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Protein

Protocadherin beta-15

Gene

PCDHB15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

GO - Molecular functioni

GO - Biological processi

  • cell adhesion Source: ProtInc
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
  • nervous system development Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin beta-15
Short name:
PCDH-beta-15
Gene namesi
Name:PCDHB15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:8686. PCDHB15.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 690664ExtracellularSequence analysisAdd
BLAST
Transmembranei691 – 71121HelicalSequence analysisAdd
BLAST
Topological domaini712 – 78776CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • photoreceptor connecting cilium Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33031.

Polymorphism and mutation databases

BioMutaiPCDHB15.
DMDMi13431379.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence analysisAdd
BLAST
Chaini27 – 787761Protocadherin beta-15PRO_0000003942Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi418 – 4181N-linked (GlcNAc...)Sequence analysis
Glycosylationi567 – 5671N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9Y5E8.
PaxDbiQ9Y5E8.
PeptideAtlasiQ9Y5E8.
PRIDEiQ9Y5E8.

PTM databases

iPTMnetiQ9Y5E8.
PhosphoSiteiQ9Y5E8.

Expressioni

Gene expression databases

BgeeiENSG00000113248.
CleanExiHS_PCDHB15.
ExpressionAtlasiQ9Y5E8. baseline and differential.
GenevisibleiQ9Y5E8. HS.

Organism-specific databases

HPAiCAB026471.
HPA007172.

Interactioni

Protein-protein interaction databases

BioGridi121061. 25 interactions.
IntActiQ9Y5E8. 25 interactions.
STRINGi9606.ENSP00000231173.

Structurei

3D structure databases

ProteinModelPortaliQ9Y5E8.
SMRiQ9Y5E8. Positions 33-677.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 13399Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini138 – 242105Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini247 – 347101Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini352 – 451100Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Domaini456 – 561106Cadherin 5PROSITE-ProRule annotationAdd
BLAST
Domaini568 – 671104Cadherin 6PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 6 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00840000129690.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.
InParanoidiQ9Y5E8.
KOiK16494.
OMAiWEPRRYS.
OrthoDBiEOG091G024L.
PhylomeDBiQ9Y5E8.
TreeFamiTF332299.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
IPR030733. PCDHB15.
[Graphical view]
PANTHERiPTHR24028:SF97. PTHR24028:SF97. 1 hit.
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y5E8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPAGERFPE QRQVLILLLL LEVTLAGWEP RRYSVMEETE RGSFVANLAN
60 70 80 90 100
DLGLGVGELA ERGARVVSED NEQGLQLDLQ TGQLILNEKL DREKLCGPTE
110 120 130 140 150
PCIMHFQVLL KKPLEVFRAE LLVTDINDHS PEFPEREMTL KIPETSSLGT
160 170 180 190 200
VFPLKKARDL DVGSNNVQNY NISPNSHFHV STRTRGDGRK YPELVLDTEL
210 220 230 240 250
DREEQAELRL TLTAVDGGSP PRSGTVQILI LVLDANDNAP EFVQALYEVQ
260 270 280 290 300
VPENSPVGSL VVKVSARDLD TGTNGEISYS LYYSSQEIDK PFELSSLSGE
310 320 330 340 350
IRLIKKLDFE TMSSYDLDIE ASDGGGLSGK CSVSVKVLDV NDNFPELSIS
360 370 380 390 400
SLTSPIPENS PETEVALFRI RDRDSGENGK MICSIQDDVP FKLKPSVENF
410 420 430 440 450
YRLVTEGALD RETRAEYNIT ITITDLGTPR LKTEQSITVL VSDVNDNAPA
460 470 480 490 500
FTQTSYTLFV RENNSPALHI GSVSATDRDS GTNAQVTYSL LPPRDPHLPL
510 520 530 540 550
TSLVSINTDN GHLFALQSLD YEALQAFEFR VGATDRGFPA LSSEALVRVL
560 570 580 590 600
VLDANDNSPF VLYPLQNGSA PCTELVPRAA EPGYLVTKVV AVDGDSGQNA
610 620 630 640 650
WLSYQLLKAT EPGLFGVWAH NGEVRTARLL SERDVAKHRL VVLVKDNGEP
660 670 680 690 700
PRSATATLQV LLVDGFSQPY LPLPEAAPAQ AQADSLTVYL VVALASVSSL
710 720 730 740 750
FLFSVFLFVA VRLCRRSRAA SVGRCSVPEG PFPGHLVDVS GTGTLSQSYQ
760 770 780
YEVCLTGGSE SNDFKFLKPI FPNIVSQDSR RKSEFLE
Length:787
Mass (Da):86,329
Last modified:November 1, 1999 - v1
Checksum:i8DE8D3A07B0B6A56
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti474 – 4741S → R.1 Publication
Corresponds to variant rs618506 [ dbSNP | Ensembl ].
VAR_019633
Natural varianti494 – 4941R → Q.1 Publication
Corresponds to variant rs618096 [ dbSNP | Ensembl ].
VAR_019634
Natural varianti719 – 7191A → V in a breast cancer sample; somatic mutation. 1 Publication
VAR_036106
Natural varianti758 – 7581G → V in a breast cancer sample; somatic mutation. 1 Publication
VAR_036107

