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Q9Y5B8

- NDK7_HUMAN

UniProt

Q9Y5B8 - NDK7_HUMAN

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Protein
Nucleoside diphosphate kinase 7
Gene
NME7
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

Catalytic activityi

ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.

Cofactori

Magnesium By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei99 – 991ATP By similarity
Binding sitei145 – 1451ATP By similarity
Binding sitei193 – 1931ATP By similarity
Binding sitei203 – 2031ATP By similarity
Active sitei206 – 2061Pros-phosphohistidine intermediate By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. nucleoside diphosphate kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. CTP biosynthetic process Source: InterPro
  2. GTP biosynthetic process Source: InterPro
  3. UTP biosynthetic process Source: InterPro
  4. brain development Source: Ensembl
  5. ciliary receptor clustering involved in smoothened signaling pathway Source: Ensembl
  6. determination of left/right symmetry Source: Ensembl
  7. epithelial cilium movement Source: Ensembl
  8. intraciliary transport Source: Ensembl
  9. left/right pattern formation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoside diphosphate kinase 7 (EC:2.7.4.6)
Short name:
NDK 7
Short name:
NDP kinase 7
Alternative name(s):
nm23-H7
Gene namesi
Name:NME7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:20461. NME7.

Subcellular locationi

GO - Cellular componenti

  1. centrosome Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134962167.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 376376Nucleoside diphosphate kinase 7
PRO_0000137130Add
BLAST

Proteomic databases

MaxQBiQ9Y5B8.
PaxDbiQ9Y5B8.
PRIDEiQ9Y5B8.

PTM databases

PhosphoSiteiQ9Y5B8.

Expressioni

Gene expression databases

ArrayExpressiQ9Y5B8.
BgeeiQ9Y5B8.
CleanExiHS_NME7.
GenevestigatoriQ9Y5B8.

Organism-specific databases

HPAiHPA038014.

Interactioni

Protein-protein interaction databases

BioGridi118963. 15 interactions.
IntActiQ9Y5B8. 12 interactions.
MINTiMINT-1452335.
STRINGi9606.ENSP00000356785.

Structurei

3D structure databases

ProteinModelPortaliQ9Y5B8.
SMRiQ9Y5B8. Positions 92-222, 240-375.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 9189DM10
Add
BLAST

Sequence similaritiesi

Belongs to the NDK family.
Contains 1 DM10 domain.

Phylogenomic databases

eggNOGiCOG0105.
HOGENOMiHOG000224566.
HOVERGENiHBG006457.
InParanoidiQ9Y5B8.
KOiK00940.
OMAiMEIQQNN.
OrthoDBiEOG7HF1JJ.
PhylomeDBiQ9Y5B8.
TreeFamiTF106374.

Family and domain databases

Gene3Di3.30.70.141. 2 hits.
InterProiIPR011410. NDK7.
IPR001564. Nucleoside_diP_kinase.
IPR006602. Uncharacterised_DM10.
[Graphical view]
PfamiPF00334. NDK. 2 hits.
[Graphical view]
PIRSFiPIRSF036503. NDK7. 1 hit.
PRINTSiPR01243. NUCDPKINASE.
SMARTiSM00676. DM10. 1 hit.
SM00562. NDK. 2 hits.
[Graphical view]
SUPFAMiSSF54919. SSF54919. 2 hits.
PROSITEiPS51336. DM10. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9Y5B8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MNHSERFVFI AEWYDPNASL LRRYELLFYP GDGSVEMHDV KNHRTFLKRT    50
KYDNLHLEDL FIGNKVNVFS RQLVLIDYGD QYTARQLGSR KEKTLALIKP 100
DAISKAGEII EIINKAGFTI TKLKMMMLSR KEALDFHVDH QSRPFFNELI 150
QFITTGPIIA MEILRDDAIC EWKRLLGPAN SGVARTDASE SIRALFGTDG 200
IRNAAHGPDS FASAAREMEL FFPSSGGCGP ANTAKFTNCT CCIVKPHAVS 250
EGLLGKILMA IRDAGFEISA MQMFNMDRVN VEEFYEVYKG VVTEYHDMVT 300
EMYSGPCVAM EIQQNNATKT FREFCGPADP EIARHLRPGT LRAIFGKTKI 350
QNAVHCTDLP EDGLLEVQYF FKILDN 376
Length:376
Mass (Da):42,492
Last modified:November 1, 1999 - v1
Checksum:i67C121D6C36E7012
GO
Isoform 2 (identifier: Q9Y5B8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: Missing.

