Q9Y597 (KCTD3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
BTB/POZ domain-containing protein KCTD3

Alternative name(s):
Renal carcinoma antigen NY-REN-45

Gene names

Name:

KCTD3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	815 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Tissue specificity	Broadly expressed in normal tissues. Ref.1
Miscellaneous	Reacts with sera from 5-25 per cent of cancer patients but not with sera from normal donors. Seventy per cent of renal cancer patients have antibodies against one or a panel of these antigens.
Sequence similarities	Belongs to the KCTD3 family. Contains 1 BTB (POZ) domain. Contains 5 WD repeats.
Sequence caution	The sequence AAH13868.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat WD repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein homooligomerization Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
NAA38	O95777	1	EBI-373299,EBI-347779

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9Y597-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9Y597-2)

The sequence of this isoform differs from the canonical sequence as follows:
     583-584: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q9Y597-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-646: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 815	815	BTB/POZ domain-containing protein KCTD3		PRO_0000247839
Regions
	Domain	18 – 87	70	BTB
	Repeat	224 – 271	48	WD 1
	Repeat	276 – 313	38	WD 2
	Repeat	315 – 350	36	WD 3
	Repeat	419 – 457	39	WD 4
	Repeat	537 – 577	41	WD 5
Natural variations
	Alternative sequence	1 – 646	646	Missing in isoform 3.		VSP_020068
	Alternative sequence	583 – 584	2	Missing in isoform 2.		VSP_020069
	Natural variant	9	1	F → V. Ref.4 Corresponds to variant rs2275768 [ dbSNP | Ensembl ].		VAR_027156
Experimental info
	Sequence conflict	207	1	C → W in AAD42876. Ref.1
	Sequence conflict	503	1	K → I in CAD38743. Ref.5
	Sequence conflict	742	1	S → P in CAD38743. Ref.5
	Sequence conflict	803	1	H → HK in CAD38743. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified August 22, 2006. Version 2. Checksum: 65131F449069B5B9	FASTA	815	88,984
	10 20 30 40 50 60 MAGGHCGSFP AAAAGSGEIV QLNVGGTRFS TSRQTLMWIP DSFFSSLLSG RISTLRDETG 70 80 90 100 110 120 AIFIDRDPAA FAPILNFLRT KELDLRGVSI NVLRHEAEFY GITPLVRRLL LCEELERSSC 130 140 150 160 170 180 GSVLFHGYLP PPGIPSRKIN NTVRSADSRN GLNSTEGEAR GNGTQPVLSG TGEETVRLGF 190 200 210 220 230 240 PVDPRKVLIV AGHHNWIVAA YAHFAVCYRI KESSGWQQVF TSPYLDWTIE RVALNAKVVG 250 260 270 280 290 300 GPHGDKDKMV AVASESSIIL WSVQDGGSGS EIGVFSLGVP VDALFFIGNQ LVATSHTGKV 310 320 330 340 350 360 GVWNAVTQHW QVQDVVPITS YDTAGSFLLL GCNNGSIYYI DMQKFPLRMK DNDLLVTELY 370 380 390 400 410 420 HDPSNDAITA LSVYLTPKTS VSGNWIEIAY GTSSGAVRVI VQHPETVGSG PQLFQTFTVH 430 440 450 460 470 480 RSPVTKIMLS EKHLVSVCAD NNHVRTWTVT RFRGMISTQP GSTPLASFKI LSLEETESHG 490 500 510 520 530 540 SYSSGNDIGP FGERDDQQVF IQKVVPITNK LFVRLSSTGK RICEIQAVDC TTISSFTVRE 550 560 570 580 590 600 CEGSSRMGSR PRRYLFTGHT NGSIQMWDLT TAMDMVNKSE DKDVGGPTEE ELLKLLDQCD 610 620 630 640 650 660 LSTSRCATPN ISPATSVVQH SHLRESNSSL QLQHHDTTHE AATYGSMRPY RESPLLARAR 670 680 690 700 710 720 RTESFHSYRD FQTINLNRNV ERAVPENGNL GPIQAEVKGA TGECNISERK SPGVEIKSLR 730 740 750 760 770 780 ELDSGLEVHK IAEGFSESKK RSSEDENENK IEFRKKGGFE GGGFLGRKKV PYLASSPSTS 790 800 810 DGGTDSPGTA SPSPTKTTPS PRHKKSDSSG QEYSL
	Isoform 2 [UniParc]. Checksum: C05036A26CBE314C	FASTA	813	88,770
	10 20 30 40 50 60 MAGGHCGSFP AAAAGSGEIV QLNVGGTRFS TSRQTLMWIP DSFFSSLLSG RISTLRDETG 70 80 90 100 110 120 AIFIDRDPAA FAPILNFLRT KELDLRGVSI NVLRHEAEFY GITPLVRRLL LCEELERSSC 130 140 150 160 170 180 GSVLFHGYLP PPGIPSRKIN NTVRSADSRN GLNSTEGEAR GNGTQPVLSG TGEETVRLGF 190 200 210 220 230 240 PVDPRKVLIV AGHHNWIVAA YAHFAVCYRI KESSGWQQVF TSPYLDWTIE RVALNAKVVG 250 260 270 280 290 300 GPHGDKDKMV AVASESSIIL WSVQDGGSGS EIGVFSLGVP VDALFFIGNQ LVATSHTGKV 310 320 330 340 350 360 GVWNAVTQHW QVQDVVPITS YDTAGSFLLL GCNNGSIYYI DMQKFPLRMK DNDLLVTELY 370 380 390 400 410 420 HDPSNDAITA LSVYLTPKTS VSGNWIEIAY GTSSGAVRVI VQHPETVGSG PQLFQTFTVH 430 440 450 460 470 480 RSPVTKIMLS EKHLVSVCAD NNHVRTWTVT RFRGMISTQP GSTPLASFKI LSLEETESHG 490 500 510 520 530 540 SYSSGNDIGP FGERDDQQVF IQKVVPITNK LFVRLSSTGK RICEIQAVDC TTISSFTVRE 550 560 570 580 590 600 CEGSSRMGSR PRRYLFTGHT NGSIQMWDLT TAMDMVNKSE DKGGPTEEEL LKLLDQCDLS 610 620 630 640 650 660 TSRCATPNIS PATSVVQHSH LRESNSSLQL QHHDTTHEAA TYGSMRPYRE SPLLARARRT 670 680 690 700 710 720 ESFHSYRDFQ TINLNRNVER AVPENGNLGP IQAEVKGATG ECNISERKSP GVEIKSLREL 730 740 750 760 770 780 DSGLEVHKIA EGFSESKKRS SEDENENKIE FRKKGGFEGG GFLGRKKVPY LASSPSTSDG 790 800 810 GTDSPGTASP SPTKTTPSPR HKKSDSSGQE YSL
