BTB/POZ domain-containing protein KCTD3

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processⁱ

• protein homooligomerization Source: InterPro

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsⁱ produced by alternative splicing. AlignAdd to basketAdded to basket

        10         20         30         40         50
MAGGHCGSFP AAAAGSGEIV QLNVGGTRFS TSRQTLMWIP DSFFSSLLSG 
        60         70         80         90        100
RISTLRDETG AIFIDRDPAA FAPILNFLRT KELDLRGVSI NVLRHEAEFY 
       110        120        130        140        150
GITPLVRRLL LCEELERSSC GSVLFHGYLP PPGIPSRKIN NTVRSADSRN 
       160        170        180        190        200
GLNSTEGEAR GNGTQPVLSG TGEETVRLGF PVDPRKVLIV AGHHNWIVAA 
       210        220        230        240        250
YAHFAVCYRI KESSGWQQVF TSPYLDWTIE RVALNAKVVG GPHGDKDKMV 
       260        270        280        290        300
AVASESSIIL WSVQDGGSGS EIGVFSLGVP VDALFFIGNQ LVATSHTGKV 
       310        320        330        340        350
GVWNAVTQHW QVQDVVPITS YDTAGSFLLL GCNNGSIYYI DMQKFPLRMK 
       360        370        380        390        400
DNDLLVTELY HDPSNDAITA LSVYLTPKTS VSGNWIEIAY GTSSGAVRVI 
       410        420        430        440        450
VQHPETVGSG PQLFQTFTVH RSPVTKIMLS EKHLVSVCAD NNHVRTWTVT 
       460        470        480        490        500
RFRGMISTQP GSTPLASFKI LSLEETESHG SYSSGNDIGP FGERDDQQVF 
       510        520        530        540        550
IQKVVPITNK LFVRLSSTGK RICEIQAVDC TTISSFTVRE CEGSSRMGSR 
       560        570        580        590        600
PRRYLFTGHT NGSIQMWDLT TAMDMVNKSE DKDVGGPTEE ELLKLLDQCD 
       610        620        630        640        650
LSTSRCATPN ISPATSVVQH SHLRESNSSL QLQHHDTTHE AATYGSMRPY 
       660        670        680        690        700
RESPLLARAR RTESFHSYRD FQTINLNRNV ERAVPENGNL GPIQAEVKGA 
       710        720        730        740        750
TGECNISERK SPGVEIKSLR ELDSGLEVHK IAEGFSESKK RSSEDENENK 
       760        770        780        790        800
IEFRKKGGFE GGGFLGRKKV PYLASSPSTS DGGTDSPGTA SPSPTKTTPS 
       810 
PRHKKSDSSG QEYSL                                       

        10         20         30         40         50
MAGGHCGSFP AAAAGSGEIV QLNVGGTRFS TSRQTLMWIP DSFFSSLLSG 
        60         70         80         90        100
RISTLRDETG AIFIDRDPAA FAPILNFLRT KELDLRGVSI NVLRHEAEFY 
       110        120        130        140        150
GITPLVRRLL LCEELERSSC GSVLFHGYLP PPGIPSRKIN NTVRSADSRN 
       160        170        180        190        200
GLNSTEGEAR GNGTQPVLSG TGEETVRLGF PVDPRKVLIV AGHHNWIVAA 
       210        220        230        240        250
YAHFAVCYRI KESSGWQQVF TSPYLDWTIE RVALNAKVVG GPHGDKDKMV 
       260        270        280        290        300
AVASESSIIL WSVQDGGSGS EIGVFSLGVP VDALFFIGNQ LVATSHTGKV 
       310        320        330        340        350
GVWNAVTQHW QVQDVVPITS YDTAGSFLLL GCNNGSIYYI DMQKFPLRMK 
       360        370        380        390        400
DNDLLVTELY HDPSNDAITA LSVYLTPKTS VSGNWIEIAY GTSSGAVRVI 
       410        420        430        440        450
VQHPETVGSG PQLFQTFTVH RSPVTKIMLS EKHLVSVCAD NNHVRTWTVT 
       460        470        480        490        500
RFRGMISTQP GSTPLASFKI LSLEETESHG SYSSGNDIGP FGERDDQQVF 
       510        520        530        540        550
IQKVVPITNK LFVRLSSTGK RICEIQAVDC TTISSFTVRE CEGSSRMGSR 
       560        570        580        590        600
PRRYLFTGHT NGSIQMWDLT TAMDMVNKSE DKGGPTEEEL LKLLDQCDLS 
       610        620        630        640        650
TSRCATPNIS PATSVVQHSH LRESNSSLQL QHHDTTHEAA TYGSMRPYRE 
       660        670        680        690        700
SPLLARARRT ESFHSYRDFQ TINLNRNVER AVPENGNLGP IQAEVKGATG 
       710        720        730        740        750
ECNISERKSP GVEIKSLREL DSGLEVHKIA EGFSESKKRS SEDENENKIE 
       760        770        780        790        800
FRKKGGFEGG GFLGRKKVPY LASSPSTSDG GTDSPGTASP SPTKTTPSPR 
       810 
HKKSDSSGQE YSL                                         

        10         20         30         40         50
MRPYRESPLL ARARRTESFH SYRDFQTINL NRNVERAVPE NGNLGPIQAE 
        60         70         80         90        100
VKGATGECNI SERKSPGVEI KSLRELDSGL EVHKIAEGFS ESKKRSSEDE 
       110        120        130        140        150
NENKIEFRKK GGFEGGGFLG RKKVPYLASS PSTSDGGTDS PGTASPSPTK 
       160 
TTPSPRHKKS DSSGQEYSL                                   

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termⁱ

Documents

1. Human chromosome 1
   Human chromosome 1: entries, gene names and cross-references to MIM
2. Human entries with polymorphisms or disease mutations
   List of human entries with polymorphisms or disease mutations
3. Human polymorphisms and disease mutations
   Index of human polymorphisms and disease mutations
4. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
5. SIMILARITY comments
   Index of protein domains and families