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Q9Y597 (KCTD3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
BTB/POZ domain-containing protein KCTD3
Alternative name(s):
Renal carcinoma antigen NY-REN-45
Gene names
Name:KCTD3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length815 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Tissue specificity

Broadly expressed in normal tissues. Ref.1

Miscellaneous

Reacts with sera from 5-25 per cent of cancer patients but not with sera from normal donors. Seventy per cent of renal cancer patients have antibodies against one or a panel of these antigens.

Sequence similarities

Belongs to the KCTD3 family.

Contains 1 BTB (POZ) domain.

Contains 5 WD repeats.

Sequence caution

The sequence AAH13868.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainRepeat
WD repeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processprotein homooligomerization

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9Y597-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9Y597-2)

The sequence of this isoform differs from the canonical sequence as follows:
     583-584: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q9Y597-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-646: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 815815BTB/POZ domain-containing protein KCTD3
PRO_0000247839

Regions

Domain18 – 8770BTB
Repeat224 – 27148WD 1
Repeat276 – 31338WD 2
Repeat315 – 35036WD 3
Repeat419 – 45739WD 4
Repeat537 – 57741WD 5

Natural variations

Alternative sequence1 – 646646Missing in isoform 3.
VSP_020068
Alternative sequence583 – 5842Missing in isoform 2.
VSP_020069
Natural variant91F → V. Ref.4
Corresponds to variant rs2275768 [ dbSNP | Ensembl ].
VAR_027156

Experimental info

Sequence conflict2071C → W in AAD42876. Ref.1
Sequence conflict5031K → I in CAD38743. Ref.5
Sequence conflict7421S → P in CAD38743. Ref.5
Sequence conflict8031H → HK in CAD38743. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified August 22, 2006. Version 2.
Checksum: 65131F449069B5B9

FASTA81588,984
        10         20         30         40         50         60 
MAGGHCGSFP AAAAGSGEIV QLNVGGTRFS TSRQTLMWIP DSFFSSLLSG RISTLRDETG 

        70         80         90        100        110        120 
AIFIDRDPAA FAPILNFLRT KELDLRGVSI NVLRHEAEFY GITPLVRRLL LCEELERSSC 

       130        140        150        160        170        180 
GSVLFHGYLP PPGIPSRKIN NTVRSADSRN GLNSTEGEAR GNGTQPVLSG TGEETVRLGF 

       190        200        210        220        230        240 
PVDPRKVLIV AGHHNWIVAA YAHFAVCYRI KESSGWQQVF TSPYLDWTIE RVALNAKVVG 

       250        260        270        280        290        300 
GPHGDKDKMV AVASESSIIL WSVQDGGSGS EIGVFSLGVP VDALFFIGNQ LVATSHTGKV 

       310        320        330        340        350        360 
GVWNAVTQHW QVQDVVPITS YDTAGSFLLL GCNNGSIYYI DMQKFPLRMK DNDLLVTELY 

       370        380        390        400        410        420 
HDPSNDAITA LSVYLTPKTS VSGNWIEIAY GTSSGAVRVI VQHPETVGSG PQLFQTFTVH 

       430        440        450        460        470        480 
RSPVTKIMLS EKHLVSVCAD NNHVRTWTVT RFRGMISTQP GSTPLASFKI LSLEETESHG 

       490        500        510        520        530        540 
SYSSGNDIGP FGERDDQQVF IQKVVPITNK LFVRLSSTGK RICEIQAVDC TTISSFTVRE 

       550        560        570        580        590        600 
CEGSSRMGSR PRRYLFTGHT NGSIQMWDLT TAMDMVNKSE DKDVGGPTEE ELLKLLDQCD 

       610        620        630        640        650        660 
LSTSRCATPN ISPATSVVQH SHLRESNSSL QLQHHDTTHE AATYGSMRPY RESPLLARAR 

       670        680        690        700        710        720 
RTESFHSYRD FQTINLNRNV ERAVPENGNL GPIQAEVKGA TGECNISERK SPGVEIKSLR 

       730        740        750        760        770        780 
ELDSGLEVHK IAEGFSESKK RSSEDENENK IEFRKKGGFE GGGFLGRKKV PYLASSPSTS 

       790        800        810 
DGGTDSPGTA SPSPTKTTPS PRHKKSDSSG QEYSL 

« Hide

Isoform 2 [UniParc].

