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Protein

Nucleoside diphosphate kinase 7

Gene

NME7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

Catalytic activityi

ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei99ATPBy similarity1
Binding sitei145ATPBy similarity1
Binding sitei193ATPBy similarity1
Binding sitei203ATPBy similarity1
Active sitei206Pros-phosphohistidine intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processNucleotide metabolism
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-499943. Interconversion of nucleotide di- and triphosphates.

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoside diphosphate kinase 7 (EC:2.7.4.6)
Short name:
NDK 7
Short name:
NDP kinase 7
Alternative name(s):
nm23-H7
Gene namesi
Name:NME7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:20461. NME7.

Subcellular locationi

GO - Cellular componenti

  • centrosome Source: UniProtKB
  • cytosol Source: Reactome

Pathology & Biotechi

Organism-specific databases

DisGeNETi29922.
OpenTargetsiENSG00000143156.
PharmGKBiPA134962167.

Polymorphism and mutation databases

DMDMi12230353.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001371301 – 376Nucleoside diphosphate kinase 7Add BLAST376

Proteomic databases

EPDiQ9Y5B8.
PaxDbiQ9Y5B8.
PeptideAtlasiQ9Y5B8.
PRIDEiQ9Y5B8.

PTM databases

iPTMnetiQ9Y5B8.
PhosphoSitePlusiQ9Y5B8.

Expressioni

Gene expression databases

BgeeiENSG00000143156.
CleanExiHS_NME7.
ExpressionAtlasiQ9Y5B8. baseline and differential.
GenevisibleiQ9Y5B8. HS.

Organism-specific databases

HPAiHPA038014.
HPA054289.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi118963. 74 interactors.
IntActiQ9Y5B8. 92 interactors.
MINTiMINT-1452335.
STRINGi9606.ENSP00000356785.

Structurei

3D structure databases

ProteinModelPortaliQ9Y5B8.
SMRiQ9Y5B8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 91DM10PROSITE-ProRule annotationAdd BLAST89

Sequence similaritiesi

Belongs to the NDK family.Curated

Phylogenomic databases

eggNOGiKOG0888. Eukaryota.
COG0105. LUCA.
GeneTreeiENSGT00760000119146.
HOGENOMiHOG000224566.
HOVERGENiHBG006457.
InParanoidiQ9Y5B8.
KOiK00940.
OMAiNLELQYM.
OrthoDBiEOG091G0FHI.
PhylomeDBiQ9Y5B8.
TreeFamiTF106374.

Family and domain databases

CDDicd04415. NDPk7A. 1 hit.
Gene3Di3.30.70.141. 2 hits.
InterProiView protein in InterPro
IPR010554. DUF1126.
IPR034907. NDK-like_dom.
IPR011410. NDPK7.
IPR035525. NDPk7A.
IPR001564. Nucleoside_diP_kinase.
IPR006602. Uncharacterised_DM10.
PfamiView protein in Pfam
PF06565. DUF1126. 1 hit.
PF00334. NDK. 2 hits.
PIRSFiPIRSF036503. NDK7. 1 hit.
PRINTSiPR01243. NUCDPKINASE.
SMARTiView protein in SMART
SM00676. DM10. 1 hit.
SM00562. NDK. 2 hits.
SUPFAMiSSF54919. SSF54919. 2 hits.
PROSITEiView protein in PROSITE
PS51336. DM10. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y5B8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNHSERFVFI AEWYDPNASL LRRYELLFYP GDGSVEMHDV KNHRTFLKRT
60 70 80 90 100
KYDNLHLEDL FIGNKVNVFS RQLVLIDYGD QYTARQLGSR KEKTLALIKP
110 120 130 140 150
DAISKAGEII EIINKAGFTI TKLKMMMLSR KEALDFHVDH QSRPFFNELI
160 170 180 190 200
QFITTGPIIA MEILRDDAIC EWKRLLGPAN SGVARTDASE SIRALFGTDG
210 220 230 240 250
IRNAAHGPDS FASAAREMEL FFPSSGGCGP ANTAKFTNCT CCIVKPHAVS
260 270 280 290 300
EGLLGKILMA IRDAGFEISA MQMFNMDRVN VEEFYEVYKG VVTEYHDMVT
310 320 330 340 350
EMYSGPCVAM EIQQNNATKT FREFCGPADP EIARHLRPGT LRAIFGKTKI
360 370
QNAVHCTDLP EDGLLEVQYF FKILDN
Length:376
Mass (Da):42,492
Last modified:November 1, 1999 - v1
Checksum:i67C121D6C36E7012
GO
Isoform 2 (identifier: Q9Y5B8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: Missing.

Show »
Length:340
Mass (Da):38,187
Checksum:i2FA9FE0342B05737
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0409961 – 36Missing in isoform 2. 1 PublicationAdd BLAST36

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF153191 mRNA. Translation: AAD34622.1.
AK094513 mRNA. Translation: BAG52881.1.
AK290701 mRNA. Translation: BAF83390.1.
AL031726, AL356852, Z99758 Genomic DNA. Translation: CAI18887.1.
Z99758, AL031726, AL356852 Genomic DNA. Translation: CAI22851.1.
AL356852, AL031726, Z99758 Genomic DNA. Translation: CAI19238.1.
CH471067 Genomic DNA. Translation: EAW90834.1.
CH471067 Genomic DNA. Translation: EAW90835.1.
BC006983 mRNA. Translation: AAH06983.1.
CCDSiCCDS1277.1. [Q9Y5B8-1]
CCDS44274.1. [Q9Y5B8-2]
RefSeqiNP_037462.1. NM_013330.4. [Q9Y5B8-1]
NP_932076.1. NM_197972.2. [Q9Y5B8-2]
UniGeneiHs.706952.

Genome annotation databases

EnsembliENST00000367811; ENSP00000356785; ENSG00000143156. [Q9Y5B8-1]
ENST00000472647; ENSP00000433341; ENSG00000143156. [Q9Y5B8-2]
GeneIDi29922.
KEGGihsa:29922.
UCSCiuc001gft.5. human. [Q9Y5B8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiNDK7_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5B8
Secondary accession number(s): A8K3T6
, A8MY09, B3KSW9, Q5TGZ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 1, 1999
Last modified: August 30, 2017
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families