Q9Y592 (CCD41_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Coiled-coil domain-containing protein 41

Alternative name(s):
Renal carcinoma antigen NY-REN-58

Gene names

Name:

CCDC41

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	693 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence caution

The sequence AAD42881.1 differs from that shown. Reason: Frameshift at positions 105, 590 and 601.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9Y592-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9Y592-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: Missing.
     562-593: RKSLHENKLKRLQEKVEVLEAKKEELETENQV → LEQDLELGCPSVTDTYRESVFPPPPLKRDLLK
     594-693: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 693	693	Coiled-coil domain-containing protein 41		PRO_0000234495
Regions
	Coiled coil	32 – 626	595	Potential
	Coiled coil	657 – 690	34	Potential
Natural variations
	Alternative sequence	1 – 25	25	Missing in isoform 2.		VSP_037760
	Alternative sequence	562 – 593	32	RKSLH…TENQV → LEQDLELGCPSVTDTYRESV FPPPPLKRDLLK in isoform 2.		VSP_037761
	Alternative sequence	594 – 693	100	Missing in isoform 2.		VSP_037762
	Natural variant	70	1	Q → R. Corresponds to variant rs2271979 [ dbSNP | Ensembl ].		VAR_058397
Experimental info
	Sequence conflict	259	1	E → G in AAD42881. Ref.1
	Sequence conflict	336	1	I → L in AAD42881. Ref.1
	Sequence conflict	536	1	E → D in AAD42881. Ref.1
	Sequence conflict	537	1	R → C in AAI25087. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 16, 2006. Version 2. Checksum: 0310952944AE6970	FASTA	693	82,059
	10 20 30 40 50 60 MDTFPNNFPP GGDSGLTGSQ SEFQKMLIDE RLRCEHHKAN YQTLKAEHTR LQNEHVKLQN 70 80 90 100 110 120 ELKHLFNEKQ TQQEKLQLLL EELRGELVEK TKDLEEMKLQ ILTPQKLELL RAQIQQELET 130 140 150 160 170 180 PMRERFRNLD EEVEKYRAVY NKLRYEHTFL KSEFEHQKEE YARILDEGKI KYESEIARLE 190 200 210 220 230 240 EDKEELRNQL LNVDLTKDSK RVEQLAREKV YLCQKLKGLE AEVAELKAEK ENSEAQVENA 250 260 270 280 290 300 QRIQVRQLAE MQATVRSLEA EKQSANLRAE RLEKELQSSS EQNTFLINKL HKAEREINTL 310 320 330 340 350 360 SSKVKELKHS NKLEITDIKL ETARAKSELE RERNKIQSEL DGLQSDNEIL KAAVEHHKVL 370 380 390 400 410 420 LVEKDRELIR KVQAAKEEGY QKLVVLQDEK LELENRLADL EKMKVEHDVW RQSEKDQYEE 430 440 450 460 470 480 KLRASQMAEE ITRKELQSVR LKLQQQIVTI ENAEKEKNEN SDLKQQISSL QIQVTSLAQS 490 500 510 520 530 540 ENDLLNSNQM LKEMVERLKQ ECRNFRSQAE KAQLEAEKTL EEKQIQWLEE KHKLHERITD 550 560 570 580 590 600 REEKYNQAKE KLQRAAIAQK KRKSLHENKL KRLQEKVEVL EAKKEELETE NQVLNRQNVP 610 620 630 640 650 660 FEDYTRLQKR LKDIQRRHNE FRSLILVPNM PPTASINPVS FQSSAMVPSM ELPFPPHMQE 670 680 690 EQHQRELSLL RKRLEELETT QRKQLEELGS SGE
	Isoform 2 [UniParc]. Checksum: 870DDD0933F30FD7	FASTA	568	67,408
