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Q9Y5B8

- NDK7_HUMAN

UniProt

Q9Y5B8 - NDK7_HUMAN

Protein

Nucleoside diphosphate kinase 7

Gene

NME7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

    Catalytic activityi

    ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.

    Cofactori

    Magnesium.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei99 – 991ATPBy similarity
    Binding sitei145 – 1451ATPBy similarity
    Binding sitei193 – 1931ATPBy similarity
    Binding sitei203 – 2031ATPBy similarity
    Active sitei206 – 2061Pros-phosphohistidine intermediateBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. nucleoside diphosphate kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. brain development Source: Ensembl
    2. ciliary receptor clustering involved in smoothened signaling pathway Source: Ensembl
    3. CTP biosynthetic process Source: InterPro
    4. determination of left/right symmetry Source: Ensembl
    5. epithelial cilium movement Source: Ensembl
    6. GTP biosynthetic process Source: InterPro
    7. intraciliary transport Source: Ensembl
    8. left/right pattern formation Source: Ensembl
    9. UTP biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Nucleotide metabolism

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nucleoside diphosphate kinase 7 (EC:2.7.4.6)
    Short name:
    NDK 7
    Short name:
    NDP kinase 7
    Alternative name(s):
    nm23-H7
    Gene namesi
    Name:NME7
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:20461. NME7.

    Subcellular locationi

    GO - Cellular componenti

    1. centrosome Source: UniProtKB

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134962167.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 376376Nucleoside diphosphate kinase 7PRO_0000137130Add
    BLAST

    Proteomic databases

    MaxQBiQ9Y5B8.
    PaxDbiQ9Y5B8.
    PRIDEiQ9Y5B8.

    PTM databases

    PhosphoSiteiQ9Y5B8.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9Y5B8.
    BgeeiQ9Y5B8.
    CleanExiHS_NME7.
    GenevestigatoriQ9Y5B8.

    Organism-specific databases

    HPAiHPA038014.

    Interactioni

    Protein-protein interaction databases

    BioGridi118963. 15 interactions.
    IntActiQ9Y5B8. 12 interactions.
    MINTiMINT-1452335.
    STRINGi9606.ENSP00000356785.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y5B8.
    SMRiQ9Y5B8. Positions 92-222, 240-375.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini3 – 9189DM10PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the NDK family.Curated
    Contains 1 DM10 domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0105.
    HOGENOMiHOG000224566.
    HOVERGENiHBG006457.
    InParanoidiQ9Y5B8.
    KOiK00940.
    OMAiMEIQQNN.
    OrthoDBiEOG7HF1JJ.
    PhylomeDBiQ9Y5B8.
    TreeFamiTF106374.

    Family and domain databases

    Gene3Di3.30.70.141. 2 hits.
    InterProiIPR011410. NDK7.
    IPR001564. Nucleoside_diP_kinase.
    IPR006602. Uncharacterised_DM10.
    [Graphical view]
    PfamiPF00334. NDK. 2 hits.
    [Graphical view]
    PIRSFiPIRSF036503. NDK7. 1 hit.
    PRINTSiPR01243. NUCDPKINASE.
    SMARTiSM00676. DM10. 1 hit.
    SM00562. NDK. 2 hits.
    [Graphical view]
    SUPFAMiSSF54919. SSF54919. 2 hits.
    PROSITEiPS51336. DM10. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9Y5B8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNHSERFVFI AEWYDPNASL LRRYELLFYP GDGSVEMHDV KNHRTFLKRT    50
    KYDNLHLEDL FIGNKVNVFS RQLVLIDYGD QYTARQLGSR KEKTLALIKP 100
    DAISKAGEII EIINKAGFTI TKLKMMMLSR KEALDFHVDH QSRPFFNELI 150
    QFITTGPIIA MEILRDDAIC EWKRLLGPAN SGVARTDASE SIRALFGTDG 200
    IRNAAHGPDS FASAAREMEL FFPSSGGCGP ANTAKFTNCT CCIVKPHAVS 250
    EGLLGKILMA IRDAGFEISA MQMFNMDRVN VEEFYEVYKG VVTEYHDMVT 300
    EMYSGPCVAM EIQQNNATKT FREFCGPADP EIARHLRPGT LRAIFGKTKI 350
    QNAVHCTDLP EDGLLEVQYF FKILDN 376
    Length:376
    Mass (Da):42,492
    Last modified:November 1, 1999 - v1
    Checksum:i67C121D6C36E7012
    GO
    Isoform 2 (identifier: Q9Y5B8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-36: Missing.

