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Q9Y5E4

- PCDB5_HUMAN

UniProt

Q9Y5E4 - PCDB5_HUMAN

Protein

Protocadherin beta-5

Gene

PCDHB5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    GO - Biological processi

    1. calcium-dependent cell-cell adhesion Source: UniProtKB
    2. homophilic cell adhesion Source: InterPro
    3. synapse assembly Source: UniProtKB
    4. synaptic transmission Source: UniProtKB

    Keywords - Biological processi

    Cell adhesion

    Keywords - Ligandi

    Calcium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protocadherin beta-5
    Short name:
    PCDH-beta-5
    Gene namesi
    Name:PCDHB5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:8690. PCDHB5.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33039.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3030Sequence AnalysisAdd
    BLAST
    Chaini31 – 795765Protocadherin beta-5PRO_0000003922Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi169 – 1691N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi417 – 4171N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi435 – 4351N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi566 – 5661N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9Y5E4.
    PeptideAtlasiQ9Y5E4.
    PRIDEiQ9Y5E4.

    PTM databases

    PhosphoSiteiQ9Y5E4.

    Expressioni

    Gene expression databases

    BgeeiQ9Y5E4.
    CleanExiHS_PCDHB5.
    GenevestigatoriQ9Y5E4.

    Organism-specific databases

    HPAiHPA013191.

    Interactioni

    Protein-protein interaction databases

    BioGridi117593. 2 interactions.
    STRINGi9606.ENSP00000231134.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y5E4.
    SMRiQ9Y5E4. Positions 31-676.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini31 – 689659ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini711 – 79585CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei690 – 71021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini35 – 13399Cadherin 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini138 – 242105Cadherin 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini247 – 346100Cadherin 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini351 – 450100Cadherin 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini455 – 560106Cadherin 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini567 – 670104Cadherin 6PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 6 cadherin domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG251260.
    HOVERGENiHBG054878.
    InParanoidiQ9Y5E4.
    KOiK16494.
    OMAiIPENVQP.
    OrthoDBiEOG7KSX80.
    PhylomeDBiQ9Y5E4.
    TreeFamiTF332299.

    Family and domain databases

    Gene3Di2.60.40.60. 5 hits.
    InterProiIPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    IPR013164. Cadherin_N.
    [Graphical view]
    PfamiPF00028. Cadherin. 5 hits.
    PF08266. Cadherin_2. 1 hit.
    [Graphical view]
    PRINTSiPR00205. CADHERIN.
    SMARTiSM00112. CA. 5 hits.
    [Graphical view]
    SUPFAMiSSF49313. SSF49313. 5 hits.
    PROSITEiPS00232. CADHERIN_1. 5 hits.
    PS50268. CADHERIN_2. 6 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9Y5E4-1 [UniParc]FASTAAdd to Basket

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    METALAKTPQ KRQVMFLAIL LLLWEAGSEA VRYSIPEETE SGYSVANLAK    50
    DLGLGVGELA TRGARMHYKG NKELLQLDIK TGNLLLYEKL DREVMCGATE 100
    PCILHFQLLL ENPVQFFQTD LQLTDINDHA PEFPEKEMLL KIPESTQPGT 150
    VFPLKIAQDF DIGSNTVQNY TISPNSHFHV ATHNRGDGRK YPELVLDKAL 200
    DREERPELSL TLTALDGGAP PRSGTTTIRI VVLDNNDNAP EFLQSFYEVQ 250
    VPENSPLNSL VVVVSARDLD AGAYGSVAYA LFQGDEVTQP FVIDEKTAEI 300
    RLKRALDFEA TPYYNVEIVA TDGGGLSGKC TVAIEVVDVN DNAPELTMST 350
    LSSPTPENAP ETVVAVFSVS DPDSGDNGRM ICSIQNDLPF LLKPTLKNFY 400
    TLVTQRTLDR ESQAEYNITI TVTDMGTPRL KTEHNITVLV SDVNDNAPAF 450
    TQTSYTLFVR ENNSPALHIG SVSATDRDSG TNAQVTYSLL PPQNPHLRLA 500
    SLVSINADNG HLFALRSLDY EALQAFEFRV GATDRGSPAL SSEALVRVLV 550
    LDANDNSPFV LYPLQNGSAP CTELVPRAAE PGYLVTKVVA VDGDSGQNAW 600
    LSYQLLKATE PGLFSMWAHN GEVRTARLLS ERDAAKHRLV VLVKDNGEPP 650
    RSATATLHVL LVDGFSQPYL PLPEAAPAQA QADSLTVYLV VALASVSSLF 700
    LFSVLLFVAV RLCRRSRAAS VGRCSVPEGP FPGHLVDVSG TGTLSQSYHY 750
    EVCLTGDSGA GEFKFLKPII PNLLPQGAGE EIGKTAAFRN SFGLN 795
    Length:795
    Mass (Da):86,423
    Last modified:November 1, 1999 - v1
    Checksum:i06F743580DC65B64
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti156 – 1561I → T.
    Corresponds to variant rs17096901 [ dbSNP | Ensembl ].
    VAR_033704
    Natural varianti720 – 7201S → P.2 Publications
    Corresponds to variant rs400562 [ dbSNP | Ensembl ].
    VAR_048552

