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Protein

Protocadherin beta-7

Gene

PCDHB7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin beta-7
Short name:
PCDH-beta-7
Gene namesi
Name:PCDHB7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:8692. PCDHB7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 688662ExtracellularSequence AnalysisAdd
BLAST
Transmembranei689 – 70921HelicalSequence AnalysisAdd
BLAST
Topological domaini710 – 79384CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33041.

Polymorphism and mutation databases

BioMutaiPCDHB7.
DMDMi13431373.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Chaini27 – 793767Protocadherin beta-7PRO_0000003926Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi169 – 1691N-linked (GlcNAc...)Sequence Analysis
Glycosylationi418 – 4181N-linked (GlcNAc...)Sequence Analysis
Glycosylationi436 – 4361N-linked (GlcNAc...)Sequence Analysis
Glycosylationi567 – 5671N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9Y5E2.
PRIDEiQ9Y5E2.

PTM databases

PhosphoSiteiQ9Y5E2.

Expressioni

Gene expression databases

BgeeiQ9Y5E2.
CleanExiHS_PCDHB7.
GenevisibleiQ9Y5E2. HS.

Organism-specific databases

HPAiHPA059271.

Interactioni

Protein-protein interaction databases

BioGridi121069. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9Y5E2.
SMRiQ9Y5E2. Positions 31-677.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 13399Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini138 – 242105Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini247 – 347101Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini352 – 451100Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Domaini456 – 561106Cadherin 5PROSITE-ProRule annotationAdd
BLAST
Domaini568 – 671104Cadherin 6PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 6 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG251260.
GeneTreeiENSGT00760000118847.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.
InParanoidiQ9Y5E2.
KOiK16494.
OMAiYFHINVR.
OrthoDBiEOG7KSX80.
PhylomeDBiQ9Y5E2.
TreeFamiTF332299.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
IPR030741. PCDHB7.
[Graphical view]
PANTHERiPTHR24028:SF69. PTHR24028:SF69. 1 hit.
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y5E2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEARVERAVQ KRQVLFLCVF LGMSWAGAEP LRYFVAEETE RGTFLTNLAK
60 70 80 90 100
DLGLGVGELR ARGTRIVSDQ NMQILLLSSL TGDLLLNEKL DREELCGPRE
110 120 130 140 150
PCVLPFQLLL EKPFQIFRAE LWVRDINDHA PVFLDREISL KILESTTPGA
160 170 180 190 200
AFLLESAQDS DVGTNSLSNY TISPNAYFHI NVHDSGEGNI YPELVLNQVL
210 220 230 240 250
DREEIPEFSL TLTALDGGSP PRSGTALVRI LVLDVNDNAP DFVRSLYKVQ
260 270 280 290 300
VPENSPVGSM VVSVSARDLD TGSNGEIAYA FSYATERILK TFQINPTSGS
310 320 330 340 350
LHLKAQLDYE AIQTYTLTIQ AKDGGGLSGK CTVVVDVTDI NDNRPELLLS
360 370 380 390 400
SLTSPIAENS PETVVAVFRI RDRDSGNNGK TVCSIQDDVP FILKPSVENF
410 420 430 440 450
YTLVTEKPLD RERNTEYNIT ITVTDLGTPR LKTEHNITVL VSDVNDNAPA
460 470 480 490 500
FTQTSYTLFV RENNSPALPI GSVSATDRDS GTNAQVIYSL LPSQDPHLPL
510 520 530 540 550
ASLVSINADN GHLFALRSLD YEALQAFEFR VGATDRGSPA LSSEALVRVL
560 570 580 590 600
VLDANDNSPF VLYPLQNSSA PCTEPLPRAA EPGYLVTKVV AVDGDSGQNA
610 620 630 640 650
WLSYQLLKAT EPGLFGVWAH NGEVRTARLL SERDAAKQRL VVLVKDNGEP
660 670 680 690 700
PRSATATLHV LLVDGFSQPY LRLPEAAPDQ ANSLTVYLVV ALASVSSLFL
710 720 730 740 750
LSVLLFVAVR LCRRSRAAPV GRCSVPEGPF PRHLVDLSGT GTLSQSYQYE
760 770 780 790
VCLTGGSGTN EFKFLKPIIP NLLPQSTGRE VEENRPFQNN LGF
Length:793
Mass (Da):86,707
Last modified:November 1, 1999 - v1
Checksum:iE5677098653CC755
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti120 – 1201E → K.
Corresponds to variant rs17286891 [ dbSNP | Ensembl ].
VAR_033708
Natural varianti187 – 1871E → K.
Corresponds to variant rs17096946 [ dbSNP | Ensembl ].
VAR_033709
Natural varianti389 – 3891V → L.
Corresponds to variant rs2910313 [ dbSNP | Ensembl ].
VAR_020367
Natural varianti575 – 5751P → L.
Corresponds to variant rs13189280 [ dbSNP | Ensembl ].
VAR_059183
Natural varianti576 – 5761L → V.
Corresponds to variant rs13174866 [ dbSNP | Ensembl ].
VAR_059184
Natural varianti716 – 7161R → W.
Corresponds to variant rs2910314 [ dbSNP | Ensembl ].
VAR_059185

