Protocadherin beta-5 precursor - Homo sapiens (Human)

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Q9Y5E4 (PCDB5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 112. History...

Clusters with 100%, 90%, 50% identity |

Documents (5) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Protocadherin beta-5
Short name=PCDH-beta-5

Gene names

Name:

PCDHB5

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	795 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
Subcellular location	Cell membrane; Single-pass type I membrane protein By similarity.
Sequence similarities	Contains 6 cadherin domains.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Repeat Signal Transmembrane Transmembrane helix
Ligand	Calcium
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	calcium-dependent cell-cell adhesion Non-traceable author statement Ref.3. Source: UniProtKB homophilic cell adhesion Inferred from electronic annotation. Source: InterPro synapse assembly Traceable author statement PubMed 12231349. Source: UniProtKB synaptic transmission Traceable author statement PubMed 12231349. Source: UniProtKB
Cellular_component	integral to membrane Non-traceable author statement Ref.3. Source: UniProtKB plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 30

Potential

Chain

31 – 795

765

Protocadherin beta-5

PRO_0000003922

Regions

Topological domain

31 – 689

659

Extracellular Potential

Transmembrane

690 – 710

Helical; Potential

Topological domain

711 – 795

Cytoplasmic Potential

Domain

35 – 133

Cadherin 1

Domain

138 – 242

105

Cadherin 2

Domain

247 – 346

100

Cadherin 3

Domain

351 – 450

100

Cadherin 4

Domain

455 – 560

106

Cadherin 5

Domain

567 – 670

104

Cadherin 6

Amino acid modifications

Glycosylation

169

N-linked (GlcNAc...) Potential

Glycosylation

417

N-linked (GlcNAc...) Potential

Glycosylation

435

N-linked (GlcNAc...) Potential

Glycosylation

566

N-linked (GlcNAc...) Potential

Natural variations

Natural variant

156

I → T.
Corresponds to variant rs17096901 [ dbSNP | Ensembl ].

VAR_033704

Natural variant

720

S → P. Ref.4 Ref.5
Corresponds to variant rs400562 [ dbSNP | Ensembl ].

VAR_048552

Sequences

Sequence

Length

Mass (Da)

Tools

Q9Y5E4 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 06F743580DC65B64
Show »

FASTA

795

86,423

        10         20         30         40         50         60 
METALAKTPQ KRQVMFLAIL LLLWEAGSEA VRYSIPEETE SGYSVANLAK DLGLGVGELA 

        70         80         90        100        110        120 
TRGARMHYKG NKELLQLDIK TGNLLLYEKL DREVMCGATE PCILHFQLLL ENPVQFFQTD 

       130        140        150        160        170        180 
LQLTDINDHA PEFPEKEMLL KIPESTQPGT VFPLKIAQDF DIGSNTVQNY TISPNSHFHV 

       190        200        210        220        230        240 
ATHNRGDGRK YPELVLDKAL DREERPELSL TLTALDGGAP PRSGTTTIRI VVLDNNDNAP 

       250        260        270        280        290        300 
EFLQSFYEVQ VPENSPLNSL VVVVSARDLD AGAYGSVAYA LFQGDEVTQP FVIDEKTAEI 

       310        320        330        340        350        360 
RLKRALDFEA TPYYNVEIVA TDGGGLSGKC TVAIEVVDVN DNAPELTMST LSSPTPENAP 

       370        380        390        400        410        420 
ETVVAVFSVS DPDSGDNGRM ICSIQNDLPF LLKPTLKNFY TLVTQRTLDR ESQAEYNITI 

       430        440        450        460        470        480 
TVTDMGTPRL KTEHNITVLV SDVNDNAPAF TQTSYTLFVR ENNSPALHIG SVSATDRDSG 

       490        500        510        520        530        540 
TNAQVTYSLL PPQNPHLRLA SLVSINADNG HLFALRSLDY EALQAFEFRV GATDRGSPAL 

