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Protein

Protocadherin beta-7

Gene

PCDHB7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Enzyme and pathway databases

BioCyciZFISH:ENSG00000113212-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin beta-7
Short name:
PCDH-beta-7
Gene namesi
Name:PCDHB7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:8692. PCDHB7.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 688ExtracellularSequence analysisAdd BLAST662
Transmembranei689 – 709HelicalSequence analysisAdd BLAST21
Topological domaini710 – 793CytoplasmicSequence analysisAdd BLAST84

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000113212.
PharmGKBiPA33041.

Polymorphism and mutation databases

BioMutaiPCDHB7.
DMDMi13431373.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000000392627 – 793Protocadherin beta-7Add BLAST767

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi169N-linked (GlcNAc...)Sequence analysis1
Glycosylationi418N-linked (GlcNAc...)Sequence analysis1
Glycosylationi436N-linked (GlcNAc...)Sequence analysis1
Glycosylationi567N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9Y5E2.
PaxDbiQ9Y5E2.
PeptideAtlasiQ9Y5E2.
PRIDEiQ9Y5E2.

PTM databases

iPTMnetiQ9Y5E2.
PhosphoSitePlusiQ9Y5E2.

Expressioni

Gene expression databases

BgeeiENSG00000113212.
CleanExiHS_PCDHB7.
GenevisibleiQ9Y5E2. HS.

Organism-specific databases

HPAiHPA059271.

Interactioni

Protein-protein interaction databases

BioGridi121069. 15 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ9Y5E2.
SMRiQ9Y5E2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 133Cadherin 1PROSITE-ProRule annotationAdd BLAST99
Domaini138 – 242Cadherin 2PROSITE-ProRule annotationAdd BLAST105
Domaini247 – 347Cadherin 3PROSITE-ProRule annotationAdd BLAST101
Domaini352 – 451Cadherin 4PROSITE-ProRule annotationAdd BLAST100
Domaini456 – 561Cadherin 5PROSITE-ProRule annotationAdd BLAST106
Domaini568 – 671Cadherin 6PROSITE-ProRule annotationAdd BLAST104

Sequence similaritiesi

Contains 6 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00840000129690.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.
InParanoidiQ9Y5E2.
KOiK16494.
OMAiYFHINVR.
OrthoDBiEOG091G024L.
PhylomeDBiQ9Y5E2.
TreeFamiTF332299.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
IPR030741. PCDHB7.
[Graphical view]
PANTHERiPTHR24028:SF69. PTHR24028:SF69. 1 hit.
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y5E2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEARVERAVQ KRQVLFLCVF LGMSWAGAEP LRYFVAEETE RGTFLTNLAK
60 70 80 90 100
DLGLGVGELR ARGTRIVSDQ NMQILLLSSL TGDLLLNEKL DREELCGPRE
110 120 130 140 150
PCVLPFQLLL EKPFQIFRAE LWVRDINDHA PVFLDREISL KILESTTPGA
160 170 180 190 200
AFLLESAQDS DVGTNSLSNY TISPNAYFHI NVHDSGEGNI YPELVLNQVL
210 220 230 240 250
DREEIPEFSL TLTALDGGSP PRSGTALVRI LVLDVNDNAP DFVRSLYKVQ
260 270 280 290 300
VPENSPVGSM VVSVSARDLD TGSNGEIAYA FSYATERILK TFQINPTSGS
310 320 330 340 350
LHLKAQLDYE AIQTYTLTIQ AKDGGGLSGK CTVVVDVTDI NDNRPELLLS
360 370 380 390 400
SLTSPIAENS PETVVAVFRI RDRDSGNNGK TVCSIQDDVP FILKPSVENF
410 420 430 440 450
YTLVTEKPLD RERNTEYNIT ITVTDLGTPR LKTEHNITVL VSDVNDNAPA
460 470 480 490 500
FTQTSYTLFV RENNSPALPI GSVSATDRDS GTNAQVIYSL LPSQDPHLPL
510 520 530 540 550
ASLVSINADN GHLFALRSLD YEALQAFEFR VGATDRGSPA LSSEALVRVL
560 570 580 590 600
VLDANDNSPF VLYPLQNSSA PCTEPLPRAA EPGYLVTKVV AVDGDSGQNA
610 620 630 640 650
WLSYQLLKAT EPGLFGVWAH NGEVRTARLL SERDAAKQRL VVLVKDNGEP
660 670 680 690 700
PRSATATLHV LLVDGFSQPY LRLPEAAPDQ ANSLTVYLVV ALASVSSLFL
710 720 730 740 750
LSVLLFVAVR LCRRSRAAPV GRCSVPEGPF PRHLVDLSGT GTLSQSYQYE
760 770 780 790
VCLTGGSGTN EFKFLKPIIP NLLPQSTGRE VEENRPFQNN LGF
Length:793
Mass (Da):86,707
Last modified:November 1, 1999 - v1
Checksum:iE5677098653CC755
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033708120E → K.Corresponds to variant rs17286891dbSNPEnsembl.1
Natural variantiVAR_033709187E → K.Corresponds to variant rs17096946dbSNPEnsembl.1
Natural variantiVAR_020367389V → L.Corresponds to variant rs2910313dbSNPEnsembl.1
Natural variantiVAR_059183575P → L.Corresponds to variant rs13189280dbSNPEnsembl.1
Natural variantiVAR_059184576L → V.Corresponds to variant rs13174866dbSNPEnsembl.1
Natural variantiVAR_059185716R → W.Corresponds to variant rs2910314dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152500 mRNA. Translation: AAD43761.1.
AF217750 mRNA. Translation: AAK51617.1.
AK315054 mRNA. Translation: BAG37530.1.
CH471062 Genomic DNA. Translation: EAW61977.1.
BC130331 mRNA. Translation: AAI30332.1.
CCDSiCCDS4249.1.
RefSeqiNP_061763.1. NM_018940.3.
UniGeneiHs.203830.

