Reviewed,
UniProtKB/Swiss-Prot Q9Y587 (AP4S1_HUMAN)
Last modified
November 24, 2009.
Version 70.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: AP-4 complex subunit sigma-1 Alternative name(s): Adapter-related protein complex 4 subunit sigma-1 AP-4 adapter complex subunit sigma-1 Sigma-1 subunit of AP-4 Sigma4-adaptin | ||
| Gene names |
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| Organism | Homo sapiens (Human) [Complete proteome] | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 144 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Subunit of novel type of clathrin- or non-clathrin-associated protein coat involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. |
| Subunit structure | Adapter-like complex 4 (AP-4) is a heterotetramer composed of two large adaptins (epsilon-type subunit AP4E1 and beta-type subunitAP4B1), a medium adaptin (mu-type subunit AP4M1) and a small adaptin (sigma-type AP4S1). |
| Subcellular location | Golgi apparatus › trans-Golgi network. Membrane › coated pit. Note: Associated with the trans-Golgi network. Found in soma and dendritic shafts of neuronal cells. |
| Tissue specificity | Widely expressed. |
| Sequence similarities | Belongs to the adaptor complexes small subunit family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Protein transport Transport |
| Cellular component | Coated pit Golgi apparatus Membrane |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | intracellular protein transport Inferred from electronic annotation. Source: InterPro vesicle-mediated transportInferred from electronic annotation. Source: InterPro |
| Cellular component | Golgi apparatus Inferred from electronic annotation. Source: UniProtKB-KW coated pitInferred from electronic annotation. Source: UniProtKB-SubCell membrane coatInferred from electronic annotation. Source: InterPro |
| Molecular function | protein binding Inferred from electronic annotation. Source: InterPro protein transporter activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 144 | 144 | AP-4 complex subunit sigma-1 | PRO_0000193820 | |||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Characterization of a fourth adaptor-related protein complex." Hirst J., Bright N.A., Rous B., Robinson M.S. Mol. Biol. Cell 10:2787-2802(1999) [PubMed: 10436028] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Placenta. |
| [2] | "Identification and characterization of epsilon-adaptin that constitutes AP-4 clathrin adaptor-related complex." Takatsu H., Sakurai M., Shiba Y., Yoshida Y., Nakayama K. Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [3] | "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [4] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Trachea. |
Cross-references
Sequence databases | |
|---|---|
| AF155159 mRNA. Translation: AAD43329.1. AB030654 mRNA. Translation: BAA82970.1. CR457100 mRNA. Translation: CAG33381.1. AK304115 mRNA. Translation: BAG65016.1. | |
| IPI | IPI00001145. |
| RefSeq | NP_001121598.1. |
| UniGene | Hs.293411 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q9Y587. 1 interaction. |
| STRING | Q9Y587. |
Proteomic databases | |
| PRIDE | Q9Y587. |
Genome annotation databases | |
| Ensembl | ENST00000313566; ENSP00000322508; ENSG00000100478; Homo sapiens. [Genome view] |
| GeneID | 11154. |
| KEGG | hsa:11154. |
| UCSC | uc001wqy.2. human. |
Organism-specific databases | |
| CTD | 11154. |
| GeneCards | GC14P030564. |
| H-InvDB | HIX0020120. |
| HGNC | HGNC:575. AP4S1. |
| MIM | 607243. gene. |
| PharmGKB | PA24867. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOVERGEN | Q9Y587. |
| OMA | YYEHVEI |
| OrthoDB | EOG94XN2K |
Gene expression databases | |
| ArrayExpress | Q9Y587. |
| Bgee | Q9Y587. |
| CleanEx | HS_AP4S1. |
| Genevestigator | Q9Y587. |
| GermOnline | ENSG00000100478. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR016635. AP_complex_ssu. IPR000804. Clathrin_sigma/coatomer_zeta. IPR011012. Longin-like. [Graphical view] |
| Pfam | PF01217. Clat_adaptor_s. 1 hit. [Graphical view] |
| PIRSF | PIRSF015588. AP_complex_sigma. 1 hit. |
| PROSITE | PS00989. CLAT_ADAPTOR_S. False negative. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 42409. |
| SOURCE | Search... |
Entry information
| Entry name | AP4S1_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9Y587 Secondary accession number(s): Q6IAQ4 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 14 Human chromosome 14: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


