Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protocadherin beta-4

Gene

PCDHB4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

GO - Molecular functioni

GO - Biological processi

  • calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
  • cell adhesion Source: ProtInc
  • chemical synaptic transmission Source: UniProtKB
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
  • nervous system development Source: ProtInc
  • synapse assembly Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Enzyme and pathway databases

BioCyciZFISH:ENSG00000081818-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin beta-4
Short name:
PCDH-beta-4
Gene namesi
Name:PCDHB4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:8689. PCDHB4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini28 – 689ExtracellularSequence analysisAdd BLAST662
Transmembranei690 – 710HelicalSequence analysisAdd BLAST21
Topological domaini711 – 795CytoplasmicSequence analysisAdd BLAST85

GO - Cellular componenti

  • cytoplasm Source: HPA
  • integral component of membrane Source: UniProtKB
  • integral component of plasma membrane Source: ProtInc
  • intermediate filament cytoskeleton Source: HPA
  • plasma membrane Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000081818.
PharmGKBiPA33038.

Polymorphism and mutation databases

BioMutaiPCDHB4.
DMDMi13431376.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000000392028 – 795Protocadherin beta-4Add BLAST768

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi183N-linked (GlcNAc...)Sequence analysis1
Glycosylationi417N-linked (GlcNAc...)Sequence analysis1
Glycosylationi435N-linked (GlcNAc...)Sequence analysis1
Glycosylationi566N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9Y5E5.
PaxDbiQ9Y5E5.
PeptideAtlasiQ9Y5E5.
PRIDEiQ9Y5E5.
TopDownProteomicsiQ9Y5E5.

PTM databases

iPTMnetiQ9Y5E5.
PhosphoSitePlusiQ9Y5E5.

Expressioni

Gene expression databases

BgeeiENSG00000081818.
CleanExiHS_PCDHB4.
GenevisibleiQ9Y5E5. HS.

Organism-specific databases

HPAiHPA014466.

Structurei

3D structure databases

ProteinModelPortaliQ9Y5E5.
SMRiQ9Y5E5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 132Cadherin 1PROSITE-ProRule annotationAdd BLAST99
Domaini137 – 241Cadherin 2PROSITE-ProRule annotationAdd BLAST105
Domaini246 – 346Cadherin 3PROSITE-ProRule annotationAdd BLAST101
Domaini351 – 450Cadherin 4PROSITE-ProRule annotationAdd BLAST100
Domaini455 – 560Cadherin 5PROSITE-ProRule annotationAdd BLAST106
Domaini567 – 670Cadherin 6PROSITE-ProRule annotationAdd BLAST104

