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Q9Y5E2 (PCDB7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protocadherin beta-7

Short name=PCDH-beta-7
Gene names
Name:PCDHB7
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length793 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

Subcellular location

Cell membrane; Single-pass type I membrane protein By similarity.

Sequence similarities

Contains 6 cadherin domains.

Ontologies

Keywords
   Biological processCell adhesion
   Cellular componentCell membrane
Membrane
   Coding sequence diversityPolymorphism
   DomainRepeat
Signal
Transmembrane
Transmembrane helix
   LigandCalcium
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processhomophilic cell adhesion

Inferred from electronic annotation. Source: InterPro

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Chain27 – 793767Protocadherin beta-7
PRO_0000003926

Regions

Topological domain27 – 688662Extracellular Potential
Transmembrane689 – 70921Helical; Potential
Topological domain710 – 79384Cytoplasmic Potential
Domain35 – 13399Cadherin 1
Domain138 – 242105Cadherin 2
Domain247 – 347101Cadherin 3
Domain352 – 451100Cadherin 4
Domain456 – 561106Cadherin 5
Domain568 – 671104Cadherin 6

Amino acid modifications

Glycosylation1691N-linked (GlcNAc...) Potential
Glycosylation4181N-linked (GlcNAc...) Potential
Glycosylation4361N-linked (GlcNAc...) Potential
Glycosylation5671N-linked (GlcNAc...) Potential

Natural variations

Natural variant1201E → K.
Corresponds to variant rs17286891 [ dbSNP | Ensembl ].
VAR_033708
Natural variant1871E → K.
Corresponds to variant rs17096946 [ dbSNP | Ensembl ].
VAR_033709
Natural variant3891V → L.
Corresponds to variant rs2910313 [ dbSNP | Ensembl ].
VAR_020367
Natural variant5751P → L.
Corresponds to variant rs13189280 [ dbSNP | Ensembl ].
VAR_059183
Natural variant5761L → V.
Corresponds to variant rs13174866 [ dbSNP | Ensembl ].
VAR_059184
Natural variant7161R → W.
Corresponds to variant rs2910314 [ dbSNP | Ensembl ].
VAR_059185

Sequences

Sequence LengthMass (Da)Tools
Q9Y5E2 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: E5677098653CC755

FASTA79386,707
        10         20         30         40         50         60 
MEARVERAVQ KRQVLFLCVF LGMSWAGAEP LRYFVAEETE RGTFLTNLAK DLGLGVGELR 

        70         80         90        100        110        120 
ARGTRIVSDQ NMQILLLSSL TGDLLLNEKL DREELCGPRE PCVLPFQLLL EKPFQIFRAE 

       130        140        150        160        170        180 
LWVRDINDHA PVFLDREISL KILESTTPGA AFLLESAQDS DVGTNSLSNY TISPNAYFHI 

       190        200        210        220        230        240 
NVHDSGEGNI YPELVLNQVL DREEIPEFSL TLTALDGGSP PRSGTALVRI LVLDVNDNAP 

       250        260        270        280        290        300 
DFVRSLYKVQ VPENSPVGSM VVSVSARDLD TGSNGEIAYA FSYATERILK TFQINPTSGS 

       310        320        330        340        350        360 
LHLKAQLDYE AIQTYTLTIQ AKDGGGLSGK CTVVVDVTDI NDNRPELLLS SLTSPIAENS 

       370        380        390        400        410        420 
PETVVAVFRI RDRDSGNNGK TVCSIQDDVP FILKPSVENF YTLVTEKPLD RERNTEYNIT 

       430        440        450        460        470        480 
ITVTDLGTPR LKTEHNITVL VSDVNDNAPA FTQTSYTLFV RENNSPALPI GSVSATDRDS 

       490        500        510        520        530        540 
GTNAQVIYSL LPSQDPHLPL ASLVSINADN GHLFALRSLD YEALQAFEFR VGATDRGSPA 

       550        560        570        580        590        600 
LSSEALVRVL VLDANDNSPF VLYPLQNSSA PCTEPLPRAA EPGYLVTKVV AVDGDSGQNA 

       610        620        630        640        650        660 
WLSYQLLKAT EPGLFGVWAH NGEVRTARLL SERDAAKQRL VVLVKDNGEP PRSATATLHV 

       670        680        690        700        710        720 
LLVDGFSQPY LRLPEAAPDQ ANSLTVYLVV ALASVSSLFL LSVLLFVAVR LCRRSRAAPV 

       730        740        750        760        770        780 
GRCSVPEGPF PRHLVDLSGT GTLSQSYQYE VCLTGGSGTN EFKFLKPIIP NLLPQSTGRE 

       790 
VEENRPFQNN LGF 

« Hide

References

« Hide 'large scale' references
[1]"A striking organization of a large family of human neural cadherin-like cell adhesion genes."
Wu Q., Maniatis T.
Cell 97:779-790(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number."
Vanhalst K., Kools P., Vanden Eynde E., van Roy F.
FEBS Lett. 495:120-125(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[4]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF152500 mRNA. Translation: AAD43761.1.
AF217750 mRNA. Translation: AAK51617.1.
AK315054 mRNA. Translation: BAG37530.1.
CH471062 Genomic DNA. Translation: EAW61977.1.
BC130331 mRNA. Translation: AAI30332.1.
RefSeqNP_061763.1. NM_018940.3.
UniGeneHs.203830.

3D structure databases

ProteinModelPortalQ9Y5E2.
SMRQ9Y5E2. Positions 31-677.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121069. 1 interaction.
STRING9606.ENSP00000231137.

PTM databases

PhosphoSiteQ9Y5E2.

Polymorphism databases

DMDM13431373.

Proteomic databases

PaxDbQ9Y5E2.
PRIDEQ9Y5E2.

Protocols and materials databases

DNASU56129.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000231137; ENSP00000231137; ENSG00000113212.
ENST00000608149; ENSP00000476752; ENSG00000272845.
GeneID56129.
KEGGhsa:56129.
UCSCuc003lit.3. human.

Organism-specific databases

CTD56129.
GeneCardsGC05P140553.
HGNCHGNC:8692. PCDHB7.
HPAHPA059271.
MIM604967. gene.
606333. gene.
neXtProtNX_Q9Y5E2.
PharmGKBPA33041.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG251260.
HOGENOMHOG000220892.
HOVERGENHBG054878.
InParanoidQ9Y5E2.
KOK16494.
OMAAFFYATE.
OrthoDBEOG7KSX80.
PhylomeDBQ9Y5E2.
TreeFamTF332299.

Gene expression databases

BgeeQ9Y5E2.
CleanExHS_PCDHB7.
GenevestigatorQ9Y5E2.

Family and domain databases

Gene3D2.60.40.60. 5 hits.
InterProIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
[Graphical view]
PRINTSPR00205. CADHERIN.
SMARTSM00112. CA. 5 hits.
[Graphical view]
SUPFAMSSF49313. SSF49313. 6 hits.
PROSITEPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiPCDHB7.
GenomeRNAi56129.
NextBio61648.
PROQ9Y5E2.
SOURCESearch...

Entry information

Entry namePCDB7_HUMAN
AccessionPrimary (citable) accession number: Q9Y5E2
Secondary accession number(s): A1L3Y8
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1999
Last modified: March 19, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM