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Q9Y586 (MB212_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein mab-21-like 2
Gene names
Name:MAB21L2
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length359 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Required for several aspects of embryonic development including normal development of the eye By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the mab-21 family.

Ontologies

Keywords
   Cellular componentNucleus
   Molecular functionDevelopmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processnervous system development

Traceable author statement. Source: ProtInc

   Cellular componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 359359Protein mab-21-like 2
PRO_0000312787

Experimental info

Sequence conflict2351G → V in AAG09800. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9Y586 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 24AFD8AF1600C1AA

FASTA35940,923
        10         20         30         40         50         60 
MIAAQAKLVY QLNKYYTERC QARKAAIAKT IREVCKVVSD VLKEVEVQEP RFISSLSEID 

        70         80         90        100        110        120 
ARYEGLEVIS PTEFEVVLYL NQMGVFNFVD DGSLPGCAVL KLSDGRKRSM SLWVEFITAS 

       130        140        150        160        170        180 
GYLSARKIRS RFQTLVAQAV DKCSYRDVVK MIADTSEVKL RIRERYVVQI TPAFKCTGIW 

       190        200        210        220        230        240 
PRSAAQWPMP HIPWPGPNRV AEVKAEGFNL LSKECYSLTG KQSSAESDAW VLQFGEAENR 

       250        260        270        280        290        300 
LLMGGCRNKC LSVLKTLRDR HLELPGQPLN NYHMKTLLLY ECEKHPRETD WDESCLGDRL 

       310        320        330        340        350 
NGILLQLISC LQCRRCPHYF LPNLDLFQGK PHSALESAAK QTWRLAREIL TNPKSLDKL

« Hide

References

« Hide 'large scale' references
[1]"Two murine and human homologs of mab-21, a cell fate determination gene involved in Caenorhabditis elegans neural development."
Mariani M., Baldessari D., Francisconi S., Viggiano L., Rocchi M., Zappavigna V., Malgaretti N., Consalez G.G.
Hum. Mol. Genet. 8:2397-2406(1999) [PubMed: 10556287] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Analysis of the vertebrate Mab21 genes suggests conserved biological roles."
Chow K.L., Wong R.L.Y., Chan K.Y., Lau G.T.C., Wong Y.-M., Ho S.H.
Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]Zhang B., Shi L., Yuan G.J., Chiang Q.B.
Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF155219 Genomic DNA. Translation: AAD40248.1.
AF262032 mRNA. Translation: AAG09800.1.
AF370007 mRNA. Translation: AAK54206.1.
AK055665 mRNA. Translation: BAG51549.1.
BC009983 mRNA. Translation: AAH09983.1.
IPIIPI00387034.
RefSeqNP_006430.1. NM_006439.4.
UniGeneHs.584852.

3D structure databases

ProteinModelPortalQ9Y586.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ9Y586.

PTM databases

PhosphoSiteQ9Y586.

Polymorphism databases

DMDM74735281.

Proteomic databases

PRIDEQ9Y586.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000317605; ENSP00000324701; ENSG00000181541.
GeneID10586.
KEGGhsa:10586.
UCSCuc003ilw.1. human.

Organism-specific databases

CTD10586.
GeneCardsGC04P151503.
H-InvDBHIX0004564.
HGNCHGNC:6758. MAB21L2.
MIM604357. gene.
neXtProtNX_Q9Y586.
PharmGKBPA30517.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG18202.
GeneTreeENSGT00510000046791.
HOGENOMHBG381681.
HOVERGENHBG053080.
InParanoidQ9Y586.
OMANERCQAR.
OrthoDBEOG4PK280.
PhylomeDBQ9Y586.

Gene expression databases

ArrayExpressQ9Y586.
BgeeQ9Y586.
CleanExHS_MAB21L2.
GenevestigatorQ9Y586.

Family and domain databases

InterProIPR004962. Mab-21-like_2.
IPR024810. Mab-21_dom.
IPR000772. Ricin_B_lectin.
[Graphical view]
PANTHERPTHR10656:SF5. Mab-21. 1 hit.
PfamPF03281. Mab-21. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio40197.
SOURCESearch...

Entry information

Entry nameMB212_HUMAN
AccessionPrimary (citable) accession number: Q9Y586
Secondary accession number(s): B3KP37, Q9HBA7
Entry history
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: November 1, 1999
Last modified: January 25, 2012
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents