Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9Y597

- KCTD3_HUMAN

UniProt

Q9Y597 - KCTD3_HUMAN

Protein

BTB/POZ domain-containing protein KCTD3

Gene

KCTD3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 2 (22 Aug 2006)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    GO - Biological processi

    1. protein homooligomerization Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    BTB/POZ domain-containing protein KCTD3
    Alternative name(s):
    Renal carcinoma antigen NY-REN-45
    Gene namesi
    Name:KCTD3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:21305. KCTD3.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134945859.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 815815BTB/POZ domain-containing protein KCTD3PRO_0000247839Add
    BLAST

    Proteomic databases

    MaxQBiQ9Y597.
    PaxDbiQ9Y597.
    PRIDEiQ9Y597.

    PTM databases

    PhosphoSiteiQ9Y597.

    Expressioni

    Tissue specificityi

    Broadly expressed in normal tissues.1 Publication

    Gene expression databases

    ArrayExpressiQ9Y597.
    BgeeiQ9Y597.
    CleanExiHS_KCTD3.
    GenevestigatoriQ9Y597.

    Organism-specific databases

    HPAiHPA015142.

    Interactioni

    Protein-protein interaction databases

    BioGridi119320. 15 interactions.
    IntActiQ9Y597. 4 interactions.
    STRINGi9606.ENSP00000259154.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y597.
    SMRiQ9Y597. Positions 17-119, 412-449.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini18 – 8770BTBPROSITE-ProRule annotationAdd
    BLAST
    Repeati224 – 27148WD 1Add
    BLAST
    Repeati276 – 31338WD 2Add
    BLAST
    Repeati315 – 35036WD 3Add
    BLAST
    Repeati419 – 45739WD 4Add
    BLAST
    Repeati537 – 57741WD 5Add
    BLAST

    Sequence similaritiesi

    Belongs to the KCTD3 family.Curated
    Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
    Contains 5 WD repeats.Curated

    Keywords - Domaini

    Repeat, WD repeat

    Phylogenomic databases

    eggNOGiNOG316237.
    HOVERGENiHBG061001.
    InParanoidiQ9Y597.
    OMAiIILWSIQ.
    OrthoDBiEOG7P8P7H.
    PhylomeDBiQ9Y597.
    TreeFamiTF313754.

    Family and domain databases

    Gene3Di2.130.10.10. 2 hits.
    3.30.710.10. 1 hit.
    InterProiIPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR003131. T1-type_BTB.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF02214. BTB_2. 1 hit.
    [Graphical view]
    SMARTiSM00225. BTB. 1 hit.
    SM00320. WD40. 3 hits.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 2 hits.
    SSF54695. SSF54695. 1 hit.
    PROSITEiPS50097. BTB. 1 hit.
    PS00678. WD_REPEATS_1. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9Y597-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAGGHCGSFP AAAAGSGEIV QLNVGGTRFS TSRQTLMWIP DSFFSSLLSG    50
    RISTLRDETG AIFIDRDPAA FAPILNFLRT KELDLRGVSI NVLRHEAEFY 100
    GITPLVRRLL LCEELERSSC GSVLFHGYLP PPGIPSRKIN NTVRSADSRN 150
    GLNSTEGEAR GNGTQPVLSG TGEETVRLGF PVDPRKVLIV AGHHNWIVAA 200
    YAHFAVCYRI KESSGWQQVF TSPYLDWTIE RVALNAKVVG GPHGDKDKMV 250
    AVASESSIIL WSVQDGGSGS EIGVFSLGVP VDALFFIGNQ LVATSHTGKV 300
    GVWNAVTQHW QVQDVVPITS YDTAGSFLLL GCNNGSIYYI DMQKFPLRMK 350
    DNDLLVTELY HDPSNDAITA LSVYLTPKTS VSGNWIEIAY GTSSGAVRVI 400
    VQHPETVGSG PQLFQTFTVH RSPVTKIMLS EKHLVSVCAD NNHVRTWTVT 450
    RFRGMISTQP GSTPLASFKI LSLEETESHG SYSSGNDIGP FGERDDQQVF 500
    IQKVVPITNK LFVRLSSTGK RICEIQAVDC TTISSFTVRE CEGSSRMGSR 550
    PRRYLFTGHT NGSIQMWDLT TAMDMVNKSE DKDVGGPTEE ELLKLLDQCD 600
    LSTSRCATPN ISPATSVVQH SHLRESNSSL QLQHHDTTHE AATYGSMRPY 650
    RESPLLARAR RTESFHSYRD FQTINLNRNV ERAVPENGNL GPIQAEVKGA 700
    TGECNISERK SPGVEIKSLR ELDSGLEVHK IAEGFSESKK RSSEDENENK 750
    IEFRKKGGFE GGGFLGRKKV PYLASSPSTS DGGTDSPGTA SPSPTKTTPS 800
    PRHKKSDSSG QEYSL 815
    Length:815
    Mass (Da):88,984
    Last modified:August 22, 2006 - v2
    Checksum:i65131F449069B5B9
    GO
    Isoform 2 (identifier: Q9Y597-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         583-584: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:813
    Mass (Da):88,770
    Checksum:iC05036A26CBE314C
    GO
    Isoform 3 (identifier: Q9Y597-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-646: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:169
    Mass (Da):18,514
    Checksum:iBD47F0FDC67AFE56
    GO