       550        560        570        580        590        600 
SSEALVRVLV LDANDNSPFV LYPLQNGSAP CTELVPRAAE PGYLVTKVVA VDGDSGQNAW 

       610        620        630        640        650        660 
LSYQLLKATE PGLFSMWAHN GEVRTARLLS ERDAAKHRLV VLVKDNGEPP RSATATLHVL 

       670        680        690        700        710        720 
LVDGFSQPYL PLPEAAPAQA QADSLTVYLV VALASVSSLF LFSVLLFVAV RLCRRSRAAS 

       730        740        750        760        770        780 
VGRCSVPEGP FPGHLVDVSG TGTLSQSYHY EVCLTGDSGA GEFKFLKPII PNLLPQGAGE 

       790 
EIGKTAAFRN SFGLN

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A striking organization of a large family of human neural cadherin-like cell adhesion genes." Wu Q., Maniatis T. Cell 97:779-790(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Cloning and characterization of a new human cDNA homologous to Rattus norvegicus protocadherin-3 (pcdh3)." Ding J.B., Yu L., Zhao S.Y. Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number." Vanhalst K., Kools P., Vanden Eynde E., van Roy F. FEBS Lett. 495:120-125(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PRO-720. Tissue: Muscle.
[5]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 95-795, VARIANT PRO-720. Tissue: Uterus.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF152498 mRNA. Translation: AAD43759.1. AF134474 mRNA. Translation: AAP97251.1. AF217753 mRNA. Translation: AAK51620.1. BC001186 mRNA. Translation: AAH01186.1. AL117449 mRNA. Translation: CAB55933.1.
IPI	IPI00001428.
PIR	T17243.
RefSeq	NP_056484.1. NM_015669.2.
UniGene	Hs.119693.
3D structure databases
ProteinModelPortal	Q9Y5E4.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000231134.
PTM databases
PhosphoSite	Q9Y5E4.
Polymorphism databases
DMDM	13431375.
Proteomic databases
PaxDb	Q9Y5E4.
PeptideAtlas	Q9Y5E4.
PRIDE	Q9Y5E4.
Protocols and materials databases
DNASU	26167.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000231134; ENSP00000231134; ENSG00000113209.
GeneID	26167.
KEGG	hsa:26167.
UCSC	uc003liq.3. human.
Organism-specific databases
CTD	26167.
GeneCards	GC05P140514.
HGNC	HGNC:8690. PCDHB5.
HPA	HPA013191.
MIM	604967. gene. 606331. gene.
neXtProt	NX_Q9Y5E4.
PharmGKB	PA33039.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG251260.
HOVERGEN	HBG054878.
InParanoid	Q9Y5E4.
KO	K16494.
OMA	GATDPCI.
OrthoDB	EOG405S19.
PhylomeDB	Q9Y5E4.
Gene expression databases
Bgee	Q9Y5E4.
CleanEx	HS_PCDHB5.
Genevestigator	Q9Y5E4.
GermOnline	ENSG00000113209. Homo sapiens.
Family and domain databases
Gene3D	2.60.40.60. 5 hits.
InterPro	IPR002126. Cadherin. IPR015919. Cadherin-like. IPR020894. Cadherin_CS. IPR013164. Cadherin_N. [Graphical view]
Pfam	PF00028. Cadherin. 5 hits. PF08266. Cadherin_2. 1 hit. [Graphical view]
PRINTS	PR00205. CADHERIN.
SMART	SM00112. CA. 5 hits. [Graphical view]
SUPFAM	SSF49313. Cadherin. 5 hits.
PROSITE	PS00232. CADHERIN_1. 5 hits. PS50268. CADHERIN_2. 6 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	PCDHB5. human.
GenomeRNAi	26167.
NextBio	48275.
SOURCE	Search...

Entry information

Entry name

PCDB5_HUMAN

Accession

Primary (citable) accession number: Q9Y5E4
Secondary accession number(s): Q549F4, Q9UFU9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	November 1, 1999
Last modified:	May 1, 2013
This is version 112 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Natural variations

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents