ID   PCDB7_HUMAN             Reviewed;         793 AA.
AC   Q9Y5E2; A1L3Y8;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   24-JAN-2024, entry version 174.
DE   RecName: Full=Protocadherin beta-7;
DE            Short=PCDH-beta-7;
DE   Flags: Precursor;
GN   Name=PCDHB7;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10380929; DOI=10.1016/s0092-8674(00)80789-8;
RA   Wu Q., Maniatis T.;
RT   "A striking organization of a large family of human neural cadherin-like
RT   cell adhesion genes.";
RL   Cell 97:779-790(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=11322959; DOI=10.1016/s0014-5793(01)02372-9;
RA   Vanhalst K., Kools P., Vanden Eynde E., van Roy F.;
RT   "The human and murine protocadherin-beta one-exon gene families show high
RT   evolutionary conservation, despite the difference in gene number.";
RL   FEBS Lett. 495:120-125(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Potential calcium-dependent cell-adhesion protein. May be
CC       involved in the establishment and maintenance of specific neuronal
CC       connections in the brain.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I
CC       membrane protein {ECO:0000250}.
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DR   EMBL; AF152500; AAD43761.1; -; mRNA.
DR   EMBL; AF217750; AAK51617.1; -; mRNA.
DR   EMBL; AK315054; BAG37530.1; -; mRNA.
DR   EMBL; CH471062; EAW61977.1; -; Genomic_DNA.
DR   EMBL; BC130331; AAI30332.1; -; mRNA.
DR   CCDS; CCDS4249.1; -.
DR   RefSeq; NP_061763.1; NM_018940.3.
DR   AlphaFoldDB; Q9Y5E2; -.
DR   SMR; Q9Y5E2; -.
DR   BioGRID; 121069; 54.
DR   IntAct; Q9Y5E2; 16.
DR   STRING; 9606.ENSP00000231137; -.
DR   GlyCosmos; Q9Y5E2; 4 sites, No reported glycans.
DR   GlyGen; Q9Y5E2; 4 sites.
DR   iPTMnet; Q9Y5E2; -.
DR   PhosphoSitePlus; Q9Y5E2; -.
DR   BioMuta; PCDHB7; -.
DR   DMDM; 13431373; -.
DR   jPOST; Q9Y5E2; -.
DR   MassIVE; Q9Y5E2; -.
DR   PaxDb; 9606-ENSP00000231137; -.
DR   PeptideAtlas; Q9Y5E2; -.
DR   Antibodypedia; 27205; 68 antibodies from 12 providers.
DR   DNASU; 56129; -.
DR   Ensembl; ENST00000231137.6; ENSP00000231137.3; ENSG00000113212.7.
DR   Ensembl; ENST00000708364.1; ENSP00000517191.1; ENSG00000291681.1.
DR   GeneID; 56129; -.
DR   KEGG; hsa:56129; -.
DR   MANE-Select; ENST00000231137.6; ENSP00000231137.3; NM_018940.4; NP_061763.1.
DR   UCSC; uc003lit.5; human.
DR   AGR; HGNC:8692; -.
DR   CTD; 56129; -.
DR   GeneCards; PCDHB7; -.
DR   HGNC; HGNC:8692; PCDHB7.
DR   HPA; ENSG00000113212; Low tissue specificity.
DR   MIM; 604967; gene.
DR   MIM; 606333; gene.
DR   neXtProt; NX_Q9Y5E2; -.
DR   OpenTargets; ENSG00000113212; -.
DR   PharmGKB; PA33041; -.
DR   VEuPathDB; HostDB:ENSG00000113212; -.
DR   eggNOG; KOG3594; Eukaryota.
DR   GeneTree; ENSGT00940000163469; -.
DR   HOGENOM; CLU_006480_3_0_1; -.
DR   InParanoid; Q9Y5E2; -.
DR   OMA; IFRAELW; -.
DR   OrthoDB; 5402790at2759; -.
DR   PhylomeDB; Q9Y5E2; -.
DR   TreeFam; TF332299; -.
DR   PathwayCommons; Q9Y5E2; -.
DR   SignaLink; Q9Y5E2; -.
DR   BioGRID-ORCS; 56129; 11 hits in 1113 CRISPR screens.
DR   ChiTaRS; PCDHB7; human.
DR   GeneWiki; PCDHB7; -.
DR   GenomeRNAi; 56129; -.
DR   Pharos; Q9Y5E2; Tdark.
DR   PRO; PR:Q9Y5E2; -.
DR   Proteomes; UP000005640; Chromosome 5.
DR   RNAct; Q9Y5E2; Protein.
DR   Bgee; ENSG00000113212; Expressed in visceral pleura and 115 other cell types or tissues.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR   GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR   GO; GO:0007399; P:nervous system development; IEA:UniProt.