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152494 mRNA. Translation: AAD43755.1.
AF217742 mRNA. Translation: AAK51610.1.
BC038797 mRNA. Translation: AAH38797.1.
CCDSiCCDS4257.1.
RefSeqiNP_061758.1. NM_018935.3.
UniGeneiHs.130757.

Genome annotation databases

EnsembliENST00000231173; ENSP00000231173; ENSG00000113248.
GeneIDi56121.
KEGGihsa:56121.
UCSCiuc003lje.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152494 mRNA. Translation: AAD43755.1.
AF217742 mRNA. Translation: AAK51610.1.
BC038797 mRNA. Translation: AAH38797.1.
CCDSiCCDS4257.1.
RefSeqiNP_061758.1. NM_018935.3.
UniGeneiHs.130757.

3D structure databases

ProteinModelPortaliQ9Y5E8.
SMRiQ9Y5E8. Positions 33-677.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121061. 25 interactions.
IntActiQ9Y5E8. 25 interactions.
STRINGi9606.ENSP00000231173.

PTM databases

iPTMnetiQ9Y5E8.
PhosphoSiteiQ9Y5E8.

Polymorphism and mutation databases

BioMutaiPCDHB15.
DMDMi13431379.

Proteomic databases

EPDiQ9Y5E8.
PaxDbiQ9Y5E8.
PeptideAtlasiQ9Y5E8.
PRIDEiQ9Y5E8.

Protocols and materials databases

DNASUi56121.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000231173; ENSP00000231173; ENSG00000113248.
GeneIDi56121.
KEGGihsa:56121.
UCSCiuc003lje.5. human.

Organism-specific databases

CTDi56121.
GeneCardsiPCDHB15.
HGNCiHGNC:8686. PCDHB15.
HPAiCAB026471.
HPA007172.
MIMi604967. gene.
606341. gene.
neXtProtiNX_Q9Y5E8.
PharmGKBiPA33031.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00840000129690.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.
InParanoidiQ9Y5E8.
KOiK16494.
OMAiWEPRRYS.
OrthoDBiEOG091G024L.
PhylomeDBiQ9Y5E8.
TreeFamiTF332299.

Miscellaneous databases

GeneWikiiPCDHB15.
GenomeRNAii56121.
PROiQ9Y5E8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000113248.
CleanExiHS_PCDHB15.
ExpressionAtlasiQ9Y5E8. baseline and differential.
GenevisibleiQ9Y5E8. HS.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
IPR030733. PCDHB15.
[Graphical view]
PANTHERiPTHR24028:SF97. PTHR24028:SF97. 1 hit.
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPCDBF_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5E8
Secondary accession number(s): Q8IUX5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1999
Last modified: September 7, 2016
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.