Q9Y5B8 (NDK7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nucleoside diphosphate kinase 7
Short name=NDK 7
Short name=NDP kinase 7
EC=2.7.4.6

Alternative name(s):
nm23-H7

Gene names

Name:

NME7

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	376 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
Catalytic activity	ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.
Cofactor	Magnesium By similarity.
Sequence similarities	Belongs to the NDK family. Contains 1 DM10 domain.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Coding sequence diversity	Alternative splicing
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	CTP biosynthetic process Inferred from electronic annotation. Source: InterPro GTP biosynthetic process Inferred from electronic annotation. Source: InterPro UTP biosynthetic process Inferred from electronic annotation. Source: InterPro brain development Inferred from electronic annotation. Source: Compara ciliary receptor clustering involved in smoothened signaling pathway Inferred from electronic annotation. Source: Compara determination of left/right symmetry Inferred from electronic annotation. Source: Compara epithelial cilium movement Inferred from electronic annotation. Source: Compara intraflagellar transport Inferred from electronic annotation. Source: Compara left/right pattern formation Inferred from electronic annotation. Source: Compara
Cellular_component	centrosome Inferred from direct assay PubMed 21399614. Source: UniProtKB
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW nucleoside diphosphate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9Y5B8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9Y5B8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 376	376	Nucleoside diphosphate kinase 7		PRO_0000137130
Regions
	Domain	3 – 91	89	DM10
Sites
	Active site	206	1	Pros-phosphohistidine intermediate By similarity
	Binding site	99	1	ATP By similarity
	Binding site	145	1	ATP By similarity
	Binding site	193	1	ATP By similarity
	Binding site	203	1	ATP By similarity
Natural variations
	Alternative sequence	1 – 36	36	Missing in isoform 2.		VSP_040996

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 67C121D6C36E7012	FASTA	376	42,492
	10 20 30 40 50 60 MNHSERFVFI AEWYDPNASL LRRYELLFYP GDGSVEMHDV KNHRTFLKRT KYDNLHLEDL 70 80 90 100 110 120 FIGNKVNVFS RQLVLIDYGD QYTARQLGSR KEKTLALIKP DAISKAGEII EIINKAGFTI 130 140 150 160 170 180 TKLKMMMLSR KEALDFHVDH QSRPFFNELI QFITTGPIIA MEILRDDAIC EWKRLLGPAN 190 200 210 220 230 240 SGVARTDASE SIRALFGTDG IRNAAHGPDS FASAAREMEL FFPSSGGCGP ANTAKFTNCT 250 260 270 280 290 300 CCIVKPHAVS EGLLGKILMA IRDAGFEISA MQMFNMDRVN VEEFYEVYKG VVTEYHDMVT 310 320 330 340 350 360 EMYSGPCVAM EIQQNNATKT FREFCGPADP EIARHLRPGT LRAIFGKTKI QNAVHCTDLP 370 EDGLLEVQYF FKILDN
	Isoform 2 [UniParc]. Checksum: 2FA9FE0342B05737	FASTA	340	38,187
	10 20 30 40 50 60 MHDVKNHRTF LKRTKYDNLH LEDLFIGNKV NVFSRQLVLI DYGDQYTARQ LGSRKEKTLA 70 80 90 100 110 120 LIKPDAISKA GEIIEIINKA GFTITKLKMM MLSRKEALDF HVDHQSRPFF NELIQFITTG 130 140 150 160 170 180 PIIAMEILRD DAICEWKRLL GPANSGVART DASESIRALF GTDGIRNAAH GPDSFASAAR 190 200 210 220 230 240 EMELFFPSSG GCGPANTAKF TNCTCCIVKP HAVSEGLLGK ILMAIRDAGF EISAMQMFNM 250 260 270 280 290 300 DRVNVEEFYE VYKGVVTEYH DMVTEMYSGP CVAMEIQQNN ATKTFREFCG PADPEIARHL 310 320 330 340 RPGTLRAIFG KTKIQNAVHC TDLPEDGLLE VQYFFKILDN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human nm23-H7 (NME7) mRNA." Mehus J.G., Lambeth D.O. Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Brain cortex and Lung.
[3]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Urinary bladder.
[6]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF153191 mRNA. Translation: AAD34622.1. AK094513 mRNA. Translation: BAG52881.1. AK290701 mRNA. Translation: BAF83390.1. AL031726, AL356852, Z99758 Genomic DNA. Translation: CAI18887.1. Z99758, AL031726, AL356852 Genomic DNA. Translation: CAI22851.1. AL356852, AL031726, Z99758 Genomic DNA. Translation: CAI19238.1. CH471067 Genomic DNA. Translation: EAW90834.1. CH471067 Genomic DNA. Translation: EAW90835.1. BC006983 mRNA. Translation: AAH06983.1.
IPI	IPI00294997. IPI00377134.
RefSeq	NP_037462.1. NM_013330.3. NP_932076.1. NM_197972.1.
UniGene	Hs.706952.
3D structure databases
ProteinModelPortal	Q9Y5B8.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9Y5B8. 10 interactions.
MINT	MINT-1452335.
STRING	9606.ENSP00000356785.
PTM databases
PhosphoSite	Q9Y5B8.
Polymorphism databases
DMDM	12230353.
Proteomic databases
PaxDb	Q9Y5B8.
PRIDE	Q9Y5B8.
Protocols and materials databases
DNASU	29922.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000367811; ENSP00000356785; ENSG00000143156. ENST00000472647; ENSP00000433341; ENSG00000143156.
GeneID	29922.
KEGG	hsa:29922.
UCSC	uc001gft.3. human.
Organism-specific databases
CTD	29922.
GeneCards	GC01M169101.
HGNC	HGNC:20461. NME7.
HPA	HPA038014.
MIM	613465. gene.
neXtProt	NX_Q9Y5B8.
PharmGKB	PA134962167.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0105.
HOGENOM	HOG000224566.
HOVERGEN	HBG006457.
InParanoid	Q9Y5B8.
KO	K00940.
OMA	MEIQQNN.
OrthoDB	EOG4JHCFT.
PhylomeDB	Q9Y5B8.
Gene expression databases
ArrayExpress	Q9Y5B8.
Bgee	Q9Y5B8.
CleanEx	HS_NME7.
Genevestigator	Q9Y5B8.
GermOnline	ENSG00000143156. Homo sapiens.
Family and domain databases
Gene3D	3.30.70.141. 2 hits.
InterPro	IPR011410. NDK7. IPR001564. Nucleoside_diP_kinase. IPR006602. Uncharacterised_DM10. [Graphical view]
PANTHER	PTHR11349. PTHR11349. 1 hit.
Pfam	PF00334. NDK. 2 hits. [Graphical view]
PIRSF	PIRSF036503. NDK7. 1 hit.
PRINTS	PR01243. NUCDPKINASE.
SMART	SM00676. DM10. 1 hit. SM00562. NDK. 2 hits. [Graphical view]
SUPFAM	SSF54919. NDK. 2 hits.
PROSITE	PS51336. DM10. 1 hit. PS00469. NDP_KINASES. False negative. [Graphical view]
ProtoNet	Search...
Other
ChEMBL	CHEMBL2229.
ChiTaRS	NME7. human.
GenomeRNAi	29922.
NextBio	52524.
SOURCE	Search...

Entry information

Entry name

NDK7_HUMAN

Accession

Primary (citable) accession number: Q9Y5B8
Secondary accession number(s): A8K3T6 , A8MY09, B3KSW9, Q5TGZ4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
Last sequence update:	November 1, 1999
Last modified:	May 1, 2013
This is version 115 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.