Checksum: C05036A26CBE314C
Show »

FASTA81388,770
Isoform 3 [UniParc].

Checksum: BD47F0FDC67AFE56
Show »

FASTA16918,514

References

« Hide 'large scale' references
[1]"Antigens recognized by autologous antibody in patients with renal-cell carcinoma."
Scanlan M.J., Gordan J.D., Williamson B., Stockert E., Bander N.H., Jongeneel C.V., Gure A.O., Jaeger D., Jaeger E., Knuth A., Chen Y.-T., Old L.J.
Int. J. Cancer 83:456-464(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
[2]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3), VARIANT VAL-9.
Tissue: Brain, Lymph and Placenta.
[5]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 158-815.
Tissue: Brain and Testis.
[6]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[7]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF155110 mRNA. Translation: AAD42876.1.
AL365315, AC092799 Genomic DNA. Translation: CAD20310.1.
CH471100 Genomic DNA. Translation: EAW93345.1.
BC013868 mRNA. Translation: AAH13868.1. Sequence problems.
BC037896 mRNA. Translation: AAH37896.1.
BC094879 mRNA. Translation: AAH94879.1.
BC117188 mRNA. Translation: AAI17189.1.
BC126173 mRNA. Translation: AAI26174.1.
AL833887 mRNA. Translation: CAD38743.2.
AL834389 mRNA. Translation: CAD39051.1.
RefSeqNP_057205.2. NM_016121.3.
XP_005273213.1. XM_005273156.1.
UniGeneHs.335139.

3D structure databases

ProteinModelPortalQ9Y597.
SMRQ9Y597. Positions 20-107, 270-450.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid119320. 15 interactions.
IntActQ9Y597. 4 interactions.
STRING9606.ENSP00000259154.

PTM databases

PhosphoSiteQ9Y597.

Polymorphism databases

DMDM112823993.

Proteomic databases

PaxDbQ9Y597.
PRIDEQ9Y597.

Protocols and materials databases

DNASU51133.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000259154; ENSP00000259154; ENSG00000136636. [Q9Y597-1]
GeneID51133.
KEGGhsa:51133.
UCSCuc001hks.3. human. [Q9Y597-1]
uc001hkt.3. human. [Q9Y597-2]

Organism-specific databases

CTD51133.
GeneCardsGC01P215740.
H-InvDBHIX0001589.
HGNCHGNC:21305. KCTD3.
HPAHPA015142.
MIM613272. gene.
neXtProtNX_Q9Y597.
PharmGKBPA134945859.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG316237.
HOVERGENHBG061001.
InParanoidQ9Y597.
OMAIILWSIQ.
OrthoDBEOG7P8P7H.
PhylomeDBQ9Y597.
TreeFamTF313754.

Gene expression databases

ArrayExpressQ9Y597.
BgeeQ9Y597.
CleanExHS_KCTD3.
GenevestigatorQ9Y597.

Family and domain databases

Gene3D2.130.10.10. 2 hits.
3.30.710.10. 1 hit.
InterProIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR003131. T1-type_BTB.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamPF02214. BTB_2. 1 hit.
[Graphical view]
SMARTSM00225. BTB. 1 hit.
SM00320. WD40. 3 hits.
[Graphical view]
SUPFAMSSF50978. SSF50978. 2 hits.
SSF54695. SSF54695. 1 hit.
PROSITEPS50097. BTB. 1 hit.
PS00678. WD_REPEATS_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi51133.
NextBio53973.
PROQ9Y597.
SOURCESearch...

Entry information

Entry nameKCTD3_HUMAN
AccessionPrimary (citable) accession number: Q9Y597
Secondary accession number(s): A0AV15 expand/collapse secondary AC list , D3DTA6, Q49AG7, Q504Q9, Q6PJN6, Q8ND58, Q8NDJ0, Q8WX16
Entry history
Integrated into UniProtKB/Swiss-Prot: August 22, 2006
Last sequence update: August 22, 2006
Last modified: March 19, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM