Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protocadherin beta-3

Gene

PCDHB3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

GO - Molecular functioni

GO - Biological processi

  • calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
  • cell adhesion Source: ProtInc
  • chemical synaptic transmission Source: UniProtKB
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
  • nervous system development Source: ProtInc
  • synapse assembly Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Enzyme and pathway databases

BioCyciZFISH:ENSG00000113205-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin beta-3
Short name:
PCDH-beta-3
Gene namesi
Name:PCDHB3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:8688. PCDHB3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 690ExtracellularSequence analysisAdd BLAST664
Transmembranei691 – 711HelicalSequence analysisAdd BLAST21
Topological domaini712 – 796CytoplasmicSequence analysisAdd BLAST85

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
  • integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi56132.
PharmGKBiPA33037.

Polymorphism and mutation databases

BioMutaiPCDHB3.
DMDMi13431377.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000000391827 – 796Protocadherin beta-3Add BLAST770

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi169N-linked (GlcNAc...)Sequence analysis1
Glycosylationi418N-linked (GlcNAc...)Sequence analysis1
Glycosylationi436N-linked (GlcNAc...)Sequence analysis1
Glycosylationi567N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9Y5E6.
PaxDbiQ9Y5E6.
PeptideAtlasiQ9Y5E6.
PRIDEiQ9Y5E6.

PTM databases

iPTMnetiQ9Y5E6.
PhosphoSitePlusiQ9Y5E6.

Expressioni

Gene expression databases

BgeeiENSG00000113205.
CleanExiHS_PCDHB3.
ExpressionAtlasiQ9Y5E6. baseline and differential.
GenevisibleiQ9Y5E6. HS.

Organism-specific databases

HPAiHPA050296.

Interactioni

Protein-protein interaction databases

BioGridi121072. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliQ9Y5E6.
SMRiQ9Y5E6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 133Cadherin 1PROSITE-ProRule annotationAdd BLAST99
Domaini138 – 242Cadherin 2PROSITE-ProRule annotationAdd BLAST105
Domaini247 – 347Cadherin 3PROSITE-ProRule annotationAdd BLAST101
Domaini352 – 451Cadherin 4PROSITE-ProRule annotationAdd BLAST100
Domaini456 – 561Cadherin 5PROSITE-ProRule annotationAdd BLAST106
Domaini568 – 671Cadherin 6PROSITE-ProRule annotationAdd BLAST104