	Isoform 3 [UniParc]. Checksum: BD47F0FDC67AFE56	FASTA	169	18,514
	10 20 30 40 50 60 MRPYRESPLL ARARRTESFH SYRDFQTINL NRNVERAVPE NGNLGPIQAE VKGATGECNI 70 80 90 100 110 120 SERKSPGVEI KSLRELDSGL EVHKIAEGFS ESKKRSSEDE NENKIEFRKK GGFEGGGFLG 130 140 150 160 RKKVPYLASS PSTSDGGTDS PGTASPSPTK TTPSPRHKKS DSSGQEYSL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Antigens recognized by autologous antibody in patients with renal-cell carcinoma." Scanlan M.J., Gordan J.D., Williamson B., Stockert E., Bander N.H., Jongeneel C.V., Gure A.O., Jaeger D., Jaeger E., Knuth A., Chen Y.-T., Old L.J. Int. J. Cancer 83:456-464(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
[2]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3), VARIANT VAL-9. Tissue: Brain, Lymph and Placenta.
[5]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 158-815. Tissue: Brain and Testis.
[6]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[7]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF155110 mRNA. Translation: AAD42876.1. AL365315, AC092799 Genomic DNA. Translation: CAD20310.1. CH471100 Genomic DNA. Translation: EAW93345.1. BC013868 mRNA. Translation: AAH13868.1. Sequence problems. BC037896 mRNA. Translation: AAH37896.1. BC094879 mRNA. Translation: AAH94879.1. BC117188 mRNA. Translation: AAI17189.1. BC126173 mRNA. Translation: AAI26174.1. AL833887 mRNA. Translation: CAD38743.2. AL834389 mRNA. Translation: CAD39051.1.
IPI	IPI00410103. IPI00783521. IPI00783650.
RefSeq	NP_057205.2. NM_016121.3.
UniGene	Hs.335139.
3D structure databases
ProteinModelPortal	Q9Y597.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9Y597. 4 interactions.
STRING	9606.ENSP00000259154.
PTM databases
PhosphoSite	Q9Y597.
Polymorphism databases
DMDM	112823993.
Proteomic databases
PaxDb	Q9Y597.
PRIDE	Q9Y597.
Protocols and materials databases
DNASU	51133.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000259154; ENSP00000259154; ENSG00000136636.
GeneID	51133.
KEGG	hsa:51133.
UCSC	uc001hks.3. human. uc001hkt.3. human.
Organism-specific databases
CTD	51133.
GeneCards	GC01P215740.
H-InvDB	HIX0001589.
HGNC	HGNC:21305. KCTD3.
HPA	HPA015142.
MIM	613272. gene.
neXtProt	NX_Q9Y597.
PharmGKB	PA134945859.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG316237.
HOVERGEN	HBG061001.
InParanoid	Q9Y597.
OMA	EASFKIV.
OrthoDB	EOG4SF959.
PhylomeDB	Q9Y597.
Gene expression databases
ArrayExpress	Q9Y597.
Bgee	Q9Y597.
CleanEx	HS_KCTD3.
Genevestigator	Q9Y597.
GermOnline	ENSG00000136636. Homo sapiens.
Family and domain databases
Gene3D	2.130.10.10. 2 hits. 3.30.710.10. 1 hit.
InterPro	IPR000210. BTB/POZ-like. IPR011333. BTB/POZ_fold. IPR003131. T1-type_BTB. IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR019775. WD40_repeat_CS. IPR017986. WD40_repeat_dom. [Graphical view]
Pfam	PF02214. K_tetra. 1 hit. [Graphical view]
SMART	SM00225. BTB. 1 hit. SM00320. WD40. 3 hits. [Graphical view]
SUPFAM	SSF54695. BTB/POZ_fold. 1 hit. SSF50978. WD40_like. 1 hit.
PROSITE	PS50097. BTB. 1 hit. PS00678. WD_REPEATS_1. 1 hit. PS50082. WD_REPEATS_2. False negative. PS50294. WD_REPEATS_REGION. False negative. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	51133.
NextBio	53973.
SOURCE	Search...

Entry information

Entry name

KCTD3_HUMAN

Accession

Primary (citable) accession number: Q9Y597
Secondary accession number(s): A0AV15 , D3DTA6, Q49AG7, Q504Q9, Q6PJN6, Q8ND58, Q8NDJ0, Q8WX16

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 22, 2006
Last sequence update:	August 22, 2006
Last modified:	May 1, 2013
This is version 102 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.