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Reviewed, UniProtKB/Swiss-Prot Q9Y597 (KCTD3_HUMAN)

Last modified July 7, 2009. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    BTB/POZ domain-containing protein KCTD3
Alternative name(s):
    Renal carcinoma antigen NY-REN-45
Gene names
Name: KCTD3
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length815 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Tissue specificity

Broadly expressed in normal tissues. Ref.1

Miscellaneous

Reacts with sera from 5-25 per cent of cancer patients but not with sera from normal donors. Seventy per cent of renal cancer patients have antibodies against one or a panel of these antigens.

Sequence similarities

Belongs to the KCTD3 family.

Contains 1 BTB (POZ) domain.

Contains 5 WD repeats.

Sequence caution

The sequence AAH13868.1 differs from that shown. Reason: Miscellaneous discrepancy. Contaminating sequence. Potential poly-A sequence.

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Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainRepeat
WD repeat
   PTMPhosphoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processpotassium ion transport

Inferred from electronic annotation. Source: InterPro

   Cellular componentvoltage-gated potassium channel complex

Inferred from electronic annotation. Source: InterPro

   Molecular functionprotein binding

Inferred from physical interaction. Source: IntAct

voltage-gated potassium channel activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Binary interactions

With

Entry

#Exp.

IntAct

Notes

LSM8O957771EBI-373299,EBI-347779

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Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9Y597-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9Y597-2)

The sequence of this isoform differs from the canonical sequence as follows:
     583-584: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q9Y597-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-646: Missing.
Note: No experimental confirmation available.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 815815BTB/POZ domain-containing protein KCTD3
PRO_0000247839

Regions

Domain18 – 8770BTB
Repeat224 – 27148WD 1
Repeat276 – 31338WD 2
Repeat315 – 35036WD 3
Repeat419 – 45739WD 4
Repeat537 – 57741WD 5

Amino acid modifications

Modified residue7111Phosphoserine Ref.5

Natural variations

Alternative sequence1 – 646646Missing in isoform 3.
VSP_020068
Alternative sequence583 – 5842Missing in isoform 2.
VSP_020069
Natural variant91F → V: dbSNP rs2275768. Ref.3
VAR_027156

Experimental info

Sequence conflict2071C → W in AAD42876. Ref.1
Sequence conflict5031K → I in CAD38743. Ref.4
Sequence conflict7421S → P in CAD38743. Ref.4
Sequence conflict8031H → HK in CAD38743. Ref.4

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Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified August 22, 2006. Version 2.
Checksum: 65131F449069B5B9

FASTA81588,984
        10         20         30         40         50         60 
MAGGHCGSFP AAAAGSGEIV QLNVGGTRFS TSRQTLMWIP DSFFSSLLSG RISTLRDETG 

        70         80         90        100        110        120 
AIFIDRDPAA FAPILNFLRT KELDLRGVSI NVLRHEAEFY GITPLVRRLL LCEELERSSC 

       130        140        150        160        170        180 
GSVLFHGYLP PPGIPSRKIN NTVRSADSRN GLNSTEGEAR GNGTQPVLSG TGEETVRLGF 

       190        200        210        220        230        240 
PVDPRKVLIV AGHHNWIVAA YAHFAVCYRI KESSGWQQVF TSPYLDWTIE RVALNAKVVG 

       250        260        270        280        290        300 
GPHGDKDKMV AVASESSIIL WSVQDGGSGS EIGVFSLGVP VDALFFIGNQ LVATSHTGKV 

       310        320        330        340        350        360 
GVWNAVTQHW QVQDVVPITS YDTAGSFLLL GCNNGSIYYI DMQKFPLRMK DNDLLVTELY 

       370        380        390        400        410        420 
HDPSNDAITA LSVYLTPKTS VSGNWIEIAY GTSSGAVRVI VQHPETVGSG PQLFQTFTVH 

       430        440        450        460        470        480 
RSPVTKIMLS EKHLVSVCAD NNHVRTWTVT RFRGMISTQP GSTPLASFKI LSLEETESHG 

       490        500        510        520        530        540 
SYSSGNDIGP FGERDDQQVF IQKVVPITNK LFVRLSSTGK RICEIQAVDC TTISSFTVRE 

       550        560        570        580        590        600 
CEGSSRMGSR PRRYLFTGHT NGSIQMWDLT TAMDMVNKSE DKDVGGPTEE ELLKLLDQCD 

