Reviewed,
UniProtKB/Swiss-Prot Q9Y5E4 (PCDB5_HUMAN)
Last modified
December 15, 2009.
Version 84.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Protocadherin beta-5 Short name=PCDH-beta-5 | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) [Complete proteome] | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 795 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. |
| Subcellular location | Cell membrane; Single-pass type I membrane protein By similarity. |
| Sequence similarities | Contains 6 cadherin domains. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Cell adhesion |
| Cellular component | Cell membrane Membrane |
| Coding sequence diversity | Polymorphism |
| Domain | Repeat Signal Transmembrane |
| Ligand | Calcium |
| PTM | Glycoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | calcium-dependent cell-cell adhesion Ref.3 Non-traceable author statement. Source: UniProtKB homophilic cell adhesionInferred from electronic annotation. Source: InterPro synapse assemblyTraceable author statement. Source: UniProtKB synaptic transmissionTraceable author statement. Source: UniProtKB |
| Cellular component | integral to membrane Ref.3 Non-traceable author statement. Source: UniProtKB plasma membraneInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | calcium ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein binding Ref.3Non-traceable author statement. Source: UniProtKB |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 30 | 30 | Potential | ||||||
| Chain | 31 – 795 | 765 | Protocadherin beta-5 | PRO_0000003922 | |||||
Regions | |||||||||
| Topological domain | 31 – 689 | 659 | Extracellular Potential | ||||||
| Transmembrane | 690 – 710 | 21 | Potential | ||||||
| Topological domain | 711 – 795 | 85 | Cytoplasmic Potential | ||||||
| Domain | 35 – 133 | 99 | Cadherin 1 | ||||||
| Domain | 138 – 242 | 105 | Cadherin 2 | ||||||
| Domain | 247 – 346 | 100 | Cadherin 3 | ||||||
| Domain | 351 – 450 | 100 | Cadherin 4 | ||||||
| Domain | 455 – 560 | 106 | Cadherin 5 | ||||||
| Domain | 567 – 670 | 104 | Cadherin 6 | ||||||
Amino acid modifications | |||||||||
| Glycosylation | 169 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 417 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 435 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 566 | 1 | N-linked (GlcNAc...) Potential | ||||||
Natural variations | |||||||||
| Natural variant | 156 | 1 | I → T: dbSNP rs17096901. | VAR_033704 | |||||
| Natural variant | 720 | 1 | S → P: dbSNP rs400562. Ref.4 Ref.5 | VAR_048552 | |||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "A striking organization of a large family of human neural cadherin-like cell adhesion genes." Wu Q., Maniatis T. Cell 97:779-790(1999) [PubMed: 10380929] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "Cloning and characterization of a new human cDNA homologous to Rattus norvegicus protocadherin-3 (pcdh3)." Ding J.B., Yu L., Zhao S.Y. Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [3] | "The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number." Vanhalst K., Kools P., Vanden Eynde E., van Roy F. FEBS Lett. 495:120-125(2001) [PubMed: 11322959] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PRO-720. Tissue: Muscle. |
| [5] | "The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 95-795, VARIANT PRO-720. Tissue: Uterus. |
Cross-references
Sequence databases | |
|---|---|
| AF152498 mRNA. Translation: AAD43759.1. AF134474 mRNA. Translation: AAP97251.1. AF217753 mRNA. Translation: AAK51620.1. BC001186 mRNA. Translation: AAH01186.1. AL117449 mRNA. Translation: CAB55933.1. | |
| IPI | IPI00001428. |
| PIR | T17243. |
| RefSeq | NP_056484.1. |
| UniGene | Hs.119693 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q9Y5E4. 1 interaction. |
| STRING | Q9Y5E4. |
Proteomic databases | |
| PeptideAtlas | Q9Y5E4. |
| PRIDE | Q9Y5E4. |
Genome annotation databases | |
| Ensembl | ENST00000231134; ENSP00000231134; ENSG00000113209; Homo sapiens. [Genome view] |
| GeneID | 26167. |
| KEGG | hsa:26167. |
| UCSC | uc003liq.1. human. |
Organism-specific databases | |
| CTD | 26167. |
| GeneCards | GC05P140494. |
| H-InvDB | HIX0005246. |
| HGNC | HGNC:8690. PCDHB5. |
| HPA | HPA013191. |
| MIM | 604967. gene. 606331. gene. |
| PharmGKB | PA33039. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOVERGEN | Q9Y5E4. |
| InParanoid | Q9Y5E4. |
| OMA | QGDEVTQ. |
| OrthoDB | EOG9GQSQ5. |
Gene expression databases | |
| ArrayExpress | Q9Y5E4. |
| Bgee | Q9Y5E4. |
| CleanEx | HS_PCDHB5. |
| Genevestigator | Q9Y5E4. |
| GermOnline | ENSG00000113209. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR002126. Cadherin. IPR015919. Cadherin-like. IPR013164. Cadherin_N. IPR015493. Protocad_beta. [Graphical view] |
| Gene3D | G3DSA:2.60.40.60. Cadherin. 5 hits. |
| PANTHER | PTHR10596:SF94. Protocad_beta. 1 hit. |
| Pfam | PF00028. Cadherin. 5 hits. PF08266. Cadherin_2. 1 hit. [Graphical view] |
| PRINTS | PR00205. CADHERIN. |
| SMART | SM00112. CA. 5 hits. [Graphical view] |
| PROSITE | PS00232. CADHERIN_1. 5 hits. PS50268. CADHERIN_2. 6 hits. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 48275. |
| SOURCE | Search... |
Entry information
| Entry name | PCDB5_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9Y5E4 Secondary accession number(s): Q549F4, Q9UFU9 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 5 Human chromosome 5: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