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF152498 mRNA. Translation: AAD43759.1.
    AF134474 mRNA. Translation: AAP97251.1.
    AF217753 mRNA. Translation: AAK51620.1.
    BC001186 mRNA. Translation: AAH01186.1.
    AL117449 mRNA. Translation: CAB55933.1.
    CCDSiCCDS4247.1.
    PIRiT17243.
    RefSeqiNP_056484.1. NM_015669.3.
    UniGeneiHs.119693.

    Genome annotation databases

    EnsembliENST00000231134; ENSP00000231134; ENSG00000113209.
    GeneIDi26167.
    KEGGihsa:26167.
    UCSCiuc003liq.3. human.

    Polymorphism databases

    DMDMi13431375.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF152498 mRNA. Translation: AAD43759.1 .
    AF134474 mRNA. Translation: AAP97251.1 .
    AF217753 mRNA. Translation: AAK51620.1 .
    BC001186 mRNA. Translation: AAH01186.1 .
    AL117449 mRNA. Translation: CAB55933.1 .
    CCDSi CCDS4247.1.
    PIRi T17243.
    RefSeqi NP_056484.1. NM_015669.3.
    UniGenei Hs.119693.

    3D structure databases

    ProteinModelPortali Q9Y5E4.
    SMRi Q9Y5E4. Positions 31-676.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117593. 2 interactions.
    STRINGi 9606.ENSP00000231134.

    PTM databases

    PhosphoSitei Q9Y5E4.

    Polymorphism databases

    DMDMi 13431375.

    Proteomic databases

    PaxDbi Q9Y5E4.
    PeptideAtlasi Q9Y5E4.
    PRIDEi Q9Y5E4.

    Protocols and materials databases

    DNASUi 26167.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000231134 ; ENSP00000231134 ; ENSG00000113209 .
    GeneIDi 26167.
    KEGGi hsa:26167.
    UCSCi uc003liq.3. human.

    Organism-specific databases

    CTDi 26167.
    GeneCardsi GC05P140514.
    HGNCi HGNC:8690. PCDHB5.
    HPAi HPA013191.
    MIMi 604967. gene.
    606331. gene.
    neXtProti NX_Q9Y5E4.
    PharmGKBi PA33039.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG251260.
    HOVERGENi HBG054878.
    InParanoidi Q9Y5E4.
    KOi K16494.
    OMAi IPENVQP.
    OrthoDBi EOG7KSX80.
    PhylomeDBi Q9Y5E4.
    TreeFami TF332299.

    Miscellaneous databases

    ChiTaRSi PCDHB5. human.
    GeneWikii PCDHB5.
    GenomeRNAii 26167.
    NextBioi 48275.
    PROi Q9Y5E4.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9Y5E4.
    CleanExi HS_PCDHB5.
    Genevestigatori Q9Y5E4.

    Family and domain databases

    Gene3Di 2.60.40.60. 5 hits.
    InterProi IPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    IPR013164. Cadherin_N.
    [Graphical view ]
    Pfami PF00028. Cadherin. 5 hits.
    PF08266. Cadherin_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00205. CADHERIN.
    SMARTi SM00112. CA. 5 hits.
    [Graphical view ]
    SUPFAMi SSF49313. SSF49313. 5 hits.
    PROSITEi PS00232. CADHERIN_1. 5 hits.
    PS50268. CADHERIN_2. 6 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A striking organization of a large family of human neural cadherin-like cell adhesion genes."
      Wu Q., Maniatis T.
      Cell 97:779-790(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Cloning and characterization of a new human cDNA homologous to Rattus norvegicus protocadherin-3 (pcdh3)."
      Ding J.B., Yu L., Zhao S.Y.
      Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number."
      Vanhalst K., Kools P., Vanden Eynde E., van Roy F.
      FEBS Lett. 495:120-125(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PRO-720.
      Tissue: Muscle.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 95-795, VARIANT PRO-720.
      Tissue: Uterus.

    Entry informationi

    Entry nameiPCDB5_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y5E4
    Secondary accession number(s): Q549F4, Q9UFU9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 119 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3