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Q9Y5E4 (PCDB5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 118. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protocadherin beta-5

Short name=PCDH-beta-5
Gene names
Name:PCDHB5
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length795 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

Subcellular location

Cell membrane; Single-pass type I membrane protein By similarity.

Sequence similarities

Contains 6 cadherin domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3030 Potential
Chain31 – 795765Protocadherin beta-5
PRO_0000003922

Regions

Topological domain31 – 689659Extracellular Potential
Transmembrane690 – 71021Helical; Potential
Topological domain711 – 79585Cytoplasmic Potential
Domain35 – 13399Cadherin 1
Domain138 – 242105Cadherin 2
Domain247 – 346100Cadherin 3
Domain351 – 450100Cadherin 4
Domain455 – 560106Cadherin 5
Domain567 – 670104Cadherin 6

Amino acid modifications

Glycosylation1691N-linked (GlcNAc...) Potential
Glycosylation4171N-linked (GlcNAc...) Potential
Glycosylation4351N-linked (GlcNAc...) Potential
Glycosylation5661N-linked (GlcNAc...) Potential

Natural variations

Natural variant1561I → T.
Corresponds to variant rs17096901 [ dbSNP | Ensembl ].
VAR_033704
Natural variant7201S → P. Ref.4 Ref.5
Corresponds to variant rs400562 [ dbSNP | Ensembl ].
VAR_048552

Sequences

Sequence LengthMass (Da)Tools
Q9Y5E4 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 06F743580DC65B64

FASTA79586,423
        10         20         30         40         50         60 
METALAKTPQ KRQVMFLAIL LLLWEAGSEA VRYSIPEETE SGYSVANLAK DLGLGVGELA 

        70         80         90        100        110        120 
TRGARMHYKG NKELLQLDIK TGNLLLYEKL DREVMCGATE PCILHFQLLL ENPVQFFQTD 

       130        140        150        160        170        180 
LQLTDINDHA PEFPEKEMLL KIPESTQPGT VFPLKIAQDF DIGSNTVQNY TISPNSHFHV 

       190        200        210        220        230        240 
ATHNRGDGRK YPELVLDKAL DREERPELSL TLTALDGGAP PRSGTTTIRI VVLDNNDNAP 

       250        260        270        280        290        300 
EFLQSFYEVQ VPENSPLNSL VVVVSARDLD AGAYGSVAYA LFQGDEVTQP FVIDEKTAEI 

       310        320        330        340        350        360 
RLKRALDFEA TPYYNVEIVA TDGGGLSGKC TVAIEVVDVN DNAPELTMST LSSPTPENAP 

       370        380        390        400        410        420 
ETVVAVFSVS DPDSGDNGRM ICSIQNDLPF LLKPTLKNFY TLVTQRTLDR ESQAEYNITI 

       430        440        450        460        470        480 
TVTDMGTPRL KTEHNITVLV SDVNDNAPAF TQTSYTLFVR ENNSPALHIG SVSATDRDSG 

       490        500        510        520        530        540 
TNAQVTYSLL PPQNPHLRLA SLVSINADNG HLFALRSLDY EALQAFEFRV GATDRGSPAL 

       550        560        570        580        590        600 
SSEALVRVLV LDANDNSPFV LYPLQNGSAP CTELVPRAAE PGYLVTKVVA VDGDSGQNAW 

       610        620        630        640        650        660 
LSYQLLKATE PGLFSMWAHN GEVRTARLLS ERDAAKHRLV VLVKDNGEPP RSATATLHVL 

       670        680        690        700        710        720 
LVDGFSQPYL PLPEAAPAQA QADSLTVYLV VALASVSSLF LFSVLLFVAV RLCRRSRAAS 

       730        740        750        760        770        780 
VGRCSVPEGP FPGHLVDVSG TGTLSQSYHY EVCLTGDSGA GEFKFLKPII PNLLPQGAGE 

       790 
EIGKTAAFRN SFGLN 

« Hide

References

« Hide 'large scale' references
[1]"A striking organization of a large family of human neural cadherin-like cell adhesion genes."
Wu Q., Maniatis T.
Cell 97:779-790(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Cloning and characterization of a new human cDNA homologous to Rattus norvegicus protocadherin-3 (pcdh3)."
Ding J.B., Yu L., Zhao S.Y.
Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number."
Vanhalst K., Kools P., Vanden Eynde E., van Roy F.
FEBS Lett. 495:120-125(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PRO-720.
Tissue: Muscle.
[5]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 95-795, VARIANT PRO-720.
Tissue: Uterus.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF152498 mRNA. Translation: AAD43759.1.
AF134474 mRNA. Translation: AAP97251.1.
AF217753 mRNA. Translation: AAK51620.1.
BC001186 mRNA. Translation: AAH01186.1.
AL117449 mRNA. Translation: CAB55933.1.
CCDSCCDS4247.1.
PIRT17243.
RefSeqNP_056484.1. NM_015669.3.
UniGeneHs.119693.

3D structure databases

ProteinModelPortalQ9Y5E4.
SMRQ9Y5E4. Positions 31-676.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid117593. 2 interactions.
STRING9606.ENSP00000231134.

PTM databases

PhosphoSiteQ9Y5E4.

Polymorphism databases

DMDM13431375.

Proteomic databases

PaxDbQ9Y5E4.
PeptideAtlasQ9Y5E4.
PRIDEQ9Y5E4.

Protocols and materials databases

DNASU26167.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000231134; ENSP00000231134; ENSG00000113209.
ENST00000608889; ENSP00000476335; ENSG00000273383.
GeneID26167.
KEGGhsa:26167.
UCSCuc003liq.3. human.

Organism-specific databases

CTD26167.
GeneCardsGC05P140514.
HGNCHGNC:8690. PCDHB5.
HPAHPA013191.
MIM604967. gene.
606331. gene.
neXtProtNX_Q9Y5E4.
PharmGKBPA33039.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG251260.
HOVERGENHBG054878.
InParanoidQ9Y5E4.
KOK16494.
OMAIPENVQP.
OrthoDBEOG7KSX80.
PhylomeDBQ9Y5E4.
TreeFamTF332299.

Gene expression databases

BgeeQ9Y5E4.
CleanExHS_PCDHB5.
GenevestigatorQ9Y5E4.

Family and domain databases

Gene3D2.60.40.60. 5 hits.
InterProIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
[Graphical view]
PRINTSPR00205. CADHERIN.
SMARTSM00112. CA. 5 hits.
[Graphical view]
SUPFAMSSF49313. SSF49313. 5 hits.
PROSITEPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSPCDHB5. human.
GeneWikiPCDHB5.
GenomeRNAi26167.
NextBio48275.
PROQ9Y5E4.
SOURCESearch...

Entry information

Entry namePCDB5_HUMAN
AccessionPrimary (citable) accession number: Q9Y5E4
Secondary accession number(s): Q549F4, Q9UFU9
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM