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Q9Y5E2

- PCDB7_HUMAN

UniProt

Q9Y5E2 - PCDB7_HUMAN

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Protein
Protocadherin beta-7
Gene
PCDHB7
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro

GO - Biological processi

  1. homophilic cell adhesion Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin beta-7
Short name:
PCDH-beta-7
Gene namesi
Name:PCDHB7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:8692. PCDHB7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 688662Extracellular Reviewed prediction
Add
BLAST
Transmembranei689 – 70921Helical; Reviewed prediction
Add
BLAST
Topological domaini710 – 79384Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33041.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626 Reviewed prediction
Add
BLAST
Chaini27 – 793767Protocadherin beta-7
PRO_0000003926Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi169 – 1691N-linked (GlcNAc...) Reviewed prediction
Glycosylationi418 – 4181N-linked (GlcNAc...) Reviewed prediction
Glycosylationi436 – 4361N-linked (GlcNAc...) Reviewed prediction
Glycosylationi567 – 5671N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9Y5E2.
PRIDEiQ9Y5E2.

PTM databases

PhosphoSiteiQ9Y5E2.

Expressioni

Gene expression databases

BgeeiQ9Y5E2.
CleanExiHS_PCDHB7.
GenevestigatoriQ9Y5E2.

Organism-specific databases

HPAiHPA059271.

Interactioni

Protein-protein interaction databases

BioGridi121069. 1 interaction.
STRINGi9606.ENSP00000231137.

Structurei

3D structure databases

ProteinModelPortaliQ9Y5E2.
SMRiQ9Y5E2. Positions 31-677.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 13399Cadherin 1
Add
BLAST
Domaini138 – 242105Cadherin 2
Add
BLAST
Domaini247 – 347101Cadherin 3
Add
BLAST
Domaini352 – 451100Cadherin 4
Add
BLAST
Domaini456 – 561106Cadherin 5
Add
BLAST
Domaini568 – 671104Cadherin 6
Add
BLAST

Sequence similaritiesi

Contains 6 cadherin domains.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG251260.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.
InParanoidiQ9Y5E2.
KOiK16494.
OMAiAFFYATE.
OrthoDBiEOG7KSX80.
PhylomeDBiQ9Y5E2.
TreeFamiTF332299.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y5E2-1 [UniParc]FASTAAdd to Basket

« Hide

MEARVERAVQ KRQVLFLCVF LGMSWAGAEP LRYFVAEETE RGTFLTNLAK    50
DLGLGVGELR ARGTRIVSDQ NMQILLLSSL TGDLLLNEKL DREELCGPRE 100
PCVLPFQLLL EKPFQIFRAE LWVRDINDHA PVFLDREISL KILESTTPGA 150
AFLLESAQDS DVGTNSLSNY TISPNAYFHI NVHDSGEGNI YPELVLNQVL 200
DREEIPEFSL TLTALDGGSP PRSGTALVRI LVLDVNDNAP DFVRSLYKVQ 250
VPENSPVGSM VVSVSARDLD TGSNGEIAYA FSYATERILK TFQINPTSGS 300
LHLKAQLDYE AIQTYTLTIQ AKDGGGLSGK CTVVVDVTDI NDNRPELLLS 350
SLTSPIAENS PETVVAVFRI RDRDSGNNGK TVCSIQDDVP FILKPSVENF 400
YTLVTEKPLD RERNTEYNIT ITVTDLGTPR LKTEHNITVL VSDVNDNAPA 450
FTQTSYTLFV RENNSPALPI GSVSATDRDS GTNAQVIYSL LPSQDPHLPL 500
ASLVSINADN GHLFALRSLD YEALQAFEFR VGATDRGSPA LSSEALVRVL 550
VLDANDNSPF VLYPLQNSSA PCTEPLPRAA EPGYLVTKVV AVDGDSGQNA 600
WLSYQLLKAT EPGLFGVWAH NGEVRTARLL SERDAAKQRL VVLVKDNGEP 650
PRSATATLHV LLVDGFSQPY LRLPEAAPDQ ANSLTVYLVV ALASVSSLFL 700
LSVLLFVAVR LCRRSRAAPV GRCSVPEGPF PRHLVDLSGT GTLSQSYQYE 750
VCLTGGSGTN EFKFLKPIIP NLLPQSTGRE VEENRPFQNN LGF 793
Length:793
Mass (Da):86,707
Last modified:November 1, 1999 - v1
Checksum:iE5677098653CC755
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti120 – 1201E → K.
Corresponds to variant rs17286891 [ dbSNP | Ensembl ].
VAR_033708
Natural varianti187 – 1871E → K.
Corresponds to variant rs17096946 [ dbSNP | Ensembl ].
VAR_033709
Natural varianti389 – 3891V → L.
Corresponds to variant rs2910313 [ dbSNP | Ensembl ].
VAR_020367
Natural varianti575 – 5751P → L.
Corresponds to variant rs13189280 [ dbSNP | Ensembl ].
VAR_059183
Natural varianti576 – 5761L → V.
Corresponds to variant rs13174866 [ dbSNP | Ensembl ].
VAR_059184
Natural varianti716 – 7161R → W.
Corresponds to variant rs2910314 [ dbSNP | Ensembl ].
VAR_059185