       610        620        630        640        650        660 
LSTSRCATPN ISPATSVVQH SHLRESNSSL QLQHHDTTHE AATYGSMRPY RESPLLARAR 

       670        680        690        700        710        720 
RTESFHSYRD FQTINLNRNV ERAVPENGNL GPIQAEVKGA TGECNISERK SPGVEIKSLR 

       730        740        750        760        770        780 
ELDSGLEVHK IAEGFSESKK RSSEDENENK IEFRKKGGFE GGGFLGRKKV PYLASSPSTS 

       790        800        810 
DGGTDSPGTA SPSPTKTTPS PRHKKSDSSG QEYSL

« Hide

Isoform 2.

Checksum: C05036A26CBE314C
Show »

FASTA81388,770
Isoform 3.

Checksum: BD47F0FDC67AFE56
Show »

FASTA16918,514

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References

« Hide 'large scale' references
[1]"Antigens recognized by autologous antibody in patients with renal-cell carcinoma."
Scanlan M.J., Gordan J.D., Williamson B., Stockert E., Bander N.H., Jongeneel C.V., Gure A.O., Jaeger D., Jaeger E., Knuth A., Chen Y.-T., Old L.J.
Int. J. Cancer 83:456-464(1999) [PubMed: 10508479] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
[2]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed: 16710414] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3), VARIANT VAL-9.
Tissue: Brain, Lymph and Placenta.
[4]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Blocker H., Heubner D., Hoerlein A., Michel G., Wedler H., Kohrer K., Ottenwalder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 158-815.
Tissue: Brain and Testis.
[5]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-711, MASS SPECTROMETRY.

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Cross-references

Sequence databases

AF155110 mRNA. Translation: AAD42876.1.
AL365315, AC092799 Genomic DNA. Translation: CAD20310.1.
BC013868 mRNA. Translation: AAH13868.1. Sequence problems.
BC037896 mRNA. Translation: AAH37896.1.
BC094879 mRNA. Translation: AAH94879.1.
BC117188 mRNA. Translation: AAI17189.1.
BC126173 mRNA. Translation: AAI26174.1.
AL833887 mRNA. Translation: CAD38743.2.
AL834389 mRNA. Translation: CAD39051.1.
IPIIPI00410103.
IPI00783521.
IPI00783650.
RefSeqNP_057205.2.
UniGeneHs.335139

3D structure databases

HSSPHSSP built from PDB template 3KVT based on UniProtKB O76457.
ModBaseSearch...

Protein-protein interaction databases

IntActQ9Y597. 2 interactions.

PTM databases

PhosphoSiteQ9Y597.

Proteomic databases

PRIDEQ9Y597.

Genome annotation databases

EnsemblENSG00000136636. Homo sapiens. [Contig view]
GeneID51133.
KEGGhsa:51133.
UCSCuc001hks.1. human.
uc001hkt.1. human.

Organism-specific databases

GeneCardsGC01P213807.
HGNCHGNC:21305. KCTD3.
HPAHPA015142.
PharmGKBPA134945859.
GenAtlasSearch...

Phylogenomic databases

HOVERGENQ9Y597.
OMAQ9Y597. HANGSIQ.

Gene expression databases

BgeeQ9Y597.
CleanExHS_KCTD3.
GermOnlineENSG00000136636. Homo sapiens.

Family and domain databases

InterProIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR003131. K_chnl_volt-dep_Kv_tetra.
IPR015943. WD40/YVTN_repeat-like.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
[Graphical view]
Gene3DG3DSA:3.30.710.10. BTB/POZ_fold. 1 hit.
G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 1 hit.
PfamPF02214. K_tetra. 1 hit.
[Graphical view]
SMARTSM00225. BTB. 1 hit.
SM00320. WD40. 3 hits.
[Graphical view]
PROSITEPS50097. BTB. 1 hit.
PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. False negative.
PS50294. WD_REPEATS_REGION. False negative.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio53973.

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Entry information

Entry nameKCTD3_HUMAN
AccessionPrimary (citable) accession number: Q9Y597
Secondary accession number(s): A0AV15 expand/collapse secondary AC list , Q49AG7, Q504Q9, Q6PJN6, Q8ND58, Q8NDJ0, Q8WX16
Entry history
Integrated into UniProtKB/Swiss-Prot: August 22, 2006
Last sequence update: August 22, 2006
Last modified: July 7, 2009
This is version 67 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents