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Protein

Zinc finger and SCAN domain-containing protein 21

Gene

ZSCAN21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Strong transcriptional activator.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri277 – 29923C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri305 – 32723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri333 – 35422C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri360 – 38223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri388 – 41023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri416 – 43823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri444 – 46623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  • regulation of transcription, DNA-templated Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and SCAN domain-containing protein 21
Alternative name(s):
Renal carcinoma antigen NY-REN-21
Zinc finger protein 38 homolog
Short name:
Zfp-38
Gene namesi
Name:ZSCAN21
Synonyms:ZFP38, ZNF38
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:13104. ZSCAN21.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162410981.

Polymorphism and mutation databases

BioMutaiZSCAN21.
DMDMi20141976.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 473473Zinc finger and SCAN domain-containing protein 21PRO_0000047297Add
BLAST

Proteomic databases

EPDiQ9Y5A6.
MaxQBiQ9Y5A6.
PaxDbiQ9Y5A6.
PeptideAtlasiQ9Y5A6.
PRIDEiQ9Y5A6.

PTM databases

iPTMnetiQ9Y5A6.
PhosphoSiteiQ9Y5A6.

Expressioni

Gene expression databases

BgeeiQ9Y5A6.
CleanExiHS_ZSCAN21.
ExpressionAtlasiQ9Y5A6. baseline and differential.
GenevisibleiQ9Y5A6. HS.

Organism-specific databases

HPAiHPA016948.
HPA023591.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KRT40Q6A1623EBI-10281938,EBI-10171697
KRTAP10-5P603703EBI-10281938,EBI-10172150
KRTAP10-8P604103EBI-10281938,EBI-10171774
KRTAP10-9P604113EBI-10281938,EBI-10172052
TRIM41Q8WV443EBI-10281938,EBI-725997
ZKSCAN7Q9P0L13EBI-10281938,EBI-743851
ZNF24P170283EBI-10281938,EBI-707773
ZNF446Q96AF53EBI-10281938,EBI-740232
ZNF496Q96IT13EBI-10281938,EBI-743906

Protein-protein interaction databases

BioGridi113416. 25 interactions.
IntActiQ9Y5A6. 9 interactions.
MINTiMINT-2823816.
STRINGi9606.ENSP00000292450.

Structurei

3D structure databases

ProteinModelPortaliQ9Y5A6.
SMRiQ9Y5A6. Positions 39-128, 273-469.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini45 – 12783SCAN boxPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 7 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 SCAN box domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri277 – 29923C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri305 – 32723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri333 – 35422C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri360 – 38223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri388 – 41023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri416 – 43823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri444 – 46623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118881.
HOGENOMiHOG000234619.
HOVERGENiHBG018163.
InParanoidiQ9Y5A6.
KOiK09230.
OMAiPRKVRDC.
OrthoDBiEOG7QRQTP.
PhylomeDBiQ9Y5A6.
TreeFamiTF338304.

Family and domain databases

Gene3Di3.30.160.60. 7 hits.
InterProiIPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 4 hits.
[Graphical view]
SMARTiSM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 7 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y5A6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMTKVLGMAP VLGPRPPQEQ VGPLMVKVEE KEEKGKYLPS LEMFRQRFRQ
60 70 80 90 100
FGYHDTPGPR EALSQLRVLC CEWLRPEIHT KEQILELLVL EQFLTILPQE
110 120 130 140 150
LQAWVQEHCP ESAEEAVTLL EDLERELDEP GHQVSTPPNE QKPVWEKISS
160 170 180 190 200
SGTAKESPSS MQPQPLETSH KYESWGPLYI QESGEEQEFA QDPRKVRDCR
210 220 230 240 250
LSTQHEESAD EQKGSEAEGL KGDIISVIIA NKPEASLERQ CVNLENEKGT
260 270 280 290 300
KPPLQEAGSK KGRESVPTKP TPGERRYICA ECGKAFSNSS NLTKHRRTHT
310 320 330 340 350
GEKPYVCTKC GKAFSHSSNL TLHYRTHLVD RPYDCKCGKA FGQSSDLLKH
360 370 380 390 400
QRMHTEEAPY QCKDCGKAFS GKGSLIRHYR IHTGEKPYQC NECGKSFSQH
410 420 430 440 450
AGLSSHQRLH TGEKPYKCKE CGKAFNHSSN FNKHHRIHTG EKPYWCHHCG
460 470
KTFCSKSNLS KHQRVHTGEG EAP
Length:473
Mass (Da):53,658
Last modified:December 19, 2001 - v2
Checksum:iD9A26694B114B96F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136865 mRNA. Translation: CAB66799.1.
CH236956 Genomic DNA. Translation: EAL23860.1.
CH471091 Genomic DNA. Translation: EAW76609.1.
CH471091 Genomic DNA. Translation: EAW76610.1.
BC047309 mRNA. Translation: AAH47309.1.
AF155100 mRNA. Translation: AAD42866.1.
CCDSiCCDS5681.1.
RefSeqiNP_666019.1. NM_145914.2.
XP_005250623.1. XM_005250566.2.
XP_005250625.1. XM_005250568.3.
XP_006716176.1. XM_006716113.2.
UniGeneiHs.632294.

