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Q9Y5E2

- PCDB7_HUMAN

UniProt

Q9Y5E2 - PCDB7_HUMAN

Protein

Protocadherin beta-7

Gene

PCDHB7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    GO - Biological processi

    1. homophilic cell adhesion Source: InterPro

    Keywords - Biological processi

    Cell adhesion

    Keywords - Ligandi

    Calcium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protocadherin beta-7
    Short name:
    PCDH-beta-7
    Gene namesi
    Name:PCDHB7
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:8692. PCDHB7.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33041.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Chaini27 – 793767Protocadherin beta-7PRO_0000003926Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi169 – 1691N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi418 – 4181N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi436 – 4361N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi567 – 5671N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9Y5E2.
    PRIDEiQ9Y5E2.

    PTM databases

    PhosphoSiteiQ9Y5E2.

    Expressioni

    Gene expression databases

    BgeeiQ9Y5E2.
    CleanExiHS_PCDHB7.
    GenevestigatoriQ9Y5E2.

    Organism-specific databases

    HPAiHPA059271.

    Interactioni

    Protein-protein interaction databases

    BioGridi121069. 1 interaction.
    STRINGi9606.ENSP00000231137.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y5E2.
    SMRiQ9Y5E2. Positions 31-677.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini27 – 688662ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini710 – 79384CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei689 – 70921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini35 – 13399Cadherin 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini138 – 242105Cadherin 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini247 – 347101Cadherin 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini352 – 451100Cadherin 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini456 – 561106Cadherin 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini568 – 671104Cadherin 6PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 6 cadherin domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG251260.
    HOGENOMiHOG000220892.
    HOVERGENiHBG054878.
    InParanoidiQ9Y5E2.
    KOiK16494.
    OMAiAFFYATE.
    OrthoDBiEOG7KSX80.
    PhylomeDBiQ9Y5E2.
    TreeFamiTF332299.

    Family and domain databases

    Gene3Di2.60.40.60. 5 hits.
    InterProiIPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    IPR013164. Cadherin_N.
    [Graphical view]
    PfamiPF00028. Cadherin. 5 hits.
    PF08266. Cadherin_2. 1 hit.
    [Graphical view]
    PRINTSiPR00205. CADHERIN.
    SMARTiSM00112. CA. 5 hits.
    [Graphical view]
    SUPFAMiSSF49313. SSF49313. 6 hits.
    PROSITEiPS00232. CADHERIN_1. 5 hits.
    PS50268. CADHERIN_2. 5 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9Y5E2-1 [UniParc]FASTAAdd to Basket

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    MEARVERAVQ KRQVLFLCVF LGMSWAGAEP LRYFVAEETE RGTFLTNLAK    50
    DLGLGVGELR ARGTRIVSDQ NMQILLLSSL TGDLLLNEKL DREELCGPRE 100
    PCVLPFQLLL EKPFQIFRAE LWVRDINDHA PVFLDREISL KILESTTPGA 150
    AFLLESAQDS DVGTNSLSNY TISPNAYFHI NVHDSGEGNI YPELVLNQVL 200
    DREEIPEFSL TLTALDGGSP PRSGTALVRI LVLDVNDNAP DFVRSLYKVQ 250
    VPENSPVGSM VVSVSARDLD TGSNGEIAYA FSYATERILK TFQINPTSGS 300
    LHLKAQLDYE AIQTYTLTIQ AKDGGGLSGK CTVVVDVTDI NDNRPELLLS 350
    SLTSPIAENS PETVVAVFRI RDRDSGNNGK TVCSIQDDVP FILKPSVENF 400
    YTLVTEKPLD RERNTEYNIT ITVTDLGTPR LKTEHNITVL VSDVNDNAPA 450
    FTQTSYTLFV RENNSPALPI GSVSATDRDS GTNAQVIYSL LPSQDPHLPL 500
    ASLVSINADN GHLFALRSLD YEALQAFEFR VGATDRGSPA LSSEALVRVL 550
    VLDANDNSPF VLYPLQNSSA PCTEPLPRAA EPGYLVTKVV AVDGDSGQNA 600
    WLSYQLLKAT EPGLFGVWAH NGEVRTARLL SERDAAKQRL VVLVKDNGEP 650
    PRSATATLHV LLVDGFSQPY LRLPEAAPDQ ANSLTVYLVV ALASVSSLFL 700
    LSVLLFVAVR LCRRSRAAPV GRCSVPEGPF PRHLVDLSGT GTLSQSYQYE 750
    VCLTGGSGTN EFKFLKPIIP NLLPQSTGRE VEENRPFQNN LGF 793
    Length:793
    Mass (Da):86,707
    Last modified:November 1, 1999 - v1
    Checksum:iE5677098653CC755
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti120 – 1201E → K.
    Corresponds to variant rs17286891 [ dbSNP | Ensembl ].
    VAR_033708
    Natural varianti187 – 1871E → K.
    Corresponds to variant rs17096946 [ dbSNP | Ensembl ].
    VAR_033709
    Natural varianti389 – 3891V → L.
    Corresponds to variant rs2910313 [ dbSNP | Ensembl ].
    VAR_020367
    Natural varianti575 – 5751P → L.
    Corresponds to variant rs13189280 [ dbSNP | Ensembl ].
    VAR_059183
    Natural varianti576 – 5761L → V.
    Corresponds to variant rs13174866 [ dbSNP | Ensembl ].
    VAR_059184
    Natural varianti716 – 7161R → W.
    Corresponds to variant rs2910314 [ dbSNP | Ensembl ].
    VAR_059185