    Show »
    Length:340
    Mass (Da):38,187
    Checksum:i2FA9FE0342B05737
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 3636Missing in isoform 2. 1 PublicationVSP_040996Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF153191 mRNA. Translation: AAD34622.1.
    AK094513 mRNA. Translation: BAG52881.1.
    AK290701 mRNA. Translation: BAF83390.1.
    AL031726, AL356852, Z99758 Genomic DNA. Translation: CAI18887.1.
    Z99758, AL031726, AL356852 Genomic DNA. Translation: CAI22851.1.
    AL356852, AL031726, Z99758 Genomic DNA. Translation: CAI19238.1.
    CH471067 Genomic DNA. Translation: EAW90834.1.
    CH471067 Genomic DNA. Translation: EAW90835.1.
    BC006983 mRNA. Translation: AAH06983.1.
    CCDSiCCDS1277.1. [Q9Y5B8-1]
    CCDS44274.1. [Q9Y5B8-2]
    RefSeqiNP_037462.1. NM_013330.4. [Q9Y5B8-1]
    NP_932076.1. NM_197972.2. [Q9Y5B8-2]
    UniGeneiHs.706952.

    Genome annotation databases

    EnsembliENST00000367811; ENSP00000356785; ENSG00000143156. [Q9Y5B8-1]
    ENST00000472647; ENSP00000433341; ENSG00000143156. [Q9Y5B8-2]
    GeneIDi29922.
    KEGGihsa:29922.
    UCSCiuc001gft.3. human. [Q9Y5B8-1]

    Polymorphism databases

    DMDMi12230353.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF153191 mRNA. Translation: AAD34622.1 .
    AK094513 mRNA. Translation: BAG52881.1 .
    AK290701 mRNA. Translation: BAF83390.1 .
    AL031726 , AL356852 , Z99758 Genomic DNA. Translation: CAI18887.1 .
    Z99758 , AL031726 , AL356852 Genomic DNA. Translation: CAI22851.1 .
    AL356852 , AL031726 , Z99758 Genomic DNA. Translation: CAI19238.1 .
    CH471067 Genomic DNA. Translation: EAW90834.1 .
    CH471067 Genomic DNA. Translation: EAW90835.1 .
    BC006983 mRNA. Translation: AAH06983.1 .
    CCDSi CCDS1277.1. [Q9Y5B8-1 ]
    CCDS44274.1. [Q9Y5B8-2 ]
    RefSeqi NP_037462.1. NM_013330.4. [Q9Y5B8-1 ]
    NP_932076.1. NM_197972.2. [Q9Y5B8-2 ]
    UniGenei Hs.706952.

    3D structure databases

    ProteinModelPortali Q9Y5B8.
    SMRi Q9Y5B8. Positions 92-222, 240-375.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 118963. 15 interactions.
    IntActi Q9Y5B8. 12 interactions.
    MINTi MINT-1452335.
    STRINGi 9606.ENSP00000356785.

    PTM databases

    PhosphoSitei Q9Y5B8.

    Polymorphism databases

    DMDMi 12230353.

    Proteomic databases

    MaxQBi Q9Y5B8.
    PaxDbi Q9Y5B8.
    PRIDEi Q9Y5B8.

    Protocols and materials databases

    DNASUi 29922.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000367811 ; ENSP00000356785 ; ENSG00000143156 . [Q9Y5B8-1 ]
    ENST00000472647 ; ENSP00000433341 ; ENSG00000143156 . [Q9Y5B8-2 ]
    GeneIDi 29922.
    KEGGi hsa:29922.
    UCSCi uc001gft.3. human. [Q9Y5B8-1 ]

    Organism-specific databases

    CTDi 29922.
    GeneCardsi GC01M169101.
    HGNCi HGNC:20461. NME7.
    HPAi HPA038014.
    MIMi 613465. gene.
    neXtProti NX_Q9Y5B8.
    PharmGKBi PA134962167.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0105.
    HOGENOMi HOG000224566.
    HOVERGENi HBG006457.
    InParanoidi Q9Y5B8.
    KOi K00940.
    OMAi MEIQQNN.
    OrthoDBi EOG7HF1JJ.
    PhylomeDBi Q9Y5B8.
    TreeFami TF106374.

    Miscellaneous databases

    ChiTaRSi NME7. human.
    GenomeRNAii 29922.
    NextBioi 52524.
    PROi Q9Y5B8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y5B8.
    Bgeei Q9Y5B8.
    CleanExi HS_NME7.
    Genevestigatori Q9Y5B8.

    Family and domain databases

    Gene3Di 3.30.70.141. 2 hits.
    InterProi IPR011410. NDK7.
    IPR001564. Nucleoside_diP_kinase.
    IPR006602. Uncharacterised_DM10.
    [Graphical view ]
    Pfami PF00334. NDK. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF036503. NDK7. 1 hit.
    PRINTSi PR01243. NUCDPKINASE.
    SMARTi SM00676. DM10. 1 hit.
    SM00562. NDK. 2 hits.
    [Graphical view ]
    SUPFAMi SSF54919. SSF54919. 2 hits.
    PROSITEi PS51336. DM10. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human nm23-H7 (NME7) mRNA."
      Mehus J.G., Lambeth D.O.
      Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain cortex and Lung.
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Urinary bladder.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiNDK7_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y5B8
    Secondary accession number(s): A8K3T6
    , A8MY09, B3KSW9, Q5TGZ4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2001
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 125 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3