Genome annotation databases

EnsembliENST00000292450; ENSP00000292450; ENSG00000166529.
GeneIDi7589.
KEGGihsa:7589.
UCSCiuc003uso.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136865 mRNA. Translation: CAB66799.1.
CH236956 Genomic DNA. Translation: EAL23860.1.
CH471091 Genomic DNA. Translation: EAW76609.1.
CH471091 Genomic DNA. Translation: EAW76610.1.
BC047309 mRNA. Translation: AAH47309.1.
AF155100 mRNA. Translation: AAD42866.1.
CCDSiCCDS5681.1.
RefSeqiNP_666019.1. NM_145914.2.
XP_005250623.1. XM_005250566.2.
XP_005250625.1. XM_005250568.3.
XP_006716176.1. XM_006716113.2.
UniGeneiHs.632294.

3D structure databases

ProteinModelPortaliQ9Y5A6.
SMRiQ9Y5A6. Positions 39-128, 273-469.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113416. 25 interactions.
IntActiQ9Y5A6. 9 interactions.
MINTiMINT-2823816.
STRINGi9606.ENSP00000292450.

PTM databases

iPTMnetiQ9Y5A6.
PhosphoSiteiQ9Y5A6.

Polymorphism and mutation databases

BioMutaiZSCAN21.
DMDMi20141976.

Proteomic databases

EPDiQ9Y5A6.
MaxQBiQ9Y5A6.
PaxDbiQ9Y5A6.
PeptideAtlasiQ9Y5A6.
PRIDEiQ9Y5A6.

Protocols and materials databases

DNASUi7589.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000292450; ENSP00000292450; ENSG00000166529.
GeneIDi7589.
KEGGihsa:7589.
UCSCiuc003uso.5. human.

Organism-specific databases

CTDi7589.
GeneCardsiZSCAN21.
HGNCiHGNC:13104. ZSCAN21.
HPAiHPA016948.
HPA023591.
neXtProtiNX_Q9Y5A6.
PharmGKBiPA162410981.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118881.
HOGENOMiHOG000234619.
HOVERGENiHBG018163.
InParanoidiQ9Y5A6.
KOiK09230.
OMAiPRKVRDC.
OrthoDBiEOG7QRQTP.
PhylomeDBiQ9Y5A6.
TreeFamiTF338304.

Miscellaneous databases

GeneWikiiZSCAN21.
GenomeRNAii7589.
PROiQ9Y5A6.

Gene expression databases

BgeeiQ9Y5A6.
CleanExiHS_ZSCAN21.
ExpressionAtlasiQ9Y5A6. baseline and differential.
GenevisibleiQ9Y5A6. HS.

Family and domain databases

Gene3Di3.30.160.60. 7 hits.
InterProiIPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 4 hits.
[Graphical view]
SMARTiSM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 7 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cervix.
  5. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 62-473, IDENTIFICATION AS A RENAL CANCER ANTIGEN.
    Tissue: Renal cell carcinoma.

Entry informationi

Entry nameiZSC21_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5A6
Secondary accession number(s): A4D2A6, D6W5T9, Q9H0B5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 19, 2001
Last modified: July 6, 2016
This is version 151 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.