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Protein

Protocadherin beta-5

Gene

PCDHB5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

GO - Molecular functioni

GO - Biological processi

  • calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
  • chemical synaptic transmission Source: UniProtKB
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
  • synapse assembly Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Enzyme and pathway databases

BioCyciZFISH:ENSG00000113209-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin beta-5
Short name:
PCDH-beta-5
Gene namesi
Name:PCDHB5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:8690. PCDHB5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini31 – 689ExtracellularSequence analysisAdd BLAST659
Transmembranei690 – 710HelicalSequence analysisAdd BLAST21
Topological domaini711 – 795CytoplasmicSequence analysisAdd BLAST85

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33039.

Polymorphism and mutation databases

BioMutaiPCDHB5.
DMDMi13431375.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000000392231 – 795Protocadherin beta-5Add BLAST765

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi169N-linked (GlcNAc...)Sequence analysis1
Modified residuei296N6-acetyllysineBy similarity1
Glycosylationi417N-linked (GlcNAc...)Sequence analysis1
Glycosylationi435N-linked (GlcNAc...)Sequence analysis1
Glycosylationi566N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Acetylation, Glycoprotein

Proteomic databases

EPDiQ9Y5E4.
PaxDbiQ9Y5E4.
PeptideAtlasiQ9Y5E4.
PRIDEiQ9Y5E4.

PTM databases

iPTMnetiQ9Y5E4.
PhosphoSitePlusiQ9Y5E4.

Expressioni

Gene expression databases

BgeeiENSG00000113209.
CleanExiHS_PCDHB5.
ExpressionAtlasiQ9Y5E4. baseline and differential.
GenevisibleiQ9Y5E4. HS.

Organism-specific databases

HPAiHPA013191.

Interactioni

Protein-protein interaction databases

BioGridi117593. 9 interactors.
IntActiQ9Y5E4. 2 interactors.
STRINGi9606.ENSP00000231134.

Structurei

3D structure databases

ProteinModelPortaliQ9Y5E4.
SMRiQ9Y5E4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 133Cadherin 1PROSITE-ProRule annotationAdd BLAST99
Domaini138 – 242Cadherin 2PROSITE-ProRule annotationAdd BLAST105
Domaini247 – 346Cadherin 3PROSITE-ProRule annotationAdd BLAST100
Domaini351 – 450Cadherin 4PROSITE-ProRule annotationAdd BLAST100
Domaini455 – 560Cadherin 5PROSITE-ProRule annotationAdd BLAST106
Domaini567 – 670Cadherin 6PROSITE-ProRule annotationAdd BLAST104