DR   CDD; cd11304; Cadherin_repeat; 5.
DR   Gene3D; 2.60.40.60; Cadherins; 6.
DR   InterPro; IPR002126; Cadherin-like_dom.
DR   InterPro; IPR015919; Cadherin-like_sf.
DR   InterPro; IPR032455; Cadherin_C.
DR   InterPro; IPR020894; Cadherin_CS.
DR   InterPro; IPR013164; Cadherin_N.
DR   PANTHER; PTHR24028; CADHERIN-87A; 1.
DR   PANTHER; PTHR24028:SF69; PROTOCADHERIN BETA-7; 1.
DR   Pfam; PF00028; Cadherin; 5.
DR   Pfam; PF08266; Cadherin_2; 1.
DR   Pfam; PF16492; Cadherin_C_2; 1.
DR   PRINTS; PR00205; CADHERIN.
DR   SMART; SM00112; CA; 5.
DR   SUPFAM; SSF49313; Cadherin-like; 6.
DR   PROSITE; PS00232; CADHERIN_1; 5.
DR   PROSITE; PS50268; CADHERIN_2; 5.
DR   Genevisible; Q9Y5E2; HS.
PE   2: Evidence at transcript level;
KW   Calcium; Cell adhesion; Cell membrane; Glycoprotein; Membrane;
KW   Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   CHAIN           27..793
FT                   /note="Protocadherin beta-7"
FT                   /id="PRO_0000003926"
FT   TOPO_DOM        27..688
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        689..709
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        710..793
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          35..133
FT                   /note="Cadherin 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   DOMAIN          138..242
FT                   /note="Cadherin 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   DOMAIN          247..347
FT                   /note="Cadherin 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   DOMAIN          352..451
FT                   /note="Cadherin 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   DOMAIN          456..561
FT                   /note="Cadherin 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   DOMAIN          568..671
FT                   /note="Cadherin 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   CARBOHYD        169
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        418
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        436
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        567
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VARIANT         120
FT                   /note="E -> K (in dbSNP:rs17286891)"
FT                   /id="VAR_033708"
FT   VARIANT         187
FT                   /note="E -> K (in dbSNP:rs17096946)"
FT                   /id="VAR_033709"
FT   VARIANT         389
FT                   /note="V -> L (in dbSNP:rs2910313)"
FT                   /id="VAR_020367"
FT   VARIANT         575
FT                   /note="P -> L (in dbSNP:rs13189280)"
FT                   /id="VAR_059183"
FT   VARIANT         576
FT                   /note="L -> V (in dbSNP:rs13174866)"
FT                   /id="VAR_059184"
FT   VARIANT         716
FT                   /note="R -> W (in dbSNP:rs2910314)"
FT                   /id="VAR_059185"
SQ   SEQUENCE   793 AA;  86707 MW;  E5677098653CC755 CRC64;
     MEARVERAVQ KRQVLFLCVF LGMSWAGAEP LRYFVAEETE RGTFLTNLAK DLGLGVGELR
     ARGTRIVSDQ NMQILLLSSL TGDLLLNEKL DREELCGPRE PCVLPFQLLL EKPFQIFRAE
     LWVRDINDHA PVFLDREISL KILESTTPGA AFLLESAQDS DVGTNSLSNY TISPNAYFHI
     NVHDSGEGNI YPELVLNQVL DREEIPEFSL TLTALDGGSP PRSGTALVRI LVLDVNDNAP
     DFVRSLYKVQ VPENSPVGSM VVSVSARDLD TGSNGEIAYA FSYATERILK TFQINPTSGS
     LHLKAQLDYE AIQTYTLTIQ AKDGGGLSGK CTVVVDVTDI NDNRPELLLS SLTSPIAENS
     PETVVAVFRI RDRDSGNNGK TVCSIQDDVP FILKPSVENF YTLVTEKPLD RERNTEYNIT
     ITVTDLGTPR LKTEHNITVL VSDVNDNAPA FTQTSYTLFV RENNSPALPI GSVSATDRDS
     GTNAQVIYSL LPSQDPHLPL ASLVSINADN GHLFALRSLD YEALQAFEFR VGATDRGSPA
     LSSEALVRVL VLDANDNSPF VLYPLQNSSA PCTEPLPRAA EPGYLVTKVV AVDGDSGQNA
     WLSYQLLKAT EPGLFGVWAH NGEVRTARLL SERDAAKQRL VVLVKDNGEP PRSATATLHV
     LLVDGFSQPY LRLPEAAPDQ ANSLTVYLVV ALASVSSLFL LSVLLFVAVR LCRRSRAAPV
     GRCSVPEGPF PRHLVDLSGT GTLSQSYQYE VCLTGGSGTN EFKFLKPIIP NLLPQSTGRE
     VEENRPFQNN LGF
//