November 1, 1999 - v1
Checksum:i8DE8D3A07B0B6A56
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_019633474S → R.1 PublicationCorresponds to variant rs618506dbSNPEnsembl.1
Natural variantiVAR_019634494R → Q.1 PublicationCorresponds to variant rs618096dbSNPEnsembl.1
Natural variantiVAR_036106719A → V in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_036107758G → V in a breast cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152494 mRNA. Translation: AAD43755.1.
AF217742 mRNA. Translation: AAK51610.1.
BC038797 mRNA. Translation: AAH38797.1.
CCDSiCCDS4257.1.
RefSeqiNP_061758.1. NM_018935.3.
UniGeneiHs.130757.

Genome annotation databases

EnsembliENST00000231173; ENSP00000231173; ENSG00000113248.
GeneIDi56121.
KEGGihsa:56121.
UCSCiuc003lje.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152494 mRNA. Translation: AAD43755.1.
AF217742 mRNA. Translation: AAK51610.1.
BC038797 mRNA. Translation: AAH38797.1.
CCDSiCCDS4257.1.
RefSeqiNP_061758.1. NM_018935.3.
UniGeneiHs.130757.

3D structure databases

ProteinModelPortaliQ9Y5E8.
SMRiQ9Y5E8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121061. 25 interactors.
IntActiQ9Y5E8. 25 interactors.
STRINGi9606.ENSP00000231173.

PTM databases

iPTMnetiQ9Y5E8.
PhosphoSitePlusiQ9Y5E8.

Polymorphism and mutation databases

BioMutaiPCDHB15.
DMDMi13431379.

Proteomic databases

EPDiQ9Y5E8.
PaxDbiQ9Y5E8.
PeptideAtlasiQ9Y5E8.
PRIDEiQ9Y5E8.

Protocols and materials databases

DNASUi56121.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000231173; ENSP00000231173; ENSG00000113248.
GeneIDi56121.
KEGGihsa:56121.
UCSCiuc003lje.5. human.

Organism-specific databases

CTDi56121.
GeneCardsiPCDHB15.
HGNCiHGNC:8686. PCDHB15.
HPAiCAB026471.
HPA007172.
MIMi604967. gene.
606341. gene.
neXtProtiNX_Q9Y5E8.
OpenTargetsiENSG00000113248.
PharmGKBiPA33031.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00840000129690.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.
InParanoidiQ9Y5E8.
KOiK16494.
OMAiWEPRRYS.
OrthoDBiEOG091G024L.
PhylomeDBiQ9Y5E8.
TreeFamiTF332299.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000113248-MONOMER.

Miscellaneous databases

GeneWikiiPCDHB15.
GenomeRNAii56121.
PROiQ9Y5E8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000113248.
CleanExiHS_PCDHB15.
ExpressionAtlasiQ9Y5E8. baseline and differential.
GenevisibleiQ9Y5E8. HS.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
IPR030733. PCDHB15.
[Graphical view]
PANTHERiPTHR24028:SF97. PTHR24028:SF97. 1 hit.
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPCDBF_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5E8
Secondary accession number(s): Q8IUX5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 142 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.