KCTD3

Functionⁱ

Miscellaneous

Reacts with sera from 5-25 per cent of cancer patients but not with sera from normal donors. Seventy per cent of renal cancer patients have antibodies against one or a panel of these antigens.

GO - Biological processⁱ

protein homooligomerization Source: InterPro

Complete GO annotation...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: BTB/POZ domain-containing protein KCTD3 Alternative name(s): Renal carcinoma antigen NY-REN-45
Gene namesⁱ	Name:KCTD3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:21305. KCTD3.

HGNCⁱ

HGNC:21305. KCTD3.

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000136636.
PharmGKBⁱ	PA134945859.

Polymorphism and mutation databases

BioMutaⁱ	KCTD3.
DMDMⁱ	112823993.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000247839	1 – 815	BTB/POZ domain-containing protein KCTD3Add BLAST		815

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	604	PhosphoserineCombined sources	1
Modified residueⁱ	664	PhosphoserineCombined sources	1
Modified residueⁱ	711	PhosphoserineCombined sources	1
Modified residueⁱ	793	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q9Y597.
PaxDbⁱ	Q9Y597.
PeptideAtlas More...PeptideAtlasⁱ	Q9Y597.
PRIDEⁱ	Q9Y597.

PTM databases

iPTMnetⁱ	Q9Y597.
PhosphoSitePlusⁱ	Q9Y597.

Expressionⁱ

Tissue specificityⁱ

Broadly expressed in normal tissues.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000136636.
CleanExⁱ	HS_KCTD3.
ExpressionAtlasⁱ	Q9Y597. baseline and differential.
Genevisibleⁱ	Q9Y597. HS.

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA015142.

HPAⁱ

HPA015142.

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	119320. 42 interactors.
IntActⁱ	Q9Y597. 11 interactors.
STRINGⁱ	9606.ENSP00000259154.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9Y597.
SMRⁱ	Q9Y597.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	18 – 87	BTBPROSITE-ProRule annotationAdd BLAST	70
Repeatⁱ	174 – 218	WD 1Add BLAST	45
Repeatⁱ	224 – 263	WD 2Add BLAST	40
Repeatⁱ	270 – 305	WD 3Add BLAST	36
Repeatⁱ	310 – 342	WD 4Add BLAST	33
Repeatⁱ	354 – 404	WD 5Add BLAST	51
Repeatⁱ	412 – 449	WD 6Add BLAST	38
Repeatⁱ	457 – 504	WD 7Add BLAST	48
Repeatⁱ	510 – 569	WD 8Add BLAST	60

Sequence similaritiesⁱ

Belongs to the KCTD3 family.Curated

Keywords - Domainⁱ

Repeat, WD repeat

Phylogenomic databases

eggNOGⁱ	KOG2714. Eukaryota. ENOG410XSWI. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000062980.
HOVERGENⁱ	HBG061001.
InParanoidⁱ	Q9Y597.
OMAⁱ	IILWSIQ.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0391.
PhylomeDBⁱ	Q9Y597.
TreeFamⁱ	TF313754.

Family and domain databases

Gene3Dⁱ	2.130.10.10. 2 hits.
InterProⁱ	View protein in InterPro IPR000210. BTB/POZ_dom. IPR011333. SKP1/BTB/POZ. IPR003131. T1-type_BTB. IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR019775. WD40_repeat_CS. IPR017986. WD40_repeat_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02214. BTB_2. 1 hit.
SMARTⁱ	View protein in SMART SM00225. BTB. 1 hit. SM00320. WD40. 3 hits.
SUPFAMⁱ	SSF50978. SSF50978. 2 hits. SSF54695. SSF54695. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50097. BTB. 1 hit. PS00678. WD_REPEATS_1. 1 hit.

