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Q9Y5E4

- PCDB5_HUMAN

UniProt

Q9Y5E4 - PCDB5_HUMAN

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Protein

Protocadherin beta-5

Gene

PCDHB5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro

GO - Biological processi

  1. calcium-dependent cell-cell adhesion Source: UniProtKB
  2. homophilic cell adhesion Source: InterPro
  3. synapse assembly Source: UniProtKB
  4. synaptic transmission Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin beta-5
Short name:
PCDH-beta-5
Gene namesi
Name:PCDHB5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:8690. PCDHB5.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33039.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030Sequence AnalysisAdd
BLAST
Chaini31 – 795765Protocadherin beta-5PRO_0000003922Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi169 – 1691N-linked (GlcNAc...)Sequence Analysis
Glycosylationi417 – 4171N-linked (GlcNAc...)Sequence Analysis
Glycosylationi435 – 4351N-linked (GlcNAc...)Sequence Analysis
Glycosylationi566 – 5661N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9Y5E4.
PeptideAtlasiQ9Y5E4.
PRIDEiQ9Y5E4.

PTM databases

PhosphoSiteiQ9Y5E4.

Expressioni

Gene expression databases

BgeeiQ9Y5E4.
CleanExiHS_PCDHB5.
ExpressionAtlasiQ9Y5E4. baseline and differential.
GenevestigatoriQ9Y5E4.

Organism-specific databases

HPAiHPA013191.

Interactioni

Protein-protein interaction databases

BioGridi117593. 2 interactions.
STRINGi9606.ENSP00000231134.

Structurei

3D structure databases

ProteinModelPortaliQ9Y5E4.
SMRiQ9Y5E4. Positions 31-676.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini31 – 689659ExtracellularSequence AnalysisAdd
BLAST
Topological domaini711 – 79585CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei690 – 71021HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 13399Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini138 – 242105Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini247 – 346100Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini351 – 450100Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Domaini455 – 560106Cadherin 5PROSITE-ProRule annotationAdd
BLAST
Domaini567 – 670104Cadherin 6PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 6 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG251260.
GeneTreeiENSGT00760000118847.
HOVERGENiHBG054878.
InParanoidiQ9Y5E4.
KOiK16494.
OMAiIPENVQP.
OrthoDBiEOG7KSX80.
PhylomeDBiQ9Y5E4.
TreeFamiTF332299.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y5E4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
METALAKTPQ KRQVMFLAIL LLLWEAGSEA VRYSIPEETE SGYSVANLAK
60 70 80 90 100
DLGLGVGELA TRGARMHYKG NKELLQLDIK TGNLLLYEKL DREVMCGATE
110 120 130 140 150
PCILHFQLLL ENPVQFFQTD LQLTDINDHA PEFPEKEMLL KIPESTQPGT
160 170 180 190 200
VFPLKIAQDF DIGSNTVQNY TISPNSHFHV ATHNRGDGRK YPELVLDKAL
210 220 230 240 250
DREERPELSL TLTALDGGAP PRSGTTTIRI VVLDNNDNAP EFLQSFYEVQ
260 270 280 290 300
VPENSPLNSL VVVVSARDLD AGAYGSVAYA LFQGDEVTQP FVIDEKTAEI
310 320 330 340 350
RLKRALDFEA TPYYNVEIVA TDGGGLSGKC TVAIEVVDVN DNAPELTMST
360 370 380 390 400
LSSPTPENAP ETVVAVFSVS DPDSGDNGRM ICSIQNDLPF LLKPTLKNFY
410 420 430 440 450
TLVTQRTLDR ESQAEYNITI TVTDMGTPRL KTEHNITVLV SDVNDNAPAF
460 470 480 490 500
TQTSYTLFVR ENNSPALHIG SVSATDRDSG TNAQVTYSLL PPQNPHLRLA
510 520 530 540 550
SLVSINADNG HLFALRSLDY EALQAFEFRV GATDRGSPAL SSEALVRVLV
560 570 580 590 600
LDANDNSPFV LYPLQNGSAP CTELVPRAAE PGYLVTKVVA VDGDSGQNAW
610 620 630 640 650
LSYQLLKATE PGLFSMWAHN GEVRTARLLS ERDAAKHRLV VLVKDNGEPP
660 670 680 690 700
RSATATLHVL LVDGFSQPYL PLPEAAPAQA QADSLTVYLV VALASVSSLF
710 720 730 740 750
LFSVLLFVAV RLCRRSRAAS VGRCSVPEGP FPGHLVDVSG TGTLSQSYHY
760 770 780 790
EVCLTGDSGA GEFKFLKPII PNLLPQGAGE EIGKTAAFRN SFGLN
Length:795
Mass (Da):86,423
Last modified:November 1, 1999 - v1
Checksum:i06F743580DC65B64
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti156 – 1561I → T.
Corresponds to variant rs17096901 [ dbSNP | Ensembl ].
VAR_033704
Natural varianti720 – 7201S → P.2 Publications
Corresponds to variant rs400562 [ dbSNP | Ensembl ].
VAR_048552