Show »
Length:340
Mass (Da):38,187
Checksum:i2FA9FE0342B05737
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3636Missing in isoform 2.
VSP_040996Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF153191 mRNA. Translation: AAD34622.1.
AK094513 mRNA. Translation: BAG52881.1.
AK290701 mRNA. Translation: BAF83390.1.
AL031726, AL356852, Z99758 Genomic DNA. Translation: CAI18887.1.
Z99758, AL031726, AL356852 Genomic DNA. Translation: CAI22851.1.
AL356852, AL031726, Z99758 Genomic DNA. Translation: CAI19238.1.
CH471067 Genomic DNA. Translation: EAW90834.1.
CH471067 Genomic DNA. Translation: EAW90835.1.
BC006983 mRNA. Translation: AAH06983.1.
CCDSiCCDS1277.1. [Q9Y5B8-1]
CCDS44274.1. [Q9Y5B8-2]
RefSeqiNP_037462.1. NM_013330.4. [Q9Y5B8-1]
NP_932076.1. NM_197972.2. [Q9Y5B8-2]
UniGeneiHs.706952.

Genome annotation databases

EnsembliENST00000367811; ENSP00000356785; ENSG00000143156. [Q9Y5B8-1]
ENST00000472647; ENSP00000433341; ENSG00000143156. [Q9Y5B8-2]
GeneIDi29922.
KEGGihsa:29922.
UCSCiuc001gft.3. human. [Q9Y5B8-1]

Polymorphism databases

DMDMi12230353.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF153191 mRNA. Translation: AAD34622.1 .
AK094513 mRNA. Translation: BAG52881.1 .
AK290701 mRNA. Translation: BAF83390.1 .
AL031726 , AL356852 , Z99758 Genomic DNA. Translation: CAI18887.1 .
Z99758 , AL031726 , AL356852 Genomic DNA. Translation: CAI22851.1 .
AL356852 , AL031726 , Z99758 Genomic DNA. Translation: CAI19238.1 .
CH471067 Genomic DNA. Translation: EAW90834.1 .
CH471067 Genomic DNA. Translation: EAW90835.1 .
BC006983 mRNA. Translation: AAH06983.1 .
CCDSi CCDS1277.1. [Q9Y5B8-1 ]
CCDS44274.1. [Q9Y5B8-2 ]
RefSeqi NP_037462.1. NM_013330.4. [Q9Y5B8-1 ]
NP_932076.1. NM_197972.2. [Q9Y5B8-2 ]
UniGenei Hs.706952.

3D structure databases

ProteinModelPortali Q9Y5B8.
SMRi Q9Y5B8. Positions 92-222, 240-375.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 118963. 15 interactions.
IntActi Q9Y5B8. 12 interactions.
MINTi MINT-1452335.
STRINGi 9606.ENSP00000356785.

PTM databases

PhosphoSitei Q9Y5B8.

Polymorphism databases

DMDMi 12230353.

Proteomic databases

MaxQBi Q9Y5B8.
PaxDbi Q9Y5B8.
PRIDEi Q9Y5B8.

Protocols and materials databases

DNASUi 29922.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000367811 ; ENSP00000356785 ; ENSG00000143156 . [Q9Y5B8-1 ]
ENST00000472647 ; ENSP00000433341 ; ENSG00000143156 . [Q9Y5B8-2 ]
GeneIDi 29922.
KEGGi hsa:29922.
UCSCi uc001gft.3. human. [Q9Y5B8-1 ]

Organism-specific databases

CTDi 29922.
GeneCardsi GC01M169101.
HGNCi HGNC:20461. NME7.
HPAi HPA038014.
MIMi 613465. gene.
neXtProti NX_Q9Y5B8.
PharmGKBi PA134962167.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0105.
HOGENOMi HOG000224566.
HOVERGENi HBG006457.
InParanoidi Q9Y5B8.
KOi K00940.
OMAi MEIQQNN.
OrthoDBi EOG7HF1JJ.
PhylomeDBi Q9Y5B8.
TreeFami TF106374.

Miscellaneous databases

ChiTaRSi NME7. human.
GenomeRNAii 29922.
NextBioi 52524.
PROi Q9Y5B8.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9Y5B8.
Bgeei Q9Y5B8.
CleanExi HS_NME7.
Genevestigatori Q9Y5B8.

Family and domain databases

Gene3Di 3.30.70.141. 2 hits.
InterProi IPR011410. NDK7.
IPR001564. Nucleoside_diP_kinase.
IPR006602. Uncharacterised_DM10.
[Graphical view ]
Pfami PF00334. NDK. 2 hits.
[Graphical view ]
PIRSFi PIRSF036503. NDK7. 1 hit.
PRINTSi PR01243. NUCDPKINASE.
SMARTi SM00676. DM10. 1 hit.
SM00562. NDK. 2 hits.
[Graphical view ]
SUPFAMi SSF54919. SSF54919. 2 hits.
PROSITEi PS51336. DM10. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human nm23-H7 (NME7) mRNA."
    Mehus J.G., Lambeth D.O.
    Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain cortex and Lung.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Urinary bladder.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiNDK7_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5B8
Secondary accession number(s): A8K3T6
, A8MY09, B3KSW9, Q5TGZ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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