Sequences (3)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: Q9Y597-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGGHCGSFP AAAAGSGEIV QLNVGGTRFS TSRQTLMWIP DSFFSSLLSG 
        60         70         80         90        100
RISTLRDETG AIFIDRDPAA FAPILNFLRT KELDLRGVSI NVLRHEAEFY 
       110        120        130        140        150
GITPLVRRLL LCEELERSSC GSVLFHGYLP PPGIPSRKIN NTVRSADSRN 
       160        170        180        190        200
GLNSTEGEAR GNGTQPVLSG TGEETVRLGF PVDPRKVLIV AGHHNWIVAA 
       210        220        230        240        250
YAHFAVCYRI KESSGWQQVF TSPYLDWTIE RVALNAKVVG GPHGDKDKMV 
       260        270        280        290        300
AVASESSIIL WSVQDGGSGS EIGVFSLGVP VDALFFIGNQ LVATSHTGKV 
       310        320        330        340        350
GVWNAVTQHW QVQDVVPITS YDTAGSFLLL GCNNGSIYYI DMQKFPLRMK 
       360        370        380        390        400
DNDLLVTELY HDPSNDAITA LSVYLTPKTS VSGNWIEIAY GTSSGAVRVI 
       410        420        430        440        450
VQHPETVGSG PQLFQTFTVH RSPVTKIMLS EKHLVSVCAD NNHVRTWTVT 
       460        470        480        490        500
RFRGMISTQP GSTPLASFKI LSLEETESHG SYSSGNDIGP FGERDDQQVF 
       510        520        530        540        550
IQKVVPITNK LFVRLSSTGK RICEIQAVDC TTISSFTVRE CEGSSRMGSR 
       560        570        580        590        600
PRRYLFTGHT NGSIQMWDLT TAMDMVNKSE DKDVGGPTEE ELLKLLDQCD 
       610        620        630        640        650
LSTSRCATPN ISPATSVVQH SHLRESNSSL QLQHHDTTHE AATYGSMRPY 
       660        670        680        690        700
RESPLLARAR RTESFHSYRD FQTINLNRNV ERAVPENGNL GPIQAEVKGA 
       710        720        730        740        750
TGECNISERK SPGVEIKSLR ELDSGLEVHK IAEGFSESKK RSSEDENENK 
       760        770        780        790        800
IEFRKKGGFE GGGFLGRKKV PYLASSPSTS DGGTDSPGTA SPSPTKTTPS 
       810 
PRHKKSDSSG QEYSL

Length:815

Mass (Da):88,984

Last modified:August 22, 2006 - v2

Checksum:ⁱ65131F449069B5B9

GO

Isoform 2 (identifier: Q9Y597-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
583-584: Missing.

« Hide

        10         20         30         40         50
MAGGHCGSFP AAAAGSGEIV QLNVGGTRFS TSRQTLMWIP DSFFSSLLSG 
        60         70         80         90        100
RISTLRDETG AIFIDRDPAA FAPILNFLRT KELDLRGVSI NVLRHEAEFY 
       110        120        130        140        150
GITPLVRRLL LCEELERSSC GSVLFHGYLP PPGIPSRKIN NTVRSADSRN 
       160        170        180        190        200
GLNSTEGEAR GNGTQPVLSG TGEETVRLGF PVDPRKVLIV AGHHNWIVAA 
       210        220        230        240        250
YAHFAVCYRI KESSGWQQVF TSPYLDWTIE RVALNAKVVG GPHGDKDKMV 
       260        270        280        290        300
AVASESSIIL WSVQDGGSGS EIGVFSLGVP VDALFFIGNQ LVATSHTGKV 
       310        320        330        340        350
GVWNAVTQHW QVQDVVPITS YDTAGSFLLL GCNNGSIYYI DMQKFPLRMK 
       360        370        380        390        400
DNDLLVTELY HDPSNDAITA LSVYLTPKTS VSGNWIEIAY GTSSGAVRVI 
       410        420        430        440        450
VQHPETVGSG PQLFQTFTVH RSPVTKIMLS EKHLVSVCAD NNHVRTWTVT 
       460        470        480        490        500
RFRGMISTQP GSTPLASFKI LSLEETESHG SYSSGNDIGP FGERDDQQVF 
       510        520        530        540        550
IQKVVPITNK LFVRLSSTGK RICEIQAVDC TTISSFTVRE CEGSSRMGSR 
       560        570        580        590        600
PRRYLFTGHT NGSIQMWDLT TAMDMVNKSE DKGGPTEEEL LKLLDQCDLS 
       610        620        630        640        650
TSRCATPNIS PATSVVQHSH LRESNSSLQL QHHDTTHEAA TYGSMRPYRE 
       660        670        680        690        700
SPLLARARRT ESFHSYRDFQ TINLNRNVER AVPENGNLGP IQAEVKGATG 
       710        720        730        740        750
ECNISERKSP GVEIKSLREL DSGLEVHKIA EGFSESKKRS SEDENENKIE 
       760        770        780        790        800
FRKKGGFEGG GFLGRKKVPY LASSPSTSDG GTDSPGTASP SPTKTTPSPR 
       810 
HKKSDSSGQE YSL

Note: No experimental confirmation available.

Show »

Length:813

Mass (Da):88,770

Checksum:ⁱC05036A26CBE314C

GO

Isoform 3 (identifier: Q9Y597-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-646: Missing.

« Hide

        10         20         30         40         50
MRPYRESPLL ARARRTESFH SYRDFQTINL NRNVERAVPE NGNLGPIQAE 
        60         70         80         90        100
VKGATGECNI SERKSPGVEI KSLRELDSGL EVHKIAEGFS ESKKRSSEDE 
       110        120        130        140        150
NENKIEFRKK GGFEGGGFLG RKKVPYLASS PSTSDGGTDS PGTASPSPTK 
       160 
TTPSPRHKKS DSSGQEYSL

Note: No experimental confirmation available.

