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Protein

Zinc finger and SCAN domain-containing protein 21

Gene

ZSCAN21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Strong transcriptional activator.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri277 – 299C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri305 – 327C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri333 – 354C2H2-type 3PROSITE-ProRule annotationAdd BLAST22
Zinc fingeri360 – 382C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri388 – 410C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri416 – 438C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri444 – 466C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

  • positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  • regulation of transcription, DNA-templated Source: UniProtKB

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and SCAN domain-containing protein 21
Alternative name(s):
Renal carcinoma antigen NY-REN-21
Zinc finger protein 38 homolog
Short name:
Zfp-38
Gene namesi
Name:ZSCAN21
Synonyms:ZFP38, ZNF38
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000166529.14.
HGNCiHGNC:13104. ZSCAN21.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000166529.
PharmGKBiPA162410981.

Polymorphism and mutation databases

BioMutaiZSCAN21.
DMDMi20141976.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000472971 – 473Zinc finger and SCAN domain-containing protein 21Add BLAST473

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki27Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki221Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki232Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki349Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ9Y5A6.
MaxQBiQ9Y5A6.
PaxDbiQ9Y5A6.
PeptideAtlasiQ9Y5A6.
PRIDEiQ9Y5A6.

PTM databases

iPTMnetiQ9Y5A6.
PhosphoSitePlusiQ9Y5A6.

Expressioni

Gene expression databases

BgeeiENSG00000166529.
CleanExiHS_ZSCAN21.
ExpressionAtlasiQ9Y5A6. baseline and differential.
GenevisibleiQ9Y5A6. HS.

Organism-specific databases

HPAiHPA016948.
HPA023591.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi113416. 42 interactors.
IntActiQ9Y5A6. 25 interactors.
MINTiMINT-2823816.
STRINGi9606.ENSP00000292450.

Structurei

3D structure databases

ProteinModelPortaliQ9Y5A6.
SMRiQ9Y5A6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini45 – 127SCAN boxPROSITE-ProRule annotationAdd BLAST83

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri277 – 299C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri305 – 327C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri333 – 354C2H2-type 3PROSITE-ProRule annotationAdd BLAST22
Zinc fingeri360 – 382C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri388 – 410C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri416 – 438C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri444 – 466C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118881.
HOGENOMiHOG000234619.
HOVERGENiHBG018163.
InParanoidiQ9Y5A6.
KOiK09230.
OMAiKPYWCNH.
OrthoDBiEOG091G02KC.
PhylomeDBiQ9Y5A6.
TreeFamiTF338304.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR036236. Znf_C2H2_sf.
IPR013087. Znf_C2H2_type.
IPR013083. Znf_RING/FYVE/PHD.
PfamiView protein in Pfam
PF02023. SCAN. 1 hit.
SMARTiView protein in SMART
SM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 7 hits.
SUPFAMiSSF47353. SSF47353. 1 hit.
SSF57667. SSF57667. 4 hits.
PROSITEiView protein in PROSITE
PS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.

Sequencei

Sequence statusi: Complete.

Q9Y5A6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMTKVLGMAP VLGPRPPQEQ VGPLMVKVEE KEEKGKYLPS LEMFRQRFRQ
60 70 80 90 100
FGYHDTPGPR EALSQLRVLC CEWLRPEIHT KEQILELLVL EQFLTILPQE
110 120 130 140 150
LQAWVQEHCP ESAEEAVTLL EDLERELDEP GHQVSTPPNE QKPVWEKISS
160 170 180 190 200
SGTAKESPSS MQPQPLETSH KYESWGPLYI QESGEEQEFA QDPRKVRDCR
210 220 230 240 250
LSTQHEESAD EQKGSEAEGL KGDIISVIIA NKPEASLERQ CVNLENEKGT
260 270 280 290 300
KPPLQEAGSK KGRESVPTKP TPGERRYICA ECGKAFSNSS NLTKHRRTHT
310 320 330 340 350
GEKPYVCTKC GKAFSHSSNL TLHYRTHLVD RPYDCKCGKA FGQSSDLLKH
360 370 380 390 400
QRMHTEEAPY QCKDCGKAFS GKGSLIRHYR IHTGEKPYQC NECGKSFSQH
410 420 430 440 450
AGLSSHQRLH TGEKPYKCKE CGKAFNHSSN FNKHHRIHTG EKPYWCHHCG
460 470
KTFCSKSNLS KHQRVHTGEG EAP
Length:473
Mass (Da):53,658
Last modified:December 19, 2001 - v2
Checksum:iD9A26694B114B96F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136865 mRNA. Translation: CAB66799.1.
CH236956 Genomic DNA. Translation: EAL23860.1.
CH471091 Genomic DNA. Translation: EAW76609.1.
CH471091 Genomic DNA. Translation: EAW76610.1.
BC047309 mRNA. Translation: AAH47309.1.
AF155100 mRNA. Translation: AAD42866.1.
CCDSiCCDS5681.1.
RefSeqiNP_666019.1. NM_145914.2.
XP_005250625.1. XM_005250568.4.
XP_006716176.1. XM_006716113.3.
XP_016868073.1. XM_017012584.1.
UniGeneiHs.632294.

Genome annotation databases

EnsembliENST00000292450; ENSP00000292450; ENSG00000166529.
GeneIDi7589.
KEGGihsa:7589.
UCSCiuc003uso.5. human.

Similar proteinsi

Entry informationi

Entry nameiZSC21_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5A6
Secondary accession number(s): A4D2A6, D6W5T9, Q9H0B5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 19, 2001
Last modified: November 22, 2017
This is version 164 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families