Sequence similaritiesi

Contains 6 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.
InParanoidiQ9Y5E6.
KOiK16494.
OrthoDBiEOG091G024L.
PhylomeDBiQ9Y5E6.
TreeFamiTF332299.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
IPR030735. PCDHB2/3.
[Graphical view]
PANTHERiPTHR24028:SF77. PTHR24028:SF77. 1 hit.
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y5E6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAGGERFLR QRQVLLLFVF LGGSLAGSES RRYSVAEEKE KGFLIANLAK
60 70 80 90 100
DLGLRVEELA ARGAQVVSKG NKQHFQLSHQ TGDLLLNEKL DREELCGPTE
110 120 130 140 150
PCILHFQILL QNPLQFVTNE LRIIDVNDHS PVFFENEMHL KILESTLPGT
160 170 180 190 200
VIPLGNAEDL DVGRNSLQNY TITPNSHFHV LTRSRRDGRK YPELVLDKAL
210 220 230 240 250
DREEQPELSL TLTALDGGSP PRSGTAQINI QVLDINDNAP EFAQPLYEVA
260 270 280 290 300
VLENTPVNSV IVTVSASDLD TGSFGTISYA FFHASEEIRK TFQLNPITGD
310 320 330 340 350
MQLVKYLNFE AINSYEVDIE AKDGGGLSGK STVIVQVVDV NDNPPELTLS
360 370 380 390 400
SVNSPIPENS GETVLAVFSV SDLDSGDNGR VMCSIENNLP FFLKPSVENF
410 420 430 440 450
YTLVSEGALD RETRSEYNIT ITITDLGTPR LKTKYNITVL VSDVNDNAPA
460 470 480 490 500
FTQISYTLFV RENNSPALHI GSVSATDRDS GTNAQVTYSL LPPQDPHLPL
510 520 530 540 550
SSLVSINADN GHLFALRSLD YEALQAFEFR VGATDRGSPA LSSEALVRVL
560 570 580 590 600
VLDANDNSPF VLYPLQNGSA PCTELVPRAA EPGYLVTKVV AVDGDSGQNA
610 620 630 640 650
WLSYQLLKAT EPGLFGVWAH NGEVRTARLL SERDAAKHRL VVLVKDNGEP
660 670 680 690 700
PRSATATLHV LLVDGFSQPY LPLPEAAPAQ AQADLLTVYL VVALASVSSL
710 720 730 740 750
FLFSVLLFVA VRLCRRSRAA SVGRCSVPEG PFPGQMVDVS GTGTLSQSYQ
760 770 780 790
YEVCLTGGSG TNEFKFLKPI IPNFVAQGAE RVSEANPSFR KSFEFS
Length:796
Mass (Da):86,773
Last modified:November 1, 1999 - v1
Checksum:iF586CF1BC3A2B0D2
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02439141K → R.Corresponds to variant rs31849dbSNPEnsembl.1
Natural variantiVAR_033703207E → K.Corresponds to variant rs12515688dbSNPEnsembl.1
Natural variantiVAR_020366414R → S.Corresponds to variant rs3733699dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152496 mRNA. Translation: AAD43757.1.
AF217755 mRNA. Translation: AAK51622.1.
AK313451 mRNA. Translation: BAG36239.1.
CH471062 Genomic DNA. Translation: EAW61981.1.
CCDSiCCDS4245.1.
RefSeqiNP_061760.1. NM_018937.4.
UniGeneiHs.508987.
Hs.674730.
Hs.708778.

Genome annotation databases

EnsembliENST00000231130; ENSP00000231130; ENSG00000113205.
GeneIDi56132.
KEGGihsa:56132.
UCSCiuc003lio.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152496 mRNA. Translation: AAD43757.1.
AF217755 mRNA. Translation: AAK51622.1.
AK313451 mRNA. Translation: BAG36239.1.
CH471062 Genomic DNA. Translation: EAW61981.1.
CCDSiCCDS4245.1.
RefSeqiNP_061760.1. NM_018937.4.
UniGeneiHs.508987.
Hs.674730.
Hs.708778.

3D structure databases

ProteinModelPortaliQ9Y5E6.
SMRiQ9Y5E6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121072. 1 interactor.

PTM databases

iPTMnetiQ9Y5E6.
PhosphoSitePlusiQ9Y5E6.

Polymorphism and mutation databases

BioMutaiPCDHB3.
DMDMi13431377.

Proteomic databases

EPDiQ9Y5E6.
PaxDbiQ9Y5E6.
PeptideAtlasiQ9Y5E6.
PRIDEiQ9Y5E6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000231130; ENSP00000231130; ENSG00000113205.
GeneIDi56132.
KEGGihsa:56132.
UCSCiuc003lio.5. human.

Organism-specific databases

CTDi56132.
DisGeNETi56132.
GeneCardsiPCDHB3.
H-InvDBHIX0032374.
HGNCiHGNC:8688. PCDHB3.
HPAiHPA050296.
MIMi604967. gene.
606329. gene.
neXtProtiNX_Q9Y5E6.
PharmGKBiPA33037.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.
InParanoidiQ9Y5E6.
KOiK16494.
OrthoDBiEOG091G024L.
PhylomeDBiQ9Y5E6.
TreeFamiTF332299.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000113205-MONOMER.

Miscellaneous databases

GeneWikiiPCDHB3.
GenomeRNAii56132.
PROiQ9Y5E6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000113205.
CleanExiHS_PCDHB3.
ExpressionAtlasiQ9Y5E6. baseline and differential.
GenevisibleiQ9Y5E6. HS.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
IPR030735. PCDHB2/3.
[Graphical view]
PANTHERiPTHR24028:SF77. PTHR24028:SF77. 1 hit.
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPCDB3_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5E6
Secondary accession number(s): B2R8P2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.