Show »

Length:169

Mass (Da):18,514

Checksum:ⁱBD47F0FDC67AFE56

GO

Sequence cautionⁱ

The sequence AAH13868 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	207	C → W in AAD42876 (PubMed:10508479).Curated	1
Sequence conflictⁱ	503	K → I in CAD38743 (PubMed:17974005).Curated	1
Sequence conflictⁱ	742	S → P in CAD38743 (PubMed:17974005).Curated	1
Sequence conflictⁱ	803	H → HK in CAD38743 (PubMed:17974005).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_027156	9	F → V1 PublicationCorresponds to variant dbSNP:rs2275768Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_020068	1 – 646	Missing in isoform 3. 1 PublicationAdd BLAST		646
Alternative sequenceⁱVSP_020069	583 – 584	Missing in isoform 2. 1 Publication		2

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF155110 mRNA. Translation: AAD42876.1. AL365315, AC092799 Genomic DNA. Translation: CAD20310.1. CH471100 Genomic DNA. Translation: EAW93345.1. BC013868 mRNA. Translation: AAH13868.1. Sequence problems. BC037896 mRNA. Translation: AAH37896.1. BC094879 mRNA. Translation: AAH94879.1. BC117188 mRNA. Translation: AAI17189.1. BC126173 mRNA. Translation: AAI26174.1. AL833887 mRNA. Translation: CAD38743.2. AL834389 mRNA. Translation: CAD39051.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1515.1. [Q9Y597-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001306223.1. NM_001319294.1. [Q9Y597-2] NP_001306224.1. NM_001319295.1. NP_057205.2. NM_016121.4. [Q9Y597-1]
UniGeneⁱ	Hs.335139.

Genome annotation databases

Ensemblⁱ	ENST00000259154; ENSP00000259154; ENSG00000136636. [Q9Y597-1]
GeneIDⁱ	51133.
KEGGⁱ	hsa:51133.
UCSC genome browser More...UCSCⁱ	uc001hks.5. human. [Q9Y597-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
Q9Y597	H2Q150 Q9Y597-3 B4DJX2	Homo sapiens (Human) Pan troglodytes (Chimpanzee)	815	UniRef100_Q9Y597	Cluster: BTB/POZ domain-containing protein KCTD3	4

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
Q9Y597	H2Q150 Q9Y597-3 B4DJX2 UPI0004DFF6BE UPI0003F13529 F6ZPV3 UPI0009521840 UPI000950CC90 UPI000A1B783B UPI000A1B7E71 +56	Homo sapiens (Human) Pan troglodytes (Chimpanzee) Ursus maritimus (Polar bear) (Thalarctos maritimus) Pteropus alecto (Black flying fox) Monodelphis domestica (Gray short-tailed opossum) Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus) Odocoileus virginianus texanus Cebus capucinus imitator Oryctolagus cuniculus (Rabbit) Ailuropoda melanoleuca (Giant panda) And more	815	UniRef90_Q9Y597	Cluster: BTB/POZ domain-containing protein KCTD3	67
Q9Y597-2	UPI0003F060D7 UPI00080A003D UPI000A2814ED UPI000980FC8F UPI000762418A UPI00062BB152 UPI000952D9F1 UPI0004420EB2 U3FJ84 UPI0003EE0622 +45	Elephantulus edwardii (Cape long-eared elephant shrew) Cebus capucinus imitator Phascolarctos cinereus (Koala) Castor canadensis (Beaver) Marmota marmota marmota (Alpine marmot) Orcinus orca (Killer whale) Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus) Lipotes vexillifer (Yangtze river dolphin) Callithrix jacchus (White-tufted-ear marmoset) Leptonychotes weddellii (Weddell seal) And more	813	UniRef90_Q9Y597-2	Cluster: Isoform 2 of BTB/POZ domain-containing protein KCTD3	56

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
Q9Y597	H2Q150 Q9Y597-3 B4DJX2 UPI0004DFF6BE UPI0003F13529 F6ZPV3 UPI00005C1271 UPI000A282AB2 UPI0001E87C47 UPI000980C76D +71	Homo sapiens (Human) Pan troglodytes (Chimpanzee) Ursus maritimus (Polar bear) (Thalarctos maritimus) Pteropus alecto (Black flying fox) Monodelphis domestica (Gray short-tailed opossum) Bos taurus (Bovine) Phascolarctos cinereus (Koala) Sus scrofa (Pig) Castor canadensis (Beaver) Ailuropoda melanoleuca (Giant panda) And more	815	UniRef50_Q9Y597	Cluster: BTB/POZ domain-containing protein KCTD3	82
Q9Y597-2	Q6P7W2 UPI0003D6DCE3 UPI000945BDE1 A0A0A0MWL5 A0A1D5Q4G9 H9F720 UPI00038EA5C8 UPI000A319FE3 L8IVR4 UPI0003EAFFED +475	Mus musculus (Mouse) Rhinolophus sinicus (Chinese rufous horseshoe bat) Papio anubis (Olive baboon) Macaca mulatta (Rhesus macaque) Chinchilla lanigera (Long-tailed chinchilla) (Chinchilla villidera) Mus caroli (Ryukyu mouse) (Ricefield mouse) Bos mutus (wild yak) Homo sapiens (Human) Macaca nemestrina (Pig-tailed macaque) Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana) And more	704	UniRef50_Q6P7W2	Cluster: SH3KBP1-binding protein 1	486