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF152500 mRNA. Translation: AAD43761.1.
    AF217750 mRNA. Translation: AAK51617.1.
    AK315054 mRNA. Translation: BAG37530.1.
    CH471062 Genomic DNA. Translation: EAW61977.1.
    BC130331 mRNA. Translation: AAI30332.1.
    CCDSiCCDS4249.1.
    RefSeqiNP_061763.1. NM_018940.3.
    UniGeneiHs.203830.

    Genome annotation databases

    EnsembliENST00000231137; ENSP00000231137; ENSG00000113212.
    GeneIDi56129.
    KEGGihsa:56129.
    UCSCiuc003lit.3. human.

    Polymorphism databases

    DMDMi13431373.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF152500 mRNA. Translation: AAD43761.1 .
    AF217750 mRNA. Translation: AAK51617.1 .
    AK315054 mRNA. Translation: BAG37530.1 .
    CH471062 Genomic DNA. Translation: EAW61977.1 .
    BC130331 mRNA. Translation: AAI30332.1 .
    CCDSi CCDS4249.1.
    RefSeqi NP_061763.1. NM_018940.3.
    UniGenei Hs.203830.

    3D structure databases

    ProteinModelPortali Q9Y5E2.
    SMRi Q9Y5E2. Positions 31-677.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121069. 1 interaction.
    STRINGi 9606.ENSP00000231137.

    PTM databases

    PhosphoSitei Q9Y5E2.

    Polymorphism databases

    DMDMi 13431373.

    Proteomic databases

    PaxDbi Q9Y5E2.
    PRIDEi Q9Y5E2.

    Protocols and materials databases

    DNASUi 56129.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000231137 ; ENSP00000231137 ; ENSG00000113212 .
    GeneIDi 56129.
    KEGGi hsa:56129.
    UCSCi uc003lit.3. human.

    Organism-specific databases

    CTDi 56129.
    GeneCardsi GC05P140553.
    HGNCi HGNC:8692. PCDHB7.
    HPAi HPA059271.
    MIMi 604967. gene.
    606333. gene.
    neXtProti NX_Q9Y5E2.
    PharmGKBi PA33041.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG251260.
    HOGENOMi HOG000220892.
    HOVERGENi HBG054878.
    InParanoidi Q9Y5E2.
    KOi K16494.
    OMAi AFFYATE.
    OrthoDBi EOG7KSX80.
    PhylomeDBi Q9Y5E2.
    TreeFami TF332299.

    Miscellaneous databases

    GeneWikii PCDHB7.
    GenomeRNAii 56129.
    NextBioi 61648.
    PROi Q9Y5E2.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9Y5E2.
    CleanExi HS_PCDHB7.
    Genevestigatori Q9Y5E2.

    Family and domain databases

    Gene3Di 2.60.40.60. 5 hits.
    InterProi IPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    IPR013164. Cadherin_N.
    [Graphical view ]
    Pfami PF00028. Cadherin. 5 hits.
    PF08266. Cadherin_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00205. CADHERIN.
    SMARTi SM00112. CA. 5 hits.
    [Graphical view ]
    SUPFAMi SSF49313. SSF49313. 6 hits.
    PROSITEi PS00232. CADHERIN_1. 5 hits.
    PS50268. CADHERIN_2. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A striking organization of a large family of human neural cadherin-like cell adhesion genes."
      Wu Q., Maniatis T.
      Cell 97:779-790(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number."
      Vanhalst K., Kools P., Vanden Eynde E., van Roy F.
      FEBS Lett. 495:120-125(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiPCDB7_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y5E2
    Secondary accession number(s): A1L3Y8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 115 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3