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF152500 mRNA. Translation: AAD43761.1.
AF217750 mRNA. Translation: AAK51617.1.
AK315054 mRNA. Translation: BAG37530.1.
CH471062 Genomic DNA. Translation: EAW61977.1.
BC130331 mRNA. Translation: AAI30332.1.
CCDSiCCDS4249.1.
RefSeqiNP_061763.1. NM_018940.3.
UniGeneiHs.203830.

Genome annotation databases

EnsembliENST00000231137; ENSP00000231137; ENSG00000113212.
ENST00000608149; ENSP00000476752; ENSG00000272845.
GeneIDi56129.
KEGGihsa:56129.
UCSCiuc003lit.3. human.

Polymorphism databases

DMDMi13431373.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF152500 mRNA. Translation: AAD43761.1 .
AF217750 mRNA. Translation: AAK51617.1 .
AK315054 mRNA. Translation: BAG37530.1 .
CH471062 Genomic DNA. Translation: EAW61977.1 .
BC130331 mRNA. Translation: AAI30332.1 .
CCDSi CCDS4249.1.
RefSeqi NP_061763.1. NM_018940.3.
UniGenei Hs.203830.

3D structure databases

ProteinModelPortali Q9Y5E2.
SMRi Q9Y5E2. Positions 31-677.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121069. 1 interaction.
STRINGi 9606.ENSP00000231137.

PTM databases

PhosphoSitei Q9Y5E2.

Polymorphism databases

DMDMi 13431373.

Proteomic databases

PaxDbi Q9Y5E2.
PRIDEi Q9Y5E2.

Protocols and materials databases

DNASUi 56129.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000231137 ; ENSP00000231137 ; ENSG00000113212 .
ENST00000608149 ; ENSP00000476752 ; ENSG00000272845 .
GeneIDi 56129.
KEGGi hsa:56129.
UCSCi uc003lit.3. human.

Organism-specific databases

CTDi 56129.
GeneCardsi GC05P140553.
HGNCi HGNC:8692. PCDHB7.
HPAi HPA059271.
MIMi 604967. gene.
606333. gene.
neXtProti NX_Q9Y5E2.
PharmGKBi PA33041.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG251260.
HOGENOMi HOG000220892.
HOVERGENi HBG054878.
InParanoidi Q9Y5E2.
KOi K16494.
OMAi AFFYATE.
OrthoDBi EOG7KSX80.
PhylomeDBi Q9Y5E2.
TreeFami TF332299.

Miscellaneous databases

GeneWikii PCDHB7.
GenomeRNAii 56129.
NextBioi 61648.
PROi Q9Y5E2.
SOURCEi Search...

Gene expression databases

Bgeei Q9Y5E2.
CleanExi HS_PCDHB7.
Genevestigatori Q9Y5E2.

Family and domain databases

Gene3Di 2.60.40.60. 5 hits.
InterProi IPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view ]
Pfami PF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
[Graphical view ]
PRINTSi PR00205. CADHERIN.
SMARTi SM00112. CA. 5 hits.
[Graphical view ]
SUPFAMi SSF49313. SSF49313. 6 hits.
PROSITEi PS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A striking organization of a large family of human neural cadherin-like cell adhesion genes."
    Wu Q., Maniatis T.
    Cell 97:779-790(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number."
    Vanhalst K., Kools P., Vanden Eynde E., van Roy F.
    FEBS Lett. 495:120-125(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiPCDB7_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5E2
Secondary accession number(s): A1L3Y8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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