Sequence similaritiesi

Contains 6 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
HOVERGENiHBG054878.
InParanoidiQ9Y5E4.
KOiK16494.
OrthoDBiEOG091G024L.
PhylomeDBiQ9Y5E4.
TreeFamiTF332299.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
IPR030730. PCDHB5.
[Graphical view]
PANTHERiPTHR24028:SF90. PTHR24028:SF90. 1 hit.
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y5E4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METALAKTPQ KRQVMFLAIL LLLWEAGSEA VRYSIPEETE SGYSVANLAK
60 70 80 90 100
DLGLGVGELA TRGARMHYKG NKELLQLDIK TGNLLLYEKL DREVMCGATE
110 120 130 140 150
PCILHFQLLL ENPVQFFQTD LQLTDINDHA PEFPEKEMLL KIPESTQPGT
160 170 180 190 200
VFPLKIAQDF DIGSNTVQNY TISPNSHFHV ATHNRGDGRK YPELVLDKAL
210 220 230 240 250
DREERPELSL TLTALDGGAP PRSGTTTIRI VVLDNNDNAP EFLQSFYEVQ
260 270 280 290 300
VPENSPLNSL VVVVSARDLD AGAYGSVAYA LFQGDEVTQP FVIDEKTAEI
310 320 330 340 350
RLKRALDFEA TPYYNVEIVA TDGGGLSGKC TVAIEVVDVN DNAPELTMST
360 370 380 390 400
LSSPTPENAP ETVVAVFSVS DPDSGDNGRM ICSIQNDLPF LLKPTLKNFY
410 420 430 440 450
TLVTQRTLDR ESQAEYNITI TVTDMGTPRL KTEHNITVLV SDVNDNAPAF
460 470 480 490 500
TQTSYTLFVR ENNSPALHIG SVSATDRDSG TNAQVTYSLL PPQNPHLRLA
510 520 530 540 550
SLVSINADNG HLFALRSLDY EALQAFEFRV GATDRGSPAL SSEALVRVLV
560 570 580 590 600
LDANDNSPFV LYPLQNGSAP CTELVPRAAE PGYLVTKVVA VDGDSGQNAW
610 620 630 640 650
LSYQLLKATE PGLFSMWAHN GEVRTARLLS ERDAAKHRLV VLVKDNGEPP
660 670 680 690 700
RSATATLHVL LVDGFSQPYL PLPEAAPAQA QADSLTVYLV VALASVSSLF
710 720 730 740 750
LFSVLLFVAV RLCRRSRAAS VGRCSVPEGP FPGHLVDVSG TGTLSQSYHY
760 770 780 790
EVCLTGDSGA GEFKFLKPII PNLLPQGAGE EIGKTAAFRN SFGLN
Length:795
Mass (Da):86,423
Last modified:November 1, 1999 - v1
Checksum:i06F743580DC65B64
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033704156I → T.Corresponds to variant rs17096901dbSNPEnsembl.1
Natural variantiVAR_048552720S → P.2 PublicationsCorresponds to variant rs400562dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152498 mRNA. Translation: AAD43759.1.
AF134474 mRNA. Translation: AAP97251.1.
AF217753 mRNA. Translation: AAK51620.1.
BC001186 mRNA. Translation: AAH01186.1.
AL117449 mRNA. Translation: CAB55933.1.
CCDSiCCDS4247.1.
PIRiT17243.
RefSeqiNP_056484.2. NM_015669.4.
UniGeneiHs.119693.

Genome annotation databases

EnsembliENST00000231134; ENSP00000231134; ENSG00000113209.
GeneIDi26167.
KEGGihsa:26167.
UCSCiuc003liq.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152498 mRNA. Translation: AAD43759.1.
AF134474 mRNA. Translation: AAP97251.1.
AF217753 mRNA. Translation: AAK51620.1.
BC001186 mRNA. Translation: AAH01186.1.
AL117449 mRNA. Translation: CAB55933.1.
CCDSiCCDS4247.1.
PIRiT17243.
RefSeqiNP_056484.2. NM_015669.4.
UniGeneiHs.119693.

3D structure databases

ProteinModelPortaliQ9Y5E4.
SMRiQ9Y5E4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117593. 9 interactors.
IntActiQ9Y5E4. 2 interactors.
STRINGi9606.ENSP00000231134.

PTM databases

iPTMnetiQ9Y5E4.
PhosphoSitePlusiQ9Y5E4.

Polymorphism and mutation databases

BioMutaiPCDHB5.
DMDMi13431375.

Proteomic databases

EPDiQ9Y5E4.
PaxDbiQ9Y5E4.
PeptideAtlasiQ9Y5E4.
PRIDEiQ9Y5E4.

Protocols and materials databases

DNASUi26167.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000231134; ENSP00000231134; ENSG00000113209.
GeneIDi26167.
KEGGihsa:26167.
UCSCiuc003liq.5. human.

Organism-specific databases

CTDi26167.
GeneCardsiPCDHB5.
HGNCiHGNC:8690. PCDHB5.
HPAiHPA013191.
MIMi604967. gene.
606331. gene.
neXtProtiNX_Q9Y5E4.
PharmGKBiPA33039.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
HOVERGENiHBG054878.
InParanoidiQ9Y5E4.
KOiK16494.
OrthoDBiEOG091G024L.
PhylomeDBiQ9Y5E4.
TreeFamiTF332299.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000113209-MONOMER.

Miscellaneous databases

ChiTaRSiPCDHB5. human.
GeneWikiiPCDHB5.
GenomeRNAii26167.
PROiQ9Y5E4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000113209.
CleanExiHS_PCDHB5.
ExpressionAtlasiQ9Y5E4. baseline and differential.
GenevisibleiQ9Y5E4. HS.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
IPR030730. PCDHB5.
[Graphical view]
PANTHERiPTHR24028:SF90. PTHR24028:SF90. 1 hit.
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPCDB5_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5E4
Secondary accession number(s): Q549F4, Q9UFU9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1999
Last modified: November 30, 2016
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.