Sequence similaritiesi

Contains 6 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00840000129690.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.
InParanoidiQ9Y5E5.
KOiK16494.
OMAiVMVRILI.
OrthoDBiEOG091G024L.
PhylomeDBiQ9Y5E5.
TreeFamiTF332299.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
IPR030729. PCDHB4.
[Graphical view]
PANTHERiPTHR24028:SF55. PTHR24028:SF55. 1 hit.
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y5E5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKLGRIHPN RQVLAFILMV FLSQVRLEPI RYSVLEETES GSFVAHLAKD
60 70 80 90 100
LGLGIGELAS RSARVLSDDD KQRLQLDRQT GDLLLREKLD REELCGPIEP
110 120 130 140 150
CVLHFQVFLE MPVQFFQGEL LIQDINDHSP IFPEREVLLK ILENSQPGTL
160 170 180 190 200
FPLLIAEDLD VGSNGLQKYT ISPNSHFHIL TRNHSEGKKY PDLVQDKPLD
210 220 230 240 250
REEQPEFSLT LVALDGGSPP RSGTVMVRIL IMDINDNAPE FVHTPYGVQV
260 270 280 290 300
LENSPLDSPI VRVLARDIDA GNFGSVSYGL FQASDEIKQT FSINEVTGEI
310 320 330 340 350
LLKKKLDFEK IKSYHVEIEA TDGGGLSGKG TVVIEVVDVN DNPPELIISS
360 370 380 390 400
LTSSIPENAP ETVVSIFRIR DRDSGENGKM ICSIPDNLPF ILKPTLKNFY
410 420 430 440 450
TLVTERPLDR ETSAEYNITI AVTDLGTPRL KTQQNITVQV SDVNDNAPAF
460 470 480 490 500
TQTSYTLFVR ENNSPALHIG SVSATDRDSG TNAQVTYSLL PPQDPHLPLA
510 520 530 540 550
SLVSINADNG HLFALRSLDY EALQAFEFRV GASDRGSPAL SSEALVRVLV
560 570 580 590 600
LDTNDNSPFV LYPLQNGSAP CTELVPRAAE PGYLVTKVVA VDGDSGQNAW
610 620 630 640 650
LSYQLLKATE PGLFGVWAHN GEVRTARLLS ERDAAKHRLV VLVKDNGEPP
660 670 680 690 700
RSATATLHVL LVDGFSQPYL PLPEAAPAQA QADSLTVYLV VALASVSSLF
710 720 730 740 750
LFSVLLFVAV RLCRRSRAAS VGRCSVPEGP FPGHLVDVSG TGTLSQSYQY
760 770 780 790
EVCLTGDSGT GEFKFLKPIF PNLLVQDTGR EVKENPKFRN SLVFS
Length:795
Mass (Da):87,270
Last modified:November 1, 1999 - v1
Checksum:i32A521247DD6A56F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048548168K → R.Corresponds to variant rs34350292dbSNPEnsembl.1
Natural variantiVAR_048549255P → L.Corresponds to variant rs3733697dbSNPEnsembl.1
Natural variantiVAR_048550255P → S.Corresponds to variant rs3733698dbSNPEnsembl.1
Natural variantiVAR_021878421A → T.Corresponds to variant rs3776099dbSNPEnsembl.1
Natural variantiVAR_048551553T → A.Corresponds to variant rs246669dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152497 mRNA. Translation: AAD43758.1.
AF217754 mRNA. Translation: AAK51621.1.
BC098139 mRNA. Translation: AAH98139.1.
BC098346 mRNA. Translation: AAH98346.1.
CCDSiCCDS4246.1.
RefSeqiNP_061761.1. NM_018938.3.
UniGeneiHs.591250.

Genome annotation databases

EnsembliENST00000194152; ENSP00000194152; ENSG00000081818.
GeneIDi56131.
KEGGihsa:56131.
UCSCiuc003lip.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152497 mRNA. Translation: AAD43758.1.
AF217754 mRNA. Translation: AAK51621.1.
BC098139 mRNA. Translation: AAH98139.1.
BC098346 mRNA. Translation: AAH98346.1.
CCDSiCCDS4246.1.
RefSeqiNP_061761.1. NM_018938.3.
UniGeneiHs.591250.

3D structure databases

ProteinModelPortaliQ9Y5E5.
SMRiQ9Y5E5.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ9Y5E5.
PhosphoSitePlusiQ9Y5E5.

Polymorphism and mutation databases

BioMutaiPCDHB4.
DMDMi13431376.

Proteomic databases

EPDiQ9Y5E5.
PaxDbiQ9Y5E5.
PeptideAtlasiQ9Y5E5.
PRIDEiQ9Y5E5.
TopDownProteomicsiQ9Y5E5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000194152; ENSP00000194152; ENSG00000081818.
GeneIDi56131.
KEGGihsa:56131.
UCSCiuc003lip.3. human.

Organism-specific databases

CTDi56131.
GeneCardsiPCDHB4.
HGNCiHGNC:8689. PCDHB4.
HPAiHPA014466.
MIMi604967. gene.
606330. gene.
neXtProtiNX_Q9Y5E5.
OpenTargetsiENSG00000081818.
PharmGKBiPA33038.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00840000129690.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.
InParanoidiQ9Y5E5.
KOiK16494.
OMAiVMVRILI.
OrthoDBiEOG091G024L.
PhylomeDBiQ9Y5E5.
TreeFamiTF332299.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000081818-MONOMER.

Miscellaneous databases

ChiTaRSiPCDHB4. human.
GeneWikiiPCDHB4.
GenomeRNAii56131.
PROiQ9Y5E5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000081818.
CleanExiHS_PCDHB4.
GenevisibleiQ9Y5E5. HS.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
IPR030729. PCDHB4.
[Graphical view]
PANTHERiPTHR24028:SF55. PTHR24028:SF55. 1 hit.
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPCDB4_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5E5
Secondary accession number(s): Q4V761
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1999
Last modified: November 30, 2016
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.