	10 20 30 40 50 60 MLIDERLRCE HHKANYQTLK AEHTRLQNEH VKLQNELKHL FNEKQTQQEK LQLLLEELRG 70 80 90 100 110 120 ELVEKTKDLE EMKLQILTPQ KLELLRAQIQ QELETPMRER FRNLDEEVEK YRAVYNKLRY 130 140 150 160 170 180 EHTFLKSEFE HQKEEYARIL DEGKIKYESE IARLEEDKEE LRNQLLNVDL TKDSKRVEQL 190 200 210 220 230 240 AREKVYLCQK LKGLEAEVAE LKAEKENSEA QVENAQRIQV RQLAEMQATV RSLEAEKQSA 250 260 270 280 290 300 NLRAERLEKE LQSSSEQNTF LINKLHKAER EINTLSSKVK ELKHSNKLEI TDIKLETARA 310 320 330 340 350 360 KSELERERNK IQSELDGLQS DNEILKAAVE HHKVLLVEKD RELIRKVQAA KEEGYQKLVV 370 380 390 400 410 420 LQDEKLELEN RLADLEKMKV EHDVWRQSEK DQYEEKLRAS QMAEEITRKE LQSVRLKLQQ 430 440 450 460 470 480 QIVTIENAEK EKNENSDLKQ QISSLQIQVT SLAQSENDLL NSNQMLKEMV ERLKQECRNF 490 500 510 520 530 540 RSQAEKAQLE AEKTLEEKQI QWLEEKHKLH ERITDREEKY NQAKEKLQRA AIAQKKLEQD 550 560 LELGCPSVTD TYRESVFPPP PLKRDLLK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Antigens recognized by autologous antibody in patients with renal-cell carcinoma." Scanlan M.J., Gordan J.D., Williamson B., Stockert E., Bander N.H., Jongeneel C.V., Gure A.O., Jaeger D., Jaeger E., Knuth A., Chen Y.-T., Old L.J. Int. J. Cancer 83:456-464(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), IDENTIFICATION AS A RENAL CANCER ANTIGEN.
[2]	"The finished DNA sequence of human chromosome 12." Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A. Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-634 (ISOFORM 1). Tissue: Retinoblastoma.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-559 (ISOFORM 1).
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF155115 mRNA. Translation: AAD42881.1. Frameshift. AC073655 Genomic DNA. No translation available. BC053614 mRNA. No translation available. BC125086 mRNA. Translation: AAI25087.1. BC125087 mRNA. Translation: AAI25088.1. AK056316 mRNA. No translation available.
IPI	IPI00180681. IPI00796371.
RefSeq	NP_057206.2. NM_016122.2.
UniGene	Hs.279209.
3D structure databases
ProteinModelPortal	Q9Y592.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-1790539.
STRING	9606.ENSP00000344655.
PTM databases
PhosphoSite	Q9Y592.
Polymorphism databases
DMDM	97045295.
Proteomic databases
PaxDb	Q9Y592.
PRIDE	Q9Y592.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000397807; ENSP00000380909; ENSG00000173588. ENST00000547232; ENSP00000447783; ENSG00000173588.
GeneID	51134.
KEGG	hsa:51134.
UCSC	uc001tdd.3. human.
Organism-specific databases
CTD	51134.
GeneCards	GC12M094702.
HGNC	HGNC:17966. CCDC41.
HPA	HPA038161.
neXtProt	NX_Q9Y592.
PharmGKB	PA142672158.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG125204.
HOGENOM	HOG000111412.
HOVERGEN	HBG053993.
InParanoid	Q9Y592.
KO	K16754.
OrthoDB	EOG418BMX.
Gene expression databases
ArrayExpress	Q9Y592.
Bgee	Q9Y592.
CleanEx	HS_CCDC41.
Genevestigator	Q9Y592.
GermOnline	ENSG00000173588. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other
ChiTaRS	CCDC41. human.
GenomeRNAi	51134.
NextBio	53977.

Entry information

Entry name

CCD41_HUMAN

Accession

Primary (citable) accession number: Q9Y592
Secondary accession number(s): A4FVB1, Q08AP1

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 16, 2006
Last sequence update:	May 16, 2006
Last modified:	April 3, 2013
This is version 73 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.