    Sequence cautioni

    The sequence AAH13868.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti207 – 2071C → W in AAD42876. (PubMed:10508479)Curated
    Sequence conflicti503 – 5031K → I in CAD38743. (PubMed:17974005)Curated
    Sequence conflicti742 – 7421S → P in CAD38743. (PubMed:17974005)Curated
    Sequence conflicti803 – 8031H → HK in CAD38743. (PubMed:17974005)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti9 – 91F → V.1 Publication
    Corresponds to variant rs2275768 [ dbSNP | Ensembl ].
    VAR_027156

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 646646Missing in isoform 3. 1 PublicationVSP_020068Add
    BLAST
    Alternative sequencei583 – 5842Missing in isoform 2. 1 PublicationVSP_020069

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF155110 mRNA. Translation: AAD42876.1.
    AL365315, AC092799 Genomic DNA. Translation: CAD20310.1.
    CH471100 Genomic DNA. Translation: EAW93345.1.
    BC013868 mRNA. Translation: AAH13868.1. Sequence problems.
    BC037896 mRNA. Translation: AAH37896.1.
    BC094879 mRNA. Translation: AAH94879.1.
    BC117188 mRNA. Translation: AAI17189.1.
    BC126173 mRNA. Translation: AAI26174.1.
    AL833887 mRNA. Translation: CAD38743.2.
    AL834389 mRNA. Translation: CAD39051.1.
    CCDSiCCDS1515.1. [Q9Y597-1]
    RefSeqiNP_057205.2. NM_016121.3. [Q9Y597-1]
    XP_005273213.1. XM_005273156.1. [Q9Y597-2]
    UniGeneiHs.335139.

    Genome annotation databases

    EnsembliENST00000259154; ENSP00000259154; ENSG00000136636. [Q9Y597-1]
    GeneIDi51133.
    KEGGihsa:51133.
    UCSCiuc001hks.3. human. [Q9Y597-1]
    uc001hkt.3. human. [Q9Y597-2]

    Polymorphism databases

    DMDMi112823993.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF155110 mRNA. Translation: AAD42876.1 .
    AL365315 , AC092799 Genomic DNA. Translation: CAD20310.1 .
    CH471100 Genomic DNA. Translation: EAW93345.1 .
    BC013868 mRNA. Translation: AAH13868.1 . Sequence problems.
    BC037896 mRNA. Translation: AAH37896.1 .
    BC094879 mRNA. Translation: AAH94879.1 .
    BC117188 mRNA. Translation: AAI17189.1 .
    BC126173 mRNA. Translation: AAI26174.1 .
    AL833887 mRNA. Translation: CAD38743.2 .
    AL834389 mRNA. Translation: CAD39051.1 .
    CCDSi CCDS1515.1. [Q9Y597-1 ]
    RefSeqi NP_057205.2. NM_016121.3. [Q9Y597-1 ]
    XP_005273213.1. XM_005273156.1. [Q9Y597-2 ]
    UniGenei Hs.335139.

    3D structure databases

    ProteinModelPortali Q9Y597.
    SMRi Q9Y597. Positions 17-119, 412-449.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119320. 15 interactions.
    IntActi Q9Y597. 4 interactions.
    STRINGi 9606.ENSP00000259154.

    PTM databases

    PhosphoSitei Q9Y597.

    Polymorphism databases

    DMDMi 112823993.

    Proteomic databases

    MaxQBi Q9Y597.
    PaxDbi Q9Y597.
    PRIDEi Q9Y597.

    Protocols and materials databases

    DNASUi 51133.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000259154 ; ENSP00000259154 ; ENSG00000136636 . [Q9Y597-1 ]
    GeneIDi 51133.
    KEGGi hsa:51133.
    UCSCi uc001hks.3. human. [Q9Y597-1 ]
    uc001hkt.3. human. [Q9Y597-2 ]

    Organism-specific databases

    CTDi 51133.
    GeneCardsi GC01P215740.
    H-InvDB HIX0001589.
    HGNCi HGNC:21305. KCTD3.
    HPAi HPA015142.
    MIMi 613272. gene.
    neXtProti NX_Q9Y597.
    PharmGKBi PA134945859.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG316237.
    HOVERGENi HBG061001.
    InParanoidi Q9Y597.
    OMAi IILWSIQ.
    OrthoDBi EOG7P8P7H.
    PhylomeDBi Q9Y597.
    TreeFami TF313754.

    Miscellaneous databases

    GenomeRNAii 51133.
    NextBioi 53973.
    PROi Q9Y597.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y597.
    Bgeei Q9Y597.
    CleanExi HS_KCTD3.
    Genevestigatori Q9Y597.

    Family and domain databases

    Gene3Di 2.130.10.10. 2 hits.
    3.30.710.10. 1 hit.
    InterProi IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR003131. T1-type_BTB.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF02214. BTB_2. 1 hit.
    [Graphical view ]
    SMARTi SM00225. BTB. 1 hit.
    SM00320. WD40. 3 hits.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 2 hits.
    SSF54695. SSF54695. 1 hit.
    PROSITEi PS50097. BTB. 1 hit.
    PS00678. WD_REPEATS_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3), VARIANT VAL-9.
      Tissue: Brain, Lymph and Placenta.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 158-815.
      Tissue: Brain and Testis.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiKCTD3_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y597
    Secondary accession number(s): A0AV15
    , D3DTA6, Q49AG7, Q504Q9, Q6PJN6, Q8ND58, Q8NDJ0, Q8WX16
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 22, 2006
    Last sequence update: August 22, 2006
    Last modified: October 1, 2014
    This is version 113 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Reacts with sera from 5-25 per cent of cancer patients but not with sera from normal donors. Seventy per cent of renal cancer patients have antibodies against one or a panel of these antigens.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3