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF155110 mRNA. Translation: AAD42876.1. AL365315, AC092799 Genomic DNA. Translation: CAD20310.1. CH471100 Genomic DNA. Translation: EAW93345.1. BC013868 mRNA. Translation: AAH13868.1. Sequence problems. BC037896 mRNA. Translation: AAH37896.1. BC094879 mRNA. Translation: AAH94879.1. BC117188 mRNA. Translation: AAI17189.1. BC126173 mRNA. Translation: AAI26174.1. AL833887 mRNA. Translation: CAD38743.2. AL834389 mRNA. Translation: CAD39051.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1515.1. [Q9Y597-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001306223.1. NM_001319294.1. [Q9Y597-2] NP_001306224.1. NM_001319295.1. NP_057205.2. NM_016121.4. [Q9Y597-1]
UniGeneⁱ	Hs.335139.

3D structure databases

ProteinModelPortalⁱ	Q9Y597.
SMRⁱ	Q9Y597.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	119320. 42 interactors.
IntActⁱ	Q9Y597. 11 interactors.
STRINGⁱ	9606.ENSP00000259154.

PTM databases

iPTMnetⁱ	Q9Y597.
PhosphoSitePlusⁱ	Q9Y597.

Polymorphism and mutation databases

BioMutaⁱ	KCTD3.
DMDMⁱ	112823993.

Proteomic databases

EPDⁱ	Q9Y597.
PaxDbⁱ	Q9Y597.
PeptideAtlas More...PeptideAtlasⁱ	Q9Y597.
PRIDEⁱ	Q9Y597.

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	51133.
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000259154; ENSP00000259154; ENSG00000136636. [Q9Y597-1]
GeneIDⁱ	51133.
KEGGⁱ	hsa:51133.
UCSC genome browser More...UCSCⁱ	uc001hks.5. human. [Q9Y597-1]

Organism-specific databases

CTDⁱ	51133.
GeneCardsⁱ	KCTD3.
H-InvDBⁱ	HIX0001589.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:21305. KCTD3.
Human Protein Atlas More...HPAⁱ	HPA015142.
MIMⁱ	613272. gene.
neXtProtⁱ	NX_Q9Y597.
Open Targets More...OpenTargetsⁱ	ENSG00000136636.
PharmGKBⁱ	PA134945859.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2714. Eukaryota. ENOG410XSWI. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000062980.
HOVERGENⁱ	HBG061001.
InParanoidⁱ	Q9Y597.
OMAⁱ	IILWSIQ.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0391.
PhylomeDBⁱ	Q9Y597.
TreeFamⁱ	TF313754.

Miscellaneous databases

ChiTaRSⁱ	KCTD3. human.
GenomeRNAiⁱ	51133.
Protein Ontology More...PROⁱ	PR:Q9Y597.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000136636.
CleanExⁱ	HS_KCTD3.
ExpressionAtlasⁱ	Q9Y597. baseline and differential.
Genevisibleⁱ	Q9Y597. HS.

Family and domain databases

Gene3Dⁱ	2.130.10.10. 2 hits.
InterProⁱ	View protein in InterPro IPR000210. BTB/POZ_dom. IPR011333. SKP1/BTB/POZ. IPR003131. T1-type_BTB. IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR019775. WD40_repeat_CS. IPR017986. WD40_repeat_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02214. BTB_2. 1 hit.
SMARTⁱ	View protein in SMART SM00225. BTB. 1 hit. SM00320. WD40. 3 hits.
SUPFAMⁱ	SSF50978. SSF50978. 2 hits. SSF54695. SSF54695. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50097. BTB. 1 hit. PS00678. WD_REPEATS_1. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	KCTD3_HUMAN
Accessionⁱ	Q9Y597Primary (citable) accession number: Q9Y597 Secondary accession number(s): A0AV15 Q8WX16
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 22, 2006
	Last sequence update:	August 22, 2006
	Last modified:	August 30, 2017
	This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

UniProtKB

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UniProtKB - Q9Y597 (KCTD3_HUMAN)

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BTB/POZ domain-containing protein KCTD3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequences (3)ⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