Reviewed, UniProtKB/Swiss-Prot Q9Y5E4 (PCDB5_HUMAN)

Names and origin

Protein names

Recommended name:
    Protocadherin beta-5
      Short name=PCDH-beta-5

Gene names

Name:

PCDHB5

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	795 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
Subcellular location	Cell membrane; Single-pass type I membrane protein By similarity.
Sequence similarities	Contains 6 cadherin domains.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Repeat Signal Transmembrane
Ligand	Calcium
PTM	Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	calcium-dependent cell-cell adhesion Ref.3 Non-traceable author statement. Source: UniProtKB homophilic cell adhesion Inferred from electronic annotation. Source: InterPro synapse assembly Traceable author statement. Source: UniProtKB synaptic transmission Traceable author statement. Source: UniProtKB
Cellular component	integral to membrane Ref.3 Non-traceable author statement. Source: UniProtKB plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	calcium ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein binding Ref.3 Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
DGKB	Q9Y6T7	1	EBI-1045222,EBI-1049421

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 30	30	Potential
	Chain	31 – 795	765	Protocadherin beta-5		PRO_0000003922
Regions
	Topological domain	31 – 689	659	Extracellular Potential
	Transmembrane	690 – 710	21	Potential
	Topological domain	711 – 795	85	Cytoplasmic Potential
	Domain	35 – 133	99	Cadherin 1
	Domain	138 – 242	105	Cadherin 2
	Domain	247 – 346	100	Cadherin 3
	Domain	351 – 450	100	Cadherin 4
	Domain	455 – 560	106	Cadherin 5
	Domain	567 – 670	104	Cadherin 6
Amino acid modifications
	Glycosylation	169	1	N-linked (GlcNAc...) Potential
	Glycosylation	417	1	N-linked (GlcNAc...) Potential
	Glycosylation	435	1	N-linked (GlcNAc...) Potential
	Glycosylation	566	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	156	1	I → T: dbSNP rs17096901.		VAR_033704
	Natural variant	720	1	S → P: dbSNP rs400562. Ref.4 Ref.5		VAR_048552

Sequences

	Sequence		Length	Mass (Da)
	Q9Y5E4-1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 06F743580DC65B64	FASTA	795	86,423
	10 20 30 40 50 60 METALAKTPQ KRQVMFLAIL LLLWEAGSEA VRYSIPEETE SGYSVANLAK DLGLGVGELA 70 80 90 100 110 120 TRGARMHYKG NKELLQLDIK TGNLLLYEKL DREVMCGATE PCILHFQLLL ENPVQFFQTD 130 140 150 160 170 180 LQLTDINDHA PEFPEKEMLL KIPESTQPGT VFPLKIAQDF DIGSNTVQNY TISPNSHFHV 190 200 210 220 230 240 ATHNRGDGRK YPELVLDKAL DREERPELSL TLTALDGGAP PRSGTTTIRI VVLDNNDNAP 250 260 270 280 290 300 EFLQSFYEVQ VPENSPLNSL VVVVSARDLD AGAYGSVAYA LFQGDEVTQP FVIDEKTAEI 310 320 330 340 350 360 RLKRALDFEA TPYYNVEIVA TDGGGLSGKC TVAIEVVDVN DNAPELTMST LSSPTPENAP 370 380 390 400 410 420 ETVVAVFSVS DPDSGDNGRM ICSIQNDLPF LLKPTLKNFY TLVTQRTLDR ESQAEYNITI 430 440 450 460 470 480 TVTDMGTPRL KTEHNITVLV SDVNDNAPAF TQTSYTLFVR ENNSPALHIG SVSATDRDSG 490 500 510 520 530 540 TNAQVTYSLL PPQNPHLRLA SLVSINADNG HLFALRSLDY EALQAFEFRV GATDRGSPAL 550 560 570 580 590 600 SSEALVRVLV LDANDNSPFV LYPLQNGSAP CTELVPRAAE PGYLVTKVVA VDGDSGQNAW 610 620 630 640 650 660 LSYQLLKATE PGLFSMWAHN GEVRTARLLS ERDAAKHRLV VLVKDNGEPP RSATATLHVL 670 680 690 700 710 720 LVDGFSQPYL PLPEAAPAQA QADSLTVYLV VALASVSSLF LFSVLLFVAV RLCRRSRAAS 730 740 750 760 770 780 VGRCSVPEGP FPGHLVDVSG TGTLSQSYHY EVCLTGDSGA GEFKFLKPII PNLLPQGAGE 790 EIGKTAAFRN SFGLN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A striking organization of a large family of human neural cadherin-like cell adhesion genes." Wu Q., Maniatis T. Cell 97:779-790(1999) [PubMed: 10380929] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Cloning and characterization of a new human cDNA homologous to Rattus norvegicus protocadherin-3 (pcdh3)." Ding J.B., Yu L., Zhao S.Y. Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number." Vanhalst K., Kools P., Vanden Eynde E., van Roy F. FEBS Lett. 495:120-125(2001) [PubMed: 11322959] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PRO-720. Tissue: Muscle.
[5]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 95-795, VARIANT PRO-720. Tissue: Uterus.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF152498 mRNA. Translation: AAD43759.1. AF134474 mRNA. Translation: AAP97251.1. AF217753 mRNA. Translation: AAK51620.1. BC001186 mRNA. Translation: AAH01186.1. AL117449 mRNA. Translation: CAB55933.1.
IPI	IPI00001428.
PIR	T17243.
RefSeq	NP_056484.1.
UniGene	Hs.119693
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9Y5E4. 1 interaction.
STRING	Q9Y5E4.
Proteomic databases
PeptideAtlas	Q9Y5E4.
PRIDE	Q9Y5E4.
Genome annotation databases
Ensembl	ENST00000231134; ENSP00000231134; ENSG00000113209; Homo sapiens. [Genome view]
GeneID	26167.
KEGG	hsa:26167.
UCSC	uc003liq.1. human.
Organism-specific databases
CTD	26167.
GeneCards	GC05P140494.
H-InvDB	HIX0005246.
HGNC	HGNC:8690. PCDHB5.
HPA	HPA013191.
MIM	604967. gene. 606331. gene.
PharmGKB	PA33039.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q9Y5E4.
InParanoid	Q9Y5E4.
OMA	QGDEVTQ.
OrthoDB	EOG9GQSQ5.
Gene expression databases
ArrayExpress	Q9Y5E4.
Bgee	Q9Y5E4.
CleanEx	HS_PCDHB5.
Genevestigator	Q9Y5E4.
GermOnline	ENSG00000113209. Homo sapiens.
Family and domain databases
InterPro	IPR002126. Cadherin. IPR015919. Cadherin-like. IPR013164. Cadherin_N. IPR015493. Protocad_beta. [Graphical view]
Gene3D	G3DSA:2.60.40.60. Cadherin. 5 hits.
PANTHER	PTHR10596:SF94. Protocad_beta. 1 hit.
Pfam	PF00028. Cadherin. 5 hits. PF08266. Cadherin_2. 1 hit. [Graphical view]
PRINTS	PR00205. CADHERIN.
SMART	SM00112. CA. 5 hits. [Graphical view]
PROSITE	PS00232. CADHERIN_1. 5 hits. PS50268. CADHERIN_2. 6 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	48275.
SOURCE	Search...

Entry information

Entry name

PCDB5_HUMAN

Accession

Primary (citable) accession number: Q9Y5E4
Secondary accession number(s): Q549F4, Q9UFU9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	November 1, 1999
Last modified:	December 15, 2009
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.