Genome annotation databases

EnsembliENST00000231137; ENSP00000231137; ENSG00000113212.
GeneIDi56129.
KEGGihsa:56129.
UCSCiuc003lit.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152500 mRNA. Translation: AAD43761.1.
AF217750 mRNA. Translation: AAK51617.1.
AK315054 mRNA. Translation: BAG37530.1.
CH471062 Genomic DNA. Translation: EAW61977.1.
BC130331 mRNA. Translation: AAI30332.1.
CCDSiCCDS4249.1.
RefSeqiNP_061763.1. NM_018940.3.
UniGeneiHs.203830.

3D structure databases

ProteinModelPortaliQ9Y5E2.
SMRiQ9Y5E2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121069. 15 interactors.

PTM databases

iPTMnetiQ9Y5E2.
PhosphoSitePlusiQ9Y5E2.

Polymorphism and mutation databases

BioMutaiPCDHB7.
DMDMi13431373.

Proteomic databases

EPDiQ9Y5E2.
PaxDbiQ9Y5E2.
PeptideAtlasiQ9Y5E2.
PRIDEiQ9Y5E2.

Protocols and materials databases

DNASUi56129.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000231137; ENSP00000231137; ENSG00000113212.
GeneIDi56129.
KEGGihsa:56129.
UCSCiuc003lit.5. human.

Organism-specific databases

CTDi56129.
GeneCardsiPCDHB7.
HGNCiHGNC:8692. PCDHB7.
HPAiHPA059271.
MIMi604967. gene.
606333. gene.
neXtProtiNX_Q9Y5E2.
OpenTargetsiENSG00000113212.
PharmGKBiPA33041.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00840000129690.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.
InParanoidiQ9Y5E2.
KOiK16494.
OMAiYFHINVR.
OrthoDBiEOG091G024L.
PhylomeDBiQ9Y5E2.
TreeFamiTF332299.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000113212-MONOMER.

Miscellaneous databases

GeneWikiiPCDHB7.
GenomeRNAii56129.
PROiQ9Y5E2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000113212.
CleanExiHS_PCDHB7.
GenevisibleiQ9Y5E2. HS.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
IPR030741. PCDHB7.
[Graphical view]
PANTHERiPTHR24028:SF69. PTHR24028:SF69. 1 hit.
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPCDB7_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5E2
Secondary accession number(s): A1L3Y8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.