Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protocadherin beta-15

Gene

PCDHB15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

GO - Molecular functioni

GO - Biological processi

  • cell adhesion Source: ProtInc
  • chemical synaptic transmission Source: GO_Central
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
  • nervous system development Source: ProtInc
  • synapse assembly Source: GO_Central

Keywordsi

Biological processCell adhesion
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin beta-15
Short name:
PCDH-beta-15
Gene namesi
Name:PCDHB15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000113248.5
HGNCiHGNC:8686 PCDHB15
MIMi604967 gene
606341 gene
neXtProtiNX_Q9Y5E8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 690ExtracellularSequence analysisAdd BLAST664
Transmembranei691 – 711HelicalSequence analysisAdd BLAST21
Topological domaini712 – 787CytoplasmicSequence analysisAdd BLAST76

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000113248
PharmGKBiPA33031

Polymorphism and mutation databases

BioMutaiPCDHB15
DMDMi13431379

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000000394227 – 787Protocadherin beta-15Add BLAST761

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi418N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi567N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9Y5E8
PaxDbiQ9Y5E8
PeptideAtlasiQ9Y5E8
PRIDEiQ9Y5E8

PTM databases

iPTMnetiQ9Y5E8
PhosphoSitePlusiQ9Y5E8

Expressioni

Gene expression databases

BgeeiENSG00000113248
CleanExiHS_PCDHB15
ExpressionAtlasiQ9Y5E8 baseline and differential
GenevisibleiQ9Y5E8 HS

Organism-specific databases

HPAiCAB026471
HPA007172

Interactioni

Protein-protein interaction databases

BioGridi121061, 25 interactors
IntActiQ9Y5E8, 25 interactors
STRINGi9606.ENSP00000231173

Structurei

3D structure databases

ProteinModelPortaliQ9Y5E8
SMRiQ9Y5E8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 133Cadherin 1PROSITE-ProRule annotationAdd BLAST99
Domaini138 – 242Cadherin 2PROSITE-ProRule annotationAdd BLAST105
Domaini247 – 347Cadherin 3PROSITE-ProRule annotationAdd BLAST101
Domaini352 – 451Cadherin 4PROSITE-ProRule annotationAdd BLAST100
Domaini456 – 561Cadherin 5PROSITE-ProRule annotationAdd BLAST106
Domaini568 – 671Cadherin 6PROSITE-ProRule annotationAdd BLAST104

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00910000143986
HOGENOMiHOG000220892
HOVERGENiHBG054878
InParanoidiQ9Y5E8
KOiK16494
OMAiRVVSEDN
OrthoDBiEOG091G024L
PhylomeDBiQ9Y5E8
TreeFamiTF332299

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin
IPR015919 Cadherin-like
IPR032455 Cadherin_C
IPR020894 Cadherin_CS
IPR013164 Cadherin_N
IPR030733 PCDHB15
PANTHERiPTHR24028:SF97 PTHR24028:SF97, 1 hit
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PF08266 Cadherin_2, 1 hit
PF16492 Cadherin_C_2, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 5 hits
SUPFAMiSSF49313 SSF49313, 6 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 5 hits
PS50268 CADHERIN_2, 6 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y5E8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPAGERFPE QRQVLILLLL LEVTLAGWEP RRYSVMEETE RGSFVANLAN
60 70 80 90 100
DLGLGVGELA ERGARVVSED NEQGLQLDLQ TGQLILNEKL DREKLCGPTE
110 120 130 140 150
PCIMHFQVLL KKPLEVFRAE LLVTDINDHS PEFPEREMTL KIPETSSLGT
160 170 180 190 200
VFPLKKARDL DVGSNNVQNY NISPNSHFHV STRTRGDGRK YPELVLDTEL
210 220 230 240 250
DREEQAELRL TLTAVDGGSP PRSGTVQILI LVLDANDNAP EFVQALYEVQ
260 270 280 290 300
VPENSPVGSL VVKVSARDLD TGTNGEISYS LYYSSQEIDK PFELSSLSGE
310 320 330 340 350
IRLIKKLDFE TMSSYDLDIE ASDGGGLSGK CSVSVKVLDV NDNFPELSIS
360 370 380 390 400
SLTSPIPENS PETEVALFRI RDRDSGENGK MICSIQDDVP FKLKPSVENF
410 420 430 440 450
YRLVTEGALD RETRAEYNIT ITITDLGTPR LKTEQSITVL VSDVNDNAPA
460 470 480 490 500
FTQTSYTLFV RENNSPALHI GSVSATDRDS GTNAQVTYSL LPPRDPHLPL
510 520 530 540 550
TSLVSINTDN GHLFALQSLD YEALQAFEFR VGATDRGFPA LSSEALVRVL
560 570 580 590 600
VLDANDNSPF VLYPLQNGSA PCTELVPRAA EPGYLVTKVV AVDGDSGQNA
610 620 630 640 650
WLSYQLLKAT EPGLFGVWAH NGEVRTARLL SERDVAKHRL VVLVKDNGEP
660 670 680 690 700
PRSATATLQV LLVDGFSQPY LPLPEAAPAQ AQADSLTVYL VVALASVSSL
710 720 730 740 750
FLFSVFLFVA VRLCRRSRAA SVGRCSVPEG PFPGHLVDVS GTGTLSQSYQ
760 770 780
YEVCLTGGSE SNDFKFLKPI FPNIVSQDSR RKSEFLE
Length:787
Mass (Da):86,329
Last modified:November 1, 1999 - v1
Checksum:i8DE8D3A07B0B6A56
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_019633474S → R1 PublicationCorresponds to variant dbSNP:rs618506Ensembl.1
Natural variantiVAR_019634494R → Q1 PublicationCorresponds to variant dbSNP:rs618096Ensembl.1
Natural variantiVAR_036106719A → V in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_036107758G → V in a breast cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152494 mRNA Translation: AAD43755.1
AF217742 mRNA Translation: AAK51610.1
BC038797 mRNA Translation: AAH38797.1
CCDSiCCDS4257.1
RefSeqiNP_061758.1, NM_018935.3
UniGeneiHs.130757

Genome annotation databases

EnsembliENST00000231173; ENSP00000231173; ENSG00000113248
GeneIDi56121
KEGGihsa:56121
UCSCiuc003lje.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPCDBF_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5E8
Secondary accession number(s): Q8IUX5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1999
Last modified: April 25, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health