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152500 mRNA. Translation: AAD43761.1.
AF217750 mRNA. Translation: AAK51617.1.
AK315054 mRNA. Translation: BAG37530.1.
CH471062 Genomic DNA. Translation: EAW61977.1.
BC130331 mRNA. Translation: AAI30332.1.
CCDSiCCDS4249.1.
RefSeqiNP_061763.1. NM_018940.3.
UniGeneiHs.203830.

Genome annotation databases

EnsembliENST00000231137; ENSP00000231137; ENSG00000113212.
GeneIDi56129.
KEGGihsa:56129.
UCSCiuc003lit.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152500 mRNA. Translation: AAD43761.1.
AF217750 mRNA. Translation: AAK51617.1.
AK315054 mRNA. Translation: BAG37530.1.
CH471062 Genomic DNA. Translation: EAW61977.1.
BC130331 mRNA. Translation: AAI30332.1.
CCDSiCCDS4249.1.
RefSeqiNP_061763.1. NM_018940.3.
UniGeneiHs.203830.

3D structure databases

ProteinModelPortaliQ9Y5E2.
SMRiQ9Y5E2. Positions 31-677.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121069. 1 interaction.

PTM databases

PhosphoSiteiQ9Y5E2.

Polymorphism and mutation databases

BioMutaiPCDHB7.
DMDMi13431373.

Proteomic databases

PaxDbiQ9Y5E2.
PRIDEiQ9Y5E2.

Protocols and materials databases

DNASUi56129.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000231137; ENSP00000231137; ENSG00000113212.
GeneIDi56129.
KEGGihsa:56129.
UCSCiuc003lit.3. human.

Organism-specific databases

CTDi56129.
GeneCardsiGC05P141360.
HGNCiHGNC:8692. PCDHB7.
HPAiHPA059271.
MIMi604967. gene.
606333. gene.
neXtProtiNX_Q9Y5E2.
PharmGKBiPA33041.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG251260.
GeneTreeiENSGT00760000118847.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.
InParanoidiQ9Y5E2.
KOiK16494.
OMAiYFHINVR.
OrthoDBiEOG7KSX80.
PhylomeDBiQ9Y5E2.
TreeFamiTF332299.

Miscellaneous databases

GeneWikiiPCDHB7.
GenomeRNAii56129.
NextBioi61648.
PROiQ9Y5E2.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y5E2.
CleanExiHS_PCDHB7.
GenevisibleiQ9Y5E2. HS.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
IPR030741. PCDHB7.
[Graphical view]
PANTHERiPTHR24028:SF69. PTHR24028:SF69. 1 hit.
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A striking organization of a large family of human neural cadherin-like cell adhesion genes."
    Wu Q., Maniatis T.
    Cell 97:779-790(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number."
    Vanhalst K., Kools P., Vanden Eynde E., van Roy F.
    FEBS Lett. 495:120-125(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiPCDB7_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5E2
Secondary accession number(s): A1L3Y8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1999
Last modified: June 24, 2015
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.