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF152498 mRNA. Translation: AAD43759.1.
AF134474 mRNA. Translation: AAP97251.1.
AF217753 mRNA. Translation: AAK51620.1.
BC001186 mRNA. Translation: AAH01186.1.
AL117449 mRNA. Translation: CAB55933.1.
CCDSiCCDS4247.1.
PIRiT17243.
RefSeqiNP_056484.1. NM_015669.3.
UniGeneiHs.119693.

Genome annotation databases

EnsembliENST00000231134; ENSP00000231134; ENSG00000113209.
GeneIDi26167.
KEGGihsa:26167.
UCSCiuc003liq.3. human.

Polymorphism databases

DMDMi13431375.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF152498 mRNA. Translation: AAD43759.1 .
AF134474 mRNA. Translation: AAP97251.1 .
AF217753 mRNA. Translation: AAK51620.1 .
BC001186 mRNA. Translation: AAH01186.1 .
AL117449 mRNA. Translation: CAB55933.1 .
CCDSi CCDS4247.1.
PIRi T17243.
RefSeqi NP_056484.1. NM_015669.3.
UniGenei Hs.119693.

3D structure databases

ProteinModelPortali Q9Y5E4.
SMRi Q9Y5E4. Positions 31-676.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117593. 2 interactions.
STRINGi 9606.ENSP00000231134.

PTM databases

PhosphoSitei Q9Y5E4.

Polymorphism databases

DMDMi 13431375.

Proteomic databases

PaxDbi Q9Y5E4.
PeptideAtlasi Q9Y5E4.
PRIDEi Q9Y5E4.

Protocols and materials databases

DNASUi 26167.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000231134 ; ENSP00000231134 ; ENSG00000113209 .
GeneIDi 26167.
KEGGi hsa:26167.
UCSCi uc003liq.3. human.

Organism-specific databases

CTDi 26167.
GeneCardsi GC05P140514.
HGNCi HGNC:8690. PCDHB5.
HPAi HPA013191.
MIMi 604967. gene.
606331. gene.
neXtProti NX_Q9Y5E4.
PharmGKBi PA33039.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG251260.
GeneTreei ENSGT00760000118847.
HOVERGENi HBG054878.
InParanoidi Q9Y5E4.
KOi K16494.
OMAi IPENVQP.
OrthoDBi EOG7KSX80.
PhylomeDBi Q9Y5E4.
TreeFami TF332299.

Miscellaneous databases

ChiTaRSi PCDHB5. human.
GeneWikii PCDHB5.
GenomeRNAii 26167.
NextBioi 48275.
PROi Q9Y5E4.
SOURCEi Search...

Gene expression databases

Bgeei Q9Y5E4.
CleanExi HS_PCDHB5.
ExpressionAtlasi Q9Y5E4. baseline and differential.
Genevestigatori Q9Y5E4.

Family and domain databases

Gene3Di 2.60.40.60. 5 hits.
InterProi IPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view ]
Pfami PF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
[Graphical view ]
PRINTSi PR00205. CADHERIN.
SMARTi SM00112. CA. 5 hits.
[Graphical view ]
SUPFAMi SSF49313. SSF49313. 5 hits.
PROSITEi PS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A striking organization of a large family of human neural cadherin-like cell adhesion genes."
    Wu Q., Maniatis T.
    Cell 97:779-790(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning and characterization of a new human cDNA homologous to Rattus norvegicus protocadherin-3 (pcdh3)."
    Ding J.B., Yu L., Zhao S.Y.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number."
    Vanhalst K., Kools P., Vanden Eynde E., van Roy F.
    FEBS Lett. 495:120-125(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PRO-720.
    Tissue: Muscle.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 95-795, VARIANT PRO-720.
    Tissue: Uterus.

Entry informationi

Entry nameiPCDB5_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5E4
Secondary accession number(s): Q549F4, Q9UFU9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1